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Association of non-synonymous variants in WIPF3 and LIPA genes with ab- dominal aortic aneurysm： an autopsy study

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Journal of Geriatric Cardiology 2016年第12期13卷 960-967页

作者： Yuko Maeda Noriko Sato Makiko Naka-Mieno Seijiro Mori Tomio Arai masashi tanaka Masaaki Muramatsu Motoji Sawabe Department of Molecular Epidemiology Medical Research Institute Tokyo Medical and Dental University Tokyo Japan Department of Medical Informatics Center of Inormation Jichi Medical University Tochigi Japan Center for Promotion of Clinical Investigation Tokyo Metropolitan Geriatric Hospital Tokyo Japan Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan Research Teams for Geriatric Pathology Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Genomics for Longevity and Health Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Molecular Pathology Graduate School of Health Care Sciences Tokyo Medical and Dental University Tokyo Japan

Background Abdominal aortic aneurysm （AAA） is a multifactorial disease with strong genetic components. Various genetic loci have been associated with clinical AAA, but few studies have investigated pathological AAA, an intermediate phenotype of the disease. Methods We examined 2263 consecutive autopsies of older Japanese subjects from a study on geriatric diseases in Japanese individuals （The JG-SNP study）. The presence of AAA was determined with a pathological diagnosis during autopsy. Single nucleotide variants （SNVs） associated with AAA were determined with an Illumina HumanExome Beadchip array. Logistic regression analyses were performed to determine ge- netic associations. Age, gender, and other risk factors of AAA were analyzed as covariates. Results 118 subjects with AAA and 2145 sub- jects without AAA were analyzed in a case-control setting. No variants reached significance after applying the Bonferroni correction （P 〈 2.05×10^-6）. The strongest associations were found with rs3750092 （p.E321G, OR： 0.36, 95% CI： 0.24-0.56, P = 6.09 ×10^-6）, a variant in the WAS/WASL interacting protein family 3 （WIPF3）, and with rs1051338 （p.T16P, OR： 2.50, 95% CI： 1.70-3.66, P = 2.79 ×10^-6） and rs2246942 （intronic, OR： 2.32, 95% CI： 1.58-3.41, P = 1.61 ×10^-5）, variants in the lysosomal acid lipase A （LIPA）. LIPA is essential for macrophage cholesterol metabolism. Immunohistological analyses of WIPF3 protein in AAA samples from three subjects revealed that WIPF3 was expressed in macrophages ofatheromatous plaques. Conclusions This study suggests that WIPF3 and LIPA, both of which are expressed in the macrophages are involved in pathological AAA. These results should be regarded as hypothesis-generating; thus, replication study is warranted.

关键词： Abdominal aortic aneurysm Lysosomal acid lipase A WAS/WASL interactingproteinfamily 3

Adjuvant chemotherapy with S-1 in oral squamous cell carcinoma

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中国口腔颌面外科杂志 2008年第B5期6卷 113-113页

作者： Katsumori Ogata Hideki Nakayama masashi Nagata Takuya tanaka Akimitsu Hiraki Masanori Shinohara Department of Oral & MaxiUofacial Surgery KumamotoUniversity Hospital Kumamoto860-8550Japan

Patellar dislocation following distal femoral replacement after extraarticular knee resection for bone sarcoma:A case report

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World Journal of Clinical Cases 2022年第11期10卷 3561-3572页

作者： Yuta Kubota Kazuhiro tanaka masashi Hirakawa Tatsuya Iwasaki Masanori Kawano Ichiro Itonaga Hiroshi Tsumura Orthopaedic Surgery Oita UniversityYufu City 879-5593OitaJapan

BACKGROUND For the treatment of bone sarcoma in the distal femur,wide-margin resection and knee reconstruction with tumor endoprosthesis are standard *** knee resection is required in cases of tumor invasion of the knee joint;however,the incidence of complications,such as aseptic loosening,prosthesis infection,and implant failure,is higher than that following intra-articular knee *** the best of our knowledge,there are three reports of patellar dislocations after replacement of a tumor *** SUMMARY A 36-year-old man with no significant past medical history was admitted to our institution with continuous pain in his left knee for 4 *** open biopsy was performed,and the patient was diagnosed with a left distal femoral malignant bone ***-articular knee resection and knee reconstruction with a tumor endoprosthesis were *** the alignment of the tumor prosthesis was acceptable,knee instability was noticed *** axial radiographic view of the patellar and computed tomography showed lateral patellar dislocation at 4 wk *** patient had to undergo a lateral release and proximal *** could perform his daily activities at 9 mo *** revealed no patellar *** Proximal realignment may be considered during primary surgery if there is an imbalance in the forces controlling the patellar tracking.

关键词： Bone tumor Distal femoral replacement Lateral release Patellar dislocation Proximal realignment Case report

Laparoscopic partial resection for hemangioma in the third portion of the duodenum

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World Journal of Gastroenterology 2014年第34期20卷 12341-12345页

作者： Shingo Kanaji Tetsu Nakamura Masayasu Nishi masashi Yamamoto Kiyonori Kanemitu Kimihiro Yamashiita Tatsuya Imanishi Yasuo Sumi Satoshi Suzuki Kenichi tanaka Yoshihiro Kakeji Department of Gastrointestinal Surgery Faculty of MedicineHyogo 650-0017Japan

Benign duodenal tumors are rare and less commonthan malignant ***,vascular lesionsof the duodenum,including hemangiomas,are rarecauses of gastrointestinal *** report describes a case with bleeding hemangiomas in the thirdportion of the duodenum and jejunum and their successful treatment using a laparoscopic *** no report of totally laparoscopic resection for tumorin the third portion of *** performinga laparoscopic Kocher maneuver,the location of theduodenal hemangioma was confirmed by endoscopicand laparoscopic *** lesion was excisedusing ultrasonic coagulating shears and the defect inthe duodenal wall was sutured *** of the jejunum was treated extracorporeally through a 3.0 cm umbilical *** operatingtime was 241 min and blood loss was *** course was *** benign duodenal tumors in the third portion,if endoscopic resection is not adapted,this less invasive technique may be a standard treatment.

关键词： Hemangioma Third portion Duodenum Total laparoscopic resection

Effectiveness of outpatient percutaneous endoscopic gastrostomy replacement using esophagogastroduodenoscopy and propofol sedation

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World Journal of Gastrointestinal Endoscopy 2012年第2期4卷 45-49页

作者： Akira Horiuchi Yoshiko Nakayama masashi Kajiyama Naoki tanaka Digestive Disease Center Showa Inan General Hospital Komagane 399-4117 Matsumoto Japan Department of Pediatrics Shinshu University School of Medicine Matsumoto 390-8621 Japan Department of Metabolic Regulation Shinshu University Graduate School of Medicine Matsumoto 390-8621 Japan

AIM: To evaluate the effectiveness of outpatient percutaneous endoscopic gastrostomy (PEG) replacement using esophagogastroduodenoscopy (EGD) and propofol sedation. METHODS: We retrospectively assessed the outcome and complications of consecutive patients referred for PEG replacement which was performed using EGD under propofol sedation in the outpatient setting. The success rate, the mean dose of propofol, procedure time, EGD findings, discharge time from endoscopy unit, respiratory depression, and complications within 72 h of the procedure were evaluated. In a subset of these patients, the blood concentrations of propofol were measured. RESULTS: All 221 patients underwent successful PEG replacement. The mean dose of propofol was 34 mg (range, 20-60 mg) with a mean procedure time of 5.9 min (range, 3-8 min). Reflux esophagitis (12 patients), gastric ulcer (5), gastric neoplasm (2), and duodenal ulcer (1) were newly diagnosed at replacement. Discharge from endoscopy unit was possible in 100% of patients 45 min after the procedure. Only 3.6% (8) required transient supplemental oxygen. No complications occurred within 72 h of the procedure. During EGD the level of sedation and propofol blood concentrations after administration of propofol (30 mg) in these PEG patients corresponded to those of propofol (60 mg) in middle aged subjects (control). CONCLUSION: PEG replacement using EGD and propofol sedationin the outpatient setting was safe and practical.

关键词： Esophagogastroduodenoscopy Gastrostomy PEG Propofol

CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy

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World Journal of Hepatology 2013年第4期5卷 189-195页

作者： Daisuke Satoh Takahito Yagi Takeshi Nagasaka Susumu Shinoura Yuzo Umeda Ryuichi Yoshida masashi Utsumi Takehiro tanaka Hiroshi Sadamori Toshiyoshi Fujiwara Department of Gastroenterological Surgery Transplantand Surgical OncologyOkayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Department of Pathology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan

AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after *** tomography(CT)images were evaluated every 6 mo after PD for *** steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield *** biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo *** compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver ***-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy ***:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after *** patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin *** biopsy was performed in four patients with NAFLD after *** four patients showed moderate-to-severe steatosis and NASH was diagnosed in *** of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy *** number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with meta

关键词： Non-alcoholic fatty liver disease Pancreatoduodenectomy CD14 Endotoxin Kupffer cells

Safety and effectiveness of propofol sedation during and after outpatient colonoscopy

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World Journal of Gastroenterology 2012年第26期18卷 3420-3425页

作者： Akira Horiuchi Yoshiko Nakayama masashi Kajiyama Naoyuki Kato Tetsuya Kamijima Yasuyuki Ichise Naoki tanaka Digestive Disease Center Showa Inan General HospitalKomagane 399-4117Japan Department of Pediatrics Shinshu University School of MedicineMatsumoto 390-8621Japan Department of Metabolic Regulation Shinshu University Graduate School of MedicineMatsumoto 390-8621Japan

AIM:To study the safety and effectiveness of propofol sedation for outpatient ***:Propofol was given by bolus injection with an age-adjusted standard protocol consisting of 60 mg for patients < 70 years old,40 mg for patients age 70-89 years,and 20 mg for those ≥ 90 years,and additional injections of 20 mg propofol were given up to a maximum of 200 *** principal parameters were the occurrence of adverse events within 24 h after colonoscopy and overall satisfaction for this *** parameters included successful procedure,respiratory depression,and other ***:Consecutive patients were entered prospectively and all 2101 entered successfully completed outpatient *** mean dose of propofol used was 96.4 mg(range 40-200 mg).Younger patients required higher doses of propofol than older patients(20-40 years vs ≥ 61 years:115.3 ± 32 mg vs 89.7 ± 21 mg,P < 0.001).Transient supplemental oxygen supply was needed by five patients(0.2%);no other complications *** questionnaires were completed by 1820(87%) of 2101 patients and most rated their overall satisfaction as excellent(80%) or good(17%).The majority(65%) of patients drove home or to their office after their ***(99%) were willing to repeat the same *** incidents occurred within 24 h after ***:Propofol sedation using a dose < 200 mg proved both safe and practical for outpatient colonoscopy.

关键词： Colonoscopy Propofol Colorectal cancer

Smoking increases risk of tooth loss: A meta-analysis of the literature

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World Journal of Meta-Analysis 2013年第1期1卷 16-26页

作者： Fumihito Sato masashi Sawamura Miki Ojima Keiko tanaka Takashi Hanioka Hideo tanaka Keitaro Matsuo Division of Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Aichi 464-8618 Japan Department of Preventive Dentistry Graduate School of Dentistry Osaka University Suita Osaka 565-0871 Japan Department of Public Health Faculty of Medicine Fukuoka University Fukuoka 814-0180 Japan Department of Preventive and Public Health Dentistry Fukuoka Dental College Fukuoka 814-0193 Japan Department of Epidemiology Nagoya University Graduate School of Medicine Nagoya Aichi 464-8601 Japan

AIM: To quantitatively evaluate the impact of smoking on tooth ***: We performed a Pub Med search to identify published articles that investigated the risk of tooth loss by smoking, from which RRs and their variance with characteristics of each study were extracted. The random-effects models were used to derive a pooled effect across studies. Potential sources of heterogeneity on the characteristics of the study and their influence on the pooled effect size were investigated using metaregression models. RESULTS: We identified 24 studies containing a total of 95973 participants for analysis. The pooled RR of ever-smokers compared with never- smokers was 1.73(95%CI: 1.60-1.86, P < 0.001). In meta-regression analysis, only the mean age of participants alone was identified as a statistically significant source of heterogeneity. The effect of smoking on tooth loss was stronger when the mean age of study participants was higher, indicating possible enhancement of tooth loss due to aging by smoking. RR was significantly lower in former smokers(1.49, 95%CI: 1.32-1.69, P < 0.001) than in current smokers(2.10, 95%CI: 1.87-2.35, P < 0.001), indicating the substantial benefit of smoking cessation for reducing the risk of tooth ***: Smoking is an independent risk factor for tooth loss regardless of many other confounders. Smoking cessation may attenuate this effect.

关键词： Meta-analysis Oral health Relative risk Smoking Tooth loss

Laparoscopic hemicolectomy in a patient with situs inversustotalis

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World Journal of Gastroenterology 2007年第37期13卷 5035-5037页

作者： Yushi Fujiwara Yosuke Fukunaga Masayuki Higashino Shinya Tanimura masashi Takemura Yoshinori tanaka Harushi Osugi Department of Gastroenterological Surgery Osaka City General Hospital 2-13-22 Miyakojima-Hondoori Miyakojima-ku Osaka 534-0021 Japan Department of Gastroenterological Surgery Osaka City University Graduate School of Medicine 1-4-3 Asahi-machi Abeno-ku Osaka 545-8585 Japan

As among persons with normal anatomy, occasional patients with situs inversus develop malignant tumors. Recently, several laparoscopic operations have been reported in patients with situs inversus. We describe laparoscopic hemicolectomy with radical lymphadenectomy in such a patient. Careful consideration of the mirror-image anatomy permitted safe operation using techniques not otherwise differing from those in ordinary cases. Thus, curative laparoscopic surgery for colon cancer in the presence of situs inversus is feasible and safe.

关键词： Situs inversus Colon cancer Laparoscopicsurgery Hemicolectomy Radical lymphadenectomy