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Aqueous extract of lavender(Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer's disease

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Neuroscience Bulletin 2011年第2期27卷 99-106页

作者： masoud soheili kashani Mostafa Rezaei Tavirani Sayyed Alireza Talaei Mahmoud Salami Shaheed Beheshti医科大学蛋白质组研究中心卡珊医科大学生理学研究中心

Objective Alzheimer＇s disease（AD） is one of the most important neurodegenerative *** is characterized by dementia including def icits in learning and *** present study aimed to evaluate the effects of aqueous extract of lavender（Lavandula angustifolia） on spatial performance of AD *** Male Wistar rats were f irst divided into control and AD *** model of AD was established by intracerebroventricular injection of 10 ？g A？1-42 20 d prior to administration of the lavender *** in both groups were then introduced to 2 stages of task learning（with an interval of 20 d） in Morris water maze,each followed by one probe *** the f irst stage of spatial learning,control and AD animals received different doses（50,100 and 200 mg/kg） of the lavender *** In the first stage of experiment,the latency to locate the hidden platform in AD group was significantly higher than that in control ***,in the second stage of experiment,control and AD rats that received distilled water（vehicle） showed similar performance,indicating that the maze navigation itself could improve the spatial learning of AD ***,in the second stage of experiment,control and AD rats that received lavender extract administration at different doses（50,100,and 200 mg/kg） spent less time locating the platform（except for the AD rats with 50 mg/kg extract treatment）,as compared with their counterparts with vehicle treatment,*** addition,lavender extract significantly improved the performance of control and AD rats in the probe test,only at the dose of 200 mg/kg,as compared with their counterparts with vehicle *** The lavender extract can effectively reverse spatial learning def icits in AD rats.

关键词： Alzheimer's disease Lavandula angustifolia spatial learning rat water maze

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An analysis of association of personality traits with job burnout among nurses working in hospital

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Journal of Integrative Nursing 2023年第1期5卷 43-49页

作者： Hossein AKBARI masoud MOTALEBI kashani Sedighe DEHGHANI BIDGOLI Masoumeh Koochaki NASRABADI Fahimeh KARAMALI Trauma Research Center Kashan University of Medical SciencesKashanIran Social Determinants of Health Research Center Kashan University of Medical SciencesKashanIran Department of Occupational Health Kashan University of Medical SciencesKashanIran Department of English Literature Kashan universityKashanIran Department of Health Safety and Environmental ManagementSchool of HealthKashan University of Medical SciencesKashanIran

Objective:The objective of the present study is to explore the effects of personality traits on job burnout among hospital *** and Methods:This cross-sectional research was done during 2019-2020 at Kashan Shahid Beheshti *** data analysis procedures included descriptive statistics and the partial least squares-based structural equation *** participants were 150 nursing professionals.A questionnaire indicating information on demographics,burnout(measured using the Maslach Burnout Inventory with three dimensions of depersonalization,emotional exhaustion,and personal accomplishment),and personality profile(measured employing the neuroticism extraversion openness five-factor inventory including extroversion,conscientiousness,agreeableness,neuroticism,and openness to experience dimensions)was used to gather the required ***:The results of the study showed that the validity and reliability of the measurement model were desirable(factor load higher than 0.5,the Cronbach’s alpha value and the composite reliability are>0.7).Structural model showed statistically drastic,negative relationship between the nurses’burnout levels and neuroticism(β=0.722)and openness to experience(β=0.437).However,the relationship was significantly positive between the nurses’burnout levels and conscientiousness(β=0.672),agreement(β=0.594),and extraversion(β=0.559)(P<0.03).Conclusions:The present study helped the recognition of burnout among nurses working in hospitals and approved the effects of personality features on the burnout experience.

关键词： Hospital nursing job burnout nurses personality traits professional burnout

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Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

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Neuroscience & Medicine 2012年第4期3卷 362-367页

作者： masoud soheili Mostafa Rezaei Tavirani Mahmoud Salami Physiology Research Center Kashan University of Medical Sciences Kashan Iran. Proteomics Research Center Faculty of Paramedical Sciences Shaheed Beheshti University of Medical Sciences Tehran Iran Student Research Committee Faculty of Paramedical Sciences Shaheed Beheshti University of Medical Sciences Tehran Iran

An important marker in neurodegenerative Alzheimer’s disease (AD) is abnormal production of amyloid beta (Aβ) peptide leading to formation of plaques in the brain. Through decreasing Aβ aggregates, anti-inflammatory agents, phagocytosis, and proteolytic enzymes are known to decline risk of Aβ plaque formation. In the previous study we showed that aqueous extract of Lavandula angustifolia (lavender), with known anti-inflammatory effects, improves memory deficits in animal model of Alzheimer. Here, we assess if lavender play a role in clearance of Aβ plaques in the hippocampus. The Alzheimeric animals were created with intracerebroventricular injection of Aβ 1-42. To confirm formation of Aβ plaques, brain sections were stained by Congo red method. Twenty days post-injection they were administered with different doses (50, 100 and 200 mg/kg) of the aqueous extract of lavender for duration of 20 days. Our results demonstrated that 50 mg/kg of lavender not effectively influenced the Aβ plaques. On the other hand, the herbal medicine at the doses of 100 and 200 mg/kg markedly decreased the extent of Aβ aggregates. We concluded that the lavender extract dose dependently underlies elimination of Aβ plaques. The exact mechanism by which the herbal medicine removes the Aβ aggregates needs to be elucidated.

关键词： Alzheimer Amyloid Beta Lavandula angustifolia

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Study of the effects of natural toothbrush (<i>Salva-dora persica</i>) in prevention of dental caries and plaque index

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Health 2012年第9期4卷 612-618页

作者： Fatemeh Ezoddini-Ardakani Mahmoud Nouri Shadkam Hasan Fotouhi Farah Bolouri kashani Mahin Abbassi Zahra Hashemian Hossein Dehghani Mohammad Ali Jaffari Hossein Barzegar Faezeh Nazarinejhad Mohammad Kazem Jafari Abas Heydaripour Mohammad Javad Dashti Atefesadat Hedayati masoud Masoumi Somaye Ebrahimi Faculty of Dentistry Shahid Sadoughi University of Medical Sciences Yazd Iran Faculty of Medicine Shahid Sadoughi University of Medical Sciences Yazd Iran Shahid Sadoughi University of Medical Sciences Yazd Iran

Background: Nowadays, though more attention is being paid to oral and dental hygiene all over the world, dental caries and periodontal diseases are increasing daily. We decided to study the effectiveness of natural toothbrush in prevention of dental caries and plaque formation. Methods: This analytic, semi-experimental clinical trial included 390 individuals. Subjects were divided into 3 groups: using natural toothbrush, using artificial toothbrush and using both natural and artificial toothbrush. The plaque index and DMFT was assessed at the beginning of the study until 1 year. ANOVA, Kruskal Wallis, LSD, Paired t-test, chi square, Fisher exact and Mc-Nemar tests were used for data analysis. Results: The plaque index in all three groups showed a mean reduction of 0.71. The mean DMFT in the samples before intervention was 8.38 ± 4.14 and increased to 9.1 ± 4.56. At the end of the study, the lowest plaque index was observed in the group using both the natural and artificial methods. During one year follow-up, the plaque index decreased 1.16, 0.83, and 0.21 degrees in the first, second and third groups. Conclusion: The increase in DMFT in the group that used artificial toothbrush was more than other groups. Thus, use of natural toothbrush leads to a decrease in growth rate of DMFT. Therefore natural toothbrush can be used for the cleaning of teeth and prevention of dental caries.

关键词： Salvadora persica Natural Toothbrush Toothbrush and Tooth Paste Caries Plaque Index

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