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Safety and efficacy of metallic stent for unresectable distal malignant biliary obstruction in elderly patients

World Journal of Gastroenterology 2018年第1期24卷 69-75页

作者： Yuji Sakai Tomohisa Iwai Kenji Shimura Katsushige Gon Kazuya Koizumi masashi ijima Kazuro Chiba Seigo Nakatani Harutoshi Sugiyama Toshio Tsuyuguchi Terumi Kamisawa Iruu Maetani Mitsuhiro Kida Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of Gastroenterology Kitasato University School of MedicineKanagawa 252-0375Japan Department of Gastroenterology Asahi Central HospitalChiba 289-2511Japan Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Ohashi Medical CenterTokyo 153-8515Japan Gastroenterology Medicine Center Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Gastroenterology Subaru Health Insurance Society Ota Memorial HospitalGunma 373-8585Japan Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyo 113-8677Japan

AIM To study the safety of insertion of metallic stents in elderly patients with unresectable distal malignant biliary *** Of 272 patients with unresectable distal malignant biliary obstruction, 184 patients under the age of 80 were classified into Group A, and 88 subjects aged 80 years or more were classified into Group B. The safety of metallic stent insertion, metal stent patency period, and the obstruction rate were examined in each *** In Group B, patients had a significantly worse per-formance status, high blood pressure, heart disease, cerebrovascular disease, and dementia; besides the rate of patients orally administered antiplatelet drugs or anticoagulants tended to be higher(P < 0.05). Metallic stents were successfully inserted in all patients. The median patency period was 265.000 ± 26.779(1-965) d; 252.000 ± 35.998(1-618) d in Group A and 269.000 ± 47.885(1-965) d in Group B, with no significant difference between the two groups. Metallic stent obstruction occurred in 82 of the 272(30.15%) patients; in 53/184(28.80%) patients in Group A and in 29/88(32.95%) of those in Group B, showing no significant difference between the two groups. Procedural accidents due to metal stent insertion occurred in 24/272(8.8%) patients; in 17/184(9.2%) of patients in Group A and in 7/88(8.0%) of those in Group B, with no significant difference between the two groups, *** These results suggested that metallic stents can be safely inserted to treat unresectable distal malignant biliary obstruction even in elderly patients aged 80 years or more.

关键词： Elderly patients Metallic stent Malignant biliary obstruction

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Endoscopic papillary large balloon dilation for removal of bile duct stones

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World Journal of Gastroenterology 2014年第45期20卷 17148-17154页

作者： Yuji Sakai Toshio Tsuyuguchi Yoshiaki Kawaguchi Nobuto Hirata So Nakaji Katsuya Kitamura Shigeru Mikami Tatsuya Fujimoto masashi ijima Eishin Kurihara Shuhei Oana Takayoshi Nishino Ryo Tamura Dai Sakamoto Masato Nakamura Takao Nishikawa Harutoshi Sugiyama Hitoshi Yoshida Tetsuya Mine Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University Department of Gastroenterology Tokai University Hospital Department of Gastroenterology Kameda Medical Center Division of Gastroenterology Department of Medicine Showa University School of Medicine Department of Internal Medicine Kikkoman General Hospital Department of Gastroenterology Kimitsu Central Hospital Department of Gastroenterology Isesaki Municipal Hospital Department of Gastroenterology Iwate Medical University Hospital Department of Gastroenterology Tokyo Women’s Medical University Yachiyo Medical Center

AIM: To investigate the efficacy and outcomes of endoscopic papillary large balloon dilation (EPLBD) for bile duct stones in a multicenter prospective study.

关键词： Endoscopic retrograde cholangiopancreatography Endoscopic sphincterotomy Endoscopic papillary large balloon dilation Large bile duct stones Multiple bile duct stones

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Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan

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World Journal of Gastroenterology 2010年第40期16卷 5084-5091页

作者： Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto masashi ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima Department of Surgery International Universi-ty of Health and Welfare Hospital Department of Molecular Epidemiology Jikei University School of Medicine Endoscopy Unit Iwate prefectural Central Hospital Department of Internal Medicine Tsuyama Chuo Hospital Department of Surgery Higashi Washi-nomiya Hospital Digestive Disease Center Showa Inan General Hospital Department of Neurology Ebina Medical Sup-port Center Department of Surgery Sumitomo Hospital Department of Gastroenterology Kiyota Hospital Department of Gastroenterology Okano Clinic Department of Geriatrics Hitachikoh Hospital Department of Internal Medicine Jomoto Gastroenteric and Internal Medical Clinic Department of Surgery Fujiyoshida Munici-pal Hospital 2nd Department of Surgery Wakayama Medical University Hospital Department of Surgery Tokatsu-clinic Hospital Department of Surgery Kure Kyosai Hospital Department of Internal Medicine Matsue Sei-kyo Genaral Hospital Department of Gastroenterology Hirano General Hospital Department of Internal Medicin Nara Prefectural Gojo Hospital Department of Internal Medicine Isesaki Mu-nicipal Hospital Department of Internal Medicine Muraka-mi Memorial Hospital Digestive Endoscopy Center Sendai Kousei Hospital Department of Surgery Onishi Hospital Department of Surgery Tokyo Metropoli-tan Ohkubo Hospital Department of Internal Medicine Tsuruoka Kyoritsu Hospital Nutritional Therapy Center Toho Uni-versity Omori Medical Center Home Care Department Kameda Medical Hospital Endoscopic Treatment Center Japan Labour Health and Welfare Organization Niigata Rousai Hospital Department of Gastroenterology and Hepatology Social Insurance Shimonoseki Welfare Hospital Department of Gastroenterology Ako City Hospital Percutaneous Endoscopic Gastrostomy Center Oita Kensei Hospital Department of Internal Medicine Nishimino Kosei Hospital Department of Pediatric Surgery Nagano Red Cross Hospital Department of Internal Medicine Sapporo Shirakaba-dai hospital Department of Gastroenterology Tachikawa

AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors.

关键词： Percutaneous endoscopic gastrostomy Enteral nutrition Comorbidity Survival Risk factor

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Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： masashi Fujitani Abu Md Mamun Tarif Yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

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Potential of non-Western medicines in chemoradiotherapy for cervical cancer

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World Journal of Clinical Cases 2025年第2期13卷 21-23页

作者： Takashi Ono masashi Koto Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical *** radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’***,most treatments are supportive,with no specific treatment options available in Western ***-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical *** these potential benefits,challenges such as limited evidence and restricted application areas *** non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.

关键词： Cervical cancer Radiotherapy Non-Western medicine Kampo Herbal medicine

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Studies on multiferroic materials in high magnetic fields

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Frontiers of physics 2012年第4期7卷 386-398页

作者： masashi Tokunaga The International MegaGauss Science Laboratory The Institute for Solid State Physics (IMGSL-ISSP) The University of Tokyo Kashiwa 277-8581 Japan

In this article, studies on the magnetoelectric effects of multiferroic materials in high magnetic fields, particularly pulsed magnetic fields, are discussed and results for some representative ma- terials are presented. In the discussions on representative materials, the relationship between the crystallographic symmetry and the linear magnetoelectric effect in Cr203 is introduced. Then dras- tic changes in polarization caused by magnetic transitions are discussed through a case study of manganites with a perovskite4ype structure. In addition, high field studies on the magnetoelectric effects in BiFeO3, which is an exceptional multiferroic material, are presented and discussed in the framework of the Landau-Ginzburg theory.

关键词： high magnetic field multiferroic materials magnetoelectric effect

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Application of the generalized body-fixed coordinate system for the wave-body interaction problem of a small-depth elastic structure in head seas

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Journal of Hydrodynamics 2021年第6期33卷 1255-1270页

作者： Kyeonguk Heo masashi Kashiwagi School of Naval Architecture and Ocean Engineering University of UlsanUlsanKorea Department of Naval Architecture and Ocean Engineering Osaka UniversitySuitaJapan

The body-fixed coordinate system is applied to the wave-body interaction problem of a small-depth elastic structure which has both rigid and elastic body motions in head *** the weakly non-linear assumption,the perturbation scheme is used and the expansion is conducted up to second-order to consider several non-linear *** solve the boundary value problem,linearization is carried out based not on inertial coordinate but on body-fixed coordinate which could be accelerated by a motion of a *** first,the main feature of the application of body-fixed coordinate system for a seakeeping problem is briefly *** that the transformation of a coordinate system is extended to consider an elastic body motion and several physical variables are re-described in the generalized *** has been found that the deformation gradient could be used for the transformation of a coordinate system if several conditions are *** there are only vertical bending in elastic modes and the structure has relatively small depth,these conditions are generally *** calculate an elastic motion of a body,the generalized mode method is adopted and the mode shape is obtained by solving eigen-value problem of dynamic beam *** the boundary condition of the body-fixed coordinate system,the motion effect reflected to free-surface boundary is considered by extrapolating each mode shape to the horizontal direction from a *** last,simple numerical tests are implemented as a validation *** second-order hydrodynamic force of a freely floating hemisphere is first calculated in zero forward speed ***,motion and added resistance of a ship with forward speed are considered at different flexibility to confirm the effect of an elastic body motion in body-fixed coordinate system.

关键词： Hydroelasticity Higher-order boundary element method(HOBEM) generalized mode method perturbation scheme body-fixed coordinate system wave-body interaction

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Two-dimensional self-assembly of melem and melemium cations at pH-controlled aqueous solution-Au（111） interfaces under electrochemical control

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Frontiers of Chemical Science and Engineering 2016年第2期10卷 294-300页

作者： Shinobu Uemura Kenki Sakata masashi Aono Yusuke Nakamura masashi Kunitake Department of Advanced Materials Sciences Faculty of Engineering Kagawa University Kagawa 761-0396 Japan Graduate School of Science and Technology Kumamoto University Kumamoto 860-8555 Japan

Two-dimensional self-assembly of melem at pH-controlled aqueous solution-Au（111） interfaces has been investigated by electrochemical scanning tunneling microscopy. In the solutions with pH 〉 pKbl of melem, two ordered self-assembled structures （honeycomb and close-packed structures） and one disordered fibrillar structure were observed as a function of the surface coverage ofmelem controlled by the electrode potential. In contrast, in the acidic solution with pH 〈 pKbl of melem, only the self-assembled honeycomb network was observed in a relatively wide potential range probably due to the presence of monoprotonated melem cations. Dots attrib- uted to counteranions were frequently observed in the pores of the honeycomb network. The lack of close-packed and fibrillar structures at low pH （〈 pKbl） is attributed to ionic repulsion of melemium cations.

关键词： self-assembly scanning tunneling micro-scopy electrochemistry structural phase transition melem

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Flow Visualization around a Double Wedge Airfoil Model with Focusing Schlieren System

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Journal of Thermal Science 2006年第1期15卷 31-36页

作者： masashi KASHITANI Yutaka YAMAGUCHI Department of Aerospace Engineering National Defense Academy 1-10-20 Hashirimizu Yokosuka Kanagawa 239-8686Japan

In the present study, aerodynamic characteristics of the double wedge airfoil model were investigated in a transonic flow by using the shock tube as an intermittent wind tunnel. The driver and driven gases of the shock tube are dry air. The airfoil model of double wedge has the span of 58 mm, chord length c = 75 mm and its maximum thickness is 7.5 mm. The apex of the double wedge airfoil model is located on the 35% chord length from the leading edge. The range of hot gas Mach numbers are from 0.80 to 0.88, and the Reynolds numbers based on chord length are 3.11× 10^5- 3.49× 10^5, respectively. The flow visualizations were performed by the sharp focusing schlieren method which can visualize the three dimensional flow fields. The results show that the present system can visualize the transonic flowfield clearer than the previous system, and the shock wave profiles of the center of span in the test section are visualized

关键词： shock wave schlieren method transonic flow double wedge airfoil model

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Regulation of hepatic function by brain neuropeptides

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World Journal of Gastroenterology 1998年第3期4卷 12-16页

作者： masashi Yoneda School of Medicine Hirosaki University Japan Postgraduate School Hirosaki University Japan University of California Los Angeles CA United States Second Department of Medicine Asahikawa Medical College Japan Department of Medicine Intl. Univ. of Health and Welfare Japan Japan. Society of Gastroenterology Japan Second Department of Medicine Asahikawa Medical College Asahikawa 078 Nishikagura 4-5-3 Japan

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关键词： liver/physiology thyrotropin releasing hormone corticotropin releasing factor neuropeptide Y central nervous system bombesin βendorphin DAlaMet enkepalinamide

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