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Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells

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Neural Regeneration Research 2024年第11期19卷 2341-2342页

作者： masato Kanazawa Itaru Ninomiya Yutaka Otsu Masahiro Hatakeyama Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Stroke is the second leading cause of death and the third leading cause of disability worldwide after heart *** predict that stroke deaths and permanent disabilities will increase worldwide by the year ***-target therapies may be insufficient,because ischemic cerebral injury involves several ***-mediated therapies are ideal,because they target multiple cell types to enhance protection and recovery.

关键词： ischemic death cerebral

Medaka factor in the germline alpha(figα)is indispensable for oogenesis but not for gonadal sex differentiation

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Aquaculture and Fisheries 2024年第3期9卷 347-354页

作者： Katsuyasu Kamimura masato Kinoshita Akira Kanamori Division of Biological Science Graduate School of ScienceNagoya UniversityNagoyaAichi464-8602Japan Division of Applied Biosciences Graduate School of AgricultureKyoto UniversityKyoto606-8502Japan

A basic helix-loop-helix transcription factor,figα,is one of the earliest marker genes of oocyte differentiation in *** the present study,we made figαknockout medaka by CRISPR/Cas9,expecting aborted progress of oogenesis,to see if differentiation of somatic ovarian tissues is ***αknockout male gonads differentiated normally into testes with functional *** females,on the other hand,were sterile;there are oocytes only up to *** growing oocytes in diplotene were *** phenotype was already apparent at 10 days after hatching,when diplotene oocytes start to develop in the ***,several putative target genes of figαwere not expressed in the mutant female *** studies showed that medaka lacking germ cells have morphologically abnormal gonads and female to male sex reversal ***αknockout female gonads differentiated morphologically into ovaries,suggesting that in medaka,figαknockout prevents oogenesis progress into diplotene stage,and ovarian differentiation do not need developed oocytes beyond pachytene *** ovarian phenotype reminded us of"pachytene checkpoint",which blocks meiotic progress into diplotene when chromosomal abnormalities are ***,we further analyzed phenotype of oocytes in the mutant *** number of oocytes at each meiotic stage suggested that oogenesis normally proceeded up to pachytene *** number of apoptotic oocytes in the knockout ovaries was ***,we did not detect any abnormal pairings or unrepaired double-strand breaks by *** together,figαknockout likely stop oocyte growth at or around pachytene via unknown mechanisms other than"pachytene checkpoint"and arrested oocytes remained in the *** is in contrast to figαknockout mice where all oocytes underwent apoptosis quickly after birth.

关键词： bHLH transcription factor CRISPR/Cas9 Pachytene checkpoint Oocyte growth Medaka

Indication of conservative treatment by antibiotics for uncomplicated and complicated acute appendicitis

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2538-2545页

作者： Yuichi Hosokawa masato Moritani Yosuke Makuuchi Yuichi Nagakawa Department of Surgery Nishitokyo Central General HospitalTokyo 188-0014Japan Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityTokyo 166-0023Japan

BACKGROUND Acute appendicitis is one of the most common emergency abdominal disease,and recent studies have evaluated conservative treatment using antibiotics for uncomplicated *** the efficacy of conservative treatment for uncomplicated appendicitis is known,its efficacy for complicated appendicitis remains unknown,so are risk factors for the conservative treatment of *** our institution,conservative treatment has long been the first choice for most appendicitis cases,except for ***,this novel study inves-tigated the outcomes of conservative treatment for uncomplicated and compli-cated acute appendicitis and the risk factors associated with conservative *** significant and independent predictors of resistance to conservative treatment were body temperature≥37.3℃,appendicolith and Douglas sinus fluid visible on computed tomography(CT).The rate of resistance to conservative treatment was 66.7%(6/9)for patients with the above three factors,22.9%(8/35)for patients with two factors(appendicolith and body temperature≥37.3℃),16.7%(2/12)for patients with two factors(Douglas sinus fluid and appendicolith)and 11.1%(1/9)for patients with two factors(Douglas sinus fluid and body temperature≥37.3℃).CONCLUSION A temperature≥37.3℃,appendicolith and Douglas sinus fluid on CT might be clinical risk factors of resistance to conservative treatment for acute appendicitis.

关键词： Acute appendicitis Conservative treatment Antibiotics Appendicolith Uncomplicated appendicitis

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未来气候条件下蒙古草原植被的预测分布

Journal of Plant Ecology 2024年第3期17卷 16-27页

作者： Kohei Suzuki Ikutaro Tsuyama Radnaakhand Tungalag Amartuvshin Narantsetseg Tsagaanbandi Tsendeekhuu masato Shinoda Norikazu Yamanaka Takashi Kamijo Department of Regional Regeneration Science Faculty of Regional Environment ScienceTokyo University of AgricultureTokyo 156-8502Japan Hokkaido Research Center Forestry and Forest Products Research InstituteHokkaido 062-8516Japan Department ofBiology School of Arts and SciencesNational University of MongoliaUlaanbaatar 210646Mongolia Botanic Garden and ResearchInstitute Mongolian Academy of ScienceUlaanbaatar 51Mongolia Department of Earth and Environmental Sciences GraduateSchool of Environmental StudiesNagoya UniversityNagoya 464-8601Japan Arid Land Research Center Tottori UniversityTottori680-0001Japan Faculty of Life and Environmental Sciences University of TsukubaIbaraki 305-8572Japan

蒙古牧民家庭通过适应当地植被分布的特点来维持牲畜的健康状况。因此,预测未来植被变化对于稳定的牲畜放牧和可持续的草原利用至关重要。本研究基于前期研究获得的植被数据预测了2081年至2100年间草原植被,尤其是沙漠草原、草原和草甸... 详细信息

蒙古牧民家庭通过适应当地植被分布的特点来维持牲畜的健康状况。因此,预测未来植被变化对于稳定的牲畜放牧和可持续的草原利用至关重要。本研究基于前期研究获得的植被数据预测了2081年至2100年间草原植被,尤其是沙漠草原、草原和草甸草原的分布范围。我们首先基于在蒙古(43–50°N,87–119°E)收集的草原植被数据(2012至2016年,278个样地)划分了不同的群落类型。其次,采用最大熵(MaxEnt)模型进行物种分布建模,其中以荒漠草原、草原和草甸草原的分布数据作为目标变量,使用WorldClim的生物气候数据作为解释变量。最后,采用WorldClim提供的CMIP6下缩放的未来气候预测数据进行未来预测。结果发现,荒漠草原、草原和草甸草原模型的曲线下面积值分别为0.850、0.847和0.873。根据所有情景和所有群落的气候变化,适宜栖息地预计将缩小。潜在适宜区域减少的程度在草甸草原群落中最为显著。上述结果表明,未来气候变化情景下草甸草原群落将转变为草原群落。

关键词：气候变化群落最大熵物种分布建模草原 WorldClim

Improving the performance of conventional base isolation systems by an external variable negative stiffness device under near-fault and long-period ground motions

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Earthquake Engineering and Engineering Vibration 2020年第4期19卷 985-1003页

作者： Sandhya Nepal masato Saitoh Graduate School of Science and Engineering Saitama University255 Shimo-OkuboSakura-kuSaitamaJapan

Recent studies have shown that base-isolated objects with long fundamental natural periods are highly influenced by long-period earthquakes. These long-period waves result in large displacements for isolators, possibly leading to exceedance of the allowable displacement limits. Conventional isolation systems, in general, fail to resist such large displacements. This has prompted the need to modify conventional base isolation systems. The current work focuses on the development of an external device, comprising a unit of negative and positive springs, for improving the performance of conventional base isolation systems. This unit accelerates the change in the stiffness of the isolation system where the stiffness of the positive spring varies linearly in terms of the displacement response of the isolated objects. The target objects of the present study are small structures such as computer servers, sensitive instruments and machinery. Numerical studies show that the increase in the damping of the system and the slope of the linear function is effective in reducing the displacement response. An optimal range of damping values and slope, satisfying the stability condition and the allowable limits of both displacement and acceleration responses when the system is subjected to near-fault and long-period ground motions simultaneously, is proposed.

关键词： base isolation near-fault earthquakes long-period earthquakes negative stiffness variable stiffness

Special variation of infiltration-growth processed bulk YBCO fabricated using new liquid source: Ba_(3)Cu_(5)O_(8) (1:1.3) and YbBa_(2)Cu_(3)O_(y)

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International Journal of Minerals,Metallurgy and Materials 2021年第6期28卷 1048-1056页

作者： Sushma Miryala masato Murakami Superconducting Material Laboratory Department of Material Science and EngineeringShibaura Institute of Technology3-7-5 ToyosuKoto-kuTokyo 135-8546Japan School of Engineering and Applied Science Princeton UniversityPrincetonNJ 08544United States

Utilization of novel materials,particularly high-T_(c)(critical temperature)superconductors,is essential to pursue the United Nations’Sustainable Goals,as well as to meet the increasing worldwide demand for clean and carbon-free electric power *** magnets are beneficial in several real-life applications including transportation,energy production,magnetic resonance imaging(MRI),and drug delivery *** achieve high performance,one must develop uniform,large-grain,infiltration-growth(IG)processed bulk YBa_(2)Cu_(3)O_(y)(Y-123)*** this study,we report the magnetic and microstructural properties of a large-grain,top-seeded,IG-processed Y-123 pellet,which is 20 mm in diameter and 6 mm in height;the pellet is produced utilizing liquid Yb-123+Ba_(3)Cu_(5)O_(8) as the liquid *** the samples cut from the top of the bulk exhibit a sharp superconducting transition(approximately 1 K wide)with the onset T_(c) of approximately 90 ***,in the samples cut from the bottom surface,the onset T_(c) values slightly decreased to between 88 and 90 K,although still exhibiting a sharp superconducting *** top and bottom samples exhibited the highest remnant value of J_(c)(critical current density)at 77 K H//c-axis of 50 and 55 kA/cm^(2),*** remnant J_(c) and irreversibility field values significantly fluctuated,being fairly low in some bottom *** electron microscopy identified nanometer size Y-211(Y2BaCuO5)secondary-phase particles dispersed in the Y-123 ***-dispersive spectroscopy clarified that the decreased both T_(c) and J_(c) for the bottom samples were attributed to liquid phase dispersion within the Y-123 phase.

关键词： infiltration growth special variation critical current density scanning electron microscopy

Application of the SCC method to the multi-O(4) model:The collective Hamiltonian

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Science China(Physics,Mechanics & Astronomy) 2009年第10期52卷 1518-1529页

作者： KOBAYASI masato Department of Physics Graduate School of ScienceKyoto University Advancesoft Center for Collaborative ResearchUniversity of Tokyo

The collective Hamiltonian up to the fourth order for a multi-O(4) model is derived for the first time based on the self-consistent collective-coordinate(SCC) method,which is formulated in the framework of the time-dependent Hartree-Bogoliubov(TDHB) *** collective Hamiltonian is valid for the spherical case where the HB equilibrium point of the multi-O(4) model is spherical as well as for the deformed case where the HB equilibrium points are *** validity is tested numerically in both the spherical and deformed *** simulations indicate that the low-lying states of the collective Hamiltonian and the transition amplitudes among them mimic fairly well those obtained by exactly diagonalizing the Hamiltonian of the multi-O(4) *** numerical results for the deformed case imply that the "optimized RPA boundary condition" is also valid for the well-known η*,η expansion around the unstable HB point of the multi-O(4) *** these illuminate the power of the SCC method.

关键词： self-consistent collective-coordinate method multi-O(4) model time-dependent Hartree-Bogoliubov theory collective Hamiltonian

Model tests and numerical analyses on horizontal impedance functions of inclined single piles embedded in cohesionless soil

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Earthquake Engineering and Engineering Vibration 2013年第1期12卷 143-154页

作者： Chandra Shekhar Goit masato Saitoh Department of Civil and Environmental Engineering Saitama University

Horizontal impedance functions of inclined single piles are measured experimentally for model soil-pile systems with both the effects of local soil nonlinearity and resonant *** practical pile inclinations of 5掳 and 10掳 in addition to a vertical pile embedded in cohesionless soil and subjected to lateral harmonic pile head loadings for a wide range of frequencies are *** obtained with low-to-high amplitude of lateral loadings on model soil-pile systems encased in a laminar shear box show that the local nonlinearities have a profound impact on the horizontal impedance functions of *** impedance functions of inclined piles are found to be smaller than the vertical pile and the values decrease as the angle of pile inclination *** values of horizontal impedance functions are obtained for the ＇positive＇ and ＇negative＇ cycles of harmonic loadings,leading to asymmetric force-displacement relationships for the inclined *** of these experimental results is carried out through three-dimensional nonlinear finite element analyses,and the results from the numerical models are in good agreement with the experimental *** analyses conducted on the numerical models suggest that the consideration of local nonlinearity at the vicinity of the soil-pile interface influence the response of the soil-pile systems.

关键词： inclined single piles harmonic loads horizontal impedance functions local nonlinearity finite element model

Motion Analysis of Trunk Using Simplified Human Model in Sagittal Plane

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 20-27页

作者： masato Kawaguchi Shoichiro Takehara Division of Mechanical Engineering Graduate School of Science and TechnologySophia University Department of Engineering and Applied Sciences Sophia University

The mass of very small vehicles is often comparable to that of their drivers,and thus there is a greater degree of coupling between the vehicle and the driver,compared with a case for traditional *** developing small vehicles,it is necessary to give ample consideration to the dynamics of the person who ride ***,a model of a human body riding a small personal vehicle was constructed to investigate the dynamics of the person inside such a ***,an experiment on posture maintenance by acceleration of direction of travel was conducted and the parameters for posture control were identified using agenetic *** shows that body behavior could be successfully simulated using the proposed model,and the control parameters were effective in determining the posture maintenance characteristics of the vehicle occupant.

关键词： human dynamics trunk simulation human body vehicles