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The protective effects of procyanidin C-1 on bisphenol A-induced testicular dysfunction in aged mice

Food Science and Human Wellness 2022年第4期11卷 965-974页

作者： mastura abd malek Razif Dasiman Nor-Ashikin Mohamed Noor Khan Sofee Mohamed-Akhlak Mohd-Hafi zi Mahmud Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam Campus42300 Puncak AlamSelangorMalaysia

The number and quality of sperm are decreased due to bisphenol A(BPA) exposure, an endocrine-disrupting chemical on the male reproductive system, especially in advanced paternal age(APA). Procyanidin C-1(PCY-1), an antioxidant from grape seed(Vitis vinifera L.), has demonstrated anti-viral, anti-melanogenic and immunostimulatory effects. Therefore, this study aims to determine the effects of PCY-1 intervention on sperm parameters, testis morphological changes, serum testosterone, oestradiol, and luteinizing hormone(LH) concentrations and the expression of apoptotic(Bax and Bcl-2) and mitochondria-related(Mfn1 and Opa1) genes in BPA-exposed aged mice. Results revealed that PCY-1 intervention improves aged male fertility in BPA-exposed conditions by decreasing abnormal sperms percentage and increasing spermatogenic cell diameter and epithelial height. PCY-1 also decreased oestradiol, and increased LH and testosterone levels. The gene expression of Bax was significantly down-regulated by PCY-1 intervention. In contrast, Bcl-2 was substantially up-regulated. Expression of Mfn1 and Opa1 genes were also significantly up-regulated in the PCY intervention group. Hence, it is demonstrated that PCY-1 was able to mitigate the adverse effects of BPA on reproductive parameters of aged mice. Collectively, we postulated that PCY-1 has a potential role in protecting the ageing male reproductive system against the damaging impacts of BPA.

关键词： Apoptosis Bisphenol A Procyanidin Mitochondrial dynamics Testis

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Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice

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Asian Journal of Andrology 2021年第3期23卷 281-287页

作者： Fathiah abdullah Mohamed Noor Khan Nor-Ashikin Renu Agarwal Yuhaniza Shafinie Kamsani mastura abd malek Nor Salmah Bakar Aqila-Akmal Mohammad Kamal Mimi-Sophia Sarbandi Nor-Shahida abdul Rahman Nurul Huda Musa Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah CampusTapah Road 35400PerakMalaysia Faculty of Medicine Universiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam 42300SelangorMalaysia Centre of Foundation Studies Universiti Teknologi MARASelangor BranchDengkil CampusDengkil 43800SelangorMalaysia

Diabetes mellitus(DM)is known to cause reproductive *** men,it has been linked to altered sperm quality and testicular *** stress(OS)plays a pivotal role in the development of DM ***(GSH)is a part of a nonenzymatic antioxidant defense system that protects lipid,protein,and nucleic acids from oxidative ***,the protective effects of exogenous GSH on the male reproductive system have not been comprehensively *** study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac *** at the doses of 15 mg kg^(-1)and 30 mg kg^(-1)was given intraperitoneally to mice weekly for 6 consecutive *** mice were then weighed,euthanized,and had their reproductive organs *** diabetic(D Group)showed significant impairment of sperm quality and testicular histology compared with the nondiabetic(ND Group).Diameters of the seminiferous lumen in diabetic mice treated with 15 mg kg^(-1) GSH(DGSH15)were decreased compared with the D *** motility was also significantly increased in the DGSH15 *** in testicular morphology might be an early indication of the protective roles played by the exogenous GSH in protecting sperm quality from effects of untreated type 1 DM or diabetic *** investigation using different doses and different routes of GSH is necessary to confirm this suggestion.

关键词： diabetes mellitus glutathione mice sperm quality testis histology

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Vitamin E supplementation may negatively affect preimplantation development and mitochondrial ultrastructure of vitrified murine embryos

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Asian pacific Journal of Reproduction 2021年第3期10卷 137-144页

作者： Mimi-Sophia Sarbandi Nor-Ashikin Mohamed Noor Khan Nor-Shahida abdul Rahman Zolkapli Eshak Fathiah abdullah mastura abd malek Aqila-Akmal Mohammad Kamal Maternofetal and Embryo Research Group Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah Campus35400 Tapah RoadPerakMalaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam42300 Kuala SelangorSelangorMalaysia Faculty of Pharmacy Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam42300 Kuala SelangorSelangorMalaysia

Objective:To observe the effects of vitamin E on post-vitrification preimplantation development,gross morphology as well as mitochondrial distribution and ***:Twenty-four female C57BL/6NTac mice,aged 12-16 weeks,were randomly divided into four *** A did not receive any treatment and served as the control *** B was treated with corn oil stripped of tocopherols and served as the vehicle *** C was treated with 60 mg/kg body weight of tocotrienol-rich-fraction with corn oil stripped of *** D was treated with 60 mg/kg body weight of alpha-tocopherol with corn oil stripped of *** treatments were administered orally for 7 consecutive *** superovulation and mating with fertile males,2-cell stage embryos were harvested for *** vitrification development in vitro,gross morphology and ultrastructure were compared between ***:The number of 2 and 8-cell embryo,and blastocysts in the treatment and control groups were not significantly different(P>0.05).Following vitrification,all 2-cell embryos had equal-sized blastomeres and intact zona *** aggregation toward the perinuclear region was seen in all of the treatment *** groups C and D had vacuolated mitochondria,which was reflected in the trend of preimplantation development ***:Vitamin E supplementation of 60 mg/kg body weight does not improve the viability of healthy embryos according to this *** a result,the most effective dose of vitamin E supplementation may be determined by the initial quality of the embryos.

关键词： Mitochondria Preimplantation Embryo Vitrification Vitamin E Alpha-tocopherol Tocotrienol-richfraction,Transmission electron microscopy

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Open-Gate Undoped-AIGaN-GaN HEMT Structure for pH Sensing Application

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材料科学与工程（中英文版） 2010年第7期4卷 1-6页

作者： Sharifabad Maneea Eizadi Zainal Abidin mastura Shafinaz Mustafa Farahiyah Hashim abdul Manaf abd Rahman Shaharin Fadzli abdul Rahman abdul Rahim Qindeel Rabia Omar Nurul Afzan Material Innovations and Nanoelectronics Research Group Faculty of Electrical Engineering Universiti Teknologi Malaysia Skudai 81310 Johor Malaysia Department of Physics Faculty of Science Universiti Teknologi Malaysia Skudai 81310 Johor Malaysia Telekom Research and Development TM Innovation Centre Cyberjaya 63000 Malaysia

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