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BEACH-Domain Proteins Act Together in a Cascade to Mediate Vacuolar Protein Trafficking and Disease Resistance in Arabidopsis

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Molecular Plant 2015年第3期8卷 389-398页

作者： Ooi-kock Teh Noriyuki Hatsugai Kentaro Tamura Kentaro Fuji Ryo Tabata Katsushi Yamaguch Shuji Shingenobu masashi yamada Mitsuyasu Hasebe Shinichiro Sawa Tomoo Shimada Ikuko Hara-Nishimura Graduate School of Science Kyoto University Sakyo-ku Kyoto 606-8502 Japan Research Centre for Cooperative Projects Hokkaido University Kita-ku Sapporo 060-8638 Japan Graduate School of Science and Technology Kumamoto University Kumamoto 860-8555 Japan Functional Genomics Facility National Institute for Basic Biology Okazaki 444-8585 Japan Department of Biology and IGSP Center for Systems Biology Duke University Durham NC 27708 USA Division of Evolutionary Biology National Institute for Basic Biology Okazaki 444-8585 Japan School of Life Science The Graduate University for Advanced Studies Okazaki 444-8585 Japan Present address: Department of Plant Biology and Forest Genetics Uppsala BioCenter Swedish University of Agricultural Sciences (SLU) and Linnean Centre ofPlant Biology Uppsala SE-75007 Sweden present address: Microbial and Plant Genomics Institute University of Minnesota St Paul MN 55108 USA Present address: RIKEN Innovation Center RIKEN 2-1 Hirosawa Wako Saitama 351-0198 Japan

Membrane trafficking to the protein storage vacuole （PSV） is a specialized process in seed plants. However, this trafficking mechanism to PSV is poorly understood. Here, we show that three types of Beige and Chediak-Higashi （BEACH）-domain proteins contribute to both vacuolar protein transport and effector- triggered immunity （ETI）. We screened a green fluorescent seed （GFS） library of Arabidopsis mutants with defects in vesicle trafficking and isolated two allelic mutants gfs3 and gfs12 with a defect in seed pro- tein transport to PSV. The gene responsible for the mutant phenotype was found to encode a putative pro- tein belonging to group D of BEACH-domain proteins, which possess kinase domains. Disruption of other BEACH-encoding loci in the gfs12 mutant showed that BEACH homologs acted in a cascading manner for PSV trafficking. The epistatic genetic interactions observed among BEACH homologs were also found in the ETI responses of the gfs12 and gfs12 bchb-1 mutants, which showed elevated avirulent bacterial growth. The GFS12 kinase domain interacted specifically with the pleckstrin homology domain of BchCl. These results suggest that a cascade of multiple BEACH-domain proteins contributes to vacuolar protein transport and plant defense.

关键词： BEACH-domain protein Arabidopsis thaliana vacuolar protein transport protein storage vacuoles,plant immunity

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Time series analysis of L-band PALSAR-2 images in Istanbul and Kocaeli,Turkey

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Big Earth Data 2024年第3期8卷 467-493页

作者： Sadra Karimzadeh Abdullah Can Zulfikar masashi Matsuoka Department of Remote Sensing and GIS University of TabrizTabrizIran Department of Architecture and Building Engineering Tokyo Institute of TechnologyYokohamaJapan Disaster Management Institute Istanbul Technical UniversityMaslakIstanbulTurkey

ABSTRACT Conducting long measurements of infrastructure deformation is a critical engineering *** methods are both timeconsuming and expensive,limiting their use for large-scale *** synergy of synthetic aperture radar(SAR)and geographic information systems(GIS)offers a complementary *** study focuses on the feasibility of using time series analysis of L-band PALSAR-2 images to discover land displacements in Istanbul and Kocaeli,significant industrial and residential areas in ***-2 phase and intensity information were *** phase analysis,14 L-band images from 2014 to 2021 were taken into *** baseline subset(SBAS)analysis was performed using 44 pairs,and results of the velocity,coherence and back-scattering values are *** of all pairs and their correlations were *** Component Analysis(PCA)reduced the dimension of coherence pairs,enhancing feature extraction and the final geocoded velocity map revealed a fastest subsidence rate of−58 mm/yr and a mean subsidence of−20 mm/*** findings were confirmed through mean vertical velocity from Sentinel-1 datasets and field *** results showed that immature land subsidence in the mentioned areas are growing slowly,which can be taken as a serious risk in future.

关键词： InSAR time series PALSAR-2 SAR intensity infrastructure deformation

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Cyclohexenonic long-chain fatty alcohol reverses diabetic induced dysfunction of ileum in the rat

Cyclohexenonic long-chain fatty alcohol reverses diabetic in...

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第十五届国际药理学大会

作者： Shinbori Chiko Saito Motoaki Kinoshita Yukako Satoh Itaru Kono To-moharu Hanada Takuya Suzuki Hiroto yamada masashi Satoh Keisuke Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Meiji Dairies Corporation Meiji Dairies Corporation Division of Molecular Pharmacology Tottori University Faculty of Medicine

＜正＞ Objective: Diabetic neuropathy is associated with development of intestinal motilitydysfunction and autonomic neuropathy. We studied the effects of cyclohexenoniclong - chain fatty alcohol （FA） on isolated- ileum in the diabetes induced *** and Results: The rats divided into 5 groups. One is the non - diabetic group,others induced diabetes. 4 weeks after induction of diabetes, one group killed immediately, while other 3 groups were administered FA （0,2 or 8 mg/kg） for more 4 weeks. The serum glucose and serum insulin levels were unchanged by FA. The contractile responses to carbachol and KCl were argumentedin the isolated - diabeticileum. Real - time PCR and histological study showed changes of muscarinic M2 and M3 receptors of the diabetic ileum. Treatment with FA improved the thickness of intestine wall and diabetic - induced hyperreactivityof the rat ileum. Furthermore. FA reversed the diabetes - induced upregulation of muscarinic mRNAs in the diabetic rat ileum. Conclusion: These results indicate that FA has therapeutic effects on hyperreactivity in the diabetic ileum by ameliorating over expression of muscarinic M2 and M3 receptors mRNAs.

关键词： FA. neuropathy muscarinic receptor ileum

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A new electric field mill array with each of the mill’s rotor controlled precisely by a GPS module:Equipment and initial results

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Earth and Planetary Physics 2024年第2期8卷 423-435页

作者： Kozo Yamashita Hironobu Fujisaka DaoHong Wang Hiroyuki Iwasaki Kazuo Yamamoto Koichiro Michimoto masashi Hayakawa Department of Production Systems Engineering and Sciences Komatsu UniversityNu 1-3 Shicho-machiKomatsuIshikawa 923-8511Japan Fujisaka Technology Office 1058-5 Yoshizawa-choOhta-shiGunma 373-0019Japan Department of Electrical Electronic and Computer EngineeringGifu University1-1 YanagidoGifu CityGifu 501-1193Japan Cooperative Faculty of Education Gunma University4-2-Aramaki-machiMaebashiGunma 371-8510Japan Department of Electrical and Electronic Engineering Chubu University1200 Matsumoto-choKasugaiAichi 487-8501Japan Independent Researcher Kosenba Town 2-44-11-406Kawagoe CitySaitama350-0036Japan Advanced Wireless&Communications Research Center The University of Electro-Communications1-5-1 ChofugaokaChofuTokyo 182-8585Japan

We have newly designed an electrostatic sensor,called an electric field mill(EFM),to simplify the estimation of the charge position and charge amount transferred by lightning *** is necessary for this remote estimation of the transferred charge to measure electric field changes caused by charge loss at the time of a lightning strike at multiple *** multiple-station measurement of electric field changes,not only speed but also phase for exposure and shielding of the sensing plates inside each EFM of the array should be synchronized to maintain the sensitivities of the deployed ***,there is no such EFM with specified speed and phase control performance of the rotary ***,we developed a new EFM in which the rotary mechanism was controlled consistently to within 3%error by a GPS *** EFMs had been distributed in the Hokuriku area of Japan during the winter season of 2022-2023 for a test *** we describe the design and a simple calibration method for our new EFM *** analysis method based on the assumption of a simple monopole charge structure is also *** validation,locations of assumed point charges were compared with three-dimensional lightning mapping data estimated by radio observations in the MF-HF *** results indicated the validity to estimate transferred charge amounts and positions of winter cloud-to-ground lightning discharges with our new EFM array.

关键词： lightning electrostatic field electric field mill electric field change

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Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： masashi Fujitani Abu Md Mamun Tarif Yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

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Radical radiotherapy without surgical tumor resection for rectal cancer

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World Journal of Clinical Oncology 2024年第11期15卷 1390-1393页

作者： Takashi Ono masashi Koto Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

In this editorial,I would like to comment on the article,recently published in the World Journal of Clinical *** article focuses on non-surgical treatments for locally recurrent rectal cancer,including the watch-and-wait(WW)strategy after total neoadjuvant therapy(TNT)and particle beam *** treatment options for rectal cancer continue to evolve,the high complete response rate achieved with TNT has led to the development of a new non-surgical approach:*** followed by consolidation chemotherapy,in particular,has a low rate of tumor growth and is a treatment aimed at achieving a cure without ***,the risk of recurrence within two years is significant,necessitating careful *** standardized follow-up methods that can be implemented by many physicians is *** ion radiotherapy has demonstrated high local control with a low incidence of severe late toxicities,even after previous pelvic *** these new non-surgical curative treatments for rectal cancer require further investigation,future advancements in this field are anticipated.

关键词： Rectal cancer Locally recurrent rectal cancer Total neoadjuvant therapy Watch-and-wait Carbon ion radiotherapy Proton beam therapy

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Variations of Atmospheric ELF/VLF Radio Noise Due to Seismogenic Modifications in Tropospheric Conductivity

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Open Journal of Earthquake Research 2024年第2期13卷 113-132页

作者： masashi Hayakawa Alexander P. Nickolaenko Hayakawa Institute of Seismo Electromagnetics Co. Ltd. (Hi-SEM) UEC Alliance Center #521 Tokyo Japan The University of Electro-Communications (UEC) Advanced Wireless & Communications Research Center (AWCC) Chofu-shi Tokyo O.Ya. Usikov Institute for Radiophysics and Electronics National Academy of Sciences of the Ukraine Kharkov Ukraine

We suggest a possible explanation of the influence of pre-seismic activity on the registration rate of natural ELF(extremely low frequency)/VLF(very low frequency) pulses and the changes of their characteristics. The main idea is as follows. The distribution of the electric field around a thundercloud depends on the conductivity profile of the atmosphere. Quasi-static electric fields of a thundercloud decrease in those tropospheric regions where an increase of air conductivity is generated by pre-seismic activities due to emanation of radioactive gas and water into the lower atmosphere. The electric field becomes reduced in the lower troposphere, and the probability decreases of the cloud-to-ground (CG) strokes in such “contaminated” areas. Simultaneously, the electric field grows inside and above the thunderclouds, and hence, we anticipate a growth in the number of horizontal and tilted inter-cloud (or intra-cloud) (both termed as IC discharges) strokes. Spatial orientation of lightning strokes reduces vertical projection of their individual amplitudes, while the rate (median number strokes per a unit time) of discharges grows. We demonstrate that channel tilt of strokes modifies the spectral content of ELF/VLF radio noise and changes the rate of detected pulses during the earthquake preparation phase.

关键词： ELF/VLF Radio Noise Earthquake Precursor Pre-Seismic Modification Conductivity Anomaly in the Lower Atmosphere Radioactive Radon Gases CG Lightning Discharges IC Discharges Cloud-to-Ionosphere Discharge

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Association of Omega-3 Polyunsaturated Fatty Acids with Sarcopenia in Liver Cirrhosis Patients with Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 613-624页

作者： Akitoshi Sano Jun Inoue Eiji Kakazu masashi Ninomiya Mio Tsuruoka Kosuke Sato Masazumi Onuki Satoko Sawahashi Keishi Ouchi Atsushi Masamune Division of Gastroenterology Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Liver Disease The Research Center for Hepatitis and ImmunologyNational Center for Global Health and MedicineIchikawaChibaJapan

Background and Aims:Sarcopenia is associated with the prognosis of patients with liver cirrhosis and hepatocellular carcinoma(HCC).Given their diverse physiological activities,we hypothesized that plasma fatty acids might influence the progression of *** study aimed to clarify the association between fatty acids and sarcopenia in cirrhotic patients with ***:In this singlecenter retrospective study,we registered 516 cases and analyzed 414 cases of liver cirrhosis and *** skeletal muscle mass index was measured using a transverse computed tomography scan image at the third lumbar *** cutoff value for sarcopenia followed the criteria set by the Japan Society of *** acid concentrations were measured by gas ***:Fatty acid levels,particularly omega-3(n-3)polyunsaturated fatty acid(PUFA),were lower in patients with poor liver function(Child-Pugh grade B/C)and were negatively correlated with the albumin-bilirubin score(p<0.0001).The prognosis of HCC patients with low PUFA levels was significantly *** the different fatty acid fractions,only n-3 PUFAs significantly correlated with skeletal muscle mass index(p=0.0026).In the multivariate analysis,the n-3 PUFA level was an independent variable associated with sarcopenia(p=0.0006).Conclusions:A low level of n-3 PUFAs was associated with sarcopenia in patients with liver cirrhosis and HCC.

关键词： Liver cirrhosis Hepatocellular carcinoma Sarcopenia Skeletal Muscle Fatty Acids Omega-3 polyunsaturated fatty acids

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Plain language in the healthcare of Japan:a systematic review of“plain Japanese”

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Global Health Journal 2024年第3期8卷 113-118页

作者： Hatsune Kido Soichiro Saeki Mayu Hiraiwa masashi Yasunaga Rie Tomizawa Chika Honde Toshio Fukuoka Kaori Minamitani Department of Medical Education Kurashiki Central HospitalKurashikiOkayama 710-8602Japan Center Hospital of the National Center for Global Health and Medicine Tokyo 162-8655Japan Department of Public Health Graduate School of MedicineOsaka UniversitySuitaOsaka 565-0871Japan School of Nursing Graduate School of NursingOsaka Metropolitan UniversityOsaka 545-0051Japan Department of Public Health Nursing Shiga University of Medical ScienceOtsuShiga 520-2192Japan Department of General Medicine Kurashiki Central HospitalKurashikiOkayama 710-8602Japan Department of International Medical Care Rinku General Medical CenterIzumisanoOsaka 598-0048Japan

Objective:Despite the decrease in the number of foreign visitors and residents in Japan due to the coronavirus disease 2019,a resurgence is remarkable from ***,Japan's medical support system for foreign patients,especially residents,is inadequate,with language barriers potentially causing health *** interpretation and translation services are challenging,but“plain Japanese”may be a viable alternative for foreign patients with basic Japanese language *** study explores the application and obstacles of plain Japanese in the medical ***:A literature review was performed across these databases:Web of Science,PubMed,Google Scholar,Scopus,CINAHL Plus,Springer Link and Ichushi-Web(Japanese medical literature).The search covered themes related to healthcare,care for foreign patients,and scholarly articles,and was conducted in July ***:The study incorporated five *** paper emphasized the language barriers foreign residents in Japan face when accessing healthcare,highlighting the critical role and necessity of plain Japanese in medical *** of the reports focused on the challenges of delivering medical care to foreign patients and the training of healthcare professionals in using plain Japanese for ***:The knowledge and application of plain Japanese among healthcare professionals are inadequate,and literature also remains *** the increasing number of foreign residents in Japan,the establishment of a healthcare system that effectively uses plain Japanese is ***,plain Japanese may not be the optimal linguistic assistance in certain situations,thus it is imperative to encourage more research and reports on healthcare services using plain Japanese.

关键词： Plain Japanese Easy Japanese Plain language Foreign residents Healthcareaccess Language barriers Emigrants and immigrants

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Enhancing clinical proficiency through laparoscopic training using Japanese origami

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 102-106页

作者： Shunsuke Furukawa Masatsugu Hiraki Naoya Kimura Ryota Sakurai Ryo Kohata Naohiko Kohya masashi Sakai Akashi Ikubo Ryuichiro Samejima Department of Surgery Japanese Red Cross Society Karatsu Red Cross HospitalSaga847-8588Japan Department of Surgery Saga University Faculty of MedicineSaga849-8501Japan

Objective This study aimed to investigate the clinical efficacy of laparoscopic training using origami,a traditional Japanese papercraft,using laparoscopic forceps to create origami *** In this retrospective study,4 surgeons were randomly divided into 2 groups:The training group,consisting of surgeons 1 and 2,and the non-training group,consisting of surgeons 3 and *** the course of a one-year study period,the training group regularly underwent laparoscopic surgery training with a dry box,wherein they folded a total of 1000 origami cranes using laparoscopic *** non-training group periodically underwent common laparoscopic surgery training of techniques such as suturing and *** surgeon regularly performed the transabdominal preperitoneal approach for inguinal *** training was conducted concurrently with the *** procedure time(peritoneum detachment,mesh placement,and closure of the peritoneum),total operation time(time from peritoneum detachment to closure of the peritoneum),and surgical outcomes were *** The training group showed greater improvement in the total operation time and more stable performance than the non-training ***,the time taken for peritoneum detachment was significantly shorter in the training *** Laparoscopic training using origami has the potential to enhance laparoscopic surgical skills and improve surgical outcomes.

关键词： Laparoscopic surgery Training Dry box Origami

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