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Device Length Dependency of Cross Gain Modulation and Cross Phase Modulation in Semiconductor Optical Amplifier

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光学学报 2003年第S1期23卷 455-456页

作者： Tomonori Yazaki Ryo Inohara Kosuke Nishimura Munefumi Tsurusawa masashi Usami KDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka-shi Saitama 356-8502 JapanKDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka-shi Saitama 356-8502 JapanKDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka-shi Saitama 356-8502 JapanKDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka-shi Saitama 356-8502 JapanKDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka-shi Saitama 356-8502 Japan

The cross gain modulation, the cross phase modulation and their recovery time in the SOAs with the various lengths were experimentally investigated. It was found that these values strongly depended on the device length.

关键词： SOA on XPM of Device Length Dependency of Cross Gain Modulation and Cross Phase Modulation in Semiconductor Optical Amplifier in

Distribution of Deviation Distance to Alternative Fuel Stations

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American Journal of Operations Research 2013年第3期3卷 363-368页

作者： masashi Miyagawa Department of Regional Social Management University of Yamanashi Kofu Japan

This paper derives the distribution of the deviation distance to visit an alternative fuel station. Distance is measured as the Euclidean distance on a continuous plane. The distribution explicitly considers the vehicle range and whether the round trip between origin and destination can be made. Three cases are examined: fuel is available at both origin and destination, fuel is available at either origin or destination, and fuel is available at neither origin nor destination. The analytical expressions for the distribution demonstrate how the vehicle range, the shortest distance, and the refueling availability at origin and destination affect the deviation distance. The distribution will thus be useful to estimate the number of vehicles refueled at a station.

关键词： Location Flow Demand Vehicle Range Shortest Distance Round Trip

Ruptured high flow gastric varices with an intratumoral arterioportal shunt treated with balloon-occluded retrograde transvenous obliteration during temporary balloon occlusion of a hepatic artery

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World Journal of Gastroenterology 2006年第33期12卷 5404-5407页

作者： Motoki Nakai Morio Sato Hirohiko Tanihata Tetsuo Sonomura Shinya Sahara Nobuyuki Kawai masashi Kimura Masaki Terada Department of Radiology Hidaka General Hospital 116-2 Sono Gobo Shi Wakayama 644-8655 Japan Department of Radiology Wakayama Medical University 811-1 Kimiidera Wakayama Shi Wakayama 641-8510 Japan

A patient presented with hematemesis due to gastric variceal bleeding with an intratumoral arterioportal shunt. Contrast-enhanced CT revealed gastric varices and hepatocellular carcinoma with tumor thrombi in the right portal vein. Angiography and angio-CT revealed a marked intratumoral arterioportal shunt accompanied with reflux into the main portal vein and gastric varices. Balloon-occluded retrograde venography from the gastro-renal shunt showed no visualization of gastric varices due to rapid blood flow through the intratumoral arterioportal shunt. The hepatic artery was temporarily occluded with a balloon catheter to reduce the blood flow through the arterioportal shunt, and then concurrent balloon-occluded retrograde transvenous obliteration （BRTO） was achieved. Vital signs stabilized immediately thereafter, and contrast-enhanced CT revealed thrombosed gastric varices. Worsening of hepatic function was not recognized. BRTO combined with temporary occlusion of the hepatic artery is a feasible interventional procedure for ruptured high flow gastric varices with an intratumoral arterioportal shunt.

关键词： Gastric varices Hepatocellular carcinoma Arterioportal shunt Balloon-occluded retrogradeobliteration Hematemesis

The ultra-low-frequency magnetic disturbances associated with earthquakes

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Earthquake Science 2011年第6期24卷 523-534页

作者： masashi Hayakawa Yasuhide Hobara Kenji Ohta Katsumi Hattori Advanced Wireless Communications Research Center The University of Electro-Communications1-5-1 ChofugaokaChofu Tokyo 182-8585Japan Research Station on Seismo Electromagnetics The University of Electro-Communications1-5-1 ChofugaokaChofu Tokyo 182-8585Japan Hayakawa Institute of Seismo Electromagnetics Co.Ltd.Incubation Center The University of Electro-Communications Chofu Tokyo182-8585Japan Information Systems Corp. Earthquake Analysis LaboratoryKita-Aoyama 2-14-42-305Minato-ku Tokyo 107-0061Japan Graduate School of Informatics and Engineering The University of Electro-CommunicationsChofu Tokyo 182-8585Japan Department of Electronic Information Chubu University1200 Matsumoto-choKasugai Aichi 487-8501Japan Faculty of Science Chiba University1-33 YayoiInage Chiba 263-8522Japan

The ultra-low-frequency （ULF） electromagnetic emission is recently recognized as one of the most promising candidates for short-term earthquake （EQ） prediction. This paper reviews previous convincing evidence on the presence of ULF emissions before three major EQs. Then, we present further statistical study on the ULF occurrence, our networks of ULF monitoring in different spatial scales in Japan and finally we present several signal processings to identify the seismogenic emissions by showing latest results for recent large EQs.

关键词： seismogenic ULF emission earthquake prediction magnetic sensor signal processing

Association of non-synonymous variants in WIPF3 and LIPA genes with ab- dominal aortic aneurysm： an autopsy study

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Journal of Geriatric Cardiology 2016年第12期13卷 960-967页

作者： Yuko Maeda Noriko Sato Makiko Naka-Mieno Seijiro Mori Tomio Arai masashi Tanaka Masaaki Muramatsu Motoji Sawabe Department of Molecular Epidemiology Medical Research Institute Tokyo Medical and Dental University Tokyo Japan Department of Medical Informatics Center of Inormation Jichi Medical University Tochigi Japan Center for Promotion of Clinical Investigation Tokyo Metropolitan Geriatric Hospital Tokyo Japan Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan Research Teams for Geriatric Pathology Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Genomics for Longevity and Health Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Molecular Pathology Graduate School of Health Care Sciences Tokyo Medical and Dental University Tokyo Japan

Background Abdominal aortic aneurysm （AAA） is a multifactorial disease with strong genetic components. Various genetic loci have been associated with clinical AAA, but few studies have investigated pathological AAA, an intermediate phenotype of the disease. Methods We examined 2263 consecutive autopsies of older Japanese subjects from a study on geriatric diseases in Japanese individuals （The JG-SNP study）. The presence of AAA was determined with a pathological diagnosis during autopsy. Single nucleotide variants （SNVs） associated with AAA were determined with an Illumina HumanExome Beadchip array. Logistic regression analyses were performed to determine ge- netic associations. Age, gender, and other risk factors of AAA were analyzed as covariates. Results 118 subjects with AAA and 2145 sub- jects without AAA were analyzed in a case-control setting. No variants reached significance after applying the Bonferroni correction （P 〈 2.05×10^-6）. The strongest associations were found with rs3750092 （p.E321G, OR： 0.36, 95% CI： 0.24-0.56, P = 6.09 ×10^-6）, a variant in the WAS/WASL interacting protein family 3 （WIPF3）, and with rs1051338 （p.T16P, OR： 2.50, 95% CI： 1.70-3.66, P = 2.79 ×10^-6） and rs2246942 （intronic, OR： 2.32, 95% CI： 1.58-3.41, P = 1.61 ×10^-5）, variants in the lysosomal acid lipase A （LIPA）. LIPA is essential for macrophage cholesterol metabolism. Immunohistological analyses of WIPF3 protein in AAA samples from three subjects revealed that WIPF3 was expressed in macrophages ofatheromatous plaques. Conclusions This study suggests that WIPF3 and LIPA, both of which are expressed in the macrophages are involved in pathological AAA. These results should be regarded as hypothesis-generating; thus, replication study is warranted.

关键词： Abdominal aortic aneurysm Lysosomal acid lipase A WAS/WASL interactingproteinfamily 3

Successful laparoscopic splenectomy after living-donor liver transplantation for thrombocytopenia caused by antiviral therapy

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World Journal of Gastroenterology 2008年第26期14卷 4245-4248页

作者： Hiroyuki Kato Masanobu Usui Yoshinori Azumi Ichiro Ohsawa masashi Kishiwada Hiroyuki Sakurai Masami Tabata Shuji Isaji Department of Hepatobiliary Pancreatic Surgery Mie University Graduate School of Medicine Tsu Mie 514-8507 Japan

Although interferon (IFN) based therapy for recurrent hepatitis C virus (HCV) infection after liver transplantation has been widely accepted, it induces various adverse effects such as thrombocytopenia, resulting in its interruption. Recently, concomitant splenectomy at the time of living donor liver transplantation (LDLT) has been tried to overcome this problem, but this procedure leads to several complications such as excessive intraoperative bleeding and serious infection. A 60-year-old female received LDLT using a left lobe graft from her second son for liver failure caused by hepatitis C-related cirrhosis. Six months after LDLT, she was diagnosed as recurrent HCV infection by liver biopsy. IFN monotherapy was started from 7 mo after LDLT and her platelet count decreased to less than 50 000/μL, which thus made it necessary to discontinue the treatment. We decided to attempt laparoscopic splenectomy (LS) under general anesthesia. Since intra-abdominal findings did not show any adhesion formations around the spleen, LS could be successfully performed. After LS, since her platelet count immediately increased to 225 000/μL 14 d after operation, IFN therapy was restarted and we could convert the combination therapy of IFN and ribavirin, resulting in no detectable viral marker. Inconclusion, LS can be performed safely even after LDLT, and LS after LDLT is a feasible and less invasive modality for thrombocytopenia caused by antiviral therapy.

关键词： Concomitant splenectomy Portal veinthrombosis Ribavirin

Transhepatic catheter-directed thrombolysis for portal vein thrombosis after partial splenic embolization in combination with balloon-occluded retrograde transvenous obliteration of splenorenal shunt

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World Journal of Gastroenterology 2006年第31期12卷 5071-5074页

作者： Motoki Nakai Morio Sato Shinya Sahara Nobuyuki Kawai masashi Kimura Yoshimasa Maeda Yumiko Ibata Katsuhiko Higashi Department of RadiologyWakayama Medical University 811-1KimiideraWakayama ShiWakayama 641-8510Japan the First Department of Internal MedicineHidaka General Hospital 116-2 SonoGobo ShiWakayama 644-8655Japan

A 66-year-old woman underwent partial splenic embolization （PSE） for hypersplenisrn with idiopathic portal hypertension （IPH）. One week later, contrast-enhanced CT revealed extensive portal vein thrombosis （PVT） and dilated portosystemic shunts. The PVT was not dissolved by the intravenous administration of urokinase. The right portal vein was canulated via the percutaneous transhepatic route under ultrasonic guidance and a 4 Fr. straight catheter was advanced into the portal vein through the thrombus. Transhepatic catheter-directed thrombolysis was performed to dissolve the PVT and a splenorenal shunt was concurrently occluded to increase portal blood flow, using balloon-occluded retrograde transvenous obliteration （BRTO） technique. Subsequent contrast-enhanced CT showed good patency of the portal vein and thrombosed splenorenal shunt. Transhepatic catheter-directed thrombolysis combined with BRTO is feasible and effective for PVT with portosystemic shunts.

关键词： Portal vein thrombosis Idiopathic portal hypertension Partial splenic embolization Portosystemic shunts Transhepatic catheter-directed thrombolysis Balloon-occluded retrograde transvenous obliteration

mpact of antioxidants on seminal vesicles function ind fertilizing potential in diabetic rats

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Asian Journal of Andrology 2017年第6期19卷 639-646页

作者： Panagiota Tsounapi masashi Honda Fotios Dimitriadis Bunya Kawamoto Katsuya Hikita Kuniyasu Muraoka Motoaki Saito Nikolaos Sofikitis Atsushi Takenaka Division of Urology Department of Surgery Tottori University School of Medicine 36-1 Nishimachi Yonago 683-8503 Japan Department of Urology University of Ioannina School of Medicine P.O. Box 1186 45110 Ioannina Greece Department of Pharmacology Kochi University Kochi Medical School Nankoku 783-8505 Japan.

Diabetes mellitus significantly affects the male reproduction and sexual function. In the present study, we investigated the diabetes-induced dysfunction of seminal vesicles （SVs） in the diabetes-rat model and the role of antioxidants. Streptozotocin-induced diabetes after 4 weeks caused smaller size of the organs, hypercontractility, histological abnormalities, increased concentrations of malondialdehyde in the serum and tissue, overexpression of oxidative stress markers, and cleaved caspase-3 as identified by immunohistochemistry in the SVs. In addition, diabetes resulted in deceased levels of serum testosterone and no newborns after the mating studies. Antioxidants significantly normalized all the above parameters, except for the severely decreased serum testosterone levels and the negative outcome of the mating studies. The present study gives evidence for the important role of diabetes-induced oxidative stress in the function and structure of these androgen-dependent organs. Antioxidants may be a promising supplementary therapy for diabetic male patients to alleviate ejaculatory disorders but alone is not efficient treatment for the mitigation of infertility.

关键词： diabetes mellitus male infertility oxidative stress seminal vesicles seminiferous epithelium smooth muscle cellcontractions

Hepatic osteodystrophy complicated with bone fracture in early infants with biliary atresia

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World Journal of Hepatology 2012年第10期4卷 284-287页

作者： Tadao Okada Shohei Honda Hisayuki Miyagi masashi Minato Akinobu Taketomi Department of Pediatric Surgery Hokkaido University HospitalSapporo 060-8648Japan Department of Gastroenterological Surgery I Hokkaido University Graduate School of MedicineSapporo 060-8638Japan

Biliary atresia(BA) is one of the major hepatobiliary abnormalities in infants and one of the causes of hepatic *** disease may be caused by the malabsorption of calcium and magnesium by vitamin D in hepatobiliary diseases in which bile flow into the intestines is deficient or *** fracture before Kasai hepatic portoenterostomy or within one month after the procedure in an infant with BA is very *** herein report two infants:one infant with BA who initially presented with a bone fracture before Kasai hepatic portoenterostomy,and the other at 4 wk after Kasai hepatic portoenterostomy,and also provide a review of the ***,we conclude that clinicians should consider BA in infants with bone fracture during early infancy.

关键词： Biliary atresia Bone fractur Hepatic osteodystrophy Kasai hepatic portoenterostomy Vitamin Ddeficiency