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Antioxidant and antiglycation properties of two mango(Mangifera indica L.) cultivars from Senegal

Asian Pacific Journal of Tropical Biomedicine 2018年第3期8卷 137-141页

作者： Samba Fama Ndoye Didier Fraisse Blandine Akendengue Mbaye Diaw Dioum Rokhaya Sylla Gueye Cheikh Sall Insa seck Catherine Felgines matar seck Francois Senejoux Laboratory of Organic and Therapeutic Chemistry Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop University Universite Clermont Auvergne INRAUNH Department of Pharmacology and Toxicology Faculty of Medicine and Health Sciences (USS) Laboratory of Chemistry Training and Research Unit of Health Thies University

Objective: To evaluate the total phenolic contents, antioxidant and antiglycation activities of leaves, barks, roots and kernels from two cultivars of Mangifera indica(Anacardiaceae). Methods: Total phenolic contents were determined by using Folin-Ciocalteu's method. The antioxidant activities were assessed by three different protocols including DPPH, oxygen radical absorbance capacity and iron(Ⅱ) chelation assays. In addition, in vitro bovine serum albumin/D-ribose assay was chosen to evaluate the antiglycation properties of the extracts. Results: All the investigated extracts were found to contain high level of total phenols as well as potent antioxidant activities. Kernel extracts showed the highest total phenol contents and DPPH radical scavenging activities whereas higher oxygen radical absorbance capacity values were observed for leave, root and bark extracts. Besides, extracts from leaves, roots and barks from both cultivars exhibited potent inhibitory effects against the formation of advanced glycation end products, with IC_(50) values lower than the standard positive control aminoguanidine. Conclusions: The potent antiglycation and antioxidative activities of these two Mangifera indica cultivars suggest a possible role in targeting aging, diabetic complications and oxidative stress related diseases.

关键词： Mangifera indica Cultivars Polyphenols Antioxidant Antiglycation

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Spectroscopic Electrochemical Properties and DFT Calculation of 1-Aryltriazenes

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International Journal of Organic Chemistry 2023年第4期13卷 109-128页

作者： Insa seck Mohamed Lamine Sall Atoumane Ndiaye Samba Fama Ndoye Lalla Aïcha Ba matar seck Organic Chemistry Coordination Laboratory Cheikh Anta Diop University of Dakar Dakar-Fann Senegal Organic Chemistry and Therapeutic Chemistry Laboratory Cheikh Anta Diop University of Dakar Dakar-Fann Senegal Organic Physical Chemistry and Environmental Analysis Laboratory Cheikh Anta Diop University of Dakar Dakar-Fann Senegal Department of Physics Cheikh Anta Diop University of Dakar Dakar-Fann Senegal Amadou Mahtar Mbow University Dakar Nafa VDN Senegal

Electrochromic materials are of great interest for their potential in eyewear protection and data storage devices, as they change colors in response to electrochemical switching. While many of the systems currently used are based on inorganic materials, organic materials such as triazenes have emerged as viable alternatives due to their unique properties, including optical properties. Triazenes are a class of organic compounds with three consecutive nitrogen atoms in an acyclic arrangement, and they have been used for a variety of applications in medicinal and synthetic chemistry. However, the effects of solvents on the UV-visible absorption spectrum of triazenes have not been fully investigated. The neutral molecules of 3,3-diisopropyl-1-phenyltriazene and 1-(4-chlorophenyl)-3-cyclopentyltriazene in acetonitrile, the UV-visible spectra corresponded respectively to HOMO → LUMO transitions with a large maximum absorption at 299.74 nm (4.1364 eV) and 299.57 nm (4.1387 eV) and the most intense oscillator strength (f = 0.6988) and (f = 0.7372). These results suggest that the electronic transitions of the compounds are highly influenced by the nature of the substituents on the triazene unit, as well as the solvent used in the experiment. The redox couple 0.92 and -0.44 V/Ag/AgCl is attributed to the phenyl group. Compound III showed an oxidation and reduction peak respectively -0.27 and -0.8 V/Ag/AgCl attributed to the phenyl molecule. The study concluded that all three compounds were electroactive and exhibited reversible characteristics with oxidizing/reducing couples. This study aims to contribute to research on the optical properties of triazenes compounds and the application of quantum chemical calculation methods for understanding their molecular structures. By investigating the solute-solvent interactions occurring in the solvation shell of the solutes, we aim to gain insights into the effects of solvents on the UV-visible absorption spectrum of triazenes. Our fin

关键词： Triazenes UV-Visible Spectroscopy Electrochemical DFT Calculations

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Histopathological study of the kidney after administration of methanolic extract of roots of <i>Leptadenia hastata</i>in the Albino Wistar rat

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Open Journal of Pathology 2020年第2期10卷 67-75页

作者： Mama Sy Diallo Fatoumata Bah Chérif Mouhamed Dial Cheikh Diop Oumar Faye matar seck Laboratory of Histology Embryology and Cytogenetics Faculty of Medicine Pharmacy and Odonto-Stomatology University Cheikh Anta Diop Dakar Senegal Laboratory of Toxicology and Hydrology Faculty of Medicine Pharmacy and Odonto-Stomatology University Cheikh Anta Diop Dakar Senegal Laboratory of Pathology Faculty of Medicine Pharmacy and Odonto-Stomatology University Cheikh Anta Diop Dakar Senegal Organic and Therapeutic Chemistry Laboratory Faculty of Medicine Pharmacy and Odonto-Stomatology University Cheikh Anta Diop Dakar Senegal

Introduction: the roots of Leptadenia hastata, (L hastata) are remedies from the Senegalese pharmacopoeia and are as widely used as the leaves. However, few researchers have devoted themselves to their toxicity, unlike the leaves. However, in the traditional pharmacopoeia, the indications for use are very different. The aim of our study was to study the effect of the administration of methanolic extracts of roots of L hastata on renal tissue, using an animal model. Materials and Methods: a cohort of 18 rats was studied with a random distribution of the animals in 3 groups (n = 6). The first group was the control group. The treated groups (Group II and III) received the methanolic extract of L. hastata with an administration of 500 mg / kg / day and 1000 mg / kg / day respectively, for 28 days. Results: The dose of 1000 mg / kg / day was lethal in group III, from the first week in females. Serum creatinine was significantly higher in rats given the root extract. There was kidney damage with vacuolar degeneration starting at 500 mg / kg / day. The lesions were more severe in group III with glomerular involvement characterized by retraction in the renal corpuscles. Conclusion: If the leaves of L hastata seem to be safe for consumption according to the majority of authors in the literature, the roots of this same plant could be harmful. In addition to the lethality observed at the doses tested, the lesions in the renal parenchyma would be dose-dependent.

关键词： Leptadenia hastata Renal Toxicity Phytotherapy Vacuolar Degeneration

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Review of Research on Li-Ion Batteries Waste Management

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Open Journal of Inorganic Chemistry 2022年第2期12卷 19-38页

作者： Rokhaya Sylla Gueye Nango Gaye Mamadou Baldé Adama Diedhiou Ngoné Diouf seck Gorgui Awa Idrissa Ndoye Yoro Tine matar seck Djibril Fall Alassane Wele Mahy Diaw Laboratory of Physical Inorganic Organic and Therapeutic Chemistry Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop Dakar University (UCAD) Dakar Senegal Gaston Berger Saint-Louis University (UGB) Saint-Louis Senegal Alioune Diop Bambey University (UADB) Bambey Senegal

Li-ion batteries (Libs) are a mature technology widely used for energy storage in various electronic devices. Nowadays, this technology has become a leading candidate for the portable electronics market and for electric vehicles due to its good performance. As a result, the demand for Libs containing critical metals, rare earth elements and precious metals is increasing day by day with the accelerated upgrades of consumer electronics, which promotes the supply risk of many mining resources. In addition, the problems associated with the production of end-of-life Lib are increasing on a global scale. Used Libs are e-waste containing significant levels of critical raw materials (such as Co, Li, Mn and Ni) along with harmful substances. Without proper management of Lib waste, these precious metals and toxic substances may end up in nature and cause environmental and public health problems. In order to preserve nature, ensure sustainable resource management and stimulate the circular economy, it has become crucial to properly manage and recycle end-of-life Li-ion batteries. By the way, conventional methods focusing on pyrometallurgical treatments combined with hydrometallurgical treatment are widely studied to recover design metals from Libs waste. It is in this context that we have conducted this bibliographic synthesis, focusing on the efficiency of the solvents employed and their competitiveness for a more environmentally friendly economic management. In this manuscript, recent leaching, solvent extraction, electrodeposition and precipitation strategies to recover precious metals from end-of-life Li-ion battery designs are reviewed and the evolution of these processes is discussed.

关键词： Libs Waste Leaching Extraction Rate Affinity Partition Coefficient

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Evaluation of Mineral Elements Content of Senegal Fruits

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Journal of Minerals and Materials Characterization and Engineering 2022年第2期10卷 163-173页

作者： Rokhaya Sylla Gueye Jérôme Ledauphin Fabienne Baraud Lydia Leleyter Mélanie Lemoine Rokhaya Gueye Adama Diedhiou Mamadou Balde Nango Gaye matar seck Djibril Fall Alassane Wele Laboratoire de Chimie Physique Minérale Organique et Thérapeutique Université Cheikh Anta Diop (UCAD) Dakar Sénégal Unité de Recherche “Aliments Bioprocédés Toxicologie Environnement” Université de Caen Normandie Caen France Laboratoire de Chimie Analytique et Bromatologie (UCAD) Dakar Sénégal

This study determined mineral value and antioxidant activity of Senegal fruits for contributing to improving healthy diet and preventing some chronic diseases. Mineral element contents of Dialium guineense, Landolphia heudelotti, Mangifera indica, Cyperus esculentus and Saba senegalensis, which are widely available and consumed, were studied. The results by ICP-OES spectrophotometry after acid mineralization showed highest levels of (per 100 g fruits), calcium (158 mg), potassium (1018 mg), magnesium (532 mg), zinc (26 mg) with juice of Landolphia heudelotti fruit pulp. Mangifera indica pulp is richer in sodium (89 mg), phosphorus (556 mg), sulphur (384 mg) and silicon (110 mg). Dialium senegalensis pulp is richer in iron (23 mg) and manganese (19 mg). Lyophilized Cyperus esculentus rhizomes analyzed by atomic absorption spectrophotometry gave highest concentrations of (per 100 g fruits), calcium (2550 mg), potassium (11,843 mg) and magnesium (7669 mg) but sodium content (22 mg) is lower. In vitro antioxidant activity evaluation with the DPPH radical showed for 10 mg/ml concentration, highest inhibition percentage for Saba senegalensis 4.03%, followed by Landolphia heudelotti and Dialium guineense, which were significantly similar 2.29% and 2.20% respectively, Mangifera indica 1.7% and finally Cyperus esculentus 0.5%, but much lower compared to the ascorbic acid equal to 96.32% used as a reference.

关键词： Fruits Senegal Mineral Elements Antioxidant Activity

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Physico-Chemical and Mineralogical Characterizations of Tchiky Clays (Thies, Senegal) for Pharmaceutical Uses

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Journal of Minerals and Materials Characterization and Engineering 2023年第2期11卷 36-48页

作者： Rokhaya Sylla Gueye Nango Gaye Ousmane Ka Mamadou Baldé Adama Diedhiou Ngoné Diouf Samba F. Ndoye Idrissa Ndoye Yoro Tine Rokhaya Gueye Mouhamadou B. Diop matar seck Djibril Fall Alassane Welé Laboratory of Physical Mineral Organic and Therapeutic Chemistry Cheikh Anta Diop University (UCAD) Dakar Senegal Laboratory of Analytical Chemistry and Bromatology UCAD Dakar Senegal Laboratory of Geomaterials Institute of Earth Sciences UCAD Dakar Senegal

Our study focused on the valuation of Tchiky clays. This work aims to evaluate its properties to explore possible uses in pharmacy. Physico-chemical and mineralogical characterizations were carried out, as well as pharmacopoeial tests and an evaluation of the antioxidant activity. Thus, chemical analysis by X-ray fluorescence spectrometry gave silicon (55.65%), iron (15.73%), aluminum (13.53%), potassium (6.05%), titanium (3.98%), magnesium (2.10%), and calcium (0.82%). X-ray diffraction showed the presence of kaolinite, quartz and illite. This study also revealed that the sample studied was essentially a plastic clay of hard consistency, with average flowability. The evaluation of the antioxidant activity gave a percentage inhibition of 62.97% for a concentration of 7.5 g/l with an IC50 of 5.5 g/l. These results should allow use as an excipient in pharmacy, particularly in liquid, semi-liquid and pasty formulations.

关键词： Clays Tchiky Minerals Pharmacopoeia Antioxidant Activity

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Spectroscopic Electrochemical Properties and DFT Calculation of 1-Aryltriazenes

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International Journal of Organic Chemistry（有机化学国际期刊） 2023年第4期

作者： Insa seck Mohamed Lamine Sall Atoumane Ndiaye Samba Fama Ndoye Lalla Aïcha Ba matar seck

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Review of Research on Li-Ion Batteries Waste Management

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Open Journal of Inorganic Chemistry（无机化学期刊） 2022年第2期

作者： rokhaya sylla gueye nango gaye mamadou baldé adama diedhiou ngoné diouf seck gorgui awa idrissa ndoye yoro tine matar seck djibril fall alassane wele mahy diaw

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Creutzfeldt Jacob’s Disease: A Senegalese Observation

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Neuroscience & Medicine 2022年第1期13卷 43-48页

作者： Ahmadou Bamba Mbodji Alassane Mamadou Diop Momo Banda Ndiaye Serigne Saliou Mbacke Khalifa Ababacar Mbaye Rokhaya Diagne Ibrahima Niang Ndiaga matar Gaye Maouly Fall Adjaratou Sow Anna Basse Lala Bouna seck Moustapha Ndiaye Amadou Gallo Diop Department of Ibrahima Pierre Ndiaye Neuroscience Fann Hospital Dakar Sénégal Department of Neurology Pikine Hospital Dakar Sénégal Department of Radiology Fann Hospital Dakar Sénégal

Creuzfelt-Jakob Disease is a rare and progressive neurodegenerative disease that results in fatal, transmissible, subacute, spongiform encephalopathy characterized by rapidly progressive dementia and movement disorder. We present a 62-year-old male with no medical history who was admitted to our hospital because of gait and balance disturbance, language impairment and progressive motor deficit of the four limbs. A neurological examination found frontal lobe syndrome signs, myoclonic movements, pyramidal and extra-pyramidal signs. Brain Magnetic Resonance Imaging detected high intensity areas in the basal ganglia. EEG showed generalized triphasic sharp-wave complexes. A Cerebro Spinal Fluid examination found protein 14-3-3. Death occurred six months after onset. This is the first known case of Creuzfelt-Jakob Disease documented in Senegal.

关键词： Creutzfeldt-Jakob Disease Protein 14-3-3 Prion Disease Rapidly Progressive Dementia

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