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Pan-peroxisome proliferator-activated receptor agonist lanifibranor as a dominant candidate pharmacological therapy for nonalcoholic fatty liver disease

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 433-435页

作者： masato Yoneda Takashi Kobayashi Nogami Asako Michihiro Iwaki Satoru Saito Atsushi Nakajima Department of Gastroenterology and Hepatology Yokohama City University HospitalKanazawa-kuYokohamaJapan

As obesity incidence increases worldwide,nonalcoholic fatty liver disease(NAFLD)has become the most common form of liver disease,with a reported global prevalence of 25.2%(1).Nonalcoholic steatohepatitis(NASH)is a severe form of ***,the precise natural history of NAFLD/NASH remains *** is rapidly becoming the leading cause of end-stage liver disorders and liver transplants and is associated with increased cardiovascular disease risk(2).As a result,it poses critical health issues globally from both medical and socioeconomic perspectives.

关键词： NAFLD liver cardiovascular

Mesomorphic behavior of new azomethine liquid crystals having terminal iodo group

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Chinese Chemical Letters 2011年第3期22卷 260-263页

作者： Sie-Tiong Ha Teck-Leong Lee Guan-Yeow Yeap masato M.Ito Ayumu Saito Masaaki Watanabe Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparPerakMalaysia Liquid Crystal Research Laboratory School of Chemical SciencesUniversiti Sains Malaysia11800 MindenPenangMalaysia Faculty of Engineering Soka University1-236 Tangi-choHachiojiTokyo 192-8577Japan

A series of azomethine esters,3-hydroxy-4-{[（4-iodophenyl）imino]methyl}phenyl alkanoates possessing even number of carbon atoms at the terminal alkanoyloxy chain（C_（n-1）H_（2n-1）COO-,n = 4,6,8,10,12,14） was synthesized.n-Butanoyloxy was found non-mesogenic,whilst n-hexanoyloxy to n-tetradecanoyloxy exhibited enantiotropic smectic A phase with fan-shaped *** was found that the length of terminal alkanoyloxy chain influenced the mesomorphic properties.

关键词： Liquid crystals Azomethine ester Enantiotropic Smectic A

Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8304-8311页

作者： Yu Ohkura Hironori Uruga masato Shiiba Shinji Ito Hayato Shimoyama Makiko Ishihara Masaki Ueno Harushi Udagawa Department of Gastroenterological Surgery Toranomon HospitalTokyo 105-8470Japan Department of Diagnostic Pathology Toranomon HospitalTokyo 105-8470Japan Department of Diagnostic Imaging Center Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Phosphoglyceride crystal deposition disease(PCDD)is a rare acquired disease in which phospholipid crystals deposit in bone and soft tissue long after surgery,trauma,or repeated *** SUMMARY A 60-year-old-woman was referred to our department because of multiple abdominal masses after open splenectomy for idiopathic thrombocytopenic purpura 29 years *** the masses showed marked fluorodeoxyglucose(FDG)uptake on ^(18)F-fluorodeoxyglucose positron emission tomography(^(18)F-FDGPET)and were strongly suspected to be malignant *** biopsies were performed,and the abdominal masses were found to be aligned vertically,three in a row,along the tissue layers cut in the patient’s previous *** finding of the specimens showed foreign body granuloma consisting of histiocytes and multinucleated giant cells accumulating around needle-like *** crystals were confirmed as phosphoglyceride by Raman spectroscopy,and PCDD was *** our knowledge,this is the first report of PCDD diagnosed by Raman *** We made a definitive diagnosis of PCDD in a patient with multiple tumors showing marked FDG uptake on ^(18)F-FDG-PET by incisional biopsy and composition analysis using Raman spectroscopy,a method that has not previously been reported for the diagnosis of PCDD.

关键词： Phosphoglyceride crystal deposition disease Raman spectroscopy Positron emission tomography Foreign body granuloma with crystal deposition Surgical scar Case report

Liver cirrhosis in a child associated with Castleman's disease: A case report

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World Journal of Clinical Cases 2020年第9期8卷 1656-1665页

作者： Soya Kobayashi Ayano Inui Tomoyuki Tsunoda Syuichiro Umetsu Tsuyoshi Sogo Masaaki Mori masato Shinkai Tomoo Fujisawa Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama City Tobu HospitalYokohama 230-8765Japan Department of Lifetime Clinical Immunology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Surgery Kanagawa Children’s Medical CenterYokohama 232-8555Japan

BACKGROUND Castleman's disease(CD)is a lymphoproliferative *** syndrome is classified as a variant of CD based on its key clinical manifestations of thrombocytopenia,anasarca(generalized edema and pleural effusion),fever(pyrexia),reticulin fibrosis in the bone marrow and the proliferation of megakaryocytes,and organomegaly(such as hepatosplenomegaly and multiple lymphadenopathies);TAFRO syndrome is mainly reported in Japanese *** our knowledge,this is the first pediatric case report detailing a CD-associated disorder progressing to *** SUMMARY A 10-year old male patient presented with fever and *** months before hospitalization,he had remarkable abdominal ***,he visited a clinic for a fever that lasted 5 *** physical findings were marked hepatosplenomegaly and cervical lymphadenopathy.A blood test revealed leukocytosis,microcytic anemia,aspartate aminotransferase-dominant transaminase elevation,high levels of C-reactive protein,polyclonal hypergammaglobulinemia,and high levels of interleukin-6 and vascular endothelial growth *** contrast computed tomography and magnetic resonance imaging suggested cirrhosis,which was confirmed by liver *** findings in the enlarged hepatic lymph nodes revealed both hyperplasia and atrophy of lymphoid follicles with some vascular hyperplasia and moderate plasmacytosis between the lymphoid follicles,which is compatible with lymph node histology in TAFRO *** was not effective in reducing the patient’s symptoms;therefore,the patient was prescribed *** date,the patient remains free of fever and continues to receive *** We described the clinicopathological features of TAFRO syndrome to highlight the clinical presentation of this rare disease in a pediatric case.

关键词： Castleman disease Case report Multi-centric Castleman’s disease Liver cirrhosis Tocilizumab Child

Regulation, Structure and Function of Aquaporin

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中国药理通讯 2008年第2期25卷 15-16页

作者： masato Yasui Dept. of Pharmacology School of Medicine Keio University Tokyo Japan

The discovery of the water channel aquaporin has greatly expanded our understanding of the regulation of the water permeability of biological membranes。The atomic structure of aquaporin-1 (AQP1) demonstrated how aquaporin is freely permeated by water but not protons and provided marked insight into several human disorders, 13 mammalian aquaporins have been identified, each with a distinct distribution, and these are selectively permeated by water or water plus glycerol。Aquaporins are suspected in numerous pathological conditions such as brain edema, diabetes mellitus。Knowledgeof structure, regulation and function of aquaporins may provide insight into the development of new therapeutics through appropriate drug design。

关键词：合理用药治疗方法水通道蛋白药理学

Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity

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World Journal of Gastroenterology 2014年第23期20卷 7197-7206页

作者： Xia Jiang Tatsuo Kanda Shuang Wu masato Nakamura Tatsuo Miyamura Shingo Nakamoto Arup Banerjee Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Molecular Virology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Vaccine and Infectious Disease Research Center and Translational Health Science and Technology Institute Gurgaon-122016HaryanaIndia

Hepatitis B virus(HBV)chronically infects more than350 million people *** causes acute and chronic hepatitis,and is one of the major causes of cirrhosis and hepatocellular *** exist complex interactions between HBV and the immune system including adaptive and innate *** receptors(TLRs)and TLR-signaling pathways are important parts of the innate immune response in HBV *** is well known that TLR-ligands could suppress HBV replication and that TLRs play important roles in anti-viral *** immunological studies demonstrated that HBV e antigen(HBeAg)is more efficient at eliciting T-cell tolerance,including production of specific cytokines IL-2 and interferon gamma,than HBV core *** downregulates cytokine production in hepatocytes by the inhibition of MAPK or NF-κB activation through the interaction with receptor-interacting serine/threonine protein ***(miRNAs)are also able to regulate various biological processes such as the innate immune *** the expressions of approximately 1000 miRNAs were compared between human hepatoma cells HepG2 and HepG2.2.15,which could produce HBV virion that infects chimpanzees,using real-time RT-PCR,we observed several different expression levels in miRNAs related to *** we and others have shown that HBV modulates the host immune response,several of the miRNAs seem to be involved in the TLR signaling *** possibility that alteration of these miRNAs during HBV infection might play a critical role in innate immunity against HBV infection should be *** article is intended to comprehensively review the association between HBV and innate immunity,and to discuss the role of miRNAs in the innate immune response to HBV infection.

关键词： Hepatitis B virus HepG2.2.15 Innate immunity MicroRNA Persistent infection Toll-like receptor

Hydrogen bond-assisted 1,2-cis O-glycosylation under mild hydrogenolytic conditions

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Chinese Chemical Letters 2023年第4期34卷 313-317页

作者： Gefei Li Yanlong Luo Juan Mo masato Noguchi Jie Jing Zhenyang Luo Shin-ichiro Shoda Xin-Shan Ye College of Science Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Biomolecular Engineering Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan

A hydrogen bond-assisted α-selective glycosylation reaction by using 4,6-dibenzyloxy-1,3,5-triazin-2-yl(DBT) β-glycosyl donors was developed for the efficient construction of 1,2-cis-α-glycosidic bond in natural products. This method was applied successfully to the direct synthesis of complex oligosaccharidederived glycolipids with simple protecting chemistry. Mechanistic studies using the NMR spectroscopy and DFT calculation provide a proof of concept for hydrogen bond-assisted glycosylation reaction towardsα-specific construction of O-glycosidic linkage.

关键词： O-Glycosylation Hydrogen bond α-Selectivity Glycolipid Natural product

Trimeric Hydrogen Bond in Geometrically Frustrated Hydroxyl Cobalt Halogenides

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Chinese Physics Letters 2011年第1期28卷 197-200页

作者： LIU Xiao-Dong Hagihala masato ZHENG Xu-Guang TAO Wan-Jun MENG Dong-Dong ZHANG Sen-Lin GUO Qi-Xin Department of Physics Graduate School of Science and Engineering Saga University Saga 840-8502 Japan Department of Physics College of Science Tianjin Polytechnic University Tianjin 300160 Department of Physics Faculty of Science and' Engineering Saga University Saga 840-8502 Japan Synchrotron Light Application Center & Department of Electrical and Electronic Engineering Saga University Saga 840-8502 Japan

The mid-infrared absorption spectra of geometrically frustrated hydroxyl cobalt halogenides Co2 （OH）3 CI and Co2 （OH）3Br are measured by FTIR spectrometers, and the stretching vibrational modes of hydroxyl groups are found to be 3549 cm-1 and 3524 cm-1 respectively. Through finding their true terminal O II group stretching vibration frequencies, we obtain 107cm-1 and 99cm-1 red shift caused by the corresponding O-H...Cl and 0 H...Br hydrogen bonds. Rarely reported trimeric hydrogen bonds （Co3≡O H）3….C1/Br are pointed out to demonstrate the relative weakness of this kind of hydrogen bond which may have a critical effect on the lattice symmetry and magnetic structures.

关键词： Condensed matter: electrical, magnetic and optical Condensed matter: structural, mechanical & thermal

Raman and Mid-IR Spectral Analysis of the Atacamite-Structure Hydroxyl/Deuteroxyl Nickel Chlorides Ni_(2)(OH/D)_(3)Cl

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Chinese Physics Letters 2011年第8期28卷 314-317页

作者： LIU Xiao-Dong Hagihala masato ZHENG Xu-Guang MENG Dong-Dong GUO Qi-Xin Department of Physics Graduate School of Science and EngineeringSaga UniversitySaga 840-8502Japan Department of Physics College of ScienceTianjin Polytechnic UniversityTianjin 300160 Department of Physics Faculty of Science and EngineeringSaga UniversitySaga 840-8502Japan Synchrotron Light Application Center&Department of Electrical and Electronic Engineering Saga UniversitySaga 840-8502Japan

Vibrational spectra(Raman 4000–95 cm−1 and mid-IR 4000–400 cm−1)of the atacamite-structure Ni_(2)(OH)3Cl,including a rarely reported kind of asymmetric trimetric hydrogen bond,as a member of the geometrically frustrated material series and its deuteride Ni_(2)(OD)3Cl are,to the best of our knowledge,reported for the first time and analyzed at room *** a comparative study of four spectra according to their crystal structural parameters,we assign OH stretching modes v(OH)in a functional group region(3700–3400 cm−1)and their deformation modesδ(NiOH/D)in the correlation peak region(900–600 cm−1)with the corresponding mode frequency ratiosωv(OD)/ωv(OH)≈73%andωδ(NiOD)/ωδ(NiOH)≈75%,and further self−consistently suggest Ni-O and Ni-Cl related modes in the fingerprint region(500–200 cm^(−1) and 200–0 cm−1,respectively)by use of the unified six-ligand NiO_(5)Cl and NiO_(4)Cl_(2) *** report may contribute to the spectral analysis of other hydroxyl transition-metal halides and to the understanding of the fundamental physics of their exotic magnetic geometrical frustration property from the spectral changes around the corresponding low transition temperatures.

关键词： temperature stretching transition