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Joint Angle Correction in Rheumatoid Arthritis and Its Reliability Analysis Based on Phase Dispersion Quantification

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Open Journal of Medical Imaging 2022年第4期12卷 171-179页

作者： Yafei Ou Prasoon Ambalathankandy Ryunosuke Furuya Tamotsu Kamishima masayuki ikebe Research Center for Integrated Quantum Electronics Hokkaido University Sapporo Japan Faculty of Health Sciences Hokkaido University Sapporo Japan

Background: Rheumatoid arthritis is a form of autoimmune disease characterized by synovitis that can ultimately cause joint deformities and impaired functioning. The cartilage destruction is one of the most important indicators for diagnosis and treatment of rheumatoid arthritis, and it is radiographically manifested as joint space narrowing. Issue: In the literature, the joint space narrowing progression between a baseline and its follow-up finger joint images can be quantified by using image registration algorithm. We found that the inconsistencies of joint angles may lead to characteristic mismatches and thus severely affect the accuracy of joint space narrowing quantifications. Methods: In this work, we introduce a rotation invariant phase only correlation in joint space narrowing quantification for the joint angle correction. Further, we propose a confidence index to quantify the quantification reliability of phase only correlation based on phase dispersion in phase difference spectrum. Conclusion: In our clinical experiments, the proposed quantification method can effectively overcome and manage the mismatch due to the inconsistency of joint angles. Additionally, the confidence index shows a high consistency with the joint space narrowing progression examinations manually done by a trained radiologist and one radiological technologist.

关键词： Rheumatoid Arthritis Joint Space Narrowing Frequency Domain Analysis Radiology Computer-Aided Diagnosis Phase Dispersion

A Multithreaded CGRA for Convolutional Neural Network Processing

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Circuits and Systems 2017年第6期8卷 149-170页

作者： Kota Ando Shinya Takamaeda-Yamazaki masayuki ikebe Tetsuya Asai Masato Motomura Hokkaido University Sapporo Japan

Convolutional neural network (CNN) is an essential model to achieve high accuracy in various machine learning applications, such as image recognition and natural language processing. One of the important issues for CNN acceleration with high energy efficiency and processing performance is efficient data reuse by exploiting the inherent data locality. In this paper, we propose a novel CGRA (Coarse Grained Reconfigurable Array) architecture with time-domain multithreading for exploiting input data locality. The multithreading on each processing element enables the input data reusing through multiple computation periods. This paper presents the accelerator design performance analysis of the proposed architecture. We examine the structure of memory subsystems, as well as the architecture of the computing array, to supply required data with minimal performance overhead. We explore efficient architecture design alternatives based on the characteristics of modern CNN configurations. The evaluation results show that the available bandwidth of the external memory can be utilized efficiently when the output plane is wider (in earlier layers of many CNNs) while the input data locality can be utilized maximally when the number of output channel is larger (in later layers).

关键词： CNN Convolutional Neural Network Deep Learning Multithreaded Architecture CGRA

A High Performance and Energy Efficient Microprocessor with a Novel Restricted Dynamically Reconfigurable Accelerator

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Circuits and Systems 2017年第5期8卷 134-147页

作者： Itaru Hida Shinya Takamaeda-Yamazaki masayuki ikebe Masato Motomura Tetsuya Asai Graduate School of Information Science and Technology Hokkaido University Sapporo Japan

In the era of Internet of Things, the battery life of edge devices must be extended for sensing connection to the Internet. We aim to reduce the power consumption of the microprocessor embedded in such devices by using a novel dynamically reconfigurable accelerator. Conventional microprocessors consume a large amount of power for memory access, in registers, and for the control of the processor itself rather than computation;this decreases the energy efficiency. Dynamically reconfigurable accelerators reduce such redundant power by computing in parallel on reconfigurable switches and processing element arrays (often consisting of an arithmetic logic unit (ALU) and registers). We propose a novel dynamically reconfigurable accelerator “DYNaSTA” composed of a dynamically reconfigurable data path and static ALU arrays. The static ALU arrays process instructions in parallel without registers and improve energy efficiency. The dynamically reconfigurable data path includes registers and many switches dynamically reconfigured to resolve operand dependencies between instructions mapped on the static ALU array, and forwards appropriate operands to the static ALU array. Therefore, the DYNaSTA accelerator has more flexibility while improving the energy efficiency compared with the conventional dynamically reconfigurable accelerators. We simulated the power consumption of the proposed DYNaSTA accelerator and measured the fabricated chip. As a result, the power consumption was reduced by 69% to 86%, and the energy efficiency improved 4.5 to 13 times compared to a general RISC microprocessor.

关键词： Embedded Microprocessor Reconfigurable Low-Power Accelerator Digital Circuit Architecture

Thermally activated delayed fluorescence carbazole-triazine dendrimer with bulky substituents

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Aggregate 2024年第1期5卷 236-243页

作者： Hiroki ikebe Kohei Nakao Eri Hisamura Minori Furukori Yasuo Nakayama Takuya Hosokai Minlang Yang Guanting Liu Takuma Yasuda Ken Albrecht Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityFukuokaJapan Institute for Materials Chemistry and Engineering Kyushu UniversityKasugaJapan Department of Pure and Applied Chemistry Graduate School of Science and TechnologyTokyo University of ScienceNodaChibaJapan National Metrology Institute of Japan(NMIJ) National Institute of Advanced Industrial Science and Technology(AIST)TsukubaIbarakiJapan Institute for Advanced Study Kyushu UniversityNishi-kuFukuokaJapan

Carbazole-triazine dendrimers with a bulky terminal substituent were synthesized,and the thermally activated delayed fluorescence(TADF)property was *** to unsubstituted carbazole dendrimers,dendrimers with bulky terminal substituents showed comparable to better photoluminescence quantum yields(PLQY)in neat ***(PF)-substituted dendrimers showed the highest PLQY of 81%,a smallΔEst of 0.06 eV,and the fastest reverse intersystem crossing(RISC)rate of∼1×10^(5 )s^(−1) compared to other *** measurements of dendrimers and dendrons(fragments)indicate that the close proximity of the triplet energy of phenylfluorene-substituted carbazole dendrons(^(3)LE)to that of phenylfluorene-substituted dendrimers(^(1)CT,^(3)CT)contributes to RISC promotion and improves TADF *** modification fine-tunes the energy level and suppresses intermolecular interactions,and this study provides a guideline for designing efficient solution-processable and non-doped TADF materials.

关键词： dendrimer OLED TADF 1 INTRODUCTION Thermally activated delayed fluorescence(TADF)materials which are inexpensive and highly efficient alternatives to fluorescent

An unusual enteropathy-associated T-cell lymphoma with MYC translocation arising in a Japanese patient:A case report

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World Journal of Gastroenterology 2012年第19期18卷 2434-2437页

作者： Kenji Okumura Masahiko ikebe Tatsuro Shimokama Morishige Takeshita Nao Kinjo Keishi Sugimachi Hidefumi Higashi Department of Surgery Nippon Steel Yawata Memorial HospitalKitakyushu 805-8508Japan Department of Pathology Nippon Steel Yawata Memorial HospitalKitakyushu 805-8508Japan Department of Pathology School of MedicineFukuoka UniversityFukuoka 814-0180Japan

Enteropathy-associated T-cell lymphoma （EATL） is a rare peripheral T-cell lymphoma classified into 2 types, with or without celiac disease, based on histology. Type 2 EATL is less commonly associated with celiac disease, in which cells are characterized by being monomorphic and small- to medium-sized. Cells are characterized by CD8 and CD56 expression and c-MYC oncogene locus gain. We present an atypical case of type 2 EATL in the jejunum, with human T-lymphotropic virus-1 that was CD4- CDS＋ CD56- CD30- CD25- TIA-I＋ and granzyme B＋ on immunohistological staining. It also displayed translocation of chromosome 8p24 （c-MYC）, as de- termined by fluorescent/n situ hybridization. Mucosalspreading and intraepithelial invasion by lymphoma with villous atrophy were detected adjacent to the mucosal layer. The lymphoma may be derived from in- traepithelial CD8＋ T cells, similar to celiac disease.

关键词： Enteropathy-associated T-cell lymphoma Celiac disease Human T-lymphotropic virus-l Fluores-cent in situ hybridization Chromosome 8p24

Cerebral lipiodol embolism related to a vascular lake during chemoembolization in hepatocellular carcinoma:A case report and review of the literature

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World Journal of Gastroenterology 2018年第37期24卷 4291-4296页

作者： Hideki Ishimaru Minoru Morikawa Takayuki Sakugawa Ichiro Sakamoto Yasuhide Motoyoshi Yohei ikebe Masataka Uetani Department of Radiology Nagasaki University HospitalNagasaki 852-8501Japan Department of Radiology Nagasaki Harbor Medical CancerNagasaki 850-8555Japan Department of Gastroenterology Nagasaki Harbor Medical CancerNagasaki 850-8555Japan Department of Radiological Sciences Nagasaki University Graduate School of Biomedical SciencesNagasaki 852-8501Japan

A male patient underwent conventional transcatheter chemoembolization for advanced recurrent hepatocellular carcinoma(HCC). Even after the injection of 7 m L of lipiodol followed by gelatin sponge particles, the flow of feeding arteries did not slow down. A repeat angiography revealed a newly developed vascular lake draining into systemic veins; however, embolization was continued without taking noticing of the vascular lake. The patient's level of consciousness deteriorated immediately after the procedure, and non-contrast computed tomography revealed pulmonary and cerebral lipiodol embolisms. The patient's level of consciousness gradually improved after 8 wk in intensive care. In this case, a vascular lake emerged during chemoembolization and drained into systemic veins, offering a pathway carrying lipiodol to pulmonary vessels, the most likely cause of this serious complication. We should be aware that vascular lakes in HCC may drain into systemic veins and can cause intratumoral arteriovenous shunts.

关键词： Transcatheter arterial chemoembolization Arteriovenous shunt Hepatocellular carcinoma Vascular lake Cerebral embolism

Proton Conductivity of Ni, Y Co-Doped BaZrO<sub>3</sub>

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Journal of Materials Science and Chemical Engineering 2018年第6期6卷 19-27页

作者： Hiroya Morishita Yumiko ikebe Eriko Ban Department of Materials Science and Engineering Meijo University Nagoya Japan Department of Applied Chemistry Meijo University Nagoya Japan

Dense sintered bodies of proton conducting BaZrO3 (BZ) and Y-doped BaZrO3 (BZ-Y) were obtained at 1600℃ for a short sintering time of 5 hours, by the addition of NiO as a sintering promotion agent. The relative density and grain growth of samples, Ni-doped BaZrO3 (BZ-N) and Ni, Y co-doped BaZrO3 (BZ-NY), were increased with increasing Ni addition. The sinterability of BZ-NY was greatly improved just to add only 0.6 mol% Ni and the relative density of this sample was more than 98%, in contrast to that of 60% at most for BZ-Y without Ni addition. Electrical conductivity of BZ-NY added Ni 1.0 mol%, BaZr0.91Ni0.01Y0.08O3-α, was more than 10-3 ***-2 at 900℃?in a wet 1% hydrogen atmosphere, which value was 10 times higher than that of BZ-Y. In addition, the kind of electrical conduction carrier and an ionic transport number were also examined by employing various concentration cells. It was found that the proton conduction was dominant for both BZ-N and BZ-NY samples, although BZ-NY showed scarcely oxygenion conduction approximately 10% in a high temperature range higher than 800℃. From these results, as mall amount of Ni addition found to be effective for improvement of both the sinterability and the electrical conductivity.

关键词： Proton Conducting Oxide Barium Zirconate Ni Y Co-Doping Electrical Con-ductivity Ionic Transport Number

Effects of Orbital Motion on the Boundary Layer Flow on a Spinning Disk

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Open Journal of Fluid Dynamics 2012年第4期2卷 187-194页

作者： Mizue Munekata Naoya Jobi Koichi ikebe Hiroyuki Yoshikawa Graduate School of Science and Technology Kumamoto University Kumamoto Japan Mechanical Engineering Department Kumamoto University Kumamoto Japan

The objective of this study is to experimentally examine the effects of orbital motion on the boundary layer flow on a spinning disk. The boundary layer flow on the disk is visualized by the oil flow method, and velocity in the boundary layer is measured by the hot-wire method. For the oil flow pattern in the case of spinning motion only, streaks are clearly observed on the disk as transient vortices, but by adding orbital motion to the spinning motion, we find that streaks are not observed in a certain range of orbital conditions. With increasing orbital motion speed, the laminar re- gion becomes narrower and transition is promoted from the inward region of the disk, regardless of the direction of ro- tation. Also, with the addition of orbital motion, the velocity profile in the boundary layer becomes more asymmetric with respect to the spin axis of the disk. Furthermore, stationary vortices do not appear on the disk when the orbital speed is beyond a certain critical value. Therefore, the lack of streaks in the oil film pattern when orbital motion is added is due to the spatiotemporal unsteadiness of the flow field on the disk.

关键词： Rotating Disk Transition Boundary Layer Flow Visualization Velocity Measurement

Direct Instruction by an Experienced Surgeon Can Shorten the Learning Curve for Laparoscopic-Assisted Distal Gastrectomy

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International Journal of Clinical Medicine 2013年第6期4卷 28-34页

作者： Masashi Takemura Katsuyuki Mayumi Takashi ikebe Sinya Tanimura Department of Gastrointestinal Surgery Osaka City General Hospital Osaka Japan Department of Surgery Gohshi Hospital Hyogo Japan

Aim: Laparoscopy-assisted distal gastrectomy (LADG) with regional lymph node dissection is a treatment option for patient with early gastric cancer. However, LADG is a technically complex and advanced procedure, which is challenging for inexperienced surgeons. In this report, we retrospectively evaluated the learning curve for LADG of a single surgeon with no previous experience in LADG and the usefulness of direct instruction by a surgeon experienced in LADG in shortening the learning curve. Patients and Methods: This study was analyzed 80 consecutive patients, who underwent LADG by a single surgeon (first assistant in 10 cases and operator in 70 cases) between January 2008 and December 2012. Patients were divided into 3 sequential groups of 10 (training period), 30 (learning period), and 40 (operating period) cases in each group. Median operation time and estimated blood loss for these 3 groups were determined. Other learning indicators, including transfusion requirement, postoperative complications, number of lymph node harvested, and rate of conversion open gastrectomy, were also evaluated. Results: During the training period, median operation time and estimated blood loss were 219.5 min and 83.0 ml, respectively. During the learning period, the operation time was significantly longer than that of training period. In the operating period, the operation time was significantly lesser than that during the learning period. However, the operation time was not different from that during the training period and reached a plateau. The estimated blood loss during the operating period was significantly lesser than that during the learning period. The difference in the number of lymph nodes retrieved between each group was not significant. Conclusions: Direct instructions by an experienced surgeon can decrease the number of cases required for learning. Because LADG is technically more complex than other laparoscopic procedures, standardization of LADG and an effective trai

关键词： Laparoscopic-Assisted Distal Gastrectomy Learning Training System