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China Foundry 2024年第4期21卷 379-386页

作者： Yang Liao Ye-yuan Hu Kosuke Ikeda Ryoji okabe Rui-fen Wu Ryota Ozaki Qing-yan Xu Key Laboratory for Advanced Materials Processing Technology School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Composite Laboratory Research&Innovation Center Mitsubishi Heavy Industries Ltd.Nagasaki 8510392Japan

Polypropylene is commonly used as a binder for ceramic injection molding,and rapid cooling is often encountered during ***,the crystallization behavior of polypropylene shows a strong dependence on cooling rate due to its semi-crystalline ***,the influence of cooling rate on the quality of final product cannot be *** this study,the fast differential scanning calorimetry(FSC)test was performed to study the influence of cooling rate on the non-isothermal crystallization behavior and non-isothermal crystallization kinetics of a copolymer polypropylene(PP BC03B).The results show that the crystallization temperatures and crystallinity decrease as the cooling rate *** addition,two exothermic peaks occur when cooling rate ranges from 30 to 300 K·s^(-1),indicating the formation of another crystal ***,Ozawa and Mo equations were used to explore the non-isothermal crystallization kinetics,and it can be concluded that the Mo method is suitable for this study.

关键词： cooling rate crystallization temperature crystallinity non-isothermal crystallization kinetics FSC copolymer polypropylene

Model Transformer Evaluation of High-Permeability Grain-Oriented Electrical Steels

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Journal of Materials Science & Technology 2000年第2期16卷 223-227页

作者： Masayoshi Ishida, Seiji okabe, Takeshi Imamura and Michiro Komatsubara (Kawasaki Steel Corporation, Kurashiki 712-8511, Japan) Kawasaki Steel Corporation Kurashiki 712-8511 Japan

The dependence of transformer performance on the material properties was investigated using two laboratory-processed 0.23 mm thick grain-oriented electrical steels domain-refined with elec-trolytically etched grooves having different magnetic properties. The iron loss at 1.7 T, 50 Hz and the flux density at 800 A/m of material A were 0.73 W/kg and 1.89 T, respectively; and those of material B, 0.83 W/kg and 1.88 T. Model stacked and wound transformer core experiments using the tested materials exhibited performance well reflecting the material characteristics. In a three-phase stacked core with step-lap joints excited to 1.7 T, 50 Hz, the core loss, the exciting current and the noise level were 0.86 W/kg, 0.74 A and 52 dB, respectively, with material A; and 0.97 W/kg, 1.0 A and 54 dB with material B. The building factors for the core losses of the two materials were almost the same in both core configurations. The effect of higher harmonics on transformer performance was also investigated.

关键词： Model Transformer Evaluation of High-Permeability Grain-Oriented Electrical Steels

Advances in low-temperature extraction of natural resources using liquefied dimethyl ether

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Resources Chemicals and Materials 2022年第1期1卷 16-26页

作者： Qingxin Zheng masaru Watanabe Research Center of Supercritical Fluid Technology Department of Chemical EngineeringGraduate School of EngineeringTohoku University6-6-11 AobaAramakiAoba-kuSendai 980-8579 Japan Environment Conservation Center Department of Chemical EngineeringGraduate School of EngineeringTohoku University6-6-11 AobaAramakiAoba-kuSendai 980-8579 Japan

This review summarized the valuable works on the extraction technologies using pure liquefied dimethyl ether(DME)as the organic *** is a colorless gas with a slight ether-like fragrance at room temperature and *** to some special properties,such as the strong ability for extracting organic compounds and water,high extraction rate,cheap price,low extraction temperature,and energy consumption,environmental friend-liness,safety,and good compressibility,the application of liquefied DME to the extraction process shows many advantages and has strong potential market *** the other hand,the drawbacks of liquefied DME extraction technology were also revealed,mainly on fire hazards,solvent loss,and lack of large-scale ***,the previous studies on the application of liquefied DME extraction technology were divided into three parts based on the extracts(water,lipid/oil,and specific ingredients)and listed one by *** research of the liquefied DME extraction process is still in *** the future,it is expected that this technology can be continuously improved and optimized in both lab and industrial scales,together with the extension of its application range to more various natural resources.

关键词： Liquefied dimethyl ether(DME) Extraction Natural resource Low temperature Subcritical fluid

Laparoscopic approach to suspected T1 and T2 gallbladder carcinoma

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World Journal of Gastroenterology 2017年第14期23卷 2556-2565页

作者： Yusuke Ome Kazuki Hashida Mitsuru Yokota Yoshio Nagahisa Michio okabe Kazuyuki Kawamoto Department of Surgery Kurashiki Central Hospital

AIM To evaluate a laparoscopic approach to gallbladder lesions including polyps, wall-thickening lesions, and suspected T1 and T2 gallbladder cancer(GBC).METHODS We performed 50 cases of laparoscopic whole-layer cholecystectomy(LCWL) and 13 cases of laparoscopic gallbladder bed resection(LCGB) for those gallbladder lesions from April 2010 to November 2016. We analyzed the short-term and long-term results of our laparoscopic approach. RESULTS The median operation time was 108 min for LCWL and 211 min for LCGB. The median blood loss was minimal for LCWL and 28 ml for LCGB. No severe morbidity occurred in either procedure. Nine patients who underwent LCWL and 7 who underwent LCGB were postoperatively diagnosed with GBC. One of these patients had undergone LCGB for pathologically diagnosed T2 GBC after LCWL. All of the final surgical margins were negative. Three of these 15 patients underwent additional open surgery. The mean follow-up period was 26 mo, and only one patient developed *** LCWL and LCGB are safe and useful procedures that allow complete resection of highly suspected or earlystage cancer and achieve good short-term and longterm results.

关键词： Laparoscopic cholecystectomy Whole-layer cholecystectomy Gallbladder bed resection Radical cholecystectomy Gallbladder carcinoma

Inhibition of glutaminolysis alone and in combination with HDAC inhibitor has anti-myeloma therapeutic effects

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Cancer Drug Resistance 2024年第1期7卷 604-619页

作者： Seiichi okabe Yuko Tanaka Mitsuru Moriyama Akihiko Gotoh Department of Hematology Tokyo Medical UniversityTokyo 160-0023Japan

Aim:This study aimed to investigate drug candidates and their efficacy in treating refractory multiple myeloma(MM)despite significant therapeutic advances and the introduction of novel *** study focused on how myeloma cells mediate the metabolic pathways essential for ***,we examined the role of glutaminolysis in this ***:We investigated the role of glutaminolysis in myeloma cell *** addition,we analyzed the ability of CB-839(telaglenastat),a glutaminase(GLS)inhibitor,to suppress myeloma cell proliferation and enhance the sensitivity to histone deacetylase(HDAC)***:Glutamate deprivation significantly reduced MM cell *** observed an upregulation of GLS1 expression in MM cell lines compared to that in normal ***-839 inhibits MM cell proliferation in a dose-dependent manner,resulting in enhanced ***,intracellularα-ketoglutarate and nicotinamide adenine dinucleotide phosphate levels decreased after CB-839 *** panobinostat with CB-839 resulted in enhanced cytotoxicity and increased caspase 3/7 *** transfected with GLS shRNA exhibited reduced cell viability and elevated sub-G1 phase according to cell cycle analysis *** to control cells,these cells also showed increased sensitivity to ***:Glutaminolysis contributes to the viability of MM cells,and the GLS inhibitor CB-839 has been proven to be an effective treatment for enhancing the cytotoxic effect of HDAC *** results are clinically relevant and suggest that CB-839 is a potential therapeutic candidate for patients with MM.

关键词： Multiple myeloma glutaminolysis GLS1 HDAC inhibitor

Hydrogen Effect on Coke Removal and Catalytic Performance in Pre-Carburization and Methane Dehydro-Aromatization Reaction on Mo/HZSM-5

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Journal of Natural Gas Chemistry 2005年第3期14卷 129-139页

作者： Ryoichi Kojima Satoshi Kikuchi masaru Ichikawa Catalysis Research Center Hokkaido University N-21 W-10 Kita-ku Sapporo 001-0021 Japan Catalysis Research Center Hokkaido University N-21 W-10 Kita-ku Sapporo 001-0021 Japan Catalysis Research Center Hokkaido University N-21 W-10 Kita-ku Sapporo 001-0021 Japan

In this study, the effects of pre-carburization of catalyst, hydrogen addition to methane feed and the space velocity of methane on the catalytic performance in methane to benzene （MTB） reaction were discussed in detail over Mo/HZSM-5 catalyst at 1023 K and 0.3 MPa. Compared with the non-precarburized catalyst, the Mo catalyst pre-carburized under the flow of CHa＋4H2 at 973 K was found to have the higher activity and better stability. Further 6% H2 addition to the methane feed suppressed the aromatic type of coke formation effectively, and improved the stability of catalyst markedly, moreover gave a much longer reaction life of catalyst （53 h at 1023 K and 5400 ml/（g-h）） and much more formation amounts of benzene and hydrogen. With increase of methane space velocity, both the naphthalene formation selectivity and the coke formation selectivity were decreased by the shortened contact time; the benzene formation selectivity and total formation amount before the complete deactivation of catalyst were increased markedly, while the total naphthalene and coke formation amounts did not change much. At high methane space velocity （≥5400 ml/（g·h））, a new middle temperature coke derived from the high temperature aromatic coke was formed on the catalyst; all the coke formed could be burnt off at lower temperature in oxygen, compared with those obtained at low space velocity. Considering the benzene formation amount and catalyst stability together, 5400 ml/（g·h） was proved to be the most efficient methane space velocity for benzene production.

关键词： methane dehydro-aromatization pre-carburization space velocity H2 addition benzene formation amount aromatic coke

Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B

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World Journal of Gastroenterology 2014年第34期20卷 12031-12038页

作者： masaru Enomoto Hiroyasu Morikawa Akihiro Tamori Norifumi Kawada Department of Hepatology Osaka City University Graduate School of MedicineOsaka 5458585Japan

Infection with hepatitis B virus is an important healthproblem worldwide:it affects more than 350 millionpeople and is a leading cause of liver-related morbidity,accounting for 1 million deaths *** fibrosis is a consequence of the accumulation of extracellular matrix components in the *** accurate diagnosis of liver fibrosis is essential for the management of chronic liver *** biopsy has been considered the gold standard for diagnosing disease,grading necroinflammatory activity,and staging ***,liver biopsy is unsuitable for repeated evaluations because it is invasive and can cause major complications,including *** noninvasive evaluations have been introduced for the assessment of liver fibrosis:serum biomarkers,combined indices or scores,and imaging techniques including transient elastography,acoustic radiation force impulse,real-time tissue elastography,and magnetic resonance ***,we review the recent progress of noninvasive assessment of liver fibrosis in patients with chronic hepatitis *** noninvasive evaluations for liver fibrosis have been validated first in patients with chronic hepatitis C,and later in those with chronic hepatitis *** establishment of a noninvasive assessment of liver fibrosis is urgently needed to aid in the management of this leading cause of chronic liver disease.

关键词： Acoustic radiation force impulse Biomarkers Biopsy Elastography Fibrosis Hepatitis B Noninvasive evaluations

Hepatitis B virus infection and alcohol consumption

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World Journal of Gastroenterology 2017年第15期23卷 2651-2659页

作者： ayako iida-ueno masaru enomoto akihiro tamori norifumi kawada Department of Hepatology Osaka City University Graduate School of Medicine

Hepatocellular carcinoma(HCC) is the most common type of primary liver cancer, and the second most common cause of cancer deaths worldwide. The top three causes of HCC are hepatitis B virus(HBV),hepatitis C virus(HCV), and alcoholic liver disease. Owing to recent advances in direct-acting antiviral agents, HCV can now be eradicated in almost all patients. HBV infection and alcoholic liver disease are expected, therefore, to become the leading causes of HCC in the future. However, the association between alcohol consumption and chronic hepatitis B in the progression of liver disease is less well understood than with chronic hepatitis C. The mechanisms underlying the complex interaction between HBV and alcohol are not fully understood, and enhanced viral replication, increased oxidative stress and a weakened immune response could each play an important role in the development of HCC. It remains controversial whether HBV and alcohol synergistically increase the incidence of HCC. Herein, we review the currently available literature regarding the interaction of HBV infection and alcohol consumption on disease progression.

关键词： Entecavir Genetic factors Hepatocellular carcinoma Interferon

Characterization of termetallic Pt-Ir-Au catalysts for NO decomposition

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Rare Metals 2011年第1期30卷 53-57页

作者： Akira Morikawa Kohei Okumura masaru Ishii Koichi Kikuta Akihiko Suda Hirofumi Shinjo Catalyst Lab. Toyota Central R&D Labs.Inc.41-1 YokomichiNagakuteNagakute-ChoAichi-GunAichi 480-1192Japan Vehicle Engineering Group Material Engineering Division ⅡToyota Motor Corporation1 Toyota-choToyotaAichi 471-8572Japan Department of Crystalline Materials Science School of EngineeringNagoya UniversityFuro-ChoChikusa-KuNagoyaAichi 464-8603Japan

A termetallic catalyst of Pt-Ir-Au/Al2O3 for NOx decomposition was prepared by loading the metallic colloids in C2H5OH-H2O solution and a surfactant of polyvinyl *** with an impregnated Pt/Al2O3 catalyst,the termetallic catalyst of PtIrAu811/Al2O3,with a Pt：Ir：Au atomic ratio of 8：1：1,exhibited higher NO decomposition and selectivity to *** electron microscopy and X-ray diffraction were conducted to clarify the state of the supported metals and indicate three precious metals alloyed on the *** the study of NO-temperature programmed desorption,oxygen desorption on the PtIrAu811 catalyst shifted to the low temperature side compared to that on Pt/Al2O3,which correlated well with its higher catalytic performance in NO decomposition.

关键词： catalysts iridium gold platinum decomposition nitrogen oxides

Perspective on ultrathin layered Ni-doped MoS_(2) hybrid nanostructures for the enhancement of electrochemical properties in supercapacitors

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Journal of Energy Chemistry 2023年第5期80卷 335-349,I0008页

作者： Kamarajar Prakash Santhanakrishnan Harish Shanmugasundaram Kamalakannan Thirumalaisamy Logu masaru Shimomura Jayaram Archana Mani Navaneethan Functional Materials and Energy Devices Laboratory Department of Physics and NanotechnologySRM Institute of Science and TechnologyKattankulathurChennai 603203Tamil NaduIndia Graduate School of Science and Technology Shizuoka University3-5-1 JohokuNaka-KuHamamatsuShizuoka 432-11Japan SPECIFIC Materials Research CentreFaculty of Science and EngineeringSwansea UniversitySwanseaUnited Kingdom Nanotechnology Research Center SRM Institute of Science and TechnologyKattankulathurChennai 603203Tamil NaduIndia

Over the last two decades,extensive study has been done on two-dimensional Molybdenum Sulphide(MoS_(2))due to its outstanding features in energy storage *** MoS_(2)has a lot of active sulphur edges,the presence of inactive surfaces leads to limit conductivity and ***,in this article,we aimed to promote the additional active sites by doping various weight percentages(2%,4%,6%,8%and 10%)of Nickel(Ni)into the MoS_(2)matrix by simple hydrothermal technique,and their doping effects were investigated with the help of Physio-chemical analyses.X-ray diffraction(XRD)pattern,Raman,and chemical composition(XPS)analyses were used to confirm the Ni incorporation in MoS_(2)*** investigations demonstrated that Ni-doped MoS_(2)nanosheets were vertically aligned with enhanced interlayer *** voltammetry,Galvanostatic charge-discharge,and electrochemical impedance spectroscopy investigations were used to characterize the electrochemical *** 6%Ni-doped MoS_(2)electrode material showed better CSPof 528.7 F/g@1 A/g and excellent electrochemical stability(85%of capacitance retention after 10,000 cycles at 5 A/g)compared to other electrode ***,the solid-state asymmetric supercapacitor was assembled using Nidoped MoS_(2)and graphite as anode and cathode materials and analysed the electrochemical properties in the two-electrode *** determine the impact of the Ni-atom on the MoS_(2)surface,firstprinciples computations were ***,it was examined for electronic band structure,the projected density of states(PDOS)and Bader charge transfer analyses.

关键词： Ni-doped MoS_(2) Supercapacitor Cyclic voltammetry Specilic surface area Specific capacitance Stability