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Valorization of semi-solid by-product from distillation of cellulosic ethanol into blends for heating and power

Waste Disposal and sustainable Energy 2021年第1期3卷 49-61页

作者： Bruno Rafael de Almeida Moreira Victor Hugo Cruz matheus luís oliveira cunha Nathaly Proença Lopes Anderson Chagas Magalhães Celso Tadao Miasaki JoséClaudio Caraschi Ronaldo da silva Viana Department of Phytosanitary Rural Engineering and SoilsSchool of EngineeringSão Paulo State University(Unesp)Ilha SolteiraSão PauloBrazil Department of Plant Production College of Agricultural and Technological SciencesSão Paulo State University(Unesp)DracenaSão PauloBrazil são Paulo state University(Unesp) ItapevaSão PauloBrazil

Burning down on semi-solid by-product from distillation of cellulosic ethanol to power upstream steps of its manufacturing is ***,this feedstock is homogenous in size and shape,hygroscopic and poorly *** disadvantages make its re-use in the industrial plant very *** of this agro-residue into high-performance blends for heating and power is,accordingly,the scientific point of this *** pilot-scale manufacturing of composite pellets consisted of systematically pressing the residue with sugarcane bagasse at the mass ratios of 1:4,2:4,and 3:4 on an automatic pelletizer machine at 200 MPa and 125℃.The process of compaction lasted for 90 *** and energy density,both increased significantly,from 95.85%to 99.55%and from 27.95 GJ m^(−3) to 32.20 GJ m^(−3) with blending at 3:***,the semi-solid by-product considerably improved the feeding,thus,enabling the layers of particles to go smoothly through the channel-forming die of the ***,blends became stiffer and denser than pellets purely consisting of sugarcane *** evidence of the process of pelleting capable of highly valorizing the semi-solid by-product from distillation of cellulosic bioethanol into mechanically stable and energetically effective hybrid fuel grade biosolids *** major findings of this paper should be of great relevance to ensure safe and effective transportation and storage of biomass in indoor facili-ties where the risk for the generation of dust and fines and the subsequent off-gassing and self-firing is ***,pelletization may optimize the co-generation of heat and steam at the large-scale bioethanol station.

关键词： Fuel grade biosolids Non-woody biomass Pelletization second-generation biofuel sustainable waste-to-energy technique

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Unveiling DNA methylation in Alzheimer’s disease:a review of array-based human brain studies

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Neural Regeneration Research 2024年第11期19卷 2365-2376页

作者： Victoria cunha Alves Eva Carro Joana Figueiro-silva Neurodegenerative Diseases Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Network Center for Biomedical Research Neurodegenerative Diseases(CIBERNED)MadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurotraumatology and subarachnoid Hemorrhage Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Neurobiology of Alzheimer’s Disease Unit Functional Unit for Research Into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpain Institute of Medical Genetics University of ZurichZurichSwitzerland Department of Molecular Life science University of ZurichZurichSwitzerland

The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA *** review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer’s disease *** examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer’s disease *** entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the ***,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal ***,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory *** complex role of BIN1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation *** the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease *** research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.

关键词： Alzheimer’s disease ANK1 BIN1 DNA methylation epigenome-wide association studies HOXA3 MCF2L RHBDF2

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Unravelling COVID-19 waves in Rio de Janeiro city:Qualitative insights from nonlinear dynamic analysis

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Infectious Disease Modelling 2024年第2期9卷 314-328页

作者： Adriane s.Reis Laurita dos santos Américo cunha Jr Thaís C.R.O.Konstantyner Elbert E.N.Macao Institute of science and Technology Federal University of São PauloSão Josédos CamposSPBrazil Physics Institute University of São PauloSão PauloSPBrazil scientific and Technological Institute Universidade BrasilSão PauloSPBrazil Department of Applied Mathematics Rio de Janeiro State UniversityRio de JaneiroRJBrazil Paulista school of Medicine Federal University of São PauloSão PauloSPBrazil

since the COVID-19 pandemic was first reported in 2019,it has rapidly spread around the *** countries implemented several measures to try to control the virus *** healthcare system and consequently the general quality of life population in the cities have all been significantly impacted by the Coronavirus *** different waves of contagious were responsible for the increase in the number of cases that,unfortunately,many times lead to *** this paper,we aim to characterize the dynamics of the six waves of cases and deaths caused by COVID-19 in Rio de Janeiro city using techniques such as the Poincaréplot,approximate entropy,second-order difference plot,and central tendency *** results reveal that by examining the structure and patterns of the time series,using a set of non-linear techniques we can gain a better understanding of the role of multiple waves of COVID-19,also,we can identify underlying dynamics of disease spreading and extract meaningful information about the dynamical behavior of epidemiological time *** findings can help to closely approximate the dynamics of virus spread and obtain a correlation between the different stages of the disease,allowing us to identify and categorize the stages due to different virus variants that are reflected in the time series.

关键词： COVID-19 Nonlinear analysis Poincaréplot Central tendency measure

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Interface engineering of Co_(9)s_(8)/sns heterostructure as a high-performance anode for lithium/sodium-ion batteries

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Rare Metals 2024年第2期43卷 612-623页

作者： Jia luo shi-Li Xiang Dan-Yang Han An Liu João cunha Gang-Yong Li Zhao-Hui Hou Hong Yin school of Chemistry and Chemical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional MaterialsHunan Institute of Science and TechnologyYueyang414006China Hubei Jiufengshan Laboratory Wuhan430206China International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga4715-330BragaPortugal

Transition metal sulfide(TMs)anodes exhibit the characteristics of phase stability and high capacity for lithium/sodium-ion batteries(LIBs/sIBs).However,the TMs anodes often suffer from poor electronic conductivity,low ionic diffusion and large volume expansion during Li/Na-ion intercalation significantly impairing the Li/Na-storage ***,a long chain heterostructure composed of the Co_(9)s_(8) and sns are first reported,which can generate rich phase interfaces,and small crystal *** unique structure can facilitate the properties of reactivity,conductivity and ionic *** addition,the heterostructure surface is modified by the N-doped carbon(N-DC@(Cosn)s),successfully improving the structural *** synergistic effects of Co_(9)s_(8)/sns heterostructure and coated carbon layer effectively increase the capacity and cycling *** N-DC@(Cosn)s anode delivers enhanced high specific capacities of 820.6 mAh·g^(−1) at 1.0 A·g^(–1) after 500 cycles for LIBs and 339.2 mAh·g^(–1)at 0.5 A·g^(–1) after 1000 cycles for sIBs,*** work is expected to provide a material design idea for preparing LIBs/sIBs with high capacity and long cycling life.

关键词： Interface engineering Long chain heterostructure High capacity Cycling stability Li Na-ion batteries

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Floristic composition and edaphic relationships in ferruginous campo rupestre reference ecosystems

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Journal of Mountain science 2024年第3期21卷 719-733页

作者： G.Wilson FERNANDEs Letícia RAMOs Dario C.PAIVA Jéssica cunha-BluM Vanessa Matos GOMEs Daniel NEGREIROs Ecologia Evolutiva&Biodiversidade Departamento de GenéticaEcologia e Evolução/ICBUniversidade Federal de Minas Gerais31270-901Belo HorizonteMGBrazil Knowledge Center for Biodiversity 31270-901Belo HorizonteMGBrazil Department of Biological sciences Institute of EnvironmentFlorida International UniversityMiamiFL 33199USA Programa de Pós Graduação em Biodiversidade e Uso dos Recursos Naturais Universidade Estadual de Montes ClarosMontes ClarosMGBrazil Laboratório de Estudo das Relações solo-Planta Departamento de SolosUniversidade Federal Rural do Rio de JaneiroSeropédicaRGBrazil

Land use change and occupation have led to modifications in the environment causing loss of biodiversity and ecosystem services throughout the *** environments with high economic relevance,such as the ferruginous campo rupestre(rupestrian grassland known as Canga in Brazil),are even more susceptible to severe impacts due to their extreme habitat conditions and low *** determination of reference ecosystems based on the intrinsic characteristics of the ecosystem is essential for conservation as well as to the implementation of ecological *** proposed the reference ecosystem of the three main types of habitats of the ferruginous campo rupestre based on their floristic *** described the floristic composition of each habitat and evaluated the physicochemical properties of the soils and the relationship between plants and *** three habitats showed high diversity of plant species and many endemic species,such as Chamaecrista choriophylla,Cuphea pseudovaccinium,Lychnophora pinaster,and Vellozia *** distribution of vegetation was strongly related with the edaphic characteristics,with a set of species more adapted to high concentration of base saturation,fine sand,organic carbon,and iron,while another set of species succeeded in more acidic soils with higher s and silt *** provide support for the contention that the ferruginous campo rupestre is a mosaic of different habitats shaped by intrinsic local *** to recognize the floristic composition of each particular habitat can lead to inappropriate restoration,increased habitat homogenization and increased loss of biodiversity and ecosystem *** study also advances the knowledge base for building the reference ecosystem for the different types of ferruginous campo rupestre habitats,as well as a key database for highlighting those species contribute most to community assembly in this diverse and threatened tropical mountain ecosystem.

关键词： Canga Ecological restoration Extreme ecosystem Non-forest ecosystems Rupestrian grassland Taxon environment relationships

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Impact of Paenibacillus elgii supernatant on screening bacterial strains with potential for biotechnological applications

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Engineering Microbiology 2024年第3期4卷 1-15页

作者： I.C.cunha-Ferreira C.s.Vizzotto T.D.Frederico J.Peixoto L.s Carvalho M.R.Tótola R.H.Krüger Laboratory of Enzymology Department of Cellular BiologyUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratory of Environmental sanitation Department of Civil and Environmental EngineeringUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratório de Biotecnologia e Biodiversidade para o Meio Ambiente Universidade Federal de Viçosa(UFV)Viçosa36570-900Brazil

The biotechnological industry faces a crucial demand for novel bioactive compounds,particularly antimicrobial agents,to address the rising challenge of bacterial resistance to current available *** strate-gies for cultivating naturally occurring microorganisms often limit the discovery of novel antimicrobial *** study presents a protocol for targeted selection of bacterial strains using the supernatant of Paenibacillus el-gii,which produces abundant signal molecules and antimicrobial *** samples were inoculated in these enriched culture media to selectively cultivate bacteria resistant to the supernatant,indicating their potential to produce similar *** bacterial strains isolated through this method were assessed for their antibac-terial *** addition,the functional annotation of the genome of one of these strains revealed several gene clusters of biotechnological *** study highlights the effectiveness of using this approach for selective cultivation of microorganisms with potential for biotechnological applications.

关键词： Prospecting supernatant Antibacterial activity

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Linking 24-h Movement Behavior Guidelines to Cognitive Difficulties,Internalizing and Externalizing Problems in Preterm Youth

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International Journal of Mental Health Promotion 2024年第8期26卷 651-662页

作者： Zhihui Cheng Ailikute Aikeremu Yanping Gao Zhihao Zhang Anthony G.Delli Paoli Paolo Marcello cunha Alyx Taylor Fabian Herold Liye Zou Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen518060China Department of Kinesiology and Health Rutgers UniversityNew BrunswickNJ 08901USA Metropolitan University Center of Maringá Maringá87020Brazil school of Health and Rehabilitation sciences AECC University CollegeBournemouthBH52DFUK Research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam14476Germany

Background:Given the heightened risk of developmental challenges associated with preterm birth,it is crucial to explore interventions that may ameliorate potential adverse *** study aimed to examine whether meeting the 24-h movement behavior(24-HMB)guidelines,which include recommendations on physical activity(PA),screen time(sT),and sleep(sL),is related to indicators of cognitive difficulties,internalizing problems(e.g.,depression and anxiety),and externalizing problems(e.g.,difficulties in making friends and arguing)in a sample of preterm youth(children and adolescents born preterm).Methods:In this cross-sectional study,data from 3410 preterm youth(aged 6 to 17 years)were included for data *** logistic regression was used to investigate associations between meeting the 24-HMB guidelines and the above-mentioned health outcomes,while controlling for sociodemographic and health-related ***:The prevalence of meeting 24-HMB guidelines varied across independent and integrated components of the 24-HMB *** the sT guideline alone(ps(i.e.,sT+sL and sT+sL+PA)were associated with fewer cognitive difficulties and reduced internalizing and externalizing problems(pspecifically,meeting the sL guideline alone and integrated guidelines(i.e.,sL+sT)were associated with lower odds of depression and anxiety(psT)guidelines were associated with less pronounced difficulties in making friends and arguing(ps in an isolated and integrated manner are linked to better cognitive performance and fewer internalizing and externalizing problems in preterm ***:Results suggest that advocating for the implementation of the 24-HMB guidelines may reduce cognitive challenges and behavioral issues,which is of high relevance for improving public *** longitudinal studies in preterm youth should inves

关键词： Cognitive difficulties externalizing problems internalizing problems physical activity preterm youth

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Non-exhaustive double effort test is reliable and estimates the firs ventilatory threshold intensity in running exercise

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Journal of sport and Health science 2018年第2期7卷 197-203页

作者： lucas Dantas Maia Forte Fúlvia Barros Manchado-Gobatto Roberta cunha matheus Rodrigues Maria Ceclia Gallani Claudio Alexandre Gobatto school of Applied science University of Campinas school of Nursing University of Campinas Faculty of Nursing Laval University

Purpose: The present study aimed to investigate the reliability of the non-exhaustive double effort(NEDE) test in running exercise and its associations with the ventilatory thresholds(VT_1 and VT_2) and the maximal lactate steady state(MLss).Methods: Ten healthy male adults(age: 23 ± 4 years, height: 176.6 ± 6.4 cm, body mass: 76.6 ± 10.7 kg) performed 4 procedures:(1) a ramp test for VT_1 and VT_2 determinations measured by ratio of expired ventilation to O_2 uptake(VE/VO_2) and expired ventilation to CO_2 output(VE/VCO_2) equivalents, respectively;(2) the NEDE test measured by blood lactate concentration(NEDE_(LAC)) and heart rate responses(NEDE_(HR));(3) a retest of NEDE for reliability analysis; and(4) continuous efforts to determine the MLss intensity. The NEDE test consisted of4 sessions at different running intensities. Each session was characterized by double efforts at the same running velocity(E1 and E2, 180 s), separated by a passive recovery period(90 s rest). LAC and HR values after E1 and E2(in 4 sessions) were used to estimate the intensity equivalent to"null delta" by linear fit. This parameter represents, theoretically, the intensity equivalent to maximal aerobic ***: The intraclass correlation coefficient indicated significant reliability for NEDE_(LAC)(0.93) and NEDE_(HR)(0.79)(both p significant correlations, no differences, and strong agreement with the intensities predicted by NEDE_(LAC)(10.1 ± 1.9 km/h) and NEDE_(HR)(9.8 ± 2.0 km/h) to VT_1(10.2 ± 1.1 km/h). In addition, despite significantly lower MLss intensity(12.2 ± 1.2 km/h), NEDE_(LAC) and NEDE_(HR) intensities were highly correlated with this parameter(0.90 and 0.88, respectively).Conclusion: The NEDE test applied to running exercise is reliable and estimates the VT_1 intensity. Additionally, NEDE intensities were lower but still correlated with VT_2 and MLss.

关键词： Aerobic exercise Anaerobic threshold Maximal lactate steady state Non-exhaustive protocol Training prescription Ventilatory threshold

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silymarin Attenuates Hepatic and Pancreatic Redox Imbalance Independent of Glycemic Regulation in the Alloxan-induced Diabetic Rat Model

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Biomedical and Environmental sciences 2020年第9期33卷 690-700页

作者： Miranda Laise Mara oliveira Agostini Livia da cunha Lima Wanderson Geraldo de Camini Fernanda Caetano Costa Daniela Caldeira Programa de Pos-graduagao em saude e Nutricao Escola de NutricaoUniversidade Federal de Ouro PretoOuro PretoMinas Gerais 35400-000Brazil Escola de Farmacia Universidade Federal de Ouro Preto.Ouro PretoMinas Gerais 35400-000Brazil Laboratorio de Morfopatologia Departamento de Ciencias BioldgicasUniversidade Federal de Ouro PretoOuro Preto 35400-000Brazil Programa de Pos-graduaqao em Ciencias Bioldgicas Nucleo de Pesquisas em Ciencias BiologicasUniversidade Federal de Ouro Preto.Ouro Preto 35400-000Brazil Laboratorio de Bioquimica Metabolica Departamento de Ciencias BiologicasUniversidade Federal de Ouro PretoOuro Preto 35400-000Brazil

Objective To evaluate the efficiency of silymarin(sMN) in modulating metabolic parameters and redox status in rats with type 1 diabetes mellitus(T1 DM).Methods Diabetes was induced by intraperitoneal injection of alloxan. The diabetic rats were administered with sMN at doses of 50 and 100 mg/kg body weight/d for 30 consecutive days. The rats were divided into the following four groups: vehicle control, diabetic(alloxan-treated), Ds50(alloxan +50 mg/kg body weight/d of sMN), and Ds100(alloxan + 100 mg/kg body weight/d of sMN) groups. The bodyweight and food and water intake were evaluated. After 30 d, the animals were euthanized and the blood was collected for measuring the serum levels of glucose, triacylglycerol(TAG), urea, and creatinine. The liver and pancreas were collected for measuring the activities of superoxide dismutase(sOD) and catalase(CAT), and the levels of carbonylated protein(PC). The pancreas sample was also used for histological *** sMN reduced hepatic(P s(P = 0.0141) in addition to decreasing food(P sMN did not improve beta-cell function or decrease blood glucose levels in diabetic *** sMN improved polyphagia and polydipsia, renal function, and protected the liver and pancreas against protein damage without affecting hyperglycemia in diabetic animals.

关键词： silymarin silybum marianum Type 1 diabetes Oxidative stress

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Comparison of surgical Techniques Used in Treating Acromioclavicular Dislocation in Patients Participating in sports: A systematic Review

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Open Journal of Orthopedics 2024年第1期14卷 41-52页

作者： Walter Hugo Brandão Nascimento Paulo Renan Matos sucupira cunha João Pedro Pimentel Abreu Lethycia Pereira Rosa Kamilly Iêda silva Veigas Rodrigo Martins silva Caetano Orthopedic and Trauma surgeon Brazilian Army Rio de Janeiro Brazil Orthopedic and Trauma surgeon S&atildeo Luís Brazil scholarship Holder National Council for Scientific and Technological Development (CNPq) S&atildeo Luís Brazil school of Medicine Federal University of Maranh&atildeo (UFMA) S&atildeo Luís Brazil Orthopedic and Trauma surgeon Shoulder and Elbow Surgery Specialist University Hospital of the Federal University of Maranh&atildeo (HUUFMA/EBSERH) S&atildeo Luís Brazil

Introduction: The acromioclavicular joint is a superficial diarthrodial joint that surrounds the medial articular facet of the acromion and the distal portion of the clavicle. Due to its anatomy and biomechanics, it is highly susceptible to trauma and in young men who play contact sports, acromioclavicular dislocation is common. This article aimed to systematically review the literature and compare the surgical techniques used in the treatment of acromioclavicular dislocation in patients who practice sports. Methods: This systematic review was conducted according to the International Preferred Reporting Items for systematic Review and Meta-Analyses guidelines. Eligible studies for this systematic review included articles in English or spanish published between 2013 and 2023, which mention the occurrence of acromioclavicular dislocation during sports practices. Additionally, only studies that addressed the surgical treatment of acromion-clavicular dislocation and contained original data on the topic were included. Results: We found 144 eligible studies after searching the LILACs and PubMed databases. Based on the inclusion and exclusion criteria and the reviewers’ consensus, we selected four studies for the systematic review. 133 patients with AC joint displacement were evaluated. Mean Age: approximately 31.90 years. 81.92 of these injuries occurred during sports practice. surgical Procedures Used: titanium plates fixation (49 patients), arthroscopy (24), single tunnel technique (30) and coracoid sling technique (30). The results of the visual analog scale and Constant-Murley scores varied between the techniques used. Twenty-two complications after surgical treatment were identified. Conclusion: A significant variability of operative techniques can be used in the surgical approach of acromioclavicular dislocation, such as arthroscopy, single tunnel, coracoid sling and titanium plates. Although it presented excellent functional results compared to the other three tech

关键词： Acromioclavicular Joint shoulder Dislocation surgical Procedure Postoperative Complications Postoperative Care

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