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Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis

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World Journal of Gastroenterology 2006年第39期12卷 6325-6330页

作者： Toshihito Kosaka Junji Yoshino Kazuo Inui Takao Wakabayashi Kazumu Okushima Takashi Kobayashi Hironao Miyoshi Yuta Nakamura Shigekazu Hayashi Taizou Shiraishi masatoshi watanabe Takayuki Yamamoto Ai Nakahara Takahiko Katoh Department of Internal Medicine Second Teaching Hospital Fujita Health University School of Medicine 3-6-10 Otobashi Nakagawaku Nagoya 454-8509 Japan Department of Gastroenterology Nagoya Ekisaikai Hospital 4-66 Shounencho Nakagawaku Nagoya 454-8502 Japan Department of Pathologic Oncology Mie University Graduate School of Medicine 2-174 Edobashi Tsu Mie 514-8507 Japan School of Engineering Yokohama National University 79-5 Tokiwadai Hodogaya-ku Yokohama 240-8501 Japan Inflammatory bowel disease centre and department of surgery Yokkaichi Social Insulance Hospital 10-8 Hazuyamacho Yokkaichi Mie Japan Department of Public Health Miyazaki Medical College University of Miyazaki 5200 Kihara Miyazaki 889-1692 Japan

AIM： To examine the influence of lipoprotein lipase （LPL） gene polymorphism in ulcerative colitis （UC） patients.METHODS： Peripheral blood was obtained from 131 patients with UC and 106 healthy controls for DNA extraction. We determined LPL gene polymorphisms affecting the enzyme at Ser447stop, as well as Hind Ⅲ and Pvu Ⅱ polymorphisms using PCR techniques. PCR products were characterized by PCR-RFLP and direct sequencing. Polymorphisms were examined for association with clinical features in UC patients. Genotype frequencies for LPL polymorphisms were also compared between UC patients and controls.RESULTS： In patients with onset at age 20 years or younger, C/G and G/G genotypes for Ser447stop polymorphism were more prevalent than C/C genotype （OR = 3.13, 95% CI = 0.95-10.33）. Patients with H^＋/- or H^-/- genotype for Hind Ⅲ polymorphism also were more nu merous than those with H^＋/＋ genotype （OR = 2.51, 95% CI = 0.85-7.45）. In the group with H^＋/＋ genotype for Hind Ⅲ polymorphism, more patients had serum triglyceride concentrations over 150 mg/dL than patients with H^＋/- or H^- genotype （P 〈 0.01, OR = 6.46, 95% CI = 1.39-30.12）. Hypertriglycemia was also more prevalent in patients with P^＋/＋ genotypes for Pvu Ⅱ polymorphism （P 〈 0.05, OR = 3.0, 95% CI = 1.06-8.50）. Genotype frequency for LPL polymorphism did not differ significantly between UC patients and controls.

关键词： Ulcerative colitis Lipoprotein lipase Lipid metabolism Triglyceride

Autoimmune hepatitis and IgG4-related disease

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World Journal of Gastroenterology 2019年第19期25卷 2308-2314页

作者： Kosuke Minaga Tomohiro watanabe Hobyung Chung masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Department of Gastroenterology and Hepatology Kobe City General Hospital

IgG4-related disease(IgG4-RD) is a chronic-fibroinflammatory disorder affecting a wide range of organs. Elevation of serum IgG4 concentrations and abundant infiltration of IgG4-expressing plasma cells are key diagnostic features of this autoimmune disease. Although common organ involvement of IgG4-RD includes the salivary glands, pancreas, and bile duct, hepatic involvement is less well established. Recently, five studies identified a subtype of autoimmune hepatitis(AIH), called IgG4-associated AIH(IgG4-AIH). IgG4-AIH is diagnosed based on significant accumulation of IgG4-expressing plasmacytes in the liver in patients who met the diagnostic criteria for classical AIH. Although four of the five reports regarded IgG4-AIH based on hepatic accumulation of IgG4-positive cells alone, one report diagnosed IgG4-AIH based on both hepatic accumulation of IgG4-positive cells and elevated serum concentrations of IgG4. IgG4-AIH diagnosed based on the latter criteria may be a hepatic manifestation of IgG4-RD whereas IgG4-AIH diagnosed based on the former criteria may be a subtype of AIH. In this review article, we summarize and discuss clinicopathological features of IgG4-AIH.

关键词： Autoimmune hepatitis IgG4 IgG4-related disease IgG4-associated autoimmune hepatitis

Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review

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World Journal of Gastroenterology 2018年第16期24卷 1725-1733页

作者： Kosuke Minaga Tomohiro watanabe Ken Kamata Naoki Asano masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Division of Gastroenterology Tohoku University Graduate School of Medicine

Nucleotide-binding oligomerization domain 1(NOD1) is an intracellular innate immune sensor for small molecules derived from bacterial cell components. NOD1 activation by its ligands leads to robust production of pro-inflammatory cytokines and chemokines by innate immune cells, thereby mediating mucosal host defense systems against microbes. Chronic gastric infection due to Helicobacter pylori(H. pylori) causes various upper gastrointestinal diseases, including atrophic gastritis, peptic ulcers, and gastric cancer. It is now generally accepted that detection of H. pylori by NOD1 expressed in gastric epithelial cells plays an indispensable role in mucosal host defense systems against this organism. Recent studies have revealed the molecular mechanism by which NOD1 activation caused by H. pylori infection is involved in the development of chronic gastritis and gastric cancer. In this review, we have discussed and summarized how sensing of H. pylori by NOD1 mediates the prevention of chronic gastritis and gastric cancer.

关键词： Nucleotide-binding oligomerization domain 1 Helicobacter pylori,gastritis gastric cancer

Alterations of autophagic and innate immune responses by the Crohn’s disease-associated ATG16L1 mutation

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World Journal of Gastroenterology 2022年第26期28卷 3063-3070页

作者： Natsuki Okai Tomohiro watanabe Kosuke Minaga Ken Kamata Hajime Honjo masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-Sayama 589-8511OsakaJapan

Crohn’s disease(CD)is driven by the loss of tolerance to intestinal microbiota and excessive production of pro-inflammatory *** pro-inflammatory cytokines are produced by macrophages and dendritic cells(DCs)upon sensing the intestinal microbiota by the pattern recognition receptors(PRRs).Impaired activation of PRR-mediated signaling pathways is associated with chronic gastrointestinal inflammation,as shown by the fact that loss-of-function mutations in the nucleotide-binding oligomerization domain 2 gene increase the risk of CD *** is an intracellular degradation process,during which cytoplasmic nutrients and intracellular pathogens are *** that impaired reaction to intestinal microbiota alters signaling pathways mediated by PRRs,it is likely that dysfunction of the autophagic machinery is involved in the development of ***,the loss-of-function mutation T300A in the autophagy related 16 like 1(ATG16L1)protein,a critical regulator of autophagy,increases susceptibility to *** studies have provided evidence that ATG16L1 is involved not only in autophagy,but also in PRR-mediated signaling ***16L1 negatively regulates pro-inflammatory cytokine responses of macrophages and DCs after these cells sense the intestinal microbiota by ***,we discuss the molecular mechanisms underlying the development of CD in the T300A ATG16L1 mutation by focusing on PRR-mediated signaling pathways.

关键词： ATG16L1 Crohn’s disease Autophagy Innate immunity Cytokine Pattern recognition receptors

Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease

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World Journal of Gastroenterology 2021年第19期27卷 2257-2269页

作者： Akane Hara Tomohiro watanabe Kosuke Minaga Tomoe Yoshikawa Ken Kamata masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-Sayama 589-8511Japan

Solitary organ autoimmune disorders,formerly known as autoimmune pancreatitis(AIP),autoimmune sialadenitis,and autoimmune sclerosing cholangitis,are now considered organ-specific manifestations of systemic immunoglobulin G4-related disease(IgG4-RD).AIP and IgG4-RD are characterized by elevated serum concentration of IgG4 antibody(Ab),accumulation of IgG4-expressing plasmacytes in the affected organs,and involvement of multiple *** is well established that enhanced IgG4 Ab responses are a hallmark of AIP and IgG4-RD for diagnosis and monitoring disease ***,a significant fraction of patients with AIP and IgG4-RD who develop chronic fibroinflammatory responses have normal serum concentrations of this IgG *** addition,disease flare-up is sometimes seen even in the presence of normalized serum concentrations of IgG4 Ab after successful induction of remission by ***,it is necessary to identify new biomarkers based on the understanding of the pathophysiology of AIP and ***,we found that activation of plasmacytoid dendritic cells producing both interferon-α(IFN-α)and interleukin-33(IL-33)mediate murine AIP and human *** importantly,we provided evidence that serum concentrations of IFN-αand IL-33 could be useful biomarkers for the diagnosis and monitoring of AIP and IgG4-RD activity after induction of remission in these autoimmune *** this Frontier article,we have summarized and discussed biomarkers of AIP and IgG4-RD,including Igs,autoAbs,and cytokines to provide useful information not only for clinicians but also for researchers.

关键词： Biomarker Autoimmune pancreatitis Immunoglobulin G4-related disease Plasmacytoid dendritic cells Cytokine Chemokine

Verrucous antral gastritis in relation to Helicobacter pylori infection,nutrition,and gastric atrophy

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Gastroenterology Report 2020年第4期8卷 293-298,I0002页

作者： Naoko Tsuji Yasuko Umehara Mamoru Takenaka Yasunori Minami Tomohiro watanabe Naoshi Nishida masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-SayamaJapan

Background:There have been few studies in the English literature regarding verrucous gastritis(VG).The present study investigated the clinical and endoscopic features of verrucous antral gastritis,especially focusing on Helicobacter pylori infection,nutrition,and gastric ***:We performed a retrospective study of patients who underwent routine endoscopy with indigo carmine chromoendoscopy and a comparative study was conducted between VG-positive and VG-negative *** was subdivided into classical and numerous types based on the number and distribution of verrucous ***,clinical,and endoscopic data including body mass index(BMI),serum albumin and cholesterol,gastric atrophy,reflux oesophagitis,Barrett’s oesophagus,and *** status were *** and multivariable analyses were performed to identify factors associated with ***:We analysed the data of 621 patients undergoing routine endoscopy and found that VG(n=352)was significantly associated with increased BMI(1.12[1.05-1.18],P<0.01),reflux esophagitis(1.96[1.10-3.28],P<0.01),and *** negativity with or without a history of eradication(9.94[6.00-16.47]and 6.12[3.51-10.68],P<0.001,respectively).Numerous-type(n=163)VG was associated with both closed-and open-type gastric atrophy(9.9[4.04-21.37]and 8.10[3.41-19.24],P<0.001,respectively).There were no statistical differences between groups regarding age,sex,total cholesterol,albumin,and bile-colored gastric ***:Verrucous antral gastritis was related to increased BMI,reflux esophagitis,and *** ***-type verrucous lesions were associated with gastric *** indicate that VG may be a physiological phenomenon due to high gastric acidity,mechanical overload,and vulnerability of background mucosa.

关键词： verrucous gastritis chromoendoscopy BMI Helicobacter pylori eradication gastric atrophy

Damped Oscillation of Liquid Column in Vertical U-Tube for Newtonian and non-Newtonian Liquids

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Journal of Thermal Science 2007年第4期16卷 289-300页

作者： Akira Ogawa Suguru Tokiwa masatoshi Mutou Kazutaka Mogi Tonau Sugawara Masahide watanabe Kouhei Satou Toshikazu Kikawada Keitarou Shishido Naoya Matumoto T110-0011.Minowa 2-14-7 Taitou-KuTokyoJapan Asnohorie Co.Ltd. Japan Yamada manufacturing Co.Ltd. Japar Polymatech Co.Ltd. japan Fujikura Rubber Com. Japan Furukawa Electric Co.Ltd. Japan GMA Co.Ltd. Japan Top Corporation Co.Ltd. Japan Hitachi Unisia Co.Ltd. Japan Research Student Japan

Damped oscillation of Newtonian liquid in a vertical U-tube is one of the well known phenomena and the solution of this liquid motion for the laminar flow regime in the circular pipe was solved, however, generally speaking, even if the period of the oscillational motion by this solution is nearly coincided with that of the experimental result, the estimation of the damped oscillational process with lapse of time by the solved equation is not in agreement with that of the experimental result. Therefore basing upon the experimental results of the velocity distributions of the oscillational motion in the circular U-tube for the Newtonian and non-Newtonian liquids, the velocity distribution of the Bingham plastic flow is assumed. The solutions of the damped oscillation and also of the vertical falling and rising velocities of the free surface in the vertical U-tube of the diameters D= 10mm, 20mm and 40mm are compared with water and water-glycerine solution for the Newtonian liquids and the acrylic co-polymer solutions for the non-Newtorlian liquid. The comparisons of these solved equations by the new flow model are shown in good agreement with the experimental results. The above stated results are described in detail.

关键词： Damped oscillation Bingham plastic flow Hagen-Poiseuille law Newtonian liquid non-Newtonian liquid.

Supramolecular liquid crystals from the dimer of L-shapedmolecules with tertiary amide end groups

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Aggregate 2024年第3期5卷 299-307页

作者： Yuki Sawatari Yoshimichi Shimomura Masato Takeuchi Riki Iwai Takuya Tanaka Eiji Tsurumaki masatoshi Tokita Junji watanabe Gen-ichi Konishi Department of Chemical Science and Engineering Tokyo Institute of TechnologyMeguro-kuTokyoJapan Department of Applied Chemistry Osaka Metropolitan UniversitySakaiOsakaJapan Department of Chemistry Tokyo Institute of TechnologyMeguro-kuTokyoJapan Department of Polymer Chemistry Tokyo Institute of TechnologyMeguro-kuTokyoJapan

Supramolecular liquid crystals(SLCs)are attractive materials for fabricating devices with new optoelectronic *** SLCs are made from hydrogen-bonded ***,these mesogens suffer from high melting points,and the types of formable aggregates are limited owing to the directionality of the hydro-gen ***,to fabricate non-hydrogen-bonded SLCs,we hypothesized that the introduction of tertiary amide groups into calamitic molecules would be advantageous because they have an L-shaped structure with N-or C-alkyl side chains not aligned along the long axis and theﬂexibility to undergo cis–trans *** this study,we developed a novel non-hydrogen-bonded SLC by assembling an L-shaped dimer composed of calamitic molecules(phenyltolanes)with tertiary amides at their *** molecules exhibited a smectic B *** phase tran-sition temperature of the SLCs from crystal to liquid crystal phase was low despite the longπ-conjugated ***-angle X-ray diffraction and variable-temperature Fourier-transform infrared measurements revealed dimer formation by weak inter-molecular interactions,that is,the molecular recognition of L-shaped molecules,and mobility of the alkyl groups attached to amide driven by cis–trans isomerization in the liquid crystal ***,cis–trans isomerization of tertiary amides contributed enormously to the formation and lower clearing points of this *** developed method can be used not only to develop non-hydrogen-bonded SLCs but also to develop novel soft matter with controlled properties by incorporating the SLCs,as the aggregates can be controlled to impart desired functionalities.

关键词： mesogen self-assembly semectic phase supramolecular liquid crystal tertiary amide variable-

Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis: Long-term outcomes after removal of a self-expandable metal stent

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World Journal of Gastroenterology 2017年第4期23卷 661-667页

作者： Ken Kamata Mamoru Takenaka Masayuki Kitano Shunsuke Omoto Takeshi Miyata Kosuke Minaga Kentaro Yamao Hajime Imai Toshiharu Sakurai Tomohiro watanabe Naoshi Nishida masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-Sayama 589-8511Japan

AIM To assess the long-term outcomes of this procedure after removal of self-expandable metal stent(SEMS). The efficacy and safety of endoscopic ultrasoundguided gallbladder drainage(EUS-GBD) with SEMS were also *** Between January 2010 and April 2015, 12 patients with acute calculous cholecystitis, who were deemed unsuitable for cholecystectomy, underwent EUSGBD with a SEMS. EUS-GBD was performed under the guidance of EUS and fluoroscopy, by puncturing the gallbladder with a needle, inserting a guidewire, dilating the puncture hole, and placing a SEMS. TheSEMS was removed and/or replaced with a 7-Fr plastic pigtail stent after cholecystitis improved. The technical and clinical success rates, adverse event rate, and recurrence rate were all *** The rates of technical success, clinical success, and adverse events were 100%, 100%, and 0%, respectively. After cholecystitis improved, the SEMS was removed without replacement in eight patients, whereas it was replaced with a 7-Fr pigtail stent in four patients. Recurrence was seen in one patient(8.3%) who did not receive a replacement pigtail stent. The median follow-up period after EUS-GBD was 304 d(78-1492).CONCLUSION EUS-GBD with a SEMS is a possible alternative treatment for acute cholecystitis. Long-term outcomes after removal of the SEMS were excellent. Removal of the SEMS at 4-wk after SEMS placement and improvement of symptoms might avoid migration of the stent and recurrence of cholecystitis due to food impaction.

关键词： Endoscopic ultrasound-guided gallbladder drainage Cholecystitis Endoscopic ultrasound-guided biliary drainage