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What do we know about the role of lncRNAs in multiple sclerosis?

Neural Regeneration Research 2021年第9期16卷 1715-1722页

作者： Viviana Nociti massimo Santoro Institute of Neurology Fondazione Policlinico Universitario‘A.Gemelli’IRCCSUniversitàCattolica del Sacro CuoreRomeItaly IRCCS Fondazione Don Carlo Gnocchi FlorenceItaly

Multiple sclerosis is a chronic, inflammatory and degenerative disease of the central nervous system of unknown aetiology although well-defined evidence supports an autoimmune pathogenesis. So far, the exact mechanisms leading to autoimmune diseases are still only partially understood. We know that genetic, epigenetic, molecular, and cellular factors resulting in pathogenic inflammatory responses are certainly involved. Long non-coding RNAs(lncRNAs) are non-protein coding transcripts longer than 200 nucleotides that play an important role in both innate and acquired immunity, so there is great interest in lncRNAs involved in autoimmune diseases. The research on multiple sclerosis has been enriched with many studies on the molecular role of lncRNAs in the pathogenesis of the disease and their potential application as diagnostic and prognostic biomarkers. In particular, many multiple sclerosis fields of research are based on the identification of lncRNAs as possible biomarkers able to predict the onset of the disease, its activity degree, its progression phase and the response to disease-modifying drugs. Last but not least, studies on lncRNAs can provide a new molecular target for new therapies, missing, so far, a cure for multiple sclerosis. While our knowledge on the role of lncRNA in multiple sclerosis has recently improved, further studies are required to better understand the specific role of lncRNAs in this neurological disease. In this review, we present the most recent studies on molecular characterization of lncRNAs in multiple sclerosis disorder discussing their clinical relevance as biomarkers for diagnosis and treatments.

关键词： antisense lncRNAs enhancer lncRNAs epigenetics immune system intergenic lncRNA intronic lncRNA multiple sclerosis sense lncRNAs single nucleotide polymorphisms

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The interplay between non-esterified fatty acids and bovine peroxisome proliferator-activated receptors: results of an in vitro hybrid approach

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Journal of Animal Science and Biotechnology 2021年第1期12卷 292-304页

作者： Sebastiano Busato massimo Bionaz Department of Animal and Rangeland Sciences Oregon State UniversityCorvallisORUSA

Background: In dairy cows circulating non-esterified fatty acids(NEFA) increase early post-partum while liver and other tissues undergo adaptation to greater lipid metabolism, mainly regulated by peroxisome proliferator-activated receptors(PPAR). PPAR are activated by fatty acids(FA), but it remains to be demonstrated that circulating NEFA or dietary FA activate bovine PPAR. We hypothesized that circulating NEFA and dietary FA activate PPAR in dairy ***: The dose-response activation of PPAR by NEFA or dietary FA was assessed using HP300 e digital dispenser and luciferase reporter in several bovine cell types. Cells were treated with blood plasma isolated from Jersey cows before and after parturition, NEFA isolated from the blood plasma, FA released from lipoproteins using milk lipoprotein lipase(LPL), and palmitic acid(C16:0). Effect on each PPAR isotype was assessed using specific synthetic ***: NEFA isolated from blood serum activate PPAR linearly up to ~ 4-fold at 400 μmol/L in MAC-T cells but had cytotoxic effect. Addition of albumin to the culture media decreases cytotoxic effects of NEFA but also PPAR activation by ~ 2-fold. Treating cells with serum from peripartum cows reveals that much of the PPAR activation can be explained by the amount of NEFA in the serum(R~2 = 0.91) and that the response to serum NEFA follows a quadratic tendency, with peak activation around 1.4 mmol/L. Analysis of PPAR activation by serum in MAC-T, BFH-12 and BPAEC cells revealed that most of the activation is explained by the activity of PPARδ and PPARγ, but not PPARα. Palmitic acid activated PPAR when added in culture media or blood serum but the activation was limited to PPARδ and PPARα and the response was nil in serum from post-partum cows. The addition of LPL to the serum increased > 1.5-fold PPAR ***: Our results support dose-dependent activation of PPAR by circulating NEFA in bovine, specifically δand γ isotypes. Data also support the

关键词： Albumin Blood serum Bovine Gene reporter Hepatocytes Lipoprotein lipase Mammary cells Non-esterified fatty acids Peroxisome proliferator-activated receptor

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Phase diagram of muonium hydride:the significant effect of dimensionality

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Communications in Theoretical Physics 2024年第2期76卷 182-187页

作者： Jieru Hu massimo Boninsegni Department of Physics University of Alberta State Key Laboratory of Precision Spectroscopy East China Normal University

We carry out a theoretical investigation of the low-temperature phase diagram of muonium hydride in two dimensions,using numerical *** is shown that the phase diagram of this substance is qualitatively different in two and three ***,while in three dimensions it is essentially identical to that of parahydrogen,i.e.,only displaying a single(crystalline)*** two dimensions it is very similar to that of^(4)He,with an equilibrium liquid phase that turns superfluid at a temperature as high as~2.2 K,and crystallizes under applied *** is a well-described case of a continuous-space condensed matter system whose ground state equilibrium phase is qualitatively altered by dimensional reduction.

关键词： quantum fuids and solids quantum Monte Carlo phase diagrams

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Global-in-time Uniform Convergence for Linear Hyperbolic-Parabolic Singular Perturbations

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Acta Mathematica Sinica,English Series 2006年第4期22卷 1161-1170页

作者： Marina GHISI massimo GOBBINO Universitàdegli Studi di Pisa Dipartimento di Matematicavia M.Buonarroti 256127 PISAItaly Universitàdegli Studi di Pisa Dipartimento di Matematica Applicata "Ulisse Dini"via Bonanno 25/B56126 PISAItaly

We consider the Cauchy problem εu^″ε ＋ δu′ε ＋ Auε = 0, uε（0） = uo, u′ε（0） = ul, where ε 〉 0, δ 〉 0, H is a Hilbert space, and A is a self-adjoint linear non-negative operator on H with dense domain D（A）. We study the convergence of （uε） to the solution of the limit problem ,δu＇＋ Au = 0, u（0） = u0. For initial data （u0, u1） ∈ D（A1/2）× H, we prove global-in-time convergence with respect to strong topologies. Moreover, we estimate the convergence rate in the case where （u0, u1）∈ D（A3/2） ∈ D（A1/2）, and we show that this regularity requirement is sharp for our estimates. We give also an upper bound for ｜u′ε（t）｜ which does not depend on ε.

关键词： Parabolic equations Damped hyperbolic equations Singular perturbations

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Bed-roughness investigation for a 2-D model calibration:the San Martin case study at Lower Parana

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International Journal of Sediment Research 2013年第4期28卷 458-469页

作者： massimo GUERRERO Alberto LAMBERTI Laboratory of Hydraulic Engineering University of Bologna Environmental and Materials Engineering Department University of Bologna

This paper illustrates how the acoustic Doppler current profiler(ADCP) and single-beam echo-sounder(SBI:S)recordings can be used for the calibration of existing software to assist in generalizing the morphodynamie processes in large rivers at key sites such as bifurcations and *** of the MIKH21C numerical model by the Danish Hydraulic Institute at the 25-km-long reach of Lower Parana near Rosario(Argentina) is *** reach includes two downstream confluences and two *** model simulates a 2-1) depth-averaged How velocity and the related sediment fluxes to predict the bifurcation morphodynamics that affects the Parana *** investigate the river channel bathymetry,roughness,flow discharge allocation at bifurcations,suspended sediment concentration and grain size distributions,several instruments were *** instruments included two ADCPs by Teledyne RDI working at frequencies of 600 and 1,200 kHz,a Sontek ADCP working at a frequency of 1,000 kHz and a *** method to assess suspended sediment concentration and grain size distributions has been previously *** paper focuses primarily on investigating dune morphology(by means of SBES depth measurements) and friction velocity(by means of ADCP profiling) to determine the river channel ***2-D model results agree with observed values of bed-roughness,flow velocity and suspended sediment concentration distributions at the investigated sections,known data of water slope and total load of bed sediment are in good agreement with model results.

关键词： 2-D model calibration ADCP Bed-roughness Parana River

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Nuclear peroxisome proliferator activated receptor-gamma(PPARγ)as a therapeutic target to treat neurodegeneration and dependence elicited by drugs of abuse

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Neural Regeneration Research 2021年第5期16卷 984-985页

作者： Roberto Ciccocioppo massimo Ubaldi School of Pharmacy Pharmacology UnitUniversity of CamerinoCamerinoItaly

Peroxisome proliferator activated receptors(PPARs)are ligand-activated transcription factors that are located in the *** activation by specific ligands,PPARs enter the nucleus and heterodimerize with the retinoid x *** heterodimer binds to PPAR response element in DNA to regulate the transcription of genes that are involved in different physiological processes,including insulin sensitization,inflammatory response,and neuroprotection(Kapadia et al.,2008).

关键词： dimer activation element

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Hydraulics and Hydrology in Mountain Areas

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Journal of Mountain Science 2014年第6期11卷 1383-1384页

作者： massimo GRECO Department of Civil Environmental and Architectural Engineering University Federico II of NaplesVia Claudio 21 80125Napoli Italy

The 35th IAHR World Congress was held in Chengdu,China from September 8 to September *** title of the conference was:'The Wise Finds Pleasure in Water:Meandering through Water Science and Engineering'.During the congress,1239 papers were presented in 139sessions for oral presentations and 7 sessions for poster *** the Congress,a Committee was appointed to select some of the best papers presented at the Congress for publication,after

关键词：水文山区液压世界大会水科学

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σ-Phase in Lean Duplex Stainless Steel Sheets

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Acta Metallurgica Sinica(English Letters) 2015年第3期28卷 331-337页

作者： Marco Breda massimo Pellizzari Marco Frigo Industrial Engineering Department(DII) University of PadovaVia Marzolo 9Int.435131 PaduaItaly Industrial Engineering Department(DII) University of TrentoVia Mesiano 7738123 TrentoItaly Outokumpu S.p.A. Piazza Piccapietra 916121 GenoaItaly

The precipitation kinetics of secondary phases in two austeno-ferritic lean duplex stainless steels（lean DSS）were examined after aging the materials at 800 ℃.Owing to the instability of ferrite,all DSS are known to be sensitive to solid-state phase transformations in the critical temperature range 600-1,000 ℃ and different secondary phases may form,depending on composition and *** performed thermodynamic simulations revealed the proneness to the precipitation of such phases also have been done in lean DSS,but only information on the equilibrium microstructures were ***,the materials were aged at various times,in order to verify the simulations and determine the precipitation *** occurred structural modifications were observed and quantified by scanning electron microscope and X-ray diffraction measurements,determining phase type,composition and volumetric *** 800 ℃,grade 2101 was found to be only affected by Cr_2N nitrides precipitation,whereas a significant amount of σ-phase was found to form in LDX 2404 for treatment longer than 1 h,almost totally replacing ferrite after 50 *** to now,the intermetallic σ-phase has been observed only in the high alloyed DSS,and the unexpected precipitation in grade 2404 highlighted that the increased content of molybdenum in this steel might be considered as determinant for the formation.

关键词： Lean duplex stainless steels Isothermal heat treatments σ-Phase Chromium nitrides Precipitation kinetics

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Correlation of powder flow properties to interparticle interactions at ambient and high temperatures

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Particuology 2014年第1期12卷 90-99页

作者： Igino Tomasetta Diego Barletta massimo Poletto Dipartimento di Ingegneria Industriale Università degli Studi di Salerno

A combination of a continuum approach and a particleparticle approach to describe the multiscale nature of the mechanical properties of bulk solids may be beneficial to scientific and engineering applica tions. In this paper, a procedure is proposed to estimate the interparticle forces beginning with the bulk flow properties as measured with standardized techniques. In particular, the relationship between inter particle forces and bulk solid tensile strength is adopted based on the microscale approaches of Rumpf （1970） and Molerus （1975）. The flow properties of fluid cracking catalyst （FCC）, corundum and glass bead powders were all characterized with a modified Schulze ring shear cell capable of operating at tempera tures up to 500 ~C. The powder test conditions were selected such that the van der Waals forces were the most significant particleparticle interactions. The model equations describe two cases, in which either elastic or plastic deformation of the contact points is assumed. The results indicate that the model pro vides the correct order of magnitude for the values of the tensile strength when proper values for the mean curvature radius at the contact points are taken into account. A sensitivity analysis for the main parameters in the model was performed. This analysis indicated that the assumption of plastic deforma tion at contact surfaces coupled with a decrease in porosity justified an increase of the tensile strength with consolidation stress. Furthermore, the effect of temperature on the measured flow behavior can be explained as a change in the strength of the material.

关键词： Shear testingYield locusvan der Waals forcelnterparticle interactionsPowder consolidationHigh temperature

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A comparison between powder flow property testers

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Particuology 2017年第3期15卷 10-20页

作者： Hamid Salehi Diego Barletta massimo Poletto Dipartimento di lngegneria lndustriale Universita degli Studi di Salerno Via Giovanni Paolo II 132 84084 Fisciano SA Italy

In this work, three different shear testers-the Jenike shear cell tester, the Schulze ring shear tester, and the Brookfield powder flow tester-were compared in terms of the raw shear stress time series, yield loci points, angle of internal friction, cohesion, and unconfined yield strength. The three different powders of dolomitic lime, calcium lactate, and calcium carbonate were used for these comparisons. These three powders were characterized into different flowability classes using the ]enike classification, wherein dolomitic lime falls into the cohesive range, calcium lactate falls into the free-flowing range, and calcium carbonate falls into the very cohesive range. Results showed that the best agreement between the testers was found with moderately cohesive powders such as dolomitic lime. Furthermore, the free-flowing material tends to produce more consistent data between the three testers in terms of shear stresses and yield loci. It should be noted that the pre-shear data of free-flowing powder obtained by the Jenike shear cell must be appropriately interpreted. The largest differences between the testers are found with calcium carbonate, which is a highly compressible powder. The ways in which a high powder compressibility can differently affect the results obtained with the different testers were discussed.

关键词： Powder flow property Shear tester Flowability Jenike tester Schulze tester Brookfield powder flow tester

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