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Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain

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Journal of Geriatric Cardiology 2016年第7期13卷 608-614页

作者： Shu Nishiguchi Yuma Nozaki masayuki Yamaji Kanako Oya Yuki Hikita Tomoki Aoyama Hiroshi Mabuchi Department of Physical Therapy School of Health Sciences Tokyo University of Technology Tokyo Japan Department of Physical Therapy Human Health Sciences Graduate School of Medicine Kyoto University Kyoto Japan Department of Cardiovascular Medicine Koto Memorial Hospital Shiga Japan Department of Rehabilitation Unit Koto Memorial Hospital Shiga Japan

Objective To determine the association between plasma brain natriuretic peptide （BNP） level in patients with heart failure （HF） and physical frailty as well as with each domain of physical frailty. Methods Two hundred and six outpatients of cardiovascular medicine aged 60 years and older who had been hospitalized for HF or had been given a prescription medication for HF were included. Physical frailty was assessed using the following five domains： slowness, weakness, exhaustion, low activity, and shrinking, according to the Cardiovascular Health Study. Patients were divided into nonfi-ailty and frailty groups according to frailty scores. Plasma BNP level was measured. The 6-min walk test was performed to measure endurance. Results Plasma BNP was significantly different between the two groups （frailty group： 158.0 i 214.7 pg/mL, nonfrailty group： 65.2 ~ 88.0 pg/mL, P 〈 0.01）. Multivariate logistic regression analysis revealed log-transformed plasma BNP （Log BNP） was significantly associated with physical frailty （OR： 1.68, 95% CI： 1.11-2.56）, and Log BNP was significantly associated with the slowness domain （walking speed 〈 1.0 m/s） of physical frailty （OR： 1.75, 95% Ch 1.15-2.67）. Additionally, Log BNP was negatively correlated to the 6-minute walk distance （6MWD）（p=0.37, P 〈 0.01）, while 6MWD was positively correlated to walking speed （p = 0.66, P 〈 0.01）. Conclusions Plasma BNP level was related to physical frailty, especially in the slowness domain. Endurance may intervene in the associations between plasma BNP level and walking speed.

关键词： Brain natriuretic peptide Heart failure Physical frailty Walking speed

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Wavelength-Dependent Transient Characteristics Caused by Gain Saturation in Highly Nonlinear Fiber-Based Raman Amplifiers

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光学学报 2003年第S1期23卷 417-418页

作者： Shinobu Tamaoki Tetsufumi Tsuzaki Motoki Kakui masayuki Shigematsu Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanSumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanSumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanSumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 Japan

We have investigated the transient characteristics of discrete Raman Amplifiers and found that the response time caused by gain saturation is dependent upon the wavelength, which corresponds to the effective length of... 详细信息

关键词： by on length in Wavelength-Dependent Transient Characteristics Caused by Gain Saturation in Highly Nonlinear Fiber-Based Raman Amplifiers

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Genetic Background Influences Brassinosteroid-Related Mutant Phenotypes in Rice

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American Journal of Plant Sciences 2013年第2期4卷 212-221页

作者： Tomoaki Sakamoto Hidemi kitano Shozo Fujioka Bioscience and Biotechnology Center Nagoya University Nagoya Japan Faculty of Bioresources and Environmental Sciences Ishikawa Prefectural University Nonoichi Japan RIKEN Advanced Science Institute Wako Japan

In two cases, mutations in the same brassinosteroid-related genes caused different phenotypes in japonica varieties Nipponbare and Taichung 65. The mutant phenotypes were less severe in the Taichung 65 background than in the Nipponbare background. Three newly isolated brassinosteroid-insensitive mutants (d61-1N, d61-11, and d61-12) derived from a Nipponbare mutant library were found to be alleles of d61, which represent defects in the OsBRI1 gene. Although the Nipponbare-derived mutant d61-1N had the same nucleotide substitution as the previously characterized Taichung 65-derived mutant d61-1T, these two mutants showed different phenotypes for plant stature, internode elongation pattern, and seed shape;in each case, d61-1N (in the Nipponbare genetic background) had the more severe mutant phenotype. Similar trends were seen for phenotypes caused by mutants of d2, a brassinosteroid biosynthesis gene. Consistent with these phenotypes, the expression of brassinosteroid-responsive genes was lower in the Nipponbare-derived mutants. These results can be explained by our findings that feed-forward up-regulation of OsBRI1 did not occur in the Nipponbare-derived mutants and that an mPing transposon is inserted into the promoter region of Nipponbare OsBRI1. Based on these results, we conclude that the expression of OsBRI1, especially its feed-forward up-regulation, is misregulated in wild-type Nipponbare and in brassinosteroid-related mutants in a Nipponbare genetic background. Although Nipponbare is a model rice genotype, it can be categorized as an OsBRI1 mutant that has reduced sensitivity to brassinosteroid.

关键词： Brassinosteroid Brassinosteroid Receptor Brassinosteroid Sensitivity miniature Ping (mPing) Mutant Nipponbare Rice

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High-pressure phase transitions of anorthosite crust in the Earth's deep mantle

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Geoscience Frontiers 2018年第6期9卷 1859-1870页

作者： masayuki Nishi Steeve Gréaux Shigehiko Tateno Yasuhiro Kuwayama Kenji Kawai Tetsuo Irifune Shigenori Maruyama Geodynamics Research Centre Ehime UniversityEhime 790-8577Japan Earth-Life Science Institute Tokyo Institute of TechnologyTokyo 152-8550Japan Institute for Planetary Materials Okayama UniversityMisasaTottori 682-0193Japan Department of Earth Planetary Science School of ScienceUniversity of Tokyo113-0033 Hongo 7-3-1BunkyoTokyoJapan Novosibirsk State University Pirogova 1630090Russia

We investigated phase relations, mineral chemistry, and density of lunar highland anorthosite at conditions up to 125 GPa and 2000 K. We used a multi-anvil apparatus and a laser-heated diamond-anvil cell for this purpose. In-situ X-ray diffraction measurements at high pressures and composition analysis of recovered samples using an analytical transmission electron microscope showed that anorthosite consists of garnet,CaAl_4Si_2O_(11)-rich phase(CAS phase), and SiO_2 phases in the upper mantle and the mantle transition *** lower mantle conditions, these minerals transform to the assemblage of bridgmanite, Ca-perovskite,corundum, stishovite, and calcium ferrite-type aluminous phase through the decomposition of garnet and CAS phase at around 700 km depth. Anorthosite has a higher density than PREM and pyrolite in the upper mantle, while its density becomes comparable or lower under lower mantle conditions. Our results suggest that ancient anorthosite crust subducted down to the deep mantle was likely to have accumulated at660-720 km in depth without coming back to the Earth's surface. Some portions of the anorthosite crust might have circulated continuously in the Earth's deep interior by mantle convection and potentially subducted to the bottom of the lower mantle when carried within layers of dense basaltic rocks.

关键词： Anorthosite Phase transformation Multi-anvil apparatus Diamond-anvil cell Mantle dynamics

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Laparoscopic hemicolectomy in a patient with situs inversustotalis

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World Journal of Gastroenterology 2007年第37期13卷 5035-5037页

作者： Yushi Fujiwara Yosuke Fukunaga masayuki Higashino Shinya Tanimura Masashi Takemura Yoshinori Tanaka Harushi Osugi Department of Gastroenterological Surgery Osaka City General Hospital 2-13-22 Miyakojima-Hondoori Miyakojima-ku Osaka 534-0021 Japan Department of Gastroenterological Surgery Osaka City University Graduate School of Medicine 1-4-3 Asahi-machi Abeno-ku Osaka 545-8585 Japan

As among persons with normal anatomy, occasional patients with situs inversus develop malignant tumors. Recently, several laparoscopic operations have been reported in patients with situs inversus. We describe laparoscopic hemicolectomy with radical lymphadenectomy in such a patient. Careful consideration of the mirror-image anatomy permitted safe operation using techniques not otherwise differing from those in ordinary cases. Thus, curative laparoscopic surgery for colon cancer in the presence of situs inversus is feasible and safe.

关键词： Situs inversus Colon cancer Laparoscopicsurgery Hemicolectomy Radical lymphadenectomy

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Helicobacter pylori infection and gastropathy:A comparison between Indonesian and Japanese patients

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World Journal of Gastroenterology 2009年第39期15卷 4928-4931页

作者： Murdani Abdullah Hiroyuki Ohtsuka Abdul Aziz Rani Tadashi Sato Ari F Syam masayuki A Fujino Division of Gastroenterology Department of Internal MedicineFaculty of Medicine University of IndonesiaCipto Mangunkusumo Hospital First Department of Medicine Yamanashi Medical University

AIM： To compare the effects of He/icobacter py/ori （Hpylon） infection on gastropathy between Indonesian and Japanese patients. METHODS： Biopsy specimens were obtained during upper gastrointestinal endoscopy from 167 subjects （125 Indonesians and 42 Japanese） with uninvestigated symptoms of dyspepsia. The specimens were analyzed for the presence of H pylori using urease analysis, histopathology, and cell culture. The grade and activity of gastritis was assessed using the updated Sydney system. RESULTS： The percentages of Indonesian and Japanese patients who were H py/ori-positive at the antrum or body of the stomach were similar （68% and 59.5%, respectively; P = 0.316）. Of those who were Hpylori-positive, more Japanese patients than Indonesian patients had high levels of polymorphonuclear cells （P = 0.001）, mononuclear cells （P = 0.013）, glandular atrophy （P = 0.000）, and intestinal metaplasia （P = 0.011） in both the antrum and body of the stomach. CONCLUSION： The grade of gastritis and prevalence of mucosal atrophy and intestinal metaplasia were higher in Japanese patients. The difference between Indonesian and Japanese patients was significant.

关键词： Helicobacterpylori Gastritis Gastric cancer Intestinal metaplasia Atrophy

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Benefits and limitations of middle bile duct segmental resection for extrahepatic cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 147-152页

作者： masayuki Akita Tetsuo Ajiki Kimihiko Ueno Daisuke Tsugawa Motofumi Tanaka Masahiro Kido Hirochika Toyama Takumi Fukumoto Department of Hepato-Biliary-Pancreatic Surgery Kobe University Graduate School of MedicineKobe650-0017Japan

Background:Pancreaticoduodenectomy(PD)is a standardized strategy for patients with middle and distal bile duct *** aim of this study was to compare clinicopathological features of bile duct segmen-tal resection(BDR)with PD in patients with extrahepatic ***:Consecutive cases with extrahepatic cholangiocarcinoma who underwent BDR(n=21)or PD(n=84)with achievement of R0 or R1 resection in Kobe University Hospital between January 2000 and December 2016 were enrolled in the present ***:Patients who underwent PD were significantly younger than those receiving *** frequency of preoperative jaundice,biliary drainage and cholangitis was not significantly different between the two *** duration of surgery was longer and there was more intraoperative bleeding in the PD than in the BDR group(553 vs.421 min,and 770 vs.402 mL;both PClavien-DindoⅢa)were observed in the PD group(46%vs.10%,P<0.01).Postoperative hospital stay was also longer in that group(30 vs.19 days,P=0.02).Pathological assessment revealed that tumors were less advanced in the BDR group but the rate of lymph node metastasis was similar in both groups(33%in BDR and 48%in PD,P=0.24).The rate of R0 resection was significantly higher in the PD group(80%vs.38%,P<0.01).Adjuvant chemotherapy was more frequently administered to patients in the BDR group(62%vs.38%,P=0.04).Although 5-year overall survival rates were similar in both groups(44%for BDR and 51%for PD,P=0.72),in patients with T1 and T2,the BDR group tended to have poorer prognosis(44%vs.68%at 5-year,P=0.09).Conclusions:BDR was comparable in prognosis to PD in middle bile duct *** invasiveness and lower morbidity of BDR justified this technique for selected patients in a poor general condition.

关键词： Cholangiocarcinoma Middle bile duct resection Pancreaticoduodenectomy

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Pyogenic liver abscess after choledochoduodenostomy for biliary obstruction caused by autoimmune pancreatitis

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World Journal of Gastroenterology 2006年第39期12卷 6397-6400页

作者： Nobuyuki Toshikuni Kyohei Kai Shizo Sato Motoko kitano Masayoshi Fujisawa Hiroaki Okushin Kazuhiko Morii Shinjiro Takagi Masahiro Takatani Hirofumi Morishita Koichi Uesaka Shiro Yuasa Department of Internal Medicine Himeji Red Cross Hospital Himeji Japan Department of Surgery Himeji Red Cross Hospital Himeji Japan Department of Pathology Himeji Red Cross Hospital Himeji Japan

A 68-year-old man underwent cholecystectomy and choledochoduodenostomy for biliary obstruction and nephrectomy for a renal tumor. Based on clinical and histopathologic findings, autoimmune pancreatitis (AIP) was diagnosed. The renal tumor was diagnosed as a renal cell cancer. Steroid therapy was started and thereafter pancreatic inflammation improved. Five years after surgery, the patient was readmitted because of pyrexia in a preshock state. A Klebsiella pneumoniae liver abscess complicated by sepsis was diagnosed. The patient recovered with percutaneous abscess drainage and administration of intravenous antibiotics. Liver abscess recurred 1 mo later but was successfully treated with antibiotics. There has been little information on long-term outcomes of patients with AIP treated with surgery. To our knowledge, this is the second case of liver abscess after surgical treatment of AIP.

关键词： Autoimmune pancreatitis Biliary reconstruction Liver abscess

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Modified Ramsey Rule and Optimal Carbon Tax

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Atmospheric and Climate Sciences 2016年第2期6卷 267-272页

作者： masayuki Otaki Institute of Social Sciences The University of Tokyo Tokyo Japan

The Ramsey rule is regarded as a convenient vehicle for estimating the social discount rate in general. Carbon pricing is treated as another theory of environmental economics. This study clarifies the theoretical relationship between the Ramsey rule and optimal carbon price, which has been overlooked in the existing research. It succeeds in deriving the optimal carbon price from the modified Ramsey rule in stationary state. Since the Ramsey rule decides the dynamics of an economy and a stationary state is its destination, by using the optimization condition of individual who are assumed to live infinitesimally short life, we can solve the optimal carbon price at stationary state.

关键词： Modified Ramsey Rule Optimal Carbon Price Social Discount Rate Carbon Cycle

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A Study on Simple Prediction Method of Heat Load： A Use of Linear Approximation Indicial Response in Basements

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Journal of Civil Engineering and Architecture 2013年第4期7卷 379-387页

作者： Kyung-Soon Park Hiroaki kitano Hisaya Nagai Department of Building Systems Engineering Dong-Eui University Busan 614-714 Korea Department of Architecture Graduate School of Engineering Mie University Tsu 514-8507 Japan

This study was conducted to establish a predictable method for a heat load of an underground structure with sufficient accuracy. As the first step, our previous paper reported the measurement results of field experiments on an underground experimental basement under internal heat generation conditions. Also, it presented the results of numerical analyses on the heat and moisture behavior and the influence of internal heat generation of the experimental basement and ground. However, it is practically impossible to utilize the model of simultaneous heat and moisture transfer at the design phase because the prediction by the model of simultaneous heat and moisture transfer requires a long calculation time. In this paper, the authors present the simple load calculation technique, using a linearized approximation indicial response of the inner surface heat flux in a basement to outdoor air temperature change. In addition, the approximation indicial responses for each part of the single-walled concrete drawn using this technique are arranged. The heat load calculation example of application to the basement of the optional size by this technique is shown.

关键词： Underground structure simultaneous heat and moisture transfer linearized prediction method indicial response.

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