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Conservative management of an early abdominal complication during a Tullio percutaneous endoscopic excision of renal pelvis urothelial carcinoma:A case report

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World Journal of Clinical Urology 2024年第1期13卷 1-6页

作者： massimiliano Bernabei NicolòFabbri Danila Romeo Elisa Paiolo Martina Bandi Maurizio Simone Department of Urology Azienda USL di FerraraFerrara 44100Italy Department of Surgery University of FerraraAzienda USL of FerraraAzienda USL of FerraraFerrara 44100FerraraItaly Local Health Agency of Ferrara Ferrara 44100Italy

BACKGROUND Upper tract urothelial carcinoma(UTUC)representing only a small fraction of all urothelial *** predominantly affects the renal pelvis in men,often coexisting with bladder *** displays a more aggressive genetic profile compared to bladder neoplasms,with the majority of patients presenting with advanced ***,about a quarter of UTUC cases exhibit high-grade subtypes,associated with a worse *** use and past exposure to aromatic amines are significant risk factors for *** modalities such as Uro-computed tomography and magnetic resonance imaging play crucial roles in *** is vital for direct visualization and biopsy sampling,but its limited sampling capacity presents challenges in determining tumor depth and ***,nephroureterectomy with bladder cuff excision has been the gold-standard treatment for *** conservative treatment has recently emerged as a viable option for selected patients,offering comparable oncological outcomes to radical *** access is also feasible for larger intrarenal *** SUMMARY We present a case of an 84-year-old woman who underwent percutaneous endoscopic excision of a renal pelvis neoplasm using the Tullio *** successful tumor removal,the patient experienced a postoperative complication with abdominal fluid *** management effectively resolved the *** the patient's age and refusal for radical surgery,the conservative approach proved to be a valid therapeutic *** Overall,UTUC remains a diagnostic and therapeutic challenge due to its ***,advances in endoscopic and percutaneous techniques provide valuable alternatives for selected patients,warranting further exploration in this evolving field.

关键词： Upper tract urothelial carcinoma Endoscopic treatment Damage management Case report

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Interleukin-21 triggers effector cell responses in the gut

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World Journal of Gastroenterology 2010年第29期16卷 3638-3641页

作者： Daniela De Nitto massimiliano Sarra Francesco Pallone Giovanni Monteleone Department of Internal Medicine University "Tor Vergata" of Rome

In the gut of patients with Crohn's disease and patients with ulcerative colitis,the major forms of inflammatory bowel diseases(IBD) in humans,the tissue-damaging immune response is mediated by an active cross-talk between immune and non-immune *** evidence indicates also that cytokines produced by these cells play a major role in initiating and shaping this pathologic *** such cytokine seems to be interleukin(IL)-21,a member of the common γ-chainreceptor ***-21 is produced in excess in the in-flamed intestine of patients with IBD mostly by activated CD4+ T helper cells co-expressing interferon-γ and follicular T helper ***,both in vitro and in vivo studies indicate that excessive IL-21 production leads to the activation of multiple signaling pathways that expand and sustain the ongoing mucosal *** this article,we review the available data supporting the pathogenic role of IL-21 in IBD.

关键词： Interleukin-21 Gut T cells Epithelial cells Fibroblasts

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Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy:Potential role of insulin

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World Journal of Gastroenterology 2008年第37期14卷 5695-5700页

作者： Valter Donadon massimiliano Balbi Pietro Casarin Alessandro Vario Alfredo Alberti Department of Medicine and Internal Medicine 3rd Pordenone HospitalPordenone 33170 Italy Department of Clinical and Experimental Medicine University of PadovaPadova 35100 Italy

AIM: To investigate the relationships between Type 2 diabetes mellitus (DM2) and the risk of hepatocellular carcinoma (HCC). METHODS: We studied the association between DM2 and HCC in a large case-control study that enrolled 465 consecutive Caucasian patients with HCC (78.3% males, mean age 68.5 ± 8.9 years) compared with an age and sex matched control group of 490 subjects. RESULTS: Prevalence of DM2 was significantly higher in HCC patients (31.2% vs 12.7%; OR = 3.12, 95% CI: 2.22-4.43) and in HCC cases with alcohol abuse. DM2 has been diagnosed before the appearance of HCC in 84.1% of diabetic HCC subjects with mean duration of 141.5 mo, higher in cases treated with insulin than in those with oral antidiabetic agents (171.5 vs 118.7 mo). Compared to controls, males DM2 with HCC were more frequently treated with insulin (38.1% vs 17.6%, P = 0.009) and with sulfonylurea with or without metformin than with diet with or without metformin (84% vs 68.3%, P = 0.049). CONCLUSION: DM2 in our patients is associated with a 3-fold increase risk of HCC. In most of our cases DM2 pre-existed to HCC. Patients with DM2 and chronic liver disease, particularly insulin treated males, should be considered for HCC close surveillance programs.

关键词： Hepatocellular carcinoma Type 2 diabetesmellitus Hepatitis virus B and C Insulin Antidiabetic therapy

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Lux in China: Focus on Fashion and Luxury Industry in China

Lux in China: Focus on Fashion and Luxury Industry in China

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作者： massimiliano CIMS 复旦大学

学位级别：硕士

即使在近期经济危机中,中国仍是奢侈品品牌增长最快的市场。到2015年时,中国将成为世界上最大的奢侈品市场。奢侈时尚品牌要经常与奢侈品消费者沟通,中国消费者实际上学习能力非常强。根据Saviolo Corbellini的研究,在时尚奢侈品运作模... 详细信息

即使在近期经济危机中,中国仍是奢侈品品牌增长最快的市场。到2015年时,中国将成为世界上最大的奢侈品市场。奢侈时尚品牌要经常与奢侈品消费者沟通,中国消费者实际上学习能力非常强。根据Saviolo Corbellini的研究,在时尚奢侈品运作模式中有两个模式:设计师品牌模式和奢侈品业务模式。这两个模式在中国市场的规模、销售和沟通上都在追寻不同的增长策略。奢侈品品牌例如Dunhill,LouisVuitton和Salvatore Ferragamo,在中国经过15年的发展,仍然投资于他们专属的品牌遗产上,并解释成遗产就是品牌历史的经典性,它以一种神秘的方式传达出品牌竞争力,同时在中国传递品牌价值。设计师品牌例如Miu Miu和Dolce&Gabbana,他们没有属于自己的遗产,所以在中国发展时,他们改变了部分收藏款系列,以符合中国人的品位。这两个策略都很有趣,而且在中国,他们都有很好的运作效果。但这里很难说哪个运作模式做的更好,因为我们是在评述两个类别。这三个之前分析的品牌Salvatore Ferragamo,Dunhill和Louis Vuitton是非常好的例子,可以表现出这些十几年前进入中国的品牌,仍在大量投资于公司遗产方面的建设上。Dunhill通过零售体验体现,Salvatore Ferragamo通过艺术品展和纪念性事件体现,这些公司的目标是基本一致的,通过建设品牌知晓度进而建设在中国的品牌形象。许多这些品牌都在多年的巨额投资后,刚刚获得部分利润。从以上一个非常简单的提纲中,我们就可以了解到通过三个豪华汽车品牌的展示,不同策略是如何体现的,以及他们在品牌知晓度和金钱上的投资回报。Dunhill通过零售遗产的经验并根据大纲,大幅度增加了它的品牌文化,这对最好的豪华车品牌而言,其策略从开始就是成功的。有一件事要考虑的就是,Dunhill在中国的成功不仅仅是庸俗的利用其遗产的历史,其他因素也造就了它的成功,这些因素的功劳,实际上我们没有忘记。Louis Vuitton也做得不错,其展览和“豪华车比赛”仍然令人难忘,除此之外该公司一直把重点放在二线城市上。SalvatoreFerragamo是一个伟大的品牌,在亚洲它具有很强的知晓度,特别是在中国,它获得了越来越多的重视,2008年公司在上海的80周年庆典证明了这一点。遗产正如我们所看到的,是一种价值观念,这是一个品牌得以在中国胜出的关键。通过例子,我们知道中国需要的是奢侈品品牌是投资于遗产的。遗产也在另一个层面上说明了质量。在中国这个日益增长的市场上,消费者愿意花更多的钱在有强烈遗产的产品上。最后,我建议每个品牌,尤其是以奢侈品的商业模式投资于遗产方面的品牌,能够结合两种不同的策略,犹如我在案例研究中提到的。

关键词：奢侈品市场 luxury heritage exhibition stores goods retail fashion advertising everything

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Fission-fusion dynamics of a pelagic delphinid in the arctic:the white-beaked dolphin(Lagenorhynchus albirostris)

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Integrative Zoology 2021年第4期16卷 512-526页

作者： Chiara G.BERTULLI Marianne H.RASMUSSEN massimiliano ROSSO Department of Life and Environmental Sciences University of IcelandReykjavikIceland Sea Watch Foundation New QuayUK Húsavík Research Centre University of IcelandHúsavíkIceland CIMA Research Foundation SavonaItaly

Delphinids exhibit great variability in their social *** is therefore important to document lesser known species,in extreme changing habitats,to compare and contrast mechanisms driving ***,we describe the first long-term assessment of social structure of white-beaked dolphins(Lagenorhynchus albirostris)using a compiled version of SOCPROG 2.8 and an 11-year photo-identification dataset(2002–2013)collected from whalewatching vessels at 2 sites(Faxaflói and Skjálfandi bays)off *** identified a total of 487 dolphins which are suggested to be part of an open population as shown by the discovery curve obtained analyzing photo-id *** social analyses were restricted to 35 adults which were sighted on≥5 different *** mean residency time of white-beaked dolphins in our 2 study areas was of 95 days(SE=35.63;95%CI:23-171),with the“migration-full interchange”model best describing movements of dolphins in and out of our 2 study *** differentiation in this population was high(Likelihood:S=0.87,SE=0.04;r=0.31,SE=0.03)indicating diverse,non-random social *** associations best fit the model of“casual acquaintances”against the standardized lagged association rates with the majority of white-beaked dolphin associations being short-term,but with a few long-term across *** for preferred companionship,long-term associations are favored over *** this study,associations among white-beaked dolphins are short-term but with desirably long-term associations fitting into a society with fission-fusion *** information expands the latitudinal range for which social structure has been described for oceanic dolphin species.

关键词： association patterns Iceland Lagenorhynchus albirostris social structure white-beaked dolphin

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Finding a way to preserve mitochondria: new pathogenic pathways in experimental multiple sclerosis

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Neural Regeneration Research 2019年第1期14卷 77-78页

作者： Andrea Mancini Lorenzo Gaetani Lucia Gentili massimiliano Di Filippo Clinica Neurologica Dipartimento di Medicina Università degli Studi di Perugia

Multiple sclerosis(MS)is a chronic disorder affecting central nervous system(CNS)in which inflammatory and neuro-degenerative features coexist since the earlier phases of the disease(Reich et al.,2018).During last years,attention has been directed toward the possible pathogenic pathways linking these two different features characterizing MS,in order to acquire a better understanding of the disease pathogenesis and to design new disease modifying *** available therapies for MS are primarily

关键词：小径病原硬化多重试验性线粒体保存疾病

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Continental accretion and incremental deformation in the thermochronologic evolution of the Lesser Caucasus

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Geoscience Frontiers 2019年第6期10卷 2189-2202页

作者： William Cavazza Irene Albino Ghazar Galoyan massimiliano Zattin Silvia Cattò Department of Biological Geologicaland Environmental SciencesUniversity of BolognaItaly Institute of Geological Sciences National Academy of SciencesYerevanArmenia Department of Geosciences University of PaduaItaly

Apatite fission-track analysis and thermochronologic statistical modeling of Precambrian-Oligocenc plutonic and metamorphic rocks from the Lesser Caucasus resolve two discrete cooling *** occurred during incremental crustal shortening due to obduction and continental accretion along the margins of the northern branch of the Neotethys.(1)The thermochronometric record of a Late Cretaceous(Turonian-Maastrichtian)cooling/exhumation event,coeval to widespread ophiolite obduction,is still present only in a relatively small area of the upper plate of the Amasia-Sevan-Akera(ASA)suture zone,*** suture marking the final closure of the northern Neotethys during the *** area has not been affected by significant later exhumation.(2)Rapid cooling/exhumation occurred in the Early-Middle Miocene in both the lower and upper plates of the ASA suture zone,obscuring previous thermochronologic signatures over most of the study *** contractional reactivation of the ASA suture zone occurred contemporaneously with the main phase of shortening and exhumation along the Bitlis suture zone marking the closure of the southern branch of the Neotethys and the ensuing ArabiaEurasia *** collisional stress from the Bitlis suture zone was transmitted northward across the Anatolian hinterland,which was left relatively undeformed,and focused along preexisting structural discontinuities such as the eastern Pontides and the ASA suture zone.

关键词： Lesser Caucasus Low-temperature thermochronology Apatite fission-track analysis Structural reactivation Far-field tectonics

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Value Creation and Stock Prices:An Empirical Analysis Across Different Financial Markets

Value Creation and Stock Prices:An Empirical Analysis Across...

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作者： massimiliano MANNIELLO 复旦大学

学位级别：硕士

现今的管理者们经常陷入互相冲突的管理目标当中。他们一方面必须为投资者们不同的利益和目标去追求,然而与此同时,管理者激励体制并不总是能使管理者的目标和投资者的目标相一致。因此作为结果,什么应该作为管理活动的主要关注点这一... 详细信息

现今的管理者们经常陷入互相冲突的管理目标当中。他们一方面必须为投资者们不同的利益和目标去追求,然而与此同时,管理者激励体制并不总是能使管理者的目标和投资者的目标相一致。因此作为结果,什么应该作为管理活动的主要关注点这一问题经常不能得到清楚的解释。什么应该作为管理者经营公司的目标这一问题一直以来是学术界长期争论的焦点。目前已经出现了很多种不同观点。然而,管理者们应该真正关心的是企业的价值创造。如果一家公司能够创造价值,那么极有可能这家公司经营活动的所有参与因素都将得到改善。在学者们提出的所有指标和模型当中,一个由两个麦肯锡季刊作者提出的模型似乎是最好的。基本上,当投资回报率(ROIC)高于其资本加权平均成本(WACC)和增长率之间的差异时,公司就将产生价值。否则,他们将摧毁价值。本研究的目的是为了验证在2005-2011年期间,在何种程度上股票价值变动的百分比已经被具体的价值创造所解释。本文将对四个不同的金融市场：纽约证券交易所,米兰证券交易所,香港联合交易所和印度国家证券交易所的金融市场中的股票价格走势和麦肯锡指数之间的关系进行相关性分析。被抽样的企业将来自于四个不同的金融市场,这将突出显示国家这一因素是否会影响价格走势和价值创造之间的关系。此外,不同模型解释短期和长期变动的效率也将被着重分析。本分共分为五个主要部分第一章中详细讨论了关于什么应当作为财务管理目标的不同看法,并着重说明了价值创造作为公司最终目标的重要性第二章总结并归纳了近年来关于价值创造的文献及所提出的不同矩阵和框架第三章详细讨论了有效财务市场的观点,并就关于市场有效性的不同主流意见当中的一些观点进行了讨论,与此同时,本文也对市场有效性的观点的主要局限性进行了详细说明。在第四章中,本文将2005至2011年四种不同的金融市场,即纽约证券交易所,米兰证券交易所,香港联合交易所和印度国家证券交易所的金融市场当中的麦肯锡价值创造指数与股票价格走向进行了联系最后,在第五章中详细讨论了本分分析的主要结论,并着重说明了对不同金融市场的影响,不同时间的关注度(短期与长期),考虑的时期(2008之前与之后)以及该模型的有效性。在本文实证分析的最后,本文将对前几章节提出的开放性问题做出一解答。特别地,本文将对市场有效性,公司经营管理的目标,以及公司价值创造活动与金融市场上的股票价格走势之间的关系等问题一一得出结论。

关键词：价值创造股票价格投资回报率加权平均成本增长率

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Immortalized hippocampal astrocytes from 3xTg-AD mice,a new model to study disease-related astrocytic dysfunction:a comparative review

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Neural Regeneration Research 2023年第8期18卷 1672-1678页

作者： Laura Tapella Giulia Dematteis Armando A Genazzani massimiliano De Paola Dmitry Lim Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Department of Neuroscience Mario Negri Institute for Pharmacological Research IRCCSMilanoItaly

Alzheimer's disease(AD)is characterized by complex etiology,long-lasting pathogenesis,and celltype-specific ***,there is no cure for AD,emphasizing the urgent need for a comprehensive understanding of cell-specific ***,principal homeostatic cells of the central nervous system,are key players in the pathogenesis of neurodegenerative diseases,including *** models greatly facilitate the investigation of cell-specific pathological alterations and the dissection of molecular mechanisms and ***-derived and immortalized astrocytic cell lines,alongside the emerging technology of adult induced pluripotent stem cells,are widely used to study cellular dysfunction in ***,no stable cell lines were available from genetic mouse AD ***,we established immortalized hippocampal astroglial cell lines from amyloid-βprecursor protein/presenilin-1/Tau triple-transgenic(3xTg)-AD mice(denominated as wild type(WT)-and 3Tg-iAstro cells)using retrovirus-mediated transduction of simian virus 40 large T-antigen and propagation without clonal selection,thereby maintaining natural heterogeneity of primary *** groups have successfully used 3Tg-iAstro cells for single-cell and omics approaches to study astrocytic AD-related alterations of calcium signaling,mitochondrial dysfunctions,disproteostasis,altered homeostatic and signaling support to neurons,and blood-brain barrier *** we provide a comparative overview of the most used models to study astrocytes in vitro,such as primary culture,tumor-derived cell lines,immortalized astroglial cell lines,and induced pluripotent stem cell-derived *** conclude that immortalized WT-and 3Tg-iAstro cells provide a noncompetitive but complementary,low-cost,easy-to-handle,and versatile cellular model for dissection of astrocyte-specific AD-related alterations and preclinical drug discovery.

关键词： Alzheimer's disease astrocytes immortalization astroglial Alzheimers's disease model blood-brain barrier calcium signaling central nervous system homeostasis disproteostasis endoplasmic reticulum-mitochondria contacts induced pluripotent stem cell-derived astrocytes protein synthesis

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Photometric light curve solutions of three ultra-short period eclipsing binaries

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Research in Astronomy and Astrophysics 2020年第4期20卷 163-170页

作者： Francesco Acerbi Raul Michel Carlo Barani massimiliano Martignoni Lexter Fox-Machado Stazione Astronomica Betelgeuse Magnago 20020Italy Instituto de Astronomia Universidad Nacional Autonoma de MexicoApartado Postal 877C.P.22800 EnsenadaB.C.Mexico

We present the results of our study of the eclipsing binary systems CSS J112237.1+395219,LINEAR 1286561 and LINEAR 2602707 based on new CCD B,V,Rcand Iccomplete light *** ultra-short period nature of these stars,as reported by Drake et al.,is confirmed and the system’s periods are *** light curves were modeled using the 2003 version of the Wilson-Devinney *** necessary,cool spots on the surface of the primary component were introduced to account for asymmetries in the light *** a result,we found that CSS J112237.1+395219 is a W UMa type contact binary system belonging to W subclass with a mass ratio of q=1.61 and a shallow degree of contact of 14.8%where the primary component is hotter than the secondary one by 500 *** 1286561 and LINEAR2602707 are detached binary systems with mass ratios q=3.467 and q=0.987 *** detached systems are low-mass M-type eclipsing binaries with similar *** marginal contact,fill-out factor and temperature difference between components of CSS J112237.1+395219 suggest that this system may be at a key evolutionary state predicted by thermal relaxation oscillation(TRO)*** the estimated absolute parameters,we conclude that our systems share common properties with other ultrashort period binaries.

关键词： techniques:photometric stars:variables:Contact Binary stars:individual:CSS J112237.1+395219 LINEAR 1286561 and LINEAR 2602707

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