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Dietary supplementation with curcumin-loaded nanocapsules in lambs:Nanotechnology as a new tool for nutrition

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Animal Nutrition 2021年第2期7卷 521-529页

作者： Hiam Marcon Luiz G.Griss Vitor L.Molosse Bruno G.O.Cecere Davi F.Alba Karoline W.Leal Gabriela M.Galli Carine F.Souza matheus D.Baldissera Samanta Gundel Vitória de A.Bassotto Aline F.Ourique Marcelo Vedovatto Aleksandro S.Da Silva Department of Animal Science Universidade Do Estado de Santa Catarina(UDESC)ChapecóSCBrazil Graduate Program in Animal Science UDESCChapecóSCBrazil Department of Physiology and Pharmacology Universidade Federal de Santa Maria(UFSM)RSBrazil Universidade Franscicana Santa MariaRSBrazil Graduate Program in Animal Science Universidade Estadual de Mato Grosso Do SulAquidauanaMSBrazil

Curcumin-containing nanocapsule powder formulations have not been used in ruminant feed to date,despite the fact that curcumin is known to be a functional food *** objective of this study was to determine whether ethyl polymethacrylate(Eudragit L-100)nanocapsules loaded with curcumin(N-CU)would improve health and growth of ***-two male Lacaune lambs(body weight[BW]=16±0.99 kg;45 d of age)were randomly assigned to 1 of 4 treatments:T0,T1,T2 and T4,representing supplementation of curcumin at 0,1,2,and 4 mg/kg concentrate,*** animals in each treatment were allocated in 4 pens of 2 lambs each(8 lambs per treatment).The experiment lasted 17 d,with samples and measurements collected on d 0,7,12,and *** T2 lambs had greater average daily gain than T0 *** analysis showed that the ideal dose of N-CU to enhance weight gain was 1.89 mg/kg *** were significant interactions(P<0.05)between treatments×time for hematological variables,particularly for increases in erythrocytes(T2)and re-ductions in counts of leukocytes,neutrophils,and lymphocytes in T1 and *** were significant interactions between treatment×time for total protein,globulin,urea,and triglyceride ***-lation of the antioxidant system was also *** were increased levels of non-protein thiols(NPSH),as well as increased activities of superoxide dismutase(SOD)and glutathione S-transferase(GST)in the supplemented *** of reactive oxygen species(ROS)were lower in the serum of sup-plemented *** general,the 4 mg/kg dose had no positive effects on growth or *** was an unexpected result,given the known properties of *** together,these findings suggest that addition of low concentrations of nanoencapsulated curcumin(T1 and T2)in lamb feed improves health,minimizing oxidative stress and generates anti-inflammatory effects that may have contributed indi-rectly to greater weight *** potentiate the effe

关键词： Antioxidant Anti-inflammatory Curcuma longa Performance Sheep

Effect of Molasses Addition at Ensiling on Ruminal In Situ Dry Matter and Nutrient Degradation of Whole-Plant Soybean Silage Harvested at Different Phenological Stages

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Agricultural Sciences 2022年第2期13卷 268-281页

作者： Lucas Ghedin Ghizzi matheus Rebouças Pupo Celso Heinzen Jr. Tiago Antônio Del Valle Francisco Palma Rennó Luiz Felipe Ferraretto Department of Animal Nutrition and Animal Production University of Sao Paulo Pirassununga Brazil Department of Animal and Dairy Sciences University of Wisconsin Madison USA Federal University of Santa Maria Santa Maria Brazil

Whole-plant soybean ensiling has limitations and challenges that affect silage fermentation patterns and reduce ruminal nutrient degradation. Perhaps either the addition of molasses at ensiling or harvesting at different phenological stages has the potential to enhance whole-plant soybean silage (WSS) ruminal degradation. This experiment was a completely randomized design with a 3 × 2 factorial arrangement of treatments evaluating the effects of molasses (0 and 40 g/kg fresh forage) and phenological stage (R5: beginning seed, R6: full seed, and R7: beginning maturity) on ruminal in situ degradation. Molasses increased effective ruminal degradability (ERD) of dry matter (DM) regardless of the phenological stage and increased ERD of crude protein at R5 and R6. The addition of molasses at later phenological stages increased ERD of neutral detergent fiber (NDF). There was a molasses × phenological stage interaction effect with greater fractions A and B of NDF at R7 and R5, respectively, but lower undegraded NDF at R5 and R6 with molasses addition. Although the benefits of adding molasses were more pronounced in R5 and R6, adding molasses to whole-plant soybean at ensiling is recommended regardless of phenological stage. Increasing the proportion of digestible nutrients at harvesting either by harvesting at later phenological stages or the addition of molasses is a powerful strategy to manage ruminal degradation of DM and nutrients in WSS.

关键词： Additive In Situ Degradation Ruminal Degradation Parameters Legume Ensiling

Occlusion of the anterior cerebral artery after head trauma

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World Journal of Radiology 2013年第5期5卷 226-228页

作者： Wellingson Silva Paiva Almir Ferreira de Andrade matheus Schmidt Soares Robson Luis Amorim Eberval Gadelha Figueiredo Manoel Jacobsen Teixeira Division of Neurological Surgery Hospital Das Clinicas University of Sao Paulo Medical School

Intracranial arterial occlusion is rarely encountered in association with head *** six cases of traumatic occlusion of the anterior cerebral artery(ACA) have previously been *** this paper,the authors describe a case of a posttraumatic occlusion of ACA.A 35-year-old male presented to the emergency room with severe head *** tomography(CT) scan displayed diffuse brain swelling with multiple skull *** up CT scan showed extensive cerebral infarction in the territory of *** patient underwent CT angiography that demonstrated occlusion of the ACA by a fracture of the anterior *** died after 3 *** traumatic occlusion is a rare condition,with poor *** this case,fracture was responsible for dissection and direct obstruction of the artery.

关键词： Anterior cerebral artery Brain vascular trauma Arterial occlusion Computed tomography Neurological diagnostic techniques Brain injury

Active Alumni in Electrical Engineering Extracurricular Activities： Innovation and Social Responsibility

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Journal of Mechanics Engineering and Automation 2017年第2期7卷 107-112页

作者： Andre Bezerra de Freitas Diniz Bruna Luisa Martins Barbosa Dennyson Eliseu Araujo Santos, Max Rodrigues Marques Victor matheus de Camara Silva Department of Electrical Engineering UFRN Natal Brazil

The project analyzes the student＇s participation in complementary activities such as Education Tutorial Program, Junior Company and Academic Center. These organizations have the goal to improve, expand and connect knowledge learned during classes with several practical activities. They can provide a huge integration between the students and the professors in order to achieve better results in the pedagogical, structural and organizational parts of an engineering major degree. Therefore, the project goes through the impact of each entity in the student＇s life and the advantages to professional future, focusing the presence of these organizations in the Electrical Engineering Course of Federal University of Rio Grande do Norte.

关键词： Complementary activities education tutorial program junior course academic center electrical engineering

Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2:In silico and in vivo evaluation in a colitis model

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World Journal of Gastroenterology 2023年第17期29卷 2628-2641页

作者： Gabrielle Caroline Peiter Thayene Kamyli Moesch Queiroz Edson Luiz Michalkiewicz Jr Raphael Henrique Chappuis Jennefer Sousa Luz Luiz Henrique Casagrande Piovezani Cleison Ferreira Silva matheus Nozomi Tsutumi Augusto Fernandes Chaves Rafael Messias Luiz Cinthia Façanha Wendel Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Programa Multicêntrico de Pós-graduação em Biquímica e Biologia Molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Programa de Pós-graduação em Biotecnologia-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil

BACKGROUND Inflammatory bowel diseases(IBD)are a worldwide health problem and mainly affect young people,consequently affecting the *** treatments are often associated with side effects,and new therapeutic options are *** centuries,plants have represented important substrates in the field of drug *** pacari(***)is a plant whose pharmaceutical potential has been described,and may have biological activity relevant to the treatment of IBD *** To investigate the activity of keto-alcoholic extracts of *** with respect to ameliorating the inflammatory and nociceptive symptoms of acute experimental colitis in *** Keto-alcoholic extracts of *** leaves and bark were administered to male andfemale Swiss mice weighing 25 g to 30 g(n=8 male mice and n=8 female mice).The effect of these extracts was observed in an acetic acid-induced acute experimental model of colitis with regard to antinociception/analgesia and inflammatory tissue *** macroscopic indices included the Wallace score and the colon weight obtained using a precision *** hyperalgesia was determined using an electronic *** related to overt pain was determined by quantifying the number of writhing instances within 20 min of administration of acetic *** docking was performed using human and murine cyclooxygenase-2(COX-2)with 3 flavonoids(ellagic acid,kaempferol,and quercetin)on the AutoDock Vina *** of variance followed by Tukey’s posttest was used with P<0.05 indicating *** In this murine model of colitis,administration of extracts from *** ameliorated acetic acidinduced writhing and colitis-associated inflammatory *** improvements may be attributable to the reduction in edema,inflammation(e.g.,ulcers,hyperemia,and bowel wall damage),and the intensity of abdominal *** keto-alcoholic extracts of *** leaves and bark administered at a

关键词： Antinociceptive activity Anti-inflammatory activity Cyclooxygenase-2 Flavonoids Inflammatory bowel disease Lafoensia pacari

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法国昂儒Fontevraud酒店

现代装饰 2014年第12期 28-41页

作者： Patrick Jouin Sanjit Manku Nlcolas matheus 姜敏华 Joun Manku studio

本案位干法国西部城市昂儒,这里起初是一家圣拉扎尔修道院,来自Jouin Manku建筑设计事务所的Patrick Jouin和Sanjit Manku将其重新改造成了一家四星级酒店。该酒店项目已成为＂当代Fbntevraud＂计划的一部分,无论是从文化活力到可持续发... 详细信息

本案位干法国西部城市昂儒,这里起初是一家圣拉扎尔修道院,来自Jouin Manku建筑设计事务所的Patrick Jouin和Sanjit Manku将其重新改造成了一家四星级酒店。该酒店项目已成为＂当代Fbntevraud＂计划的一部分,无论是从文化活力到可持续发展,还是从数字化创新到热情好客的欢迎姿态,Fontevraud酒店都有着广阔的发展前景。此次改造,设计师采用以包容为主的当代设计语言,将项目优雅地与旧建筑原有细节进行融合,力求在数字化时代宜扬一种修道精神,

关键词：四星级酒店法国数字化时代可持续发展西部城市建筑设计发展前景设计语言

Efficacy and safety of endoscopic prophylactic treatment with undiluted cyanoacrylate for gastric varices

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World Journal of Gastrointestinal Endoscopy 2014年第6期6卷 254-259页

作者： matheus Cavalcante Franco Gustavo Flores Gomes Frank Shigeo Nakao Gustavo Andrade de Paulo Angelo Paulo Ferrari Jr Ermelindo Della Libera Jr Digestive Endoscopy Unit Division of GastroenterologyFederal University of Sao Paulo Endoscopy Division Fleury Medicina e Saúde Endoscopy Division Hospital Israelita Albert Einstein

AIM:To evaluate the efficacy and safety of undiluted N-butyl-2 cyanoacrylate plus methacryloxysulfolane(NBCM)as a prophylactic treatment for gastric varices(GV)***:This prospective study was conducted at a single tertiary-care teaching hospital between October 2009 and March *** with portal hypertension(PH)and GV,with no active gastrointestinal bleeding,were enrolled in primary prophylactic treatment with NBCM injection without lipiodol *** diagnosis of GV was based on endoscopy and confirmed with endosonography(EUS); the same procedure was used after treatment to confirm eradication of *** puncturing the GV with a regular injection needle,1 mL of undiluted NBCM was injected intranasally into *** injection was repeated as necessary to achieve eradication or until a maximum total volume of 3 mL of NBCM had been *** were followed clinically and evaluated with endoscopy at 3,6 and 12 *** follow-ups were performed *** main outcome measures were efficacy(GV eradication),safety(adverse events related to cyanoacrylate injection),recurrence,bleeding from GV and mortality related to GV ***:A total of 20 patients(15 male)with PH and GV were enrolled in the study and treated with undiluted NBCM *** 2(10%)patients had no esophageal varices(EV); 18(90%)patients were treated with endoscopic band ligation to eradicate EV before inclusion in the *** patients were followed clinically and endoscopically for a median of 31 mo(range:6-40 mo).Eradication of GV was observed in all patients(13 patients were treated with 1 session and 7 patients with 2 sessions),with a maximum injected volume of 2 mL *** patient had GV recurrence,confirmed by EUS,at 6-mo follow-up,and another had late recurrence with GV bleeding after 35 mo of follow-up; overall,GV recurrence was observed in 2 patients(10%),after 6 and 35 mo of follow-up,and GV bleeding rate was 5%(1 patient).Mild epigastric pain was r

关键词： Gastric varices Primary prevention Endoscopy Gastrointestinal Cyanoacrylates Gastrointestinal hemorrhage

Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article

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World Journal of Cardiology 2015年第1期7卷 26-30页

作者： Marco Aurélio Lumertz Saffi Mariana Vargas Furtado Carisi Anne Polanczyk Márlon Munhoz Montenegro Ingrid Webb Josephson Ribeiro Cassio Kampits Alex Nogueira Haas Cassiano kuchenbecker Rosing Eneida Rejane Rabelo-Silva Cardiovascular Division Hospital de Clínicas de Porto Alegre Porto Alegre 90035-003 Brazil Federal University of Rio Grande do Sul Faculty of Dentistry Periodontology Porto Alegre 90030-035 Brazil School of Nursing Federal University of Rio Grande do Sul Porto Alegre 90620-110 Brazil

Inflammation and endothelial dysfunction are linked to the pathogenesis of atherosclerotic disease. Recent studies suggest that periodontal infection and the ensuing increase in the levels of inflammatory markers may be associated with myocardial infarction, peripheral vascular disease and cerebrovascular disease. The present article aimed at reviewing contemporary data on the pathophysiology of vascular endothelium and its association with periodontitis in the scenario of cardiovascular disease.

关键词： Endothelium Vascular Atherosclerosis Periodontal diseases Nitric oxide Cardiovascular diseases

Stability of Brazilian Seasonally Dry Forests under Climate Change: Inferences for Long-Term Conservation

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American Journal of Plant Sciences 2013年第4期4卷 792-805页

作者： Rosane G. Collevatti matheus Souza Lima-Ribeiro José Alexandre F. Diniz-Filho Guilherme Oliveira Ricardo Dobrovolski Levi Carina Terribile Departamento de Ecologia Instituto de Ciências Biológicas Universidade Federal de Goiás Goiania Brazil Laboratório de Genética & Biodiversidade Instituto de Ciências Biológicas Universidade Federal de Goiás Goiania Brazil Laboratório de Macroecologia Universidade Federal de Goiás Jataí Brazil

We identified climatically stable areas of seasonally dry forests (SDFs) from Central Brazil through time and assessed the effectiveness of the current reserves network in representing these climatically stable areas, as well as areas of high suitability in the present or in the future only. We used an ensemble approach based on several methods for ecological niche modelling (ENMs) to obtain potential distributions 16 SDF’ species for past (last glacial maximum), present, and future (end of XXI century) climate scenarios. We then computed how many current Brazilian reserves matched both stable areas (suitable areas for all time periods), present and future geographical ranges alone for each species, in a multi-level gap analysis. We found range shifts due to climate changes for SDF’ species. Although the future geographical range and stable areas for all analyzed species matched at least with one reserve, many protected areas will lose importance in protecting suitable areas for species in the future. Moreover, the current Brazilian reserves cover only a small amount of their climatically stable areas. However, some reserves will be suitable for many SDF’ species (90%) at the same time, but climatically stable for only half of them. Our findings show that vegetation community from SDFs may persist in Brazilian territories until the end of XXI century, and challenges about long-term conservation of the SDFs may be partially reached with already existing Brazilian reserve network, however the reserves should be connected to permit habitat tracking.

关键词： Cerrado Biome Ecological Niche Modelling Global Climate Change Quaternary Climate Change Gap Analysis