Whole-body optical imaging of post-embryonic stage model organisms is a challenging and long sought-after *** requires a combination of high-resolution performance and high-penetration ***(photoacoustic)mesoscopy hold...
详细信息
Whole-body optical imaging of post-embryonic stage model organisms is a challenging and long sought-after *** requires a combination of high-resolution performance and high-penetration ***(photoacoustic)mesoscopy holds great promise,as it penetrates deeper than optical and optoacoustic microscopy while providing high-spatial ***,optoacoustic mesoscopic techniques only offer partial visibility of oriented structures,such as blood vessels,due to a limited angular detection aperture or the use of ultrasound frequencies that yield insufficient *** introduce 3601 multi orientation(multi-projection)raster scan optoacoustic mesoscopy(MORSOM)based on detecting an ultra-wide frequency bandwidth(up to 160 MHz)and weighted deconvolution to synthetically enlarge the angular *** report unprecedented isotropic inplane resolution at the 9–17μm range and improved signal to noise ratio in phantoms and opaque 21-day-old *** find that MORSOM performance defines a new operational specification for optoacoustic mesoscopy of adult organisms,with possible applications in the developmental biology of adulthood and aging.
暂无评论