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Nicotine Treatment Induces Expression of Matrix Metalloproteinases in Human Osteoblastic Saos-2 Cells

Acta Biochimica et Biophysica Sinica 2006年第12期38卷 874-882页

作者： Tomoko KATONO Takayuki KAWATO Natsuko TANABE Naoto SUZUKI Kazuhiro YAMANAKA Hitoshi OKA Masafumi MOTOHASHI masao maeno Kanda Surugadai Chiyoda-kuTokyo 101-8310Japan Department of Oral Health Sciences Nihon UniversitySchool of DentistryTokyo 101-8310Japan Japan Department of Biochemistry Nihon University School of Dentistry.Tokyo 101-8310Japan

Tobacco smoking is an important risk factor for the development of severe ***,we showed that nicotine affected mineralized nodule formation,and that nicotine andlipopolysaccharide stimulated the formation of osteoclast-like cells by increasing production of macrophagecolony-stimulating factor （M-CSF） and prostaglandin E2（PGE2） by human osteoblastic Saos-2 *** thepresent study,we examined the effects of nicotine on the expression of matrix metalloproteinases （MMPs）,tissue inhibitors of matrix metalloproteinases （TIMPs）,the plasminogen activation system including thecomponent of tissue-type plasminogen activator （tPA）,urokinase-type PA （uPA）,and PA inhibitor type 1（PAI-1）,α7 nicotine receptor,and *** also examined the effect of the nicotine antagonist D-tubocurarineon nicotine-induced expression of *** expression was examined using real-time polymerase chainreaction （PCR） to estimate mRNA *** addition,expression of the MMP,TIMP,uPA,tPA,and PAI-1proteins was determined by Western blotting *** treatment caused expression of MMP-1,2,3,and 13,but not MMP-14,to increase significantly after 5 or 10 d of culture;MMP-14 expression did notchange through day *** of MMP-1 expression by nicotine treatment was eliminated bysimultaneous treatment with *** the presence of nicotine,expression of uPA,PAI-1,orTIMP-1,2,3,or 4 did not change over 14 d of culture,whereas expression of tPA increased significantly byday *** also increased expression of the α7 nicotine receptor and c-fos *** results suggestthat nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1,2,3,and 13,thereby tipping the balance between bone matrix formation and resorption toward the latter process.

关键词： nicotine matrix metalloproteinase tissue inhibitor of matrix metalloproteinase plasminogen activation system

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Lipopolysaccharide Enhances the Production of Nicotine-Induced Prostaglandin E2 by an Increase in Cyclooxygenase-2 Expression in Osteoblasts

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Acta Biochimica et Biophysica Sinica 2007年第3期39卷 163-172页

作者： Maiko SHOJI Natsuko TANABE Narihiro MITSUI Naoto SUZUKI Osamu TAKEICHI Tomoko KATONO Akira MOROZUMI masao maeno Department of Oral Health Sciences Nihon University School of DentistryTokyo 101-8310Japan Division of Functional Morphology Dental Research Center.Nihon University School ofDentistryTokyo 101-8310Japan Nihon University Grndudte School of Dentistry Tokyo 101-8310Japan Division of Functional Morphology Dental Research Center.Nihon University School of DentistryTokyo 101-8310Japan Department of Endodontics Nihon University School of DentisityTokyo 101-8310Japan Division of Advanced Dental Treatment Dental Research CenterNihon University School of DentistryTokyo 101-8310Japan Nihon University Graduate School of Dentistry Tokyo 101-8310Japan

Previous studies have indicated that lipopolysaccharide（LPS）from Gram-negative bacteria inplaque induces the release of prostaglandin E2（PGE2）,which promotes alveolar bone resorption in periodontitis,and that tobacco smoking might be an important risk factor for the development and severity of *** determined the effect of nicotine and LPS on alkaline phosphatase（ALPase）activity,PGE2production,and the expression of cyclooxygenase（COX-1,COX-2）,PGE2receptors Ep1-4,and macrophage colonystimulating factor（M-CSF）in human osteoblastic Saos-2 *** cells were cultured with 10-3M nicotinein the presence of 0,1,or 10μg/ml LPS,or with LPS *** activity decreased in cells cultured withnicotine or LPS alone,and decreased further in those cultured with both nicotine and LPS,whereas PGE2production significantly increased in the former and increased further in the *** itself,nicotine did notaffect expression of COX-1,COX-2,any of the PGE2receptors,or M-CSF,but when both nicotine and LPSwere present,expression of COX-2,Ep3,Ep4,and M-CSF increased *** addition of10-4M indomethacin eliminated the effects of nicotine and LPS on ALPase activity,PGE2production,and M-CSF *** of protein kinase A was high in cells cultured with nicotine and *** suggest that LPS enhances the production of nicotine-induced PGE2by an increase in COX-2 expres-sion in osteoblasts,that nicotine-LPS-induced PGE2interacts with the osteoblast Ep4 receptor primarily inautocrine or paracrine mode,and that the nicotine-LPS-induced PGE2then decreases ALPase activity andincreases M-CSF expression.

关键词： nicotine lipopolysaccharide prostaglandin E2 cyclooxygenase-2 Ep4 receptor

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PREDICTING RELEVANT EMPTY SPOTS IN SOCIAL INTERACTION

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Journal of Systems Science & Complexity 2008年第2期21卷 161-171页

作者： Yoshiharu maeno Yukio OHSAWA Graduate School of Systems Management Tsukuba University School of Engineering University of Tokyo

An empty spot refers to an empty hard-to-fill space which can be found in the records of the social interaction, and is the clue to the persons in the underlying social network who do not appear in the records. This contribution addresses a problem to predict relevant empty spots in social interaction. Homogeneous and inhomogeneous networks are studied as a model underlying the social interaction. A heuristic predictor function method is presented as a new method to address the problem. Simulation experiment is demonstrated over a homogeneous network. A test data set in the form of market baskets is generated from the simulated communication. Precision to predict the empty spots is calculated to demonstrate the performance of the presented method.

关键词： Communication empty spot predictor function social interaction social network.

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DATA CRYSTALLIZATION APPLIED FOR DESIGNING NEW PRODUCTS

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Journal of Systems Science and Systems Engineering 2007年第1期16卷 34-49页

作者： Kenichi HORIE Yoshiharu maeno Yukio OHSAWA School of Engineering the University of Tokyo Graduate School of System Management the University of Tsukuba maeno

It is only the observable part of the real world that can be stored in data. For such incomplete and ill-structured data, data crystallizing aims at presenting the hidden structure among events including unobservable events. This is realized by data crystallization, where dummy items, corresponding to potential existence ofunobservable events, are inserted to the given data. These dummy items and their relations with observable events are visualized by applying KeyGraph to the data with dummy items, like the crystallization of snow where dusts are involved in the formation of crystallization of water molecules. For tuning the granularity level of structure to be visualized, the tool of data crystallization is integrated with human＇s process of understanding significant scenarios in the real world. This basic method is expected to be applicable for various real world domains where previous methods of chance-discovery lead human to successful decision making. In this paper, we apply the data crystallization with human-interactive annealing （DCHA） to the design of products in a real company. The results show its effect to industrial decision making.

关键词： Chance discovery data crystallization unobservable events human machine interaction,design

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Camera array calibration for light field acquisition

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Frontiers of Computer Science 2015年第5期9卷 691-702页

作者： Yichao XU Kazuki maeno Hajime NAGAHARA Rin-ichiro TANIGUCHI Graduate School of Information Science and Electrical Engineering Kyushu University Fukuoka 819-0395 Japan

Light field cameras are becoming popular in com- puter vision and graphics, with many research and commercial applications already having been proposed. Various types of cameras have been developed with the camera array being one of the ways of acquiring a 4D light field image using multiple cameras. Camera calibration is essential, since each application requires the correct projection and ray geometry of the fight field. The calibrated parameters are used in the fight field image rectified from the images captured by multiple cameras. Various camera calibration approaches have been proposed for a single camera, multiple cameras, and a moving camera. However, although these approaches can be applied to calibrating camera arrays, they are not effective in terms of accuracy and computational cost. Moreover, less attention has been paid to camera calibration of a light field camera. In this paper, we propose a calibration method for a camera array and a rectification method for generating a light field image from the captured images. We propose a two-step algorithm consisting of closed form initialization and nonlinear refinement, which extends Zhang＇s well-known method to the camera array. More importantly, we introduce a rigid camera constraint whereby the array of cameras is rigidly aligned in the camera array and utilize this constraint in our calibration. Using this constraint, we obtained much faster and more accurate calibration results in the experiments.

关键词： light field camera array calibration rectification digital refocusing

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持续性细胞皱缩在人上皮细胞凋亡过程中的必要性(英文)

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生理学报 2007年第4期59卷 512-516页

作者： SHIMIZU Takahiro maeno Emi OKADA Yasunobu 国立生理学研究所细胞生理学部

持续性细胞皱缩是凋亡发生的一个主要标志。近期研究发现细胞皱缩在细胞凋亡过程中并不是一个被动的次要事件。在各种细胞中,包括人上皮细胞,凋亡因子(apoptogen)刺激后马上发生全细胞皱缩,又称为凋亡性容积减小(apoptotic volume decre... 详细信息

持续性细胞皱缩是凋亡发生的一个主要标志。近期研究发现细胞皱缩在细胞凋亡过程中并不是一个被动的次要事件。在各种细胞中,包括人上皮细胞,凋亡因子(apoptogen)刺激后马上发生全细胞皱缩,又称为凋亡性容积减小(apoptotic volume decrease,AVD),继而发生caspase激活、DNA片段化、细胞破裂死亡。K^+和Cl^-通道的激活导致KCl外流,诱导AVD发生。抑制AVD发生可以抑制细胞凋亡。AVD与调节性容积增加(regulatory volume increase,RVI)异常相伴发生时,人上皮性HeLa细胞发生持续性细胞皱缩。RVI功能受损时,高渗本身就能诱导HeLa细胞持续性细胞皱缩,继而凋亡。即使在正常渗透压、无凋亡因子刺激的情况下,将HeLa细胞置于缺乏Na^+或Cl^-的溶液也会导致细胞持续性皱缩,继而凋亡。因此,AVD诱导和RVI异常所导致的持续性细胞皱缩是人上皮细胞发生凋亡的首要条件。

关键词：凋亡凋亡性容积减小持续性细胞皱缩细胞容积调节人上皮细胞

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Reconstruction of the Unsteady Supersonic Flow around a Spike Using the Colored Background Oriented Schlieren Technique

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Journal of Flow Control, Measurement & Visualization 2013年第2期1卷 69-76页

作者： Friedrich Leopold Masanori Ota Daniel Klatt Kazuo maeno French-German Research Institute of Saint-Louis (ISL) Saint-Louis France Graduate School of Engineering Chiba University Chiba Japan

In this paper, the improved Background Oriented Schlieren technique called CBOS (Colored Background Oriented Schlieren) is described and used to reconstruct the density fields of three-dimensional flows. The Background Oriented Schlieren technique (BOS) allows the measurement of the light deflection caused by density gradients in a compressible flow. For this purpose the distortion of the image of a background pattern observed through the flow is used. In order to increase the performance of the conventional Background Oriented Schlieren technique, the monochromatic background is replaced by a colored dot pattern. The different colors are treated separately using suitable correlation algorithms. Therefore, the precision and the spatial resolution can be highly increased. Furthermore a special arrangement of the different colored dot patterns in the background allows astigmatism in the region with high density gradients to be overcome. For the first time an algebraic reconstruction technique (ART) is then used to reconstruct the density field of unsteady flows around a spike-tipped model from CBOS measurements. The obtained images reveal the interaction between the free-stream flow and the high-pressure region in front of the model, which leads to large-scale instabilities in the flow.

关键词： Unsteady Spike Flow Reconstruction Density Field Schlieren Technique

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经睫状体平坦部行颞上或鼻下Baerveldt青光眼植入术的短期临床疗效比较

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国际眼科杂志 2021年第1期21卷 15-20页

作者： Masashi Sakamoto Izumi Yoshida Takahiro Sodeno Kenichirou Aso Ryuya Hashimoto Hidetaka Masahara Takatoshi maeno Toho大学Sakura医疗中心眼科日本樱井市2858741

目的:研究并探讨Baerveldt青光眼植入术(BGI)的不同植入部位对眼压(IOP)的影响。方法:对日本Toho大学Sakura医疗中心接受BGI治疗的新生血管性青光眼的病例进行回顾性分析。所有患者分为两组:颞上植入组(16例患者18眼,其中男性13例,女性3... 详细信息

目的:研究并探讨Baerveldt青光眼植入术(BGI)的不同植入部位对眼压(IOP)的影响。方法:对日本Toho大学Sakura医疗中心接受BGI治疗的新生血管性青光眼的病例进行回顾性分析。所有患者分为两组:颞上植入组(16例患者18眼,其中男性13例,女性3例;平均年龄62.9±14.4岁)和鼻下植入组(15例患者17眼,其中男性11例,女性4例;平均年龄56.9±10.7岁)。术后12mo随访复查。比较两组术后12mo与术前相比的眼压降低率。结果:颞上植入组:术前平均IOP为31.1±10.0 mmHg,术后平均IOP为14.4±4.5 mmHg;鼻下植入组:术前平均IOP为34.9±9.7 mmHg,术后平均IOP为15.9±3.7 mmHg。颞上植入组IOP降低率为(50.0±19.0)%,鼻下植入组降低率为(51.2±16.3)%。两组间无显著统计学差异(t-test,P=0.590)。结论:经睫状体平坦部行颞上或鼻下BGI的短期临床疗效无差异。

关键词： Baerveldt青光眼植入术眼压颞上鼻下睫状体平坦部

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Sr_2RuO_4的热电势

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物理学报 2002年第3期51卷 655-658页

作者：郑萍陈兆甲王楠林王玉鹏毛志强 Y.maeno 中国科学院物理研究所极端条件物理实验室北京100080 Department of Physics Kyoto UniversityKyoto606-8502Japan

Sr2 RuO4是第一个无CuO面的层状强关联氧化物超导体 .测量了 9至 2 6 0K温度范围内Sr2 RuO4的热电势 ,观测到在此温度范围内其热电势为正值 .用两种载流子模型对实验数据进行了拟合 ,并且与Hall系数的实验结果进行了比较 ,发现低温下两... 详细信息

Sr2 RuO4是第一个无CuO面的层状强关联氧化物超导体 .测量了 9至 2 6 0K温度范围内Sr2 RuO4的热电势 ,观测到在此温度范围内其热电势为正值 .用两种载流子模型对实验数据进行了拟合 ,并且与Hall系数的实验结果进行了比较 ,发现低温下两种载流子对热电势和Hall系数的贡献比较类似 ,但在高温区空穴对热电势的贡献很大而相应地对Hall系数的贡献不占主要地位 .

关键词： Sr2RuO4 热电势层状强关联氧化超导体超导性载流子模型钌氧锶化合物

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Sr_2RuO_4正常态的c方向的磁阻的研究

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物理学报 2001年第9期50卷 1824-1828页

作者：郭忠诚郑萍王楠林陈兆甲 Y.maeno Z.Q.Mao 中国科学院物理研究所极端条件物理开放实验室重庆大学理学院凝聚态物理实验室重庆400044 Department of Physics Kyoto UniversityKyoto 606-8502Japan

研究了典型的层状钙钛矿结构超导单晶Sr2 RuO4在c方向的磁阻 (Δρ ρ0 ) (H∥ab ,J∥c)的变化 .实验发现 ,磁阻表现出强烈的各向异性 ,并且随着温度T的降低 ,磁阻效应越明显 ;当在平面ab内旋转磁场H的方向时 ,磁阻成周期性变化 ;实验表... 详细信息

研究了典型的层状钙钛矿结构超导单晶Sr2 RuO4在c方向的磁阻 (Δρ ρ0 ) (H∥ab ,J∥c)的变化 .实验发现 ,磁阻表现出强烈的各向异性 ,并且随着温度T的降低 ,磁阻效应越明显 ;当在平面ab内旋转磁场H的方向时 ,磁阻成周期性变化 ;实验表明 ,磁场沿 (110 )方向时 ,出现磁阻的极大值 .分别从Sr2 RuO4的费米面的各向异性、载流子散射率、c方向能带色散的各向异性等方面来解释这些输运性质 .

关键词： Sr2RuO4 磁阻正常态高温超导体 c方向各向异性载流子散射率 c方向带色散输运性质

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