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Journal of Thermal Science 2010年第3期19卷 218-221页

作者： Hideki Yamamoto masayuki Irie Yoshiaki Miyazato Kazuyasu Matsuo Department of Mechanical Systems Engineering Faculty of Environmental EngineeringThe University of Kitakyushu1-1 HibikinoWakamatsu-kuKitakyushuFukuoka 808-0135Japan

This paper analyzes the correctly-expanded supersonic jet from a convergent-divergent axisymmetric nozzle by using numerical simulation of turbulent *** the calculated density distributions in this flow are compared with the present experimental data using rainbow schlieren *** value of the density from the experimental data agrees well with the results calculated by this ***,the present method of the measurement using rainbow schlieren deflectometry is useful for the measurement of the density of the correctly-expanded supersonic jet.

关键词：超音速射流实验数据轴对称数值分析彩虹偏折纹影数值模拟计算

Comparison of Anticancer Drug Preparation Techniques between Chemotherapy Specialist Pharmacists and Non-Chemotherapy Pharmacists Using Eye-Tracking Techniques

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Pharmacology & Pharmacy 2023年第8期14卷 229-238页

作者： Yuka Miyachi Yukina Miyagi Saori Gocho Chika Nakayama masayuki Ejiri masayuki Takeuchi Masafumi Ohnishi Taeyuki Oshima College of Pharmacy Kinjo Gakuin University Nagoya Japan Graduate School of Medicine Aichi Medical University Nagakute Japan Department of Pharmacy Nagoya Ekisaikai Hospital Nagoya Japan Faculty of Pharmacy Gifu University of Medical Science Kani Japan Department of Pharmacy Aichi Medical University Hospital Nagakute Japan

Anticancer drug preparation by pharmacists is a critical task directly related to medical incidents. This study examined the factors influencing medical errors in chemotherapy, that is, errors by specialist pharmacists (CPh) and pharmacists in other departments (NCPh), by measuring their gaze during the preparation of anticancer drugs. The eye-tracking results showed that the gazing time of NCPh was significantly longer than that of CPh for items such as “preparation of a closed-system device” and “preparation of the syringe” and all preparation times (P < 0.05). The NCPh were not assigned to prepare drugs on a regular basis, indicating their lack of familiarity with the process. There was no significant difference in gaze ratio between CPh and NCPh. This outcome was suggested to be a result of the use of an anticancer drug preparation support system. The results for the pupil diameter variation rate showed that NCPh were significantly more mydriatic in the “mixing injections” category than CPh. However, CPh tended to be more mydriatic in the “checking” category. CPh exhibited a smooth workflow and focused on the important items to be checked. This study showed that the differences in procedure flow and concentration points may lead to errors. Furthermore, the results are of interest from the perspective of medical incident prevention. They will be useful in identifying potential human factors, such as where the pharmacist focuses their attention by measuring eye movements.

关键词： Eye Tracking Medicine Inspection Anticancer Drug Pharmacists

Evaluation of precipitation behavior of zirconium molybdate hydrate

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 65-71页

作者： Liang ZHANG masayuki TAKEUCHI Tsutomu KOIZUMI Izumi HIRASAWA Graduate School of Applied Chemistry Faculty of Science and Engineering Waseda University Tokyo 169-8555 Japan Japan Atomic Energy Agency Ibaraki 319-1194 Japan

In the dissolution step of spent nuclear fuel, there is a world-concern problem that zirconium molybdate hydrate precipitates as a byproduct, and accumulates in some reprocessing equipments. In order to prevent this accumulation, we have developed a new method based on the controlled reaction crystallization of zirconium molybdate hydrate （ZMH） in the reprocessing solution, followed by solid liquid separation. In order to measure the particle size of ZMH, batch crystallization experiments were conducted by varying nitric acid concentration and operating temperature. In result, almost all particle sizes scatter around 1μm on average, despite the higher concentration of nitric aid and operating temperature, and then small particles grow up as an aggregate sticking to the crystallizer. Moreover, polymorph and color changing were observed by varying the concentration of nitric acid and reaction time. These results suggest that crystal color and adhesiveness are closely related to the particle size of ZMH. And the control of nitric acid concentration and small particle growth would be the useful technique to prevent the ZMH sticking.

关键词： spent nuclear fuel zirconium molybdate hydrate cleaning method accumulation

The simplest route to generating a train of attosecond pulses

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Light(Science & Applications) 2013年第1期2卷 204-208页

作者： Kazumichi Yoshii John Kiran Anthony masayuki Katsuragawa Department of Engineering Science University of Electro-CommunicationsTokyoJapan

We report on two novel routes to generating a train of attosecond pulses from a broad discrete spectrum in the near-infrared–visible–ultraviolet *** extends an integer-temporal-Talbot(ITT)concept to include high-order spectral dispersions and generates a pulse train that completely satisfies the transform-limited *** other numerically explores the optimum conditions under which we can obtain an attosecond pulse train that approximately satisfies the transform-limited *** second method is more practical than the *** of these methods is extremely simple and robust;we need only to place a few thin dispersive materials in the optical path and to adjust their thicknesses without spatially dispersing the frequency *** numerically demonstrate the generation of a train of attosecond pulses with a transform-limited pulse duration of 728 as and a repetition period of 8.03 fs in gaseous parahydrogen.

关键词： adiabatic excitation of Raman transition attosecond pulse generation integer-temporal-Talbot(ITT)method molecular modulation

Impact of changing our cannulation method on the incidenceof post-endoscopic retrograde cholangiopancreatography pancreatitis after pancreatic guidewire placement

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World Journal of Gastroenterology 2011年第48期17卷 5289-5294页

作者： Takeshi Hisa Ryusuke Matsumoto Masato Takamatsu masayuki Furutake Department of Internal Medicine Saku Central Hospital

AIM: To clarify whether the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) after pancreatic guidewire placement (PGW) can be reduced by using a different cannulation method. METHODS: Between April 2001 and October 2009, PGW was performed in 142 patients with native papilla to overcome difficult biliary cannulation. Our cannulation method for ERCP was changed from contrast injection (CI) using a single-lumen catheter (April 2001-May 2008) to wire-guided cannulation (WGC) using a double-lumen catheter (June 2008-October 2009). The CI protocol was also changed during the study period: in the first period it was used for routine pancreatography for detecting small pancreatic cancer (April 2001-November 2002), whereas in the second period it was not (December 2002-May 2008). In PGW with CI using a singlelumen catheter, the contrast medium in the catheter lumen was injected into the pancreatic duct. The success rate of biliary cannulation, the incidence of PEP according to the cannulation method, and the impact of CI using a single-lumen catheter on PEP in comparison with WGC using a double-lumen catheter were ***: CI with routine pancreatography, CI without routine pancreatography, and WGC were performed in 27 patients, 77 patients and 38 patients, respectively. Routine pancreatography did not contribute to the early diagnosis of pancreatic cancer in our study period. In CI without routine pancreatography and WGC, diagnostic pancreatography was performed in 17 patients and no patients, respectively. The success rate of biliary cannulation by PGW alone was 69%, and the final success rate was increased to 80.3% by the addition of consecutive maneuvers or a second ERCP. PEP occurred in 22 patients (15.5%), and the severity was mild in all cases. When analyzed according to cannulation method, the incidence of PEP was 37.0% (10/27) in the patients who underwent CI with routine pancreatography, 14.3% (11/77) in those

关键词：胰腺的 guidewire 放置指导电线的管子对比注射困难的胆汁的管子 endoscopic 以后后退 cholangiopancreatography 胰腺炎

Activation of protein kinase A alters subnuclear distribution pattern of human steroidogenic factor 1 in living cells

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Chinese Medical Journal 2004年第7期117卷 1017-1022页

作者：刘伟范吴强 Toshihiko Yanase masayuki Saitoh 吴茵 Department of Medicine and Endocrinology Department of Medicine and Bioregulatory Science Department of Geriatric Medicine

Background The aim of this study was to identify the subnuclear distribution pattern of human orphan nuclear receptor steroidogenic factor 1 (SF-1) in living cells with and without the activation of protein kinase A (PKA) signal pathway, and thus try to explain the unknown mechanism by which PKA potentiates SF-1 transactivation. Methods Full-length cDNAs of wild type and a naturally occurring mutant (G35E) human SF-1 were cloned and fused with green fluorescent protein (GFP). Subcellular distribution pattern of human SF-1 in living cells, whose PKA signaling was either activated or not, was studied by laser confocal microscopy after the validity of the gene sequence was *** The transactivation ability of the GFP-SF-1 chimeric protein was highly conserved. Wild type human SF-1 diffused homogeneously within the nuclei of cells when PKA was not active, and converged to clear foci when PKA was activated. Mutant SF-1 diffused within the nuclei even in the presence of PKA activation, surprisingly aggregating as fluorescent dots inside the nucleoli, a phenomenon not altered by *** Activation of PKA causes wild type, but not mutant SF-1 to alter its subnuclear distribution pattern to a transactivationally active form (foci formation). This finding may throw new light on the mechanism by which PKA activates the orphan nuclear receptor.

关键词： steroidogenic factor 1· protein kinase A· green fluorescent protein

Temporal adjustment of short calls according to a partner during vocal turn-taking in Japanese macaques

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Current Zoology 2019年第1期65卷 99-105页

作者： Noriko KATSu Kazunori Yamada Kazuo Okanoya masayuki Nakamichi Graduate School of Arts and Sciences The University of Tokyo Meguro Tokyo Japan Graduate School of Human Sciences Osaka University Suita Osaka Japan Japan Society for the Promotion of Science Tokyo Japan

Turn-taking is a common feature in human speech, and is also seen in the communication of other primate species. However, evidenee of turn-taking in vocal exchanges within a short time frame is still scarce in non human primates. This study in vestigated whether dynamic adjustme nt during turn-taking in short calls exists in Japanese macaques Macaca fuscata. We observed exchanges of short calls such as grunts, girneys, and short, low coos during social interactions in a free-ranging group of Japanese macaques. We found that the median gap between the turns of two callers was 250 ms. Call intervals varied among individuals, suggesting that call intervals were not fixed among individuals. Solo call intervals were shorter than call intervals interrupted by responses from partn ers (i.e., excha nges) and Ion ger than those between the partner's reply and the reply to that call, indicating that the monkeys did not just repeat calls at certain intervals irrespective of the social situation. The differences in call intervals during exchanged and solo call sequences were explained by the response interval of the partner, suggesting an adjustment of call timing according to the tempo of the part ner's call utterance. These findi ngs suggest that mon keys display dyn amic temporal adjustment in a short time window, which is comparable with turn-taking in human speech.

关键词： turn-taking rhythm vocalization primate

Curative resection with endoscopic submucosal dissection of early gastric cancer in Helicobacter pylori-negative Ménétrier’s disease:A case report

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World Journal of Gastroenterology 2022年第5期28卷 594-601页

作者： Koh Fukushi Kenichi Goda Hitoshi Kino masayuki Kondo Mimari Kanazawa Ken Kashima Akira Kanamori Keiichiro Abe Tsunehiro Suzuki Keiichi Tominaga Hidetsugu Yamagishi Atsushi Irisawa Department of Gastroenterology Dokkyo Medical UniversityMibu 321-0293TochigiJapan Department of Diagnostic Pathology Dokkyo Medical UniversityMibu 321-0293TochigiJapan

BACKGROUND Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori(***)infection and an elevated risk of *** of early-stage gastric cancer developed in ***-negative Ménétrier’s disease are extremely *** report a case of early gastric cancer in ***-negative Ménétrier’s disease that was curatively resected with endoscopic submucosal dissection(ESD).CASE SUMMARY A 60-year-old woman was referred to our hospital after her medical examination detected ***-enhanced upper gastrointestinal(UGI)radiography revealed translucency of the nodule-aggregating surface with giant *** tests showed hypoproteinemia and were negative for serum *** immunoglobulin G *** 99mTc-DTPA-human serum albumin scintigraphy showed protein loss from the *** endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body,suggesting early-stage gastric cancer due to Ménétrier’s *** bloc resection with ESD was performed for diagnosis and *** of ESD showed well-differentiated tubular *** cancer was confined to the mucosa,and complete curative resection was *** hyperplasia and atrophy of the gastric glands were observed in non-tumor areas,histologically corresponding to Ménétrier’s *** years after ESD,gastric cancer had not recurred,and Ménétrier’s disease remained in remission with spontaneous regression of giant gastric *** Complete curative resection was achieved through ESD in a patient with earlystage gastric cancer and ***-negative Ménétrier’s disease.

关键词： Ménétrier’s disease Helicobacter pylori Gastric cancer Endoscopic resection Endoscopic submucosal dissection Case report

The roles of tubulin-folding cofactors in neuronal morphogenesis and disease

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Neural Regeneration Research 2015年第9期10卷 1388-1389页

作者： Misako Okumura masayuki Miura Takahiro Chihara Department of Genetics Graduate School of Pharmaceutical Sciences The University of Tokyo Core Research for Evolutional Science and Technology Japan Science and Technology Agency

Microtubules play important roles in neuronal morphogenesis, including cellular polarization, neurite growth, and branching. A microtubule is a polymer of a- and β-tubulin heterodimers that are formed by a multistep process assisted by at least five tubulin-fold- ing cofactors （TBCA-E）（Lopez-Fanarraga et al., 2001）. Newly syn- thesized α- and β-tubulins associate with the cytosolic chaperonin complex （CCT）, and then the quasi-native tubulins interact with five tubulin-folding cofactors. The α- and β-tubulins first interact with TBCB and TBCA, which are further transferred to TBCE and TBCD, respectively. The α- and β-tubulins, TBCC, TBCD, and TBCE form a supercomplex, and guanosine triphosphate （GTP） hydrolysis occurs within the supercomplex, releasing a tubulin heterodimer. In addition to their functions in tubulin folding and tubulin heterodimer formation, excess amounts of TBCD or TBCE may interact with tubulin heterodimers, leading to their degrada- tion. Thus, tubulin-folding cofactors may play a role in both the synthesis and degradation of tubulin heterodimers.

关键词： The roles of tubulin-folding cofactors in neuronal morphogenesis and disease Figure

Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells

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Cellular & Molecular Immunology 2010年第6期7卷 440-446页

作者： Tomoyuki Suzuki Myint Oo Chang masayuki Kitajima Hiroshi Takaku Department of Life and Environmental Sciences Chiba Institute of TechnologyChibaJapan High Technology Research Center Chiba Institute of TechnologyChibaJapan Immunology Program Benaroya Research InstituteSeattleWAUSA

A dendritic cell(DC)vaccine strategy has been developed as a new cancer immunotherapy,but the goal of complete tumor eradication has not yet been *** have previously shown that baculoviruses potently infect DCs and induce antitumor immunity against hepatomas in a mouse ***-infected,bone marrow-derived DCs(BMDCs)display increased surface expression of costimulatory molecules,such as CD80,CD86 and major histocompatibility complex(MHC)classes I and II,and secrete interferons and other proinflammatory *** this study,we evaluated the induction of antitumor immunity in mice by baculovirus-infected BMDCs against lung cancer and *** treatment with baculovirus-infected BMDCs,murine lung tumors caused by Lewis lung carcinoma(LLC)cells were significantly reduced in size,and the survival of the mice was *** addition,experiments using a melanoma mouse model showed that baculovirus-infected BMDCs inhibited tumor growth and improved survival compared with *** alanine aminotransferase(ALT),aspartate aminotransferase(AST)and creatinine levels remained normal in baculovirus-infected BMDC-treated *** findings show that baculovirus-infected DCs induce antitumor immunity and pave the way for the use of this technique as an effective tool for DC immunotherapy against malignancies.

关键词： dendritic cells natural killer cells T cells tumor Immunity