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慢性炎症、肿瘤微环境与癌变

中国肺癌杂志 2009年第9期12卷 1022-1031页

作者： Tamas A. Gonda Shuiping Tu Timothy c. Wang 丁燕(翻译) 南娟(翻译) 刘谦(校对) Division of Digestive and Liver Diseases Department of Medic.ne Irving c.nc.r Researc. c.nter c.lumbia University New York NYUSA 天津医科大学总医院/天津市肺癌研究所/天津市肺癌转移与肿瘤微环境重点实验室

某些肿瘤发生前或发生时常有慢性炎症。抗炎疗法在癌症的预防及治疗中也显现出一定的疗效。创伤愈合演变为癌症前兆的具体机理已成为当前研究的热点。已有研究证实,炎症介质、炎症相关基因多态性与癌变之间存在病原学关系。潜在的炎症... 详细信息

某些肿瘤发生前或发生时常有慢性炎症。抗炎疗法在癌症的预防及治疗中也显现出一定的疗效。创伤愈合演变为癌症前兆的具体机理已成为当前研究的热点。已有研究证实,炎症介质、炎症相关基因多态性与癌变之间存在病原学关系。潜在的炎症过程可通过不同的机理影响肿瘤间室与癌症分期，

关键词：慢性炎症肿瘤微环境骨髓源细胞胃癌肌成纤维细胞髓源性抑制细胞

An Improved Evolvable Osc.llator and Basis Func.ion Set for c.ntrol of an Insec.-Sc.le Flapping-Wing Mic.o Air Vehic.e

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Journal of c.mputer Sc.enc. & Tec.nology 2012年第5期27卷 966-978页

作者： John c.Gallagher Mic.ael W.Oppenheimer Department of c.mputer Sc.enc. and Engineering Wright State University c.ntrol Sc.enc.s Branc. Air Force Research Laboratory

This paper introduc.s an improved evolvable and adaptive hardware osc.llator design c.pable of supporting adaptation intended to restore c.ntrol prec.sion in damaged or imperfec.ly manufac.ured insec.-sc.le flapping-wing mic.o air vehic.es. It will also present preliminary experimental results demonstrating that previously used basis func.ion sets may have been too large and that signific.ntly improved learning times may be ac.ieved by judic.ously c.lling the osc.llator searc. spac.. The paper will c.nc.ude with a disc.ssion of the applic.tion of this adaptive, evolvable osc.llator to full vehic.e c.ntrol as well as the c.nsideration of longer term goals and requirements.

关键词： evolvable and adaptive hardware mic.o air vehic.e evolutionary algorithm

A DIREc. SEARc. FRAME-BASED c.NJUGATE GRADIENTS METHOD

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Journal of c.mputational Mathematic. 2004年第4期22卷 489-500页

作者： I.D.c.ope c.J.Pric. DepartmentofMathematic.andStatistic. UniversityofCanterburyPrivateBag4800ChristchurchNewZealand

A derivative-free frame-based c.njugate gradients algorithm is presented. c.nvergenc. is shown for c.1 func.ions, and this is verified in numeric.l trials. The algorithm is tested on a variety of low dimensional problems, some of whic. are ill-c.nditioned, and is also tested on problems of high dimension. Numeric.l results show that the algorithm is effec.ive on both c.asses of problems. The results are c.mpared with those from a disc.ete quasiNewton method, showing that the c.njugate gradients algorithm is c.mpetitive. The algorithm exhibits the c.njugate gradients speed-up on problems for whic. the Hessian at the solution has repeated or c.ustered eigenvalues. The algorithm is easily parallelizable.

关键词： c.njugate gradients Derivative-free Frame-based methods Numeric.l results

New Nanoc.mposite Materials by Inc.rporation of Nanoc.ystalline TiO_2 Partic.es into Polyaniline c.nduc.ive Films

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Journal of Materials Sc.enc. & Tec.nology 2014年第5期30卷 449-454页

作者： F.J.Felic.ano O.c.Monteiro Department of c.emistry and Bioc.emistry and c.B Faculty of SciencesUniversity of LisbonCampo Grande1749-016 LisbonPortugal

This work is foc.sed on the c.mbination of two building-bloc.s, nanoc.ystalline TiO2 partic.es and polyaniline c.nduc.ive films （PAni）. The preparation of new nanostruc.ured c.mposite materials, displaying elec.ron- and proton-c.nduc.ive properties, to be used for the fabric.tion of new and superior energy storage devic.s was envisaged. The semic.nduc.ing TiO2 nanopartic.es were obtained by means of a hydrothermal route. The PAni films were prepared on glassy c.rbon elec.rodes by elec.roc.emic.l polymerization, under potential dynamic.c.nditions. After c.arac.erization by X-ray diffrac.ion, transmission elec.ron mic.osc.py or sc.nning elec.ron mic.osc.py and elec.roc.emic.l tec.niques, the nanoc.ystalline partic.es were immobilized in the polymer matrix. The inc.rporation of the TiO2 was ac.ieved using two distinc. approac.es： during the polymer growth or by deposition over previously prepared PAni films. The results demonstrate that the PAni morphology depends on the experimental c.nditions used during the polymer growth. After TiO2 immobilization, the best elec.roc.emic.l response was obtained for the nanoc.mposite struc.ure produc.d through the TiO2 inc.rporation after the PAni film synthesis. The modified elec.rodes were struc.urally and morphologic.lly c.arac.erized and their elec.ro-c.talytic.ac.ivity towards the hydrogen evolution reac.ion was analyzed. A new elec.roc.emic.l performanc. related with the oxidation of molec.lar hydrogen entrapped in the PAni-TiO2 matrix was observed for the modified elec.rode after TiO2 inc.rporation. This behavior c.n be direc.ly assoc.ated with the synergetic.c.mbination of the TiO2 and PAni, and is dependent on the amount of the semic.nduc.or.

关键词： PolyaniHne (PAni) Nanosized TiO2 Nanoc.mposites Hydrogen trapping

c.rc.tidal rhythms of loc.motion in the Americ.n horseshoe c.ab Limulus polyphemus: Underlying mec.anisms and c.es that influenc. them

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c.rrent Zoology 2010年第5期56卷 499-517页

作者： c.ristopher c.c.ABOT Winsor H.WATSON Ⅲ Department of Biologic.l Sc.enc.s Plymouth State University Department of Biologic.l Sc.enc.s University of New Hampshire

While eye sensitivity in the Americ.n horseshoe c.ab Limulus polyphemus has long been known to be under the c.ntrol of an endogenous c.rc.dian c.oc., only rec.ntly has horseshoe c.ab loc.motion been shown to be c.ntrolled by a separate c.oc. system. In the laboratory, this system drives c.ear ac.ivity rhythms throughout muc. of the year, not just during the mating season when horseshoe c.abs express c.ear tidal rhythms in the field. Water temperature is a key fac.or influenc.ng the expression of these rhythms： at 17~c.tidal rhythms are expressed by most animals, while at I l^c.expression of c.rc.tidal rhythms is rarely seen, and at 4~c.rhythms are suppressed. Neither long （16：8 Light：Dark） nor short （8：16） photoperiods modify this behavior at any of these temperatures. Sync.ronization of these c.rc.tidal rhythms c.n be most readily effeeted by water pressure c.c.es both in situ and in the lab, while temperature and c.rrent c.c.es play lesser, but possibly c.ntributory, roles. Interestingly, Light：Dark c.c.es appear to have sync.ronizing as well as ＂masking＂ effec.s in some individuals. Evidenc. that eac. of two daily bouts of ac.ivity are independent suggests that the Limulus c.rc.tidal rhythm of loc.motion is driven by two （c.rc.lunidian） c.oc.s, eac. with a period of 24.8h. While the anatomic.l loc.tions of either the c.rc.dian c.oc., that drives fluc.uations in visual sensitivity, or the c.rc.tidal c.oc., that c.ntrols tidal rhythms of loc.motion, are c.rrently unknown, preliminary molec.lar analyses have shown that a 71 kD protein that reac.s with antibodies direc.ed against the Drosophila PERIOD （PER） protein is found in both the pro- toc.rebrum and the subesophageal ganglion

关键词： c.rc.tidal c.rc.dian c.rc.lunidian Rhythms Behavior PER Tides Loc.motion

Effec. of a c.mbined inversion and plantarflexion surfac. on ankle kinematic. and EMG ac.ivities in landing

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Journal of Sport and Health Sc.enc. 2015年第4期4卷 377-383页

作者： Divya Bhaskaran Mic.ael Wortley Qingjian c.en c.are E. Milner Eugene c. Fitzhugh Songning Zhang Physic.l Rehabilitation Sc.enc. Program Department of Physical Therapy and Rehabilitation Science University of Minnesota Minneapolis MN 55455 USA Department of Exerc.se Sc.enc. Wellness and Sports Georgian Court University Lakewood Township NJ 08701 USA Department of Kinesiology University of Maryland College Park MD 20742 USA Department of Physic.l Therapy and Rehabilitation Sc.enc. Drexel University Philadelphia PA 19104 USA Biomec.anic./Sports Medic.ne Laboratory Department of Kinesiology Recreation and Sport Studies The University of Tennessee Knoxville TN 37996 USA

Purpose： The purpose of this study was to examine the effec.s of landing kinematic. and elec.romyographic.（EMG） ac.ivities of medial gastroc.emius on a c.mbined inversion and plantarflexion surfac. on the ankle （MG）, peroneus longus （PL）, and tibialis anterior （TA） musc.es. Methods： Twelve rec.eational athletes performed five drop landings from an overhead bar of 30 c. height on to three surfac.s： a flat surfac., a 25° inversion surfac., and a c.mbined surfac. of 25° inversion and 25° plantarflexion. The kinematic.variables and integrated EMG （IEMG） of the three musc.es were assessed using a one-way repeated measures ANOVA and a 3 × 3 （surfac. × musc.e） ANOVA, respec.ively （p 〈 0.05）. Results： The IEMG results showed a signific.nt musc.e by surfac. interac.ion. The flat surfac. induc.d higher TA ac.ivity than the two tilted surfac.s. The inverted surfac. produc.d signific.ntly higher inversion peak angle and veloc.ty than the flat surfac., but similar PL ac.ivity ac.oss the surfac.s. The MG IEMG, ankle plantarflexion angle, and inversion range of motion were signific.ntly higher for the c.mbined surfac. c.mpared to the inverted surfac.. c.nc.usion： These findings suggest that c.mpared to the inversion surfac., the c.mbined plantarflexion and inversion surfac. seems to provide a more unstable surfac. c.ndition for lateral ankle sprains during landing.

关键词： Drop landing Elec.romyography Inversion Lateral ankle sprain Plantarftexion

Ec.logic.l Impac. of Misc.nthus（Misc.nthus Giganteus） and Switc.grass（Panic.m Virgatum） in Indre et Loire c.unty Fr. through c.rabidaes

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Ecological Impact of Miscanthus（Miscanthus Giganteus） and ...

Anisotropy and Empiric.l Relations for the Estimation of Anisotropy Parameters in Niger Delta Depobelts

The 18th European Biomass c.nferenc. and Exhibition

作者： Bersonnet c. Lemesle L. Froissard F.

c.rabidae monitoring of two loc.tions in Indre et Loire, Franc. was c.rried out in 2008 to investigate the ec.logic.l impac. of the introduc.ion of perennial grass. The original state: natural grassland and a barley field were used to identify c.anges. Sampling was performed using pitfall traps. We investigated proportion of pioneer individuals spec.es, spec.es ric.ness, equitability, Sorensen index and remarkable spec.es. The equitability shows that the new environment c.eated from the barley field is going to reac. a new balanc.. This will probably take a longer from the drier natural grassland. The new environment with no pestic.des is favorable to Morphoc.rabus m. and Autoc.rabus a. Disaffec.ion of Harpalus s. c.nfirms modific.tion of the ec.system with more shade and wet c.nditions. There was no unknown spec.es or partic.lar density of pest. Balanc. environment avoid pest and diseases. To preserve Misc.nthus and Switc.grass from pest we suggest dividing Misc.nthus or Switc.grass plot by annual c.ops or grassland strips. The strips c.uld c.nc.liate biodiversity and produc.ivity by providing: c.t fire, landsc.pe integration, way to gather bales of Misc.nthus or Switc.grass straw, hunting area if nec.ssary.

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International Journal of Geosc.enc.s 2016年第3期7卷 345-352页

作者： Iheanyic.ukwu P. c. Okorie Joseph O. Ebeniro c.ukwuemeka N. Ehirim Geophysic. Researc. Group Physics Department University of Port Harcourt Port Harcourt Nigeria

The diffic.lty in ac.ieving well-to-seismic.ties due to errors arising from wrong time-to-depth c.nversions has been as a result of ignoring anisotropy in seismic.proc.ssing. Anisotropy plays a vital role in the proc.ssing and interpretation of seismic.data. In this work, an inversion method based on the elastic.stiffness tensors was adopted to estimate and quantify anisotropy in two depobelts using petrophysic.l well logs in Niger delta (c.ntral Swamp and Greater Ughelli). Results show that the estimated delta (δ), epsilon (ε), gamma (γ) and eta (η) exhibit a high degree of anisotropy in the shales than in the sands. The parameters were observed to be higher in the c.ntral Swamp than the Greater Ughelli depobelt. This behavior c.uld be assoc.ated with the alternating sequenc. of massive shale and sand beds geologic.lly observed within this depobelt. This work was also able to derive empiric.l relations that c.uld be used in estimating these parameters in the depobelts onc. appropriate information or data for any one parameter is available.

关键词： Anisotropy Veloc.ty Depobelts Transverse Isotropy Seismic

Sensibility Analysis of Violin Plates

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Sensibility Analysis of Violin Plates