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Journal of Bioresources and Bioproducts 2022年第4期7卷 221-244页

作者： Qingxin Zheng Zixian Li masaru watanabe Research Center of Supercritical Fluid Technology Department of Chemical EngineeringGraduate School of EngineeringTohoku UniversitySendai 980-8579Japan Department of Chemical Engineering Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan

Traditional disposal methods of biomass and plastic waste,such as landfill,combustion,and compost,no longer meet the requirements of carbon reduction,carbon neutrality,and sustain-able society due to low utilization efficiency and severe *** a green,efficient and environmentally-friendly method,hydrothermal technology has been paid much attention to and has already been applied to recycle or reuse various plastic and biomass *** matter for the single or mixed type of waste,it is expected to achieve efficient recycling and obtain value-added products through the hydrothermal *** review summarized the basic knowledge of hydrothermal technology and the possible reaction mechanism of biomass and plastics un-der hydrothermal conditions and listed the previous reports on the application of hydrothermal technology for converting wastes of biomass,plastic,and biomass/plastic mixtures to solid ***,regarding the future of hydrothermal technology,four points related to reaction mech-anism,synergistic effect,catalysis,and scaled-up application,were provided for consideration.

关键词： Hydrothermal Supercritical water Subcritical water Biomass Plastic Waste treatment Solid fuels

Recent advances in treatment of follicular lymphoma: efficacy of PI3Kα/δ inhibitor (TQ-B3525)

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2341-2343页

作者： Takuya watanabe Department of Internal Medicine and Gastroenterology Watanabe Internal Medicine Aoyama ClinicNiigata-city 9502002Japan

The commented study reports the results of monotherapy using TQ-B3525,a novel phosphatidylinositol-3 kinase(PI3K)inhibitor developed in China,in patients with refractory/relapsed follicular lymphoma(r/r FL).

关键词： PI3K lymphoma treatment

Field induced Chern insulating states in twisted monolayer–bilayer graphene

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Chinese Physics B 2024年第6期33卷 69-73页

作者：王政文韩英卓 Kenji watanabe Takashi Taniguchi 姜宇航毛金海 School of Physical Science and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100049China College of Materials Science and Optoelectronic Technology Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Advanced Materials Laboratory National Institute for Materials ScienceTsukuba 305-0044Japan

Unraveling the mechanism underlying topological phases, notably the Chern insulators(Ch Is) in strong correlated systems at the microscopy scale, has captivated significant research interest. Nonetheless, Ch Is harboring topological information have not always manifested themselves, owing to the constraints imposed by displacement fields in certain experimental configurations. In this study, we employ density-tuned scanning tunneling microscopy(DT-STM) to investigate the Ch Is in twisted monolayer–bilayer graphene(t MBG). At zero magnetic field, we observe correlated metallic *** under a magnetic field, a metal–insulator transition happens and an integer Ch I is formed emanating from the filling index s = 3 with a Chern number C = 1. Our results underscore the pivotal role of magnetic fields as a powerful probe for elucidating topological phases in twisted Van der Waals heterostructures.

关键词： Chern insulators strong correlation effects two-dimensional van der Waals heterostructure density-tuned scanning tunneling microscopy(DT-STM)

Dynamic Hand Gesture-Based Person Identification Using Leap Motion and Machine Learning Approaches

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Computers, Materials & Continua 2024年第4期79卷 1205-1222页

作者： Jungpil Shin Md.AlMehedi Hasan Md.Maniruzzaman Taiki watanabe Issei Jozume School of Computer Science and Engineering The University of AizuAizuwakamatsuFukushima965-8580Japan Department of Computer Science&Engineering Rajshahi University of Engineering&TechnologyRajshahi6204Bangladesh

Person identification is one of the most vital tasks for network security. People are more concerned about theirsecurity due to traditional passwords becoming weaker or leaking in various attacks. In recent decades, fingerprintsand faces have been widely used for person identification, which has the risk of information leakage as a resultof reproducing fingers or faces by taking a snapshot. Recently, people have focused on creating an identifiablepattern, which will not be reproducible falsely by capturing psychological and behavioral information of a personusing vision and sensor-based techniques. In existing studies, most of the researchers used very complex patternsin this direction, which need special training and attention to remember the patterns and failed to capturethe psychological and behavioral information of a person properly. To overcome these problems, this researchdevised a novel dynamic hand gesture-based person identification system using a Leap Motion sensor. Thisstudy developed two hand gesture-based pattern datasets for performing the experiments, which contained morethan 500 samples, collected from 25 subjects. Various static and dynamic features were extracted from the handgeometry. Randomforest was used to measure feature importance using the Gini Index. Finally, the support vectormachinewas implemented for person identification and evaluate its performance using identification accuracy. Theexperimental results showed that the proposed system produced an identification accuracy of 99.8% for arbitraryhand gesture-based patterns and 99.6% for the same dynamic hand gesture-based patterns. This result indicatedthat the proposed system can be used for person identification in the field of security.

关键词： Person identification leap motion hand gesture random forest support vector machine

Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia

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Neural Regeneration Research 2025年第6期20卷 1705-1706页

作者： Kazuki watanabe Atsuhiko Hattori Department of Immunobiology Institute of Development Aging and CancerTohoku UniversitySendaiMiyagiJapan Department of Sport and Wellness College of Sport and WellnessRikkyo UniversityNiizaSaitamaJapan

Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian *** hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关键词： metabolism primarily agent

Moving doubly heavy baryon in a strongly coupled plasma via holography

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Chinese Physics C 2024年第8期48卷 42-55页

作者： Xuan Liu Jia-Jie Jiang Xun Chen Mitsutoshi Fujita Akira watanabe School of Nuclear Science and Technology University of South ChinaHengyang 421001China School of Mathematics and Physics University of South ChinaHengyang 421001China

Gauge/gravity duality is used to study the properties of the doubly heavy baryon(QQq)at finite rapidity and temperature in heavy-ion *** investigate the impact of rapidity on string breaking and screening of QQq and compare these effects with the results for QQ¯in *** reveal that the string-breaking distances of QQq and QQ¯are close in the confined state,and the effects of rapidity and temperature on the string breaking are not *** interesting result shows that QQq cannot be determined at sufficiently high temperatures and ***,QQ¯can exist under any conditions as long as the separation distance is sufficiently ***,the screening distances of QQq and QQ¯are compared at finite rapidity and *** on the above analysis,we infer that QQ¯is more stable than QQq at finite rapidity and temperature.

关键词： holographic QCD QGP heavy quark

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变流变压器及平波电抗器的发展

变压器 1988年第2期 35-37页

作者： masaru watanabe 贾杰红

在降低500～600kV级超高压直流输电系统的变流变压器及平波电抗器绝缘尺寸的研究和试制中,应用了从超高压交流变压器发展中所获得的最新技术。用超高压变流变压器直流侧绕组的端部结构的小型绝缘模型,进行了直流击穿电压试验。结果证明... 详细信息

在降低500～600kV级超高压直流输电系统的变流变压器及平波电抗器绝缘尺寸的研究和试制中,应用了从超高压交流变压器发展中所获得的最新技术。用超高压变流变压器直流侧绕组的端部结构的小型绝缘模型,进行了直流击穿电压试验。结果证明,采用L型隔板、介电屏蔽环等结构,降低其绝缘尺寸近似于超高压交流设备的尺寸是可能的。同时,改进了直流局部放电测量系统。经过击穿电压试验证明,它的性能稳定,改进的高压变流设备的绝缘是可靠的,可应用于将来的系统之中。

关键词：变流变压器滤波电抗器直流闪络电压局部放电

Examining the Hypothesis of Common Factors Shared by Different Addictive Behaviors and Gender Effects on Propensity to Addiction Type

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Open Journal of Medical Psychology 2024年第3期13卷 58-70页

作者： Masayo Uji Junko watanabe Toshinori Kitamura Department of Clinical Psychology Human Development Education Graduate School of Education Hyogo University of Teacher Education Kat Japan Academic Skill Support Center Kumamoto Health Science University Kumamoto Japan Kitamura Institute Mental Health Tokyo Tokyo Japan

Background: From the two facts reported by previous research: 1) frequent co-occurrence of more than one addictive behavior, 2) childhood adversities identified as origins of different types of addictive behaviors, it is assumed that all types of addictive behaviors, regardless of substance, behavioral, or relationship, share common factors which have not yet been proven by epidemiological research. The Shorter PROMIS Questionnaire (SPQ) was previously developed to assess 16 types of addictive behaviors. Its factor structure, however, has not been fully investigated. Confirming the factor structure will enable us to hypothesize the common factor(s) shared by all, or if not all, most types of addictive behaviors. Aims: This study aimed at 1) examining the factor structure of the SPQ, 2) confirming the reliability of the questionnaire, and 3) examining the impacts of gender and age on each addictive behavior. Methods: Data obtained from 232 Japanese adults who completed all items of the SPQ were used for the analyses. After confirming the one-factor structure model for each of the 16 subscales, the validity of the one-factor structure of the SPQ was evaluated using Confirmatory Factor Analysis (CFA), by adapting 16 subscale scores as observed variables. If its validity was not confirmed, another model which showed better compatibility to the data was explored. The reliability of the SPQ as well as that of all 16 subscales was evaluated. Also, the impacts of gender and age on each subscale score were examined. Results: The one-factor structure for each of the 16 subscales was confirmed. The compatibility of the SPQ one-factor model was not acceptable. The best fit model was a bi-factor model in which one main factor was shared by all 16 subscales, and three factors were shared by some specific addictive behaviors. Male respondents were more likely than female respondents to show high scores in Alcohol, Tobacco, Gambling, Sex, and Recreational Drugs, and low scores only

关键词： Addictive Behaviors Shorter PROMIS Questionnaire Confirmatory Factor Analysis

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro Kojima Kenji watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

Direct Correlation among Telomere Length, Cellular Aging, and Rejuvenation Effects of Honey Child Powder

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Journal of Biosciences and Medicines 2024年第7期12卷 55-70页

作者： Naofumi Shiomi Keiko watanabe Yuki Fujiwara Takae Yamasaki Hideto Matsuyama Research Center for Membrane and Film Technology Kobe University Kobe Japan School of Human Sciences Kobe College Nishinomiya Japan Department of Chemical Science and Engineering Kobe University Kobe Japan

Purpose: Telomere length (TL) is an indicator of age;however, hormonal influences complicate individual aging. It remains unclear whether TL shortening is a direct factor in both individual and cellular aging. Therefore, we examined the direct relationship between TL and cellular senescence at the cellular level. Methods: Telomerase activity, TL, and gene expression were measured in cultured human lung-, fetal-, and skin-derived fibroblasts, human skin keratinocytes, and telomerase reverse transcriptase (TERT) gene-immortalized cells using detection kits, Cawthon’s method, and reverse transcription-quantitative polymerase chain reaction, respectively. Novel substances that elongate telomeres were screened to confirm cell rejuvenation effects. Results: Long-term cell culture of TIG-1-20 normal human fibroblasts resulted in TL shortening, decreased division rate, and senescence progression, whereas in OUMS-36T-2 cells, TL elongation via TERT gene transfer increased the division rate, reduced endoplasmic reticulum stress, and upregulated genes associated with young individuals, indicating that cellular rejuvenation occurs via TL elongation. In addition, a honey child powder (HCP) extract was found through screening, and the HCP extract strongly suppressed the menin gene, resulting in increased telomerase activity and extended cell lifespan. Upon addition of the HCP extract to skin fibroblasts, gene expression of moisturizing components, including collagen, hyaluronic acid, and elastin, increased, and exhibited a rejuvenating effect with an increase in elastin amount. Conclusions: TL elongation or shortening is involved in cell proliferation rate and cellular aging, and TL elongation rejuvenates cells. In addition, HCP extract has a rejuvenating effect on cells and is expected to be a rejuvenating compound.

关键词： Telomere Cellular Aging Telomerase Reverse Transcriptase Gene Rejuvenation Honey Child Powder