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Outcome of simple use of mechanical lithotripsy of difficult common bile duct stones

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World Journal of Gastroenterology 2005年第4期11卷 593-596页

作者： Wen-Hsiung Chang Cheng-Hsin Chu tsang-En Wang Ming-Jen Chen Ching-Chung Lin Division of Gastroenterology Department of Internal Medicine Mackay Memorial HospitalMackay MedicineNursing and Management college TaipeiTaiwan

AIM: The usual bile duct stone may be removed by means of Dormia basket or balloon catheter, and results are quite good. However, the degree of difficulty is increased when stones are larger. Studies on the subject reported many cases where mechanical lithotripsy is combined with a second technique, e.g. electrohydraulic lithotripsy (EHL), where stones are crushed using baby-mother scope electric shock. The extracorporeal shock-wave lithotripsy (ESWL) or laser lithotripsy also yields an excellent success rate of greater than 90%. However, the equipment for these techniques are very expensive; hence we opted for the simple mechanical lithotripsy and evaluated its performance. METHODS: During the period from August 1996 to December 2002, Mackay Memorial Hospital treated 304 patients suffering from difficult bile duct stones (stone>1.5 cm or stones that could not be removed by the ordinary Dormia basket or balloon catheter). These patients underwent endoscopic papillotomy (EPT) procedure, and stones were removed by means of the Olympus BML-4Q lithotripsy. A follow-up was conducted on the post-treatment conditions and complications of the patients. RESULTS: Out of the 304 patients, bile duct stones were successfully removed from 272 patients, a success rate of about 90%. The procedure failed in 32 patients, for whom surgery was needed. Out of the 272 successfully treated patients, 8 developed cholangitis, 21 developed pancreatitis, and 10 patients had delayed bleeding, and no patient died. Among these 272 successful removal cases, successful bile duct stone removal was achieved after the first lithotripsy in 211 patients, whereas 61 patients underwent multiple sessions of lithotripsy. As for the 61 patients that underwent multiple sessions of mechanical lithotripsy, 6 (9.8%) had post-procedure cholangitis, 12 (19.6%) had pancreatitis, and 9 patients (14.7%) had delayed bleeding. Compared with the 211 patients undergoing a single session of mechanical lithotripsy, 3 (1.4

关键词： Common bile duct stones Mechanical lithotripsy

High-speed high-resolution laser diode-based photoacoustic microscopy for in vivo microvasculature imaging

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Visual Computing for Industry,Biomedicine,and Art 2021年第1期4卷 1-6页

作者： Xiufeng Li Victor T C tsang Lei Kang Yan Zhang Terence T W Wong Translational and Advanced Bioimaging Laboratory Department of Chemical and Biological EngineeringHong Kong University of Science and TechnologyHong KongChina

Laser diodes(LDs)have been considered as cost-effective and compact excitation sources to overcome the requirement of costly and bulky pulsed laser sources that are commonly used in photoacoustic microscopy(PAM).However,the spatial resolution and/or imaging speed of previously reported LD-based PAM systems have not been optimized *** this paper,we developed a high-speed and high-resolution LD-based PAM system using a continuous wave LD,operating at a pulsed mode,with a repetition rate of 30 kHz,as an excitation source.A hybrid scanning mechanism that synchronizes a one-dimensional galvanometer mirror and a two-dimensional motorized stage is applied to achieve a fast imaging capability without signal averaging due to the high signal-to-noise *** optimizing the optical system,a high lateral resolution of 4.8μm has been *** vivo microvasculature imaging of a mouse ear has been demonstrated to show the high performance of our LD-based PAM system.

关键词： Photoacoustic microscopy Laser diode In vivo imaging Microvasculature imaging

Mochi and the Soccer Team Tryout

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小学生时代（大嘴英语） 2023年第10期 10-16页

作者： Fiona tsang 不详

Mochi,a red panda,wantsto join the soccerteam andatryout is waiting for *** shemake it?

关键词： panda waiting chi

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采用主从型逆变器结构的静态同步补偿器

中国电机工程学报 2003年第11期23卷 95-99页

作者：王江王民 K.M.tsang 天津大学电气与自动化学院天津300072 香港理工大学电机工程系

针对6kV中压电网三相平衡负载的无功功率补偿,结合二极管箱位多电平逆变器和H桥级联多电平逆变器的特点,提出了一种能够直接并入电网的新型主从式逆变器结构:主逆变器采用二极管箱位三电平逆变器,从逆变器采用3个H桥(即全桥)逆变器。主... 详细信息

针对6kV中压电网三相平衡负载的无功功率补偿,结合二极管箱位多电平逆变器和H桥级联多电平逆变器的特点,提出了一种能够直接并入电网的新型主从式逆变器结构:主逆变器采用二极管箱位三电平逆变器,从逆变器采用3个H桥(即全桥)逆变器。主逆变器和H桥逆变器采用级联的形式连接,构成一个五电平的混联逆变器。H桥逆变器负贡产生一个方波电压,构成输出正弦电压的基本成分;主逆变器产生输出电压的补偿部分并负责消除低次谐波。最后通过仿真结果证明了所提出的这种主从型逆变器STATCOM结构在消除谐波方面的优越性。

关键词：静态同步补偿器无功功率补偿电力系统电网主从型结构逆变器

Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells

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Chinese Journal of Cancer 2014年第11期33卷 549-555页

作者： Chi Man tsang Wen Deng Yim Ling Yip Mu-Sheng Zeng Kwok Wai Lo Sai Wah Tsao Department of Anatomy Li Ka Shing Faculty of MedicineThe University of Hong Kong School of Nursing Li Ka Shing Faculty of MedicineThe University of Hong Kong State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong

Epstein-Barr virus(EBV) infection is closely associated with undifferentiated nasopharyngeal carcinoma(NPC), strongly implicating a role for EBV in NPC pathogenesis; conversely, EBV infection is rarely detected in normal nasopharyngeal epithelial tissues. In general, EBV does not show a strong tropism for infecting human epithelial cells, and EBV infection in oropharyngeal epithelial cells is believed to be lytic in nature. To establish life-long infection in humans, EBV has evolved efficient strategies to infect B cells and hijack their cellular machinery for latent infection. Lytic EBV infection in oropharyngeal epithelial cells, though an infrequent event, is believed to be a major source of infectious EBV particles for salivary transmission. The biological events associated with nasopharyngeal epithelial cells are only beginning to be understood with the advancement of EBV infection methods and the availability of nasopharyngeal epithelial cell models for EBV infection studies. EBV infection in human epithelial cells is a highly inefficient process compared to that in B cells, which express the complement receptor type 2(CR2) to mediate EBV infection. Although receptor(s) on the epithelial cell surface for EBV infection remain(s) to be identified, EBV infection in epithelial cells could be achieved via the interaction of glycoproteins on the viral envelope with surface integrins on epithelial cells, which might trigger membrane fusion to internalize EBV in cells. Normal nasopharyngeal epithelial cells are not permissive for latent EBV infection, and EBV infection in normal nasopharyngeal epithelial cells usually results in growth arrest. However, genetic alterations in premalignant nasopharyngeal epithelial cells, including p16 deletion and cyclin D1 overexpression, could override the growth inhibitory effect of EBV infection to support stable and latent EBV infection in nasopharyngeal epithelial cells. The EBV episome in NPC is clonal in nature, suggesting that

关键词：病毒感染上皮细胞鼻咽癌持久性细胞周期蛋白D1 全国人民代表大会生长抑制作用 EB病毒

Spring Theory as an Approach to the Unification of Fields

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Journal of Modern Physics 2016年第15期7卷 2219-2230页

作者： Ling Man tsang Fisica Laboratorio TIS Macao University of Science and Technology Macao China

The cosmological constant is necessary to be retained in Einstein’s field equations with value depending on the mass of the source. An overview of the spring theory in astrophysics and cosmology is included in this paper. In short range force, the two interacting particles are point-like vertices connected by a bosonic spring. We also suspect that electron may contain negative sterile neutrino. The self energy of a point charge is not infinite so that renormalisation is not necessary.

关键词： Cosmological Constant Dark Matter Classical Electrostatics Short Range Interaction

High-Q germanium optical nanocavity

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Photonics Research 2018年第9期6卷 925-928页

作者： TING-HUI XIAO ZIQIANG ZHAO WEN ZHOU MITSURU TAKENAKA HON Ki tsang ZHENZHOU CHENG KEISUKE GODA Department of Chemistry The University of TokyoTokyo 113-0033Japan Department of Electrical Engineering and Information Systems The University of TokyoTokyo 113-0033Japan Department of Electronic Engineering The Chinese University of Hong KongShatinHong Kong SARChina Department of Electrical Engineering University of CaliforniaLos AngelesCalifornia 90095USA

Mid-infrared(MIR) integrated photonics has attracted broad interest due to its promising applications in biochemical sensing, environmental monitoring, disease diagnosis, and optical communication. Among MIR integration platforms, germanium-based platforms hold many excellent properties, such as wide transparency windows, high refractive indices, and high nonlinear coefficients; however, the development of MIR germanium photonic devices is still in its infancy. Specifically, MIR high-Q germanium resonators with comparable performance to their silicon counterparts remain unprecedented. Here we experimentally demonstrate an MIR germanium nanocavity with a Q factor of ~18,000, the highest-to-date of reported nanocavities across MIR germanium-based integration platforms. This is achieved through a combination of a feasible theoretical design,Smart-Cut methods for wafer development, and optimized device fabrication processes. Our nanocavity, with its high Q factor and ultrasmall mode volume, opens new avenues for on-chip applications in the MIR spectral range.

关键词：薄膜热光性能通讯技术发展现状

Versatile and scalable chemical vapor deposition of vertically aligned MoTe2 on reusable Mo foils

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Nano Research 2020年第9期13卷 2371-2377页

作者： Jinjun Lin Hong Wang Roland Yingjie Tay Hongling Li Maziar Shakerzadeh Siu Hon tsang Zheng Liu Edwin Hang Tong Teo School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Temasek Laboratories@NTU 50 Nanyang AvenueSingapore 639798Singapore School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Layered MoTe2 has shown great promises for optoelectronics and energy-storage applications due to its exceptional optical and electrochemical *** date,considerable efforts have been devoted to fabricating layered MoTe2 with lateral orientation by means of mechanical/chemical exfoliation and chemical vapor deposition(CVD)*** compared to its horizontal counterparts,vertically aligned MoTe2 with higher density of active edge sites is expected to possess unique optoelectronic and electrochemical properties,while which has not been reported *** this work,we report a versatile and scalable CVD growth of vertically aligned MoTe2 with length of up to〜7.5 fjm on Mo ***,the dominant phase of the vertically aligned MoTe2 can be tuned from 2H to 1T’by increasing the growth temperature from 630 to *** to the weak interaction between the as-grown MoTe2 and Mo foil,the as-grown MoTe2 can be easily detached from the Mo *** in turn enabled economic reuse of the Mo foil for multiple ***,the vertical growth of the MoTe2 is proposed to be caused by the internal strain generated during tellurization of Mo ***,the as-grown MoTe2 can also be directly dispersed in solvent to produce high-quality MoTe2 *** versatility of this growth strategy was further demonstrated by fabricating other vertically aligned transition metal chalcogenides(TMDs)such as TaTe2 and ***,this work paves the path towards achieving unique TMDs structures to enable high-performance optoelectronic and electrochemical devices.

关键词： molybdenum dltelluride chemical vapor deposition vertical growth reusable substrate

B-cell-targeted therapies in systemic lupus erythematosus

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Cellular & Molecular Immunology 2013年第2期10卷 133-142页

作者： Vera Sau-Fong Chan Helen Hoi-Lun tsang Rachel Chun-Yee Tam Liwei Lu Chak-Sing Lau Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China

Autoreactive B cells are one of the key immune cells that have been implicated in the pathogenesis of systemic lupus erythematosus （SLE）. In addition to the production of harmful auto-antibodies （auto-Abs）, B cells prime autoreactive T cells as antigen-presenting cells and secrete a wide range of pro-inflammatory cytokines that have both autocrine and paracrine effects. Agents that modulate B cells may therefore be of potential therapeutic value. Current strategies include targeting B-cell surface antigens, cytokines that promote B-cell growth and functions, and B- and T-cell interactions. In this article, we review the role of B cells in SLE in animal and human studies, and we examine previous reports that support B-cell modulation as a promising strategy for the treatment of this condition. In addition, we present an update on the clinical trials that have evaluated the therapeutic efficacy and safety of agents that antagonize CD20, CD22 and B-lymphocyte stimulator （BLyS） in human SLE. While the results of many of these studies remain inconclusive, belimumab, a human monoclonal antibody against BLyS, has shown promise and has recently been approved by the US Food and Drug Administration as an indicated therapy for patients with mild to moderate SLE. Undoubtedly, advances in B-cell immunology will continue to lead us to a better understanding of SLE pathogenesis and the development of novel specific therapies that target B cells.

关键词： Systemic lupus erythematosus B-cell autoimmunity therapy