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Preventive approach against drug-induced pulmonary fibrosis through the suppression of epithelial-mesenchymal transition

引用

BIOCELL 2022年第8期46卷 1861-1865页

作者： masashi kawami RYOKO YUMOTO MIKIHISA TAKANO Graduate School of Biomedical and Health Sciences Hiroshima UniversityHiroshima7348553Japan

A number of drugs induce pulmonary injury and subsequently lead to serious lung diseases such as pulmonary fibrosis as the adverse drug ***,an effective preventive approach against drug-induced pulmonary fibrosis has not been established due to poor understanding of common preventive targets in a variety of drugs showing pulmonary ***-mesenchymal transition(EMT),a cellular phenotypic change of the epithelial to mesenchymal state,contributes to the development of pulmonary fibrosis through the conversion of damaged alveolar epithelium into *** several drugs with pulmonary toxicity have been reported to induce EMT,EMT serves as a bridge between the drugs and pulmonary *** evidence supports the potential of EMT as a preventive target against drug-induced pulmonary ***,since there are mechanistic differences between the main pharmacological effect and EMT induced by the drug,prevention based on EMT suppression would be possible and would contribute to continuous clinical treatment with the drug to avoid EMT-mediated serious pulmonary ***,targeting EMT seems to be adequate for exerting a preventive effect since EMT in damaged alveolar epithelial cells occurs prior to the development of the pathophysiological state of the whole lung in a bleomycin-induced lung injury rat *** viewpoint deals with the benefits and perspectives of preventive approaches against druginduced pulmonary fibrosis through the suppression of EMT,which has rarely been addressed.

关键词： Drug-induced lung injury Epithelial-mesenchymal transition Pulmonary fibrosis α-smooth muscle actin

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