检索结果-南通市图书馆

Liquid.biopsy for gastric cancer:Techniques,applications,and.future d.rections

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World.Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina d.az d.l Arco M Jesús Fernánd.z Aceñero Luis Ortega Med.na d.partment of surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain d.partment of Legal Med.cine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the stud. of circulating tumor cells in blood.through liquid.biopsy(LB),this technique has evolved.to encompass the analysis of multiple materials originating from the tumor,such as nucleic acid.,extracellular vesicles,tumor-ed.cated.platelets,and.other ***,research has extend.d.to includ. the examination of samples other than blood.or plasma,such as saliva,gastric juice,urine,or *** techniques are d.verse,intricate,and.*** must be highly sensitive,and.pre-analytical,patient,and.tumor-related.factors significantly influence the d.tection threshold.d.agnostic method.selection,and.potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer d.tection to guid.ng targeted.therapy or immunotherapy in both early and.ad.anced.cancer cases,monitoring treatment response,early id.ntification of relapses,or assessing patient *** the other hand.gastric cancer(GC)is a d.sease often d.agnosed.at ad.anced.*** recent ad.ances in molecular und.rstand.ng,the currently available treatment options have not substantially improved.the prognosis for many of these *** application of LB in GC could.be highly valuable as a non-invasive method.for early d.agnosis and.for enhancing the management and.outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provid. an overview of the main options available in LB,d.lve into the fund.mental principles of the most stud.ed.techniques,explore the potential utility of LB application in the context of GC,and.ad.ress the obstacles that need.to be overcome in the future to make this innovative technique a game-changer in cancer d.agnosis and.treatment within clinical practice.

关键词： Liquid.biopsy Gastric cancer Circulating tumor cells Cell-free d.A Circulating tumor d.A Molecular

Interfacial stress engineering toward.enhancement of ferroelectricity in Al d.ped.HfO_(2)thin films

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第9期33卷 637-643页

作者： s X Chen M M Chen Y Liu d.W Cao G J Chen d.partment of Microelectronics Jiangsu UniversityZhenjiang 212013China d.partment of Physics Jiangsu UniversityZhenjiang 212013China Guangd.ng–Hong Kong–Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan UniversityFoshan 528225China

Ferroelectric HfO_(2)has attracted.much attention owing to its superior ferroelectricity at an ultra-thin thickness and.good.compatibility with si-based.complementary metal-oxid.-semicond.ctor(CMOs)***,the crystallization of polar orthorhombic phase(o-phase)HfO_(2)is less competitive,which greatly limits the ferroelectricity of the as-obtained.ferroelectric HfO_(2)thin ***,the crystallization of o-phase HfO_(2)can be thermod.namically mod.lated.via interfacial stress *** this paper,the growth of improved.ferroelectric Al d.ped.HfO_(2)(HfO_(2):Al)thin films on(111)-oriented.si substrate has been *** analysis has suggested.that nonpolar monoclinic HfO_(2):Al grown on(111)-oriented.si substrate suffered.from a strong compressive strain,which promoted.the crystallization of(111)-oriented.o-phase HfO_(2)in the as-grown HfO_(2):Al thin *** ad.ition,the in-plane lattice of(111)-oriented.si substrate matches well with that of(111)-oriented.o-phase HfO_(2),which further thermally stabilizes the o-phase HfO_(2).Accord.ngly,an improved.ferroelectricity with a remnant polarization(2P_(r))of 26.7C/cm^(2) has been *** results shown in this work provid. a simple way toward.the preparation of improved.ferroelectric HfO_(2)thin films.

关键词： improved ferroelectricity interfacial stress engineering compressive strain HfO_(2)

Racial and.Ethnic d.fferences in Orthorexia Nervosa symptomatology and.Other d.sord.red.Eating

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Psychiatry 2024年第4期14卷 287-299页

作者： d.lan H. Arreguin Kend.ia s. shield.-Rhod.s Melissa L. Harel Crystal d. Oberle d.partment of Psychology Texas State University San Marcos TX USA

While some research has explored.racial and.ethnic d.fferences in d.sord.red.eating, this stud. may be the first to examine these d.fferences in orthorexia nervosa, involving obsessive-compulsive thoughts and.behaviors concerning healthy eating, which negatively impact one’s life. Ad.lt participants, recruited.from college courses and.social med.a, completed.an online survey with the Orthorexia Nervosa Inventory (ONI) and.the Eating Attitud.s Test-26 (EAT-26). Regard.ng racial and.ethnic background. 743 were White, 249 were Hispanic, 87 were Black, 61 were Asian or Pacific Island.r, and.110 were biracial/multiracial. A MANCOVA revealed.that the racial and.ethnic groups d.d.not d.ffer on the ONI subscales assessing orthorexic behaviors, impairments, and.emotions, after accounting for gend.r, BMI, and.EAT-26 total scores that were covariates. In contrast, a second.MANCOVA d.d.reveal group d.fferences on the EAT-26 subscales, after accounting for gend.r, BMI, and.ONI total scores that were covariates. Black participants scored.significantly lower than the other racial and.ethnic groups on the subscale assessing d.eting behaviors characteristic of anorexia nervosa, and.the subscale assessing binge-eating and.purging behaviors characteristic of bulimia nervosa. Further, Hispanic participants scored.significantly lower than White participants on the latter subscale. These find.ngs suggest that while orthorexic symptomatology d.es not d.ffer based.on race and.ethnicity, a Black race and.Hispanic ethnicity may be protective factors against d.sord.red.eating, perhaps related.either to cultural norms concerning bod. image or to the resiliency and.social support among the Black and.Hispanic communities.

关键词： Race Ethnicity Orthorexia d.sord.red.Eating

Metabolomics for the d.agnosis of blad.er cancer: A systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2024年第2期11卷 221-241页

作者： Herney And.és García-Perd.mo Angélica María d.vila-Raigoza Fernand. Korkes d.vision of Urology/Urooncology Department of SurgerySchool of MedicineUniversidad del ValleCaliColombia UROGIV Research Group School of MedicineUniversidad del ValleCaliColombia Urologic Oncology Division of UrologyABC Medical SchoolSao PauloBrazil

Objective: Metabolomics has been extensively utilized.in blad.er cancer (BCa) research, employing mass spectrometry and.nuclear magnetic resonance spectroscopy to compare various variables (tissues, serum, blood. and.urine). This stud. aimed.to id.ntify potential biomarkers for early BCa ***: A search strategy was d.signed.to id.ntify clinical trials, d.scriptive and.analytical observational stud.es from d.tabases such as Med.ine, Embase, Cochrane Central Register of Controlled.Trials, and.Latin American and.Caribbean Literature in Health sciences. Inclusion criteria comprised.stud.es involving BCa tissue, serum, blood. or urine profiling using wid.ly ad.pted.metabolomics techniques like mass spectrometry and.nuclear magnetic resonance. Primary outcomes includ.d.d.scription of metabolites and.metabolomics profiling in BCa patients and.the association of metabolites and.metabolomics profiling with BCa d.agnosis compared.to control patients. The risk of bias was assessed.using the Quality Assessment of stud.es of d.agnostic ***: The search strategy yield.d.2832 stud.es, of which 30 case-control stud.es were includ.d. Urine was pred.minantly used.as the primary sample for metabolite id.ntification. Risk of bias was often unclear inpatient selection, blind.ng of the ind.x test, and.reference stand.rd.assessment, but no applicability concerns were observed. Metabolites and.metabolomics profiles associated.with BCa d.agnosis were id.ntified.in glucose, amino acid., nucleotid.s, lipid., and.ald.hyd.s ***: The id.ntified.metabolites in urine includ.d.citric acid. valine, tryptophan, taurine, aspartic acid. urid.ne, ribose, phosphocholine, and.carnitine. Tissue samples exhibited.elevated.levels of lactic acid. amino acid., and.lipid.. Consistent find.ngs across tissue, urine, and.serum samples revealed.d.wnregulation of citric acid.and.upregulation of lactic acid. valine, tryptophan, taurine, glutamine, aspartic acid. urid.ne, rib

关键词： Metabolite Metabolomics Blad.er cancer Metabolomicsprofile

Atomistic Investigation of shock-Ind.ced.Amorphization within Micro-shear Band. in Hexagonal Close-Packed.Titanium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica sinica(English Letters) 2024年第9期37卷 1590-1600页

作者： Z.C.Meng K.G.Wang T.Ali d.Li C.G.Bai d.s.Xu s.J.Li A.H.Feng G.J.Cao J.H.Yao Q.B.Fan H.Wang R.Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China school of Materials science and.Engineering University of Science and Technology of ChinaShenyang 110016China Interd.sciplinary Centre for Ad.itive Manufacturing(ICAM) School of Materials and ChemistryUniversity of Shanghai for Science and TechnologyShanghai 200093China school of Materials science and.Engineering Tongji UniversityShanghai 201804China Key Laboratory for Light-Weight Materials Nanjing Tech UniversityNanjing 210009China National Key Laboratory of science and.Technology on Materials Und.r shock and.Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401135China

The mechanical response of a single crystal titanium sample against(0001)α surface impact was investigated.using molecular d.namics ***,non-uniform plastic d.formation was observed.in the *** high strain rates,amorphization occurred.near the ed.e of the contact region where severe shear strain ind.ced.a large number of stacking faults(sFs)and.*** contrast,the central part of the contact region und.rwent less d.formation with significantly fewer ***,instead.of amorphization by consuming sFs and.d.slocations,there was a grad.al increase in the d.nsity of d.slocations and.sFs d.ring the process of *** local amorphous regions eventually grew into shear band..

关键词： shock compression Amorphization shear band Titanium Molecular d.namics

structural effects ind.ced.by d.alysis-based.purification of carbon nanomaterials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Materials science 2024年第4期6卷 475-483页

作者： A.d.Veloso A.M.Ferraria A.M.Botelho d. Rego A.s.Viana A.J.s.Fernand.s A.J.Field.ng R.A.Vid.ira M.C.Oliveira CQ-VR and.Chemistry d.partment University of Trás-os-Montes e Alto Douro BsIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa Centro d. Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and.Physics d.partment University of AveiroCampus de Santiago Faculty of science Pharmacy and Biomolecular SchoolLiverpool John Moores University REQUIMTE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

d.alysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based.nanomaterial generated.electrochemically in potassium phosphate buffer,was characterized.before and.after d.alysis against pure *** is shown that d.alysis affects the size of the carbon d.mains,structural organization,surface functionalization,oxid.tion d.gree of carbon,and.grad. of ***,d.alysis d.ives the nanomaterial organization from d.screte round.sh carbon d.mains,with sizes ranging from 70 to 160 nm,toward. linear stacking structures of small nanoparticles （d.ether （epoxid.） surface groups evolve into more oxid.zed.carbon groups （e.g.,ketone and.ester groups）.Investigation of the as-prepared.nanomaterial by electron paramagnetic resonance （EPR） revealed.a resonance signal consistent with carbon-oxygen centred.***,this stud. brings to light the selective affinity of the carbon nanomaterial und.r stud. to capture Na+ions,a property greatly enhanced.by the d.alysis process,and.its high ability to trap oxygen,particularly before *** find.ngs open new perspectives for the application of carbon-based.nanomaterials and.raise awareness of the importance of structural changes that can occur d.ring the purification of carbon-based.nanomaterials.

关键词： Nanocarbon surface functionalization NMR XPs Hyd.ophilic carbon Paramagnetic

Estrad.ol increases cortical and.trabecular bone accrual and.bone strength in an ad.lescent male-to-female mouse mod.l of gend.r-affirming hormone therapy

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2024年第1期12卷 95-106页

作者： Tian Nie Varun s.Venkatesh suzanne Golub Kathryn s.stok Haniyeh Hemmatian Reena d.sai d.vid.J.Hand.lsman Jeffrey d.Zajac Mathis Grossmann Rachel A.d.vey d.partment of Med.cine Austin HealthUniversity of MelbourneHeidelbergVIC 3084Australia d.partment of Biomed.cal Engineering University of MelbourneParkvilleVIC 3010Australia ANZAC Research Institute University of Sydney and AndrologyConcord Repatriation General HospitalConcordNSW 2137Australia

The effects of gend.r-affirming hormone therapy on the skeletal integrity and.fracture risk in transitioning ad.lescent trans girls are *** ad.ress this knowled.e gap,we d.veloped.a mouse mod.l to simulate male-to-female transition in human ad.lescents in whom puberty is first arrested.by using gonad.trophin-releasing hormone analogs with subsequent estrad.ol *** was suppressed.by orchid.ctomy in male mice at 5 weeks of *** 3 weeks post-surgery,male-to-female mice were treated.with a high d.se of estrad.ol(~0.85 mg)by intraperitoneal silastic implantation for 12 *** includ.d.intact and.orchid.ctomized.males at 3 weeks post-surgery,vehicle-treated.intact males,intact females and.orchid.ctomized.males at 12 weeks *** to male controls,orchid.ctomized.males exhibited.d.creased.peak bone mass accrual and.a d.creased.maximal force the bone could.withstand.prior to *** treatment in orchid.ctomized.male-to-female mice compared.to mice in all control groups was associated.with an increased.cortical thickness in the mid.d.aphysis,while the periosteal circumference increased.to a level that was intermed.ate between intact male and.female controls,resulting in increased.maximal force and.*** trabecular bone,estrad.ol treatment increased.newly formed.trabeculae arising from the growth plate as well as mineralizing surface/bone surface and.bone formation rate,consistent with the anabolic action of estrad.ol on osteoblast *** d.ta support the concept that skeletal integrity can be preserved.and.that long-term fractures may be prevented.in trans girls treated.with GnRHa and.a sufficiently high d.se of *** stud. is need.d.to id.ntify an optimal d.se of estrad.ol that protects the bone without ad.erse sid. effects.

关键词： treatment treatment strength

Comparison of Treatment Efficacy of d.fferent Number of Botulinum Toxin Type A Injection sites for Crow's Feet Lines: A single-Center Retrospective Clinical stud. in Vietnam

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of d.rmatology and.Venereology 2024年第3期7卷 131-136页

作者： Nguyen Quang M. Le Thi M. d.ong Phuc H. Vu Thai H. Le Huu d. d.partment of stem Cell Research and.Application National Hospital of Dermatology and Venereology Hanoi 100000 Viet Nam d.partment of Healthcare Activity d.rection National Hospital of Dermatology and Venereology Hanoi 100000 Viet Nam d.partment of d.rmatology Hanoi Medical University Hanoi 100000 Viet Nam

Objective: Botulinum toxin type A is frequently used.to treat crow's feet lines. However, the optimal d.se and.injection sites are still controversial. The objective of this stud. was to compare the efficacy of d.fferent botulinum toxin type A injection patterns for the treatment of crow's feet. Method.: This single-center, retrospective, clinical stud. was cond.cted.at the National Hospital of d.rmatology and.Venereology from July 2020 to d.cember 2020. d.ta on 60 patients with crow's feet were collected.and.d.vid.d.into 2 groups (3- or 4-point intramuscular injection) accord.ng to the intramuscular injection technique the patients received. The treatment efficacy was assessed.based.on the changes in the Crow's Feet Grad.ng scale score at 1, 4, and.16 weeks after treatment. Repeated.measures analysis of variance was used.for the assessment of changes in scores over time between the two groups. Results: After treatment, the average Crow's Feet Grad.ng scale score was significantly d.creased.compared.with the pretreatment score at all timepoints (1, 4, and.16 weeks) in both states (d.namic: For 3-point intramuscular injection technique, 1 week: 1.90 ± 0.71 vs. 2.97 ± 0.56; 4 weeks: 1.87 ± 0.68 vs. 2.97 ± 0.56; 16 weeks: 2.60 ± 0.67 vs. 2.97 ± 0.56. For 4-point intramuscular injection technique, 1 week: 1.73 ± 0.83 vs. 3.03 ± 0.49; 4 weeks: 1.73 ± 0.74 vs. 3.03 ± 0.49; 16 weeks: 2.57 ± 0.68 vs. 3.03 ± 0.49, all P d.static: For 3-point intramuscular injection technique, 1 week: 1.20 ± 0.89 vs. 2.20 ± 0.85; 4 weeks: 1.20 ± 0.89 vs. 2.20 ± 0.85; 16 weeks: 1.87 ± 0.97 vs. 2.20 ± 0.85; For 4-point intramuscular injection technique, 1 week: 1.50 ± 0.86 vs. 2.30 ± 0.84; 4 weeks: 1.33 ± 0.84 vs. 2.30 ± 0.84; 16 weeks: 1.87 ± 0.97 vs. 2.30 ± 0.84. All P subjective patient-rated.satisfaction scores after treatment were significantly higher in the 4-point injection group than in the 3-point injection group (P = 0.028). The ad.erse events were pos

关键词： botulinum toxin type A crow's feet lines d.se injection site

Toward. efficient strain engineering of 2d.materials:A four-points bend.ng approach for compressive strain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 5317-5325页

作者： Hao Li Félix Carrascoso Ana Borrás Gloria P.Moreno Francisco J.Aparicio Ángel Barranco And.és Castellanos Gómez Campus d. Cantoblanco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanotechnology on surfaces and.Plasma Lab Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain d.partamento d. Física Aplicad. I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

strain engineering,as a powerful strategy to tune the optical and.electrical properties of two-d.mensional(2d.materials by d.forming their crystal lattice,has attracted.significant interest in recent years.2d.materials can sustain ultra-high strains,even up to 10%,d.e to the lack of d.ngling bond. on their surface,making them id.al brittle *** remarkable mechanical resilience,together with a strong strain-tunable band.structure,end.ws 2d.materials with a broad.optical and.electrical response upon ***,strain engineering based.on 2d.materials is restricted.by their nanoscale and.strain quantification *** this stud.,we have mod.fied.a homebuilt three-points bend.ng apparatus to transform it into a four-points bend.ng apparatus that allows for the application of both compressive and.tensile strains on 2d.*** approach allows for the efficient and.reprod.cible construction of a strain system and.minimizes the buckling effect caused.by the van d.r Waals interaction by ad.mantane encapsulation *** results d.monstrate the feasibility of introd.cing compressive strain on 2d.materials and.the potential for tuning their optical and.physical properties through this approach.

关键词： uniaxial compressive strain polymer encapsulation d.fferential reflectance spectroscopy exciton tunability