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Preventive approach against drug-induced pulmonary fibrosis through the suppression of epithelial-mesenchymal transition

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BIOCELL 2022年第8期46卷 1861-1865页

作者： masashi KAWAMI RYOKO YUMOTO MIKIHISA TAKANO Graduate School of Biomedical and Health Sciences Hiroshima UniversityHiroshima7348553Japan

A number of drugs induce pulmonary injury and subsequently lead to serious lung diseases such as pulmonary fibrosis as the adverse drug ***,an effective preventive approach against drug-induced pulmonary fibrosis has not been established due to poor understanding of common preventive targets in a variety of drugs showing pulmonary ***-mesenchymal transition(EMT),a cellular phenotypic change of the epithelial to mesenchymal state,contributes to the development of pulmonary fibrosis through the conversion of damaged alveolar epithelium into *** several drugs with pulmonary toxicity have been reported to induce EMT,EMT serves as a bridge between the drugs and pulmonary *** evidence supports the potential of EMT as a preventive target against drug-induced pulmonary ***,since there are mechanistic differences between the main pharmacological effect and EMT induced by the drug,prevention based on EMT suppression would be possible and would contribute to continuous clinical treatment with the drug to avoid EMT-mediated serious pulmonary ***,targeting EMT seems to be adequate for exerting a preventive effect since EMT in damaged alveolar epithelial cells occurs prior to the development of the pathophysiological state of the whole lung in a bleomycin-induced lung injury rat *** viewpoint deals with the benefits and perspectives of preventive approaches against druginduced pulmonary fibrosis through the suppression of EMT,which has rarely been addressed.

关键词： Drug-induced lung injury Epithelial-mesenchymal transition Pulmonary fibrosis α-smooth muscle actin

Probing the lower ionospheric perturbations associated with earthquakes by means of subionospheric VLF/LF propagation

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Earthquake Science 2011年第6期24卷 609-637页

作者： masashi Hayakawa Advanced Wireless Communications Research Center and Research Station on Seismo Electromagnetics The University of Electro-Communications1-5-1 ChofugaokaChofu Tokyo 182-8585Japan Earthquake Analysis Laboratory Information Systems Inc.Kita-Aoyama 2-12-42-R305Minato-kuTokyo 107-0061Japan

There have been reports for many years that the ionosphere is very sensitive to seismic effects, and the detection of ionospheric perturbations associated with earthquakes （EQs） attracts a lot of attention as a very promising candidate for short-term EQ prediction. In this review we present a possible use of VLF/LF （very low frequency （3-30 kHz）/low frequency （30-300 kHz）） radio sounding of seismo-ionospheric perturbations. In order to avoid the overlapping with my own previous reviews, we first show some pioneering results for the Kobe EQ and we try to present the latest results including the statistical evidence on the correlation between the VLF/LF propagation anomalies （ionospheric perturbations） and EQs （especially with large magnitude and with shallow depth）, medium-distance （6-8 Mm） propagation anomalies, the fluctuation spectra of subionospheric VLF/LF data （the effect of atmospheric gravity waves, the effect of Earth＇s tides, etc.）, and the mechanism of lithosphere-atmosphere-ionosphere coupling. Finally, we indicate the present situation of this kind of VLF/LF activities going on in different parts of the globe and we suggest the importance of international collaboration in this seismo-electromagnetic study.

关键词： Earth-ionosphere waveguide subionospheric VLF/LF propagation seismo-ionosphericperturbation earthquake lithosphere-atmosphere-ionosphere coupling

Quantitative determination of erlotinib in human serum using competitive enzyme-linked immunosorbent assay

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Journal of Pharmaceutical Analysis 2018年第2期8卷 119-123页

作者： Yuta Yamamoto Tetsuya Saita Yutaro Yamamoto masashi Shin Applied Life Science Department Faculty of Biotechnology and Life Science Sojo University

A selective and sensitive competitive enzyme-linked immunosorbent assay(ELISA) method was developed and validated for the quantification of erlotinib in 50 mL of samples of human serum. Anti-erlotinib serum was obtained by immunizing mice with an antigen conjugated with bovine serum albumin and 3,4-bis(2-methoxyethoxy)benzoic acid using the N-succinimidyl ester method. Enzyme labeling of erlotinib with horseradish peroxidase was similarly performed using 3,4-bis(2-methoxyethoxy)benzoic acid. A simple competitive ELISA for erlotinib was developed using the principle of direct competition between erlotinib and the enzyme marker for anti-erlotinib antibody, which had been immobilized on the plastic surface of a microtiter plate. Serum erlotinib concentrations lower than 40 ng/mL were reproducibly measurable using the ELISA. This ELISA was specific to erlotinib and showed very slight cross-reactivity(6.7%) with a major metabolite, O-desmethyl erlotinib. Using this assay, drug levels were easily measured in the blood of mice after oral administration of erlotinib at a single dose of 30 mg/kg. ELISA should be used as a valuable tool for therapeutic drug monitoring and in pharmacokinetic studies of erlotinib.

关键词： Erlotinib Enzyme-linked immunosorbent assay O-desmethyl erlotinib Tyrosine-kinase inhibitor

Fluorescence quantum yield of Gd_(0.9-x)R_xEu_(0.1)OOH(R=Y, La) crystals

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Journal of Rare Earths 2015年第12期33卷 1256-1260页

作者： Hiroaki Samata Katsutoshi Kobayashi masashi Hanioka Tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University Materials Development Group Superconducting Properties Unit National Institute for Materials Science

*** （R=Y, La） crystals were synthesized by a flux method using a mixture of NaOH and KOH as the flux. X-ray diffraction data were well refined using the Rietveld method assuming that the crystals had a monoclinic structre belonging to the P21/m space group. The unit cell volumes of the Gdo.9 *** crystals increased with increasing x, whereas those of *** decreased with increasing x. The Commission Internationale de IEclairage （CIE） chromaticity coordinates of Gdo.9 *** （R=Y, La） crystals were located in the red region and were nearly constant over the range ofx values considered. The fluorescence quantum yield Dr monotonically decreased with increasing x regardless of the ionic radii of the substitute ions. The fact that the Dr value of Lao.9EuoAOOH was greater than that of *** indicated that the observed decrease in the values of the Gdo.9-,LaxEuo.1OOH crystals up to x=0.3 could not be attributed to an increase in the distance between Eu3＋ ions or to a decrease in the Gd3＋ content. The decrease might be due to an increase of killer centers introduced by elemental substitutions with the larger ion.

关键词： rare-earth oxyhydroxide phosphor elemental substitution fluorescence quantum yield

Yellow luminescence of co-doped gadolinium oxyhydroxide

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Journal of Rare Earths 2015年第7期33卷 712-716页

作者： Hiroaki Samata Shungo Imanaka masashi Hanioka Tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University Fukaeminami International Center for Materials Nanoarchitectonics National Institute for Materials Science

Crystals of co-doped gadolinium oxyhydroxide （GdOOH）, Gd0.98Eu0.02-xTbxOOH and Gd1-y-zDyyBizOOH, were synthesized by a flux method. The color coordinates in the Commission Internationale de I＇Eelairage （CIE） chromaticity diagram of Gd0.98Eu0.02-xTbxOOH, obtained under 254 nm irradiation, shifted along a straight line with the changing values ofx to include the yellow region. The CIE coordinates of Dy^3＋ doped in GdOOH were located in the yellow region, while the emission intensity of Dy^3＋ under 286 nm irradiation increased by more than 40 times when co-doped with Bi^3＋.

关键词： gadolinium oxyhydroxide phosphor co-doping yellow luminescence rare earths

Recent Progress of Optical Fibers

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光学学报 2003年第S1期23卷 61-62页

作者： masashi Onishi Eisuke Sasaoka Sumitomo Electric Ind. Ltd. Taya-cho Sakae-ku Yokohama 244-8588 JapanSumitomo Electric Ind. Ltd. Taya-cho Sakae-ku Yokohama 244-8588 Japan

This paper reviews recent progress of advanced optical fibers that are expected to be as candidates for the future trunk-line systems, metropolitan networks and access lines for subscribers.

关键词： of been Recent Progress of Optical Fibers for have in that

Computed tomography attenuation values of ascites are helpful to predict perforation site

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World Journal of Gastroenterology 2015年第5期21卷 1573-1579页

作者： Ryo Seishima Koji Okabayashi Hirotoshi Hasegawa masashi Tsuruta Hiroki Hoshino Toru Yamada Yuko kitagawa Department of Surgery Keio University School of MedicineTokyo 1608582Japan

AIM:To evaluate the effect of computed tomography(CT) attenuation values of ascites on gastrointestinal(GI) perforation site ***:The CT attenuation values of the ascites from 51 patients with GI perforations were measured by volume rendering to calculate the mean *** effect of the CT attenuation values of the ascites on perforation site prediction and postoperative complications was ***:Of 24 patients with colorectal perforations,the CT attenuation values of ascites were significantly higher than those in patients with perforations at other sites [22.5 Hounsfield units(HU) vs 16.5 HU,respectively,P = 0.006].Colorectal perforation was significantly associated with postoperative complications(P = 0.038).The prediction rate of colorectal perforation using attenuation values as an auxiliary diagnosis improved by 9.8% compared to that of CT findings alone(92.2% vs 82.4%).CONCLUSION:The CT attenuation values of ascites could facilitate the prediction of perforation sites and postoperative complications in GI perforations,particularly in cases in which the perforation sites are difficult to predict by CT findings alone.

关键词： Perforation site prediction Gastrointestinal perfo

Large-Scale Electromagnetic Modeling for Multiple Inhomogeneous Domains

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Communications in Computational Physics 2009年第7期6卷 269-289页

作者： masashi Endo Martin Cuma Michael S.Zhdanov Department of Geology and Geophysics University of Utah135S 1460ERm 719Salt Lake CityUT 84112USA

We develop a new formulation of the integral equation(IE)method for three-dimensional(3D)electromagnetic(EM)field computation in large-scale models with multiple inhomogeneous *** problem arises in many practical applications including modeling the EM fields within the complex geoelectrical structures in geophysical *** geophysical applications,it is difficult to describe an earth structure using the horizontally layered background conductivity model,which is required for the efficient implementation of the conventional IE *** a result,a large domain of interest with anomalous conductivity distribution needs to be discretized,which complicates the *** new method allows us to consider multiple inhomogeneous domains,where the conductivity distribution is different from that of the background,and to use independent discretizations for different *** reduces dramatically the computational resources required for largescale *** addition,using this method,we can analyze the response of each domain separately without an inappropriate use of the superposition principle for the EM field *** method was carefully tested for the modeling the marine controlled-source electromagnetic(MCSEM)fields for complex geoelectric structures with multiple inhomogeneous domains,such as a seafloor with the rough bathymetry,salt domes,and *** have also used this technique to investigate the return induction effects from regional geoelectrical structures,e.g.,seafloor bathymetry and salt domes,which can distort the EM response from the geophysical exploration target.

关键词： Large-scale EM modeling multiple inhomogeneous domains marine CSEM

An extended Fibonacci sequence associated with the discrete hungry Lotka-Volterra system

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International Journal of Biomathematics 2017年第3期10卷 245-260页

作者： Masato Shinjo Kanae Akaiwa masashi Iwasaki Yoshimasa Nakamura Graduate School of Informatics Kyoto University Yoshida-Hommachi Sakyo-ku Kyoto 606-8501 Japan Faculty of Life and Environmental Sciences Kyoto Prefectural University Nakaragi-cho Shimogamo Sakyo-ku Kyoto 606-8522 Japan

The integrable hungry Lotka-Volterra （hLV） system stands for a prey-predator model in mathematical biology. The discrete-time hLV （dhLV） system is derived from a time discretization of the hLV system. The solution to the dhLV system is known to be represented by using the Casorati determinant. In this paper, we show that if the entries of the Casorati determinant become an extended Fibonacci sequence at the initial discrete time, then those are also an extended Fibonacci sequence at any discrete time. In other words, the extended Fibonacci sequence always appears in the entries of the Casorati determinant under the time evolution of the dhLV system with suitable initial setting. We also show that one of the dhLV variables converges to the ratio of two successive extended Fibonacci numbers as the discrete time goes to infinity.

关键词： Fibonacci sequence Casorati determinant discrete hungry Lotka Volterra system.