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In situ mass spectrometry of autoimmune liver diseases

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Cellular & Molecular Immunology 2011年第3期8卷 237-242页

作者： Christopher L Bowlus Erin H Seeley Joanna roder Julia Grigorieva Heinrich roder Richard M Caprioli M Eric Gershwin Division of Gastroenterology and Hepatology University of CaliforniaDavisCAUSA Mass Spectrometry Research Center Vanderbilt University School of MedicineNashvilleTNUSA Biodesix Steamboat SpringsCOUSA Division of Clinical Immunology Allergy and RheumatologyUniversity of CaliforniaDavisCAUSA

Primary biliary cirrhosis(PBC),primary sclerosing cholangitis(PSC)and autoimmune hepatitis(AIH)are the major forms of autoimmune liver diseases each characterized by the destruction of a specific liver cell type and the presence of differing *** took a proteomic approach utilizing in situ matrix-assisted laser desorption/ionization mass spectrometry(MALDI MS)to obtain profiles directly from liver samples of patients with PBC,PSC,AIH and *** ability to precisely localize the region for acquisition of MALDI MS allowed us to obtain profiles from bile ducts,inflammatory infiltrates and hepatocytes from each biopsy *** tools developed to identify peaks and compare peaks across diseases and cell types were used to develop models to classify the *** an initial set of testing samples from PBC patients and controls,we identified unique peaks present in bile ducts,inflammatory infiltrates and hepatocytes that could classify samples in a validation cohort with 88–91%***,profiles of PSC and AIH did not differ significantly from *** of proteins in these peaks may represent novel autoantigens or effector *** findings illustrate the potential of a proteomic approach to autoimmune diseases with in situ MALDI MS.

关键词： autoimmune hepatitis mass spectrometry primary biliary cirrhosis primary sclerosing cholangitis

Schoolchildren from disadvantaged backgrounds present a loss of lean tissue mass and significant increase of body fat mass during the COVID-19 lockdown in Germany:results from the MEDdirect study

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World Journal of Pediatrics 2022年第5期18卷 363-367页

作者： David Muhmann Marvin Droste Jorn Schulz Frederike Linge Lea Ladewig Ursula Eisenberg Susanne roder Rainer Buscher University Hospital Essen PediatricsⅡHufelandstr.5545147 EssenGermany Be Strong for Kids E.V Sundernholz 10845134 EssenGermany Schule Am Steeler Tor Engelbertstr.445127 EssenGermany

Children from socio-economically disadvantaged backgrounds receive unequal opportunities to succeed in school,which will lead to a decreased health literacy as adults[U].This is not only directly associated with an impaired eco-nomic and mental health and wellbeing of young people,but above all with an in creased adult mortality[1-4].While this problem is well known and described,only few and even fewer pediatric studies suggest how to interrupt this downward spiral consistently[5,6].

关键词： disadvantage adult impaired

Brain metastasis in advanced colorectal cancer： results from the South Australian metastatic colorectal cancer (SAmCRC) registry

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Cancer Biology & Medicine 2017年第4期14卷 371-376页

作者： Gonzalo Tapia Rico Timothy J. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern James Moore Scott Carruthers David roder Amanda R. Townsend Department of Medical Oncology The Queen Elizabeth Hospital and University of Adelaide Adelaide SA 5011 Australia Department of Medical Oncology Flinders Medical Center and Flinders University Adelaide SA 5042 Australia Department of Surgery Flinders Medical Center Bedford Park SA 5042 Australia Department of Surgery The Queen Elizabeth Hospital Adelaide SA 5011 Australia Department of Surgery University of South Australia Adelaide SA 5005 Australia Department of Surgery Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Radiation Oncology Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Epidemiology University of South Australia Adelaide SA 5005 Australia

Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the *** reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their *** to small numbers,a descriptive analysis is ***:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were *** the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain *** median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 ***:Brain metastasis is a rare outcome in advanced *** within the registry tended to be female,young in age,and harbored with higher rates of KRAS *** routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease.

关键词： Brain metastasis colorectal cancer survival surveillance

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“I Am Getting Healthier”. Perceptions of Urban Aboriginal and Torres Strait Islander People in a Chronic Disease Self-Management and Rehabilitation Program

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Health 2016年第6期8卷 538-547页

作者： Alison Nelson Kyly Mills Samara Dargan Chantel roder The Institute for Urban Indigenous Health Bowen Hills Australia Queensland University of Technology Brisbane Australia

Chronic disease is a main contributor to the disproportionately high burden of illness experienced by Aboriginal and Torres Strait Islander Australians. However, there are very few programs addressing chronic disease self-management and rehabilitation which are designed specifically for urban Aboriginal and Torres Strait Islander people. This paper aims to explore client and staff perceptions of the Work It out Program, a chronic disease rehabilitation and self-management program designed for urban Aboriginal and Torres Strait Islander people. The study used a mixed methods approach to explore the success, barriers and self-reported outcomes of the program. Quantitative data were collected through a structured survey, comprising social and demographic data. Qualitative data were collected through interviews using Most Significant Change theory. Twenty-eight participants were recruited, 6 staff and 22 clients (M = 7, F = 21) with an age range between 21 and 79 years of age (Mean = 59.00, SD = 17.63). Interviews were completed in 2013 across four Work It out locations in Southeast Queensland. Semi-structured interviews were conducted either individually or in groups of two or three, depending on the participants’ preference. Thematic analysis of the data revealed six main themes;physical changes, lifestyle improvements, social and emotional well-being, perceptions about the successful features of the program, perceived barriers to the program and changes for the future. This exploratory study found that clients and staff involved in the Work It out Program perceived it as an effective self-management and rehabilitation program for urban Aboriginal and Torres Strait Islander Australians. Further evaluation with a larger sample size is warranted in order to establish further outcomes of the program.

关键词： Indigenous Health Chronic Disease Self-Management Rehabilitation

Lifestyle intervention by group-based rehabilitation versus individual counseling in type 2 diabetes: 1-year follow-up of the Copenhagen type 2 diabetes rehabilitation project

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Journal of Diabetes Mellitus 2012年第3期2卷 308-315页

作者： Eva Soelberg Vadstrup A.Frolich H.Perrild *** M.roder Department of Endocrinology and Gastroenterology Bispebjerg University HospitalCopenhagenDenmark Department of Integrated Healthcare Bispebjerg University HospitalCopenhagenDenmark Health Care Center Oesterbro CopenhagenDenmark Department of Cardiology and Endocrinology Hillerød University HospitalHillerodDenmark

Background: Today most guidelines on the management of type 2 diabetes incorporate lifestyle intervention including patient education, physical activity and dietary modification. However, the content and organization of lifestyle intervention programs are still debatable. Aims: To compare the longer term effectiveness of a group-based rehabilitation program with an individual counseling program at improving glycemic control, cardiovascular risk factors and quality of life among type 2 diabetes patients. Methods: We randomized 143 type 2 diabetes patients to either a 6-month group-based rehabilitation program, including patient education, supervised exercise, and diet intervention, or a 6-month individual counseling program. Follow-up time was 12 months after baseline. Outcome measures were glycated hemoglobin (HbA1c), cardiovascular risk factors, quality-of-life and self-rated health. Results: In the rehabilitation group, HbA1c decreased 0.2%-point (95% confidence interval [CI] = -0.4, -0.03), systolic blood pressure decreased 6 mmHg (95% CI = -9.3, -2.5), diastolic blood pressure decreased 4 mmHg (95% CI = -6.3, -2.4), weight decreased 2.2 kg (95% CI = -3.2, -1.3), and waist circumference decreased 2.0 cm (95% CI = -2.9, -1.1). In the individual group, HbA1c decreased 0.4% (95% CI = -0.6, -0.1), systolic blood pressure decreased 3 mmHg (95% CI = -6.3, -0.7), diastolic blood pressure decreased 3 mmHg (95% CI = -4.7, -0.7), weight decreased 1.6 kg (95% CI = -2.6, -.7]), and waist circumference decreased 1.6 cm (95% CI = -2.5, -0.6). Vitality, fatigue distress, physical functioning and cardiovascular distress improved over time (P < 0.05) in the two groups combined. Repeated measurement analysis did not result in significant differences between the groups of any outcome. Conclusions: This study demonstrates that group-based rehabilitation in a primary healthcare center is a comparable alternative to individual counseling in an outpatient clinic. However, the resource

关键词： Rehabilitation Lifestyle Intervention Glycemic Control Quality of Life Cardiovascular Risk Factors

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基因重组的单克隆抗体

国外医学情报 1987年第21期 365-367页

作者： John roder 多伦多大学免疫学和医学遗传学系副教授

近年来有许多实验室用遗传工程技术和体细胞诱变方法制备新一代单克隆抗体McAb,包括嵌合抗体、酶抗体和具有新型功能的抗体等,获得了初步成果。这种抗体将更有效地用于体内诊断、治疗疾病、提高免疫化学分析及有助于分析研究抗原抗体相... 详细信息

近年来有许多实验室用遗传工程技术和体细胞诱变方法制备新一代单克隆抗体McAb,包括嵌合抗体、酶抗体和具有新型功能的抗体等,获得了初步成果。这种抗体将更有效地用于体内诊断、治疗疾病、提高免疫化学分析及有助于分析研究抗原抗体相互作用的机理。一、基本原理免疫球蛋白分子Ig是由两条相同的重链(H)和两条相同的轻链(L)组成的糖蛋白。每条链又分为恒定区(C_H、C_L)和可变区(V_H,V_L),V_H、V_L决定Ig结合抗原

关键词：单克隆抗体嵌合抗体结合抗原杂交瘤细胞杂种细胞基因重组

自然(NK)杀伤细胞在抗肿瘤免疫监视中的作用

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国外医学情报 1987年第21期 363-365页

作者： John roder 多伦多大学免疫学和医学遗传学系副教授

NK细胞是动物体内存在的一组淋巴细胞亚群,含有特征性嗜天青颗粒,因而也称为大颗粒淋巴细胞（LGL）。NK细胞表面具有许多标志性抗原,其中多数与其它免疫细胞共有,比较特异的有NK-1抗原,人类NK细胞的NK-1抗原（HNK-1）也称为Leu-7抗原、A... 详细信息

NK细胞是动物体内存在的一组淋巴细胞亚群,含有特征性嗜天青颗粒,因而也称为大颗粒淋巴细胞（LGL）。NK细胞表面具有许多标志性抗原,其中多数与其它免疫细胞共有,比较特异的有NK-1抗原,人类NK细胞的NK-1抗原（HNK-1）也称为Leu-7抗原、Asaiolo-GM1或ASGM1抗原。 NK细胞起源于骨髓干细胞,并在骨髓的微环境中发育成熟。小鼠在出生后头两周内无NK细胞活性,2～3周龄时出现低NK细胞活性,6周左右达高峰,以后逐渐下降。人类NK

关键词： NK CHS 癌基因肿瘤细胞膜杀伤活性抗肿瘤

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人单克隆抗体的制备

国外医学情报 1987年第21期 361-363页

作者： John roder 多伦多大学免疫学和医学遗传学系副教授

制备人单克隆抗体(以下简称单抗)涉及EB病毒转化技术、抗原特异的B淋巴细胞的6一硫代鸟傈吟(6一TGr)抗性人浆细胞瘤或淋巴母细胞与免疫的人淋巴细胞融合技术,或两者相结合。 EB病毒转化抗原待异B细胞的方法最早由Steinitz等于1977年提出... 详细信息

制备人单克隆抗体(以下简称单抗)涉及EB病毒转化技术、抗原特异的B淋巴细胞的6一硫代鸟傈吟(6一TGr)抗性人浆细胞瘤或淋巴母细胞与免疫的人淋巴细胞融合技术,或两者相结合。 EB病毒转化抗原待异B细胞的方法最早由Steinitz等于1977年提出,EB病毒为多克隆刺激剂,可使少数抗原特异B细胞前体融合克懂扩增,带有EB病毒受体的小B淋巴细胞,体外经EB病毒感染

关键词：人单克隆抗体杂交瘤细胞病毒转化抗原特异性淋巴母细胞浆细胞瘤病毒感染多克隆刺激剂病毒受体扁桃体细胞

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髓磷脂相关糖蛋白

国外医学情报 1987年第21期 368-369页

作者： John roder 多伦多大学免疫学和医学遗传学系副教授

自70年代阐明了免疫球蛋白的结构后,人们又致力于神经系统免疫学的研究,以期了解神经系统的免疫反应是如何产生的,神经系统建立的分子基础是什么。 Buge建立了髓鞘形成的连锁放大的学说,包括四个步骤:①少突神经胶质细胞识别神经元并与... 详细信息

自70年代阐明了免疫球蛋白的结构后,人们又致力于神经系统免疫学的研究,以期了解神经系统的免疫反应是如何产生的,神经系统建立的分子基础是什么。 Buge建立了髓鞘形成的连锁放大的学说,包括四个步骤:①少突神经胶质细胞识别神经元并与其结合;②少突神经胶质细胞增殖;③神经元的再附着和鞘包裹;④多膜模型和髓磷脂的形成。连锁放大过程受一组分子的介导,如神经细胞粘附分子(neural cell adhesion mo-lecular N-CAM)和髓磷脂相关糖蛋白(mye-lin associated glycoprotein MAG)。这组

关键词：髓磷脂相关糖蛋白神经元细胞神经组织 MAG 少突神经胶质序列轴索神经纤维轴突同源性 McAb CAM 分子基础氮基酸