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Effects of Bacillus subtilis Var. Natto Products on Capillary Blood Flow in Healthy Subjects with Peripheral Coldness: A Double-Blind, Placebo-Controlled, Randomized Parallel Study

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Food and Nutrition Sciences 2022年第3期13卷 211-223页

作者： Chiharu Fujita Yukio Usui masanori Inoue Laboratory of Cell Applied Technology Kawasaki Kanagawa Japan

Purpose: NKCP®, a natto-derived dietary food supplement whose main component is bacillopeptidase F produced by Bacillus subtilis var. natto, has antithrombotic, fibrinolytic, and pressure-lowering effects, and also is suggested to improve peripheral coldness. However, existing data are based on subjective evaluations with no scientific basis about the effects on peripheral coldness. Therefore, we aimed to investigate the effectiveness of NKCP®for peripheral coldness by measuring changes in blood flow using a laser doppler rheometer and biochemical indices. Patients and Methods: This was a double-blind, randomized, controlled study of individuals aged 30 - 70 years who complained of subjective symptoms of cold hands and feet. They were randomly divided into the NKCP®group and the placebo group to receive NKCP®250 mg once daily and dextrin 250 mg as placebo once daily, respectively. The experiment lasted 8 weeks, with an intervention period of 4 weeks and a washout period of 4 weeks. Results: One-month intake of NKCP®significantly increased blood flow rate for 1 min between 4 and 5 minutes after the end of cold loading compared to that before feeding (p = 0.038). Also, analysis of the 5-minute blood flow rate before and after 4 weeks of feeding showed a significant improvement in the NKCP®group (p = 0.007), although there was no significant difference in the placebo group (p = 0.215). Furthermore, the 5-minute blood flow at 4 weeks after the end of feeding was significantly improved compared to that before feeding in the NKCP®group (p = 0.049). Therefore, the effect continued for at least 1 month after discontinuation of administration. Conclusions: It is possible that NKCP®intake effectively improves blood flow in subjects with peripheral coldness. Therefore, continuous intake of NKCP®is expected to reduce the symptoms of peripheral coldness. In the future, it needs to investigate whether the effect of increasing blood flo

关键词： Peripheral Coldness Blood Flow Bacillus subtilis Functional Foods

Linear Stability Analysis on the Influences of the Spatial Variations in Thermal Conductivity and Expansivity on the Flow Patterns of Thermal Convection with Strongly Temperature-Dependent Viscosity

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Journal of Earth Science 2014年第1期25卷 126-139页

作者： Arata Miyauchi masanori Kameyama Hiroki Ichikawa Geodynamics Research Center Ehime University

A series of linear stability analysis is carried out on the onset of thermal convection in the presence of spatial variations of viscosity, thermal conductivity and expansivity. We consider the temporal evolution of an infinitesimal perturbation superimposed to a static （motionless） and con- ductive state in a basally-heated planar layer. From the changes in flow patterns with increasing the amplitudes of temperature dependence of viscosity, we identified the transition into the ＂stagnant-lid＂（ST） regime, where the convection occurs only beneath a thick and stagnant-lid of cold fluid at the top surface. Detailed analysis showed a significant increase of the aspect ratio of convection cells in ST regime induced by the spatial variations in thermal conductivity and/or expansivity： the horizon- tal length scale of ST convection can be enlarged by up to 50% with 10 times increase of thermal conductivity with depth. We further developed an analytical model of ST convection which success- fully reproduced the mechanism of increasing horizontal length scale of ST regime convection cells for given spatial variations in physical properties. Our findings may highlight the essential roles of the spatial variation of thermal conductivity on the convection patterns in the mantle.

关键词： mantle convection stagnant-lid temperature-dependent viscosity pressure- dependent thermal conductivity pressure-dependent thermal expansivity linear stability analysis.

Protein-losing enteropathy caused by a jejunal ulcer after an internal hernia in Petersen's space: A case report

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World Journal of Clinical Cases 2022年第1期10卷 323-330页

作者： Tomohiko Yasuda Nobuyuki Sakurazawa Komei Kuge Jun Omori Hiroki Arai Daisuke Kakinuma masanori Watanabe Hideyuki Suzuki Katsuhiko Iwakiri Hiroshi Yoshida Department of Gastrointestinal Surgery Nippon Medical School Chiba Hokusoh HospitalChiba 270-1694Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 113-8603Japan Department of Gastroenterology Nippon Medical SchoolTokyo 113-8603Japan

BACKGROUND The incidence of internal hernias has recently increased in concordance with the popularization of laparoscopic *** particular concern are internal hernias occurring in Petersen's space,a space that is surgically created after treatment for gastric cancer and *** hernias cause devastating sequelae,such as massive intestinal necrosis,fatal Roux limb necrosis,and superior mesenteric vein *** addition,protein-losing enteropathy(PLE)is a rare syndrome involving gastrointestinal protein loss,although its relationship with internal Petersen’s hernias remains *** SUMMARY A 75-year-old man with a history of laparotomy for early gastric cancer developed Petersen's hernia 1 year and 5 mo after *** was successfully treated by reducing the incarcerated small intestine and closure of Petersen’s defect without resection of the small *** 3 mo after his surgery for Petersen’s hernia,he developed bilateral leg edema and *** was diagnosed with PLE with an alpha-1 antitrypsin clearance of 733 mL/24 ***-balloon enteroscopy revealed extensive jejunal ulceration as the etiology,and it facilitated minimum bowel *** analysis showed extensive jejunal ulceration and collagen hyperplasia with nonspecific inflammation of all layers without lymphangiectasia,lymphoma,or vascular *** postoperative course was unremarkable,and his bilateral leg edema and hypoalbuminemia improved after 1 *** was no relapse over the 5-year follow-up *** PLE and extensive jejunal ulceration may occur after Petersen's *** enteroscopy helps identify and resect these lesions.

关键词： Internal hernia Ulcer Protein-losing enteropathy Double-balloon enteroscopy Ischemia-reperfusion injury Case report

Cryopreserved fat: our clinical experience and applications

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Plastic and Aesthetic Research 2020年第5期7卷 47-56页

作者： masanori Ohashi The Clinic Tokyo Minato-kuTokyo 106-0031Japan

Aim:Cryopreservation of fat is an effective method for repeat fat grafting,but there are few reports about the clinical use of cryopreserved *** aim of this study was to determine the effectiveness and safety of cryopreserved fat for clinical ***:Between Aug 2015 and Dec 2018,we investigated 590 patients who underwent fat harvesting at our *** harvested fat was cryopreserved at a temperature of-196°C at a cell processing center and injections were performed in our ***:Of the 590 patients studied,216(312 cases)have undergone fat injections so *** augmentations using harvested fat,such as facial and breast augmentations,were performed on 180 *** 84 patients,harvested fat was utilized only for revitalization/fertilization purposes,such as to improve skin *** were no severe complications in any ***,volume maintenance was rarely *** rejuvenation effects were comparable to that in cases using fresh ***:The clinical use of cryopreserved fat is thought to be safe and effective.

关键词： Cryopreserved fat frozen fat fat grafting skin rejuvenation

A New Compound from Chaenomeles sinensis (Thouin) Koehne

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Chinese Chemical Letters 2003年第3期14卷 274-275页

作者： Hui Yuan GAO masanori KUROYANAGI 等 DepartmentofNaturalProductsChemistry ShenyangPharmaceuticaluniverityShenyang110016 SchoolofBioresources HiroshimaPrefecturaluniversity 562Nanatsukacho ShobaraHiroshima727-0023Japan

A new dihydrochromone derivative, named chaenomone, was isolated from the twigs of Chaenomeles sinensis (Thouin) Koehne. The structure was determined by spectroscopic methods.

关键词： Chaenomone Chaenomeles sinensis Rosaceae twigs.

Hydrogen Gas Filling into an Actual Tank at High Pressure and Optimization of Its Thermal Characteristics

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Journal of Thermal Science 2009年第3期18卷 235-240页

作者： Md.Tawhidul Islam Khan masanori Monde Toshiaki Setoguchi Department of Mechanical Engineering Saga University

Gas with high pressure is widely used at present as fuel storage mode for different hydrogen vehicles. Differenttypes of materials are used for constructing these hydrogen pressure vessels. An aluminum lined vessel and typicallycarbon fiber reinforced plastic (CFRP) materials are commercially used in hydrogen vessels. An aluminumlined vessel is easy to construct and posses high thermal conductivity compared to other commercially availablevessels. However, compared to CFRP lined vessel, it has low strength capacity and safety factors. Therefore,nowadays, CFRP lined vessels are becoming more popular in hydrogen vehicles. Moreover, CFRP lined vesselhas an advantage of light weight. CFRP, although, has many desirable properties in reducing the weight and inincreasing the strength, it is also necessary to keep the material temperature below 85 ℃ for maintaining stringentsafety requirements. While filling process occurs, the temperature can be exceeded due to the compression worksof the gas flow. Therefore, it is very important to optimize the hydrogen filling system to avoid the crossing of thecritical limit of the temperature rise. Computer-aided simulation has been conducted to characterize the hydrogenfilling to optimize the technique. Three types of hydrogen vessels with different volumes have been analyzed foroptimizing the charging characteristics of hydrogen to test vessels. Gas temperatures are measured inside representativevessels in the supply reservoirs (H2 storages) and at the inlet to the test tank during filling.

关键词：特性优化充填高压坦克氢气

Optical and scintillation properties of Nd-doped SrAl2O4 crystals

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Journal of Rare Earths 2016年第8期34卷 757-762页

作者： Daisuke Nakauchi Go Okada masanori Koshimizu Takayuki Yanagida Graduate School of Materials Science.Nara Institute of Science and Technology(NAIST)8916-5 Takayama-cho lkoma-shiNara 630-0192Japan Department of Applied Chemistry Graduate School of EngineeringTohoku University 6-6-07 AobaAramakiAoba-ku.Sendai 980-8579.Japan

Nd-doped SrA1204 （Nd：SrA1204） crystals were prepared by a floating zone （FZ） method with different dopant concentra- tions. The photoluminescence （PL） measurements under visible light excitations confirmed strong near infrared （NIR） emissions around 890 nm, which is due to the 4f-4f transitions of Nd3＋, and the decay time constants were 300-400 μs. Furthermore, VUV ex- citations revealed two broad emissions around 250450 and 500-700 run, which were attributed to self-trapped excitons （STEs） perturbed by Nd3＋. Moreover, the X-ray induced scintillation spectra showed some small peaks at around 380 nm in addition to NIR emissions at 1064 nm similarly seen in PL. The former scintillation decay time constants were 30-40 Its. In the undoped sample, these emissions mentioned above were not present but a weak broad emission around 450 nm appeared. In thermally stimulated lu- minescence （TSL） after X-ray irradiation, strong TSL glow peaks were observed in the Nd-doped samples at around 100 and 250 ℃.

关键词： scintillation photoluminescence storage luminescence single crystal rare earths

Optimal turning method of composting regarding hygienic safety

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Journal of Environmental Sciences 2005年第2期17卷 194-199页

作者： Masafumi Tateda Le Duc Trung Michihiko Ike masanori Fujita Department of Environmental Systems Engineering College of Technology Toyama Prefectural University 5180 Kurokawa Kosugi Imizu Toyama 939-0398 JapanDepartment of Environmental Engineering Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 JapanDepartment of Environmental Engineering Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 JapanDepartment of Environmental Engineering Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan

The new turning method was proposed and verified its effectiveness to pathogens by laboratory scale experiments. Considering the results obtained from the previous studies, it could be said that turning of a composting pile was essential in terms of hygienic aspects but the number of turning should be minimized. Effectiveness of inactivation was estimated for each composting run. From this estimation, turning by layers, which is different from conventional turning that mixes compost pile entirely, was proposed and investigated its performance by experiments. Composting operations with static pile method, complete mix(conventional) turning method, and proposed turning(layer turning) method were done and their effectiveness on inactivation of indicator microorganism was evaluated and compared. As results, the conventional turning method was not a proper method in terms of pathogen inactivation, whereas, the proposed turning method showed an excellent performance and should be employed in a composting operation.

关键词： composting turning inactivation hygienic safety

Understanding of the activity difference between nanogold and bulk gold by relativistic effects

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Journal of Energy Chemistry 2015年第4期24卷 485-489页

作者： Keju Sun masanori Kohyama Shingo Tanaka Seiji Takeda The Institute of Scientific and Industrial Research Osaka University Research Institute for Ubiquitous Energy Devices National Institute of Advanced Industrial Science and Technology (AIST)

It is a challenge to thoroughly understand the astonishing difference in catalytic activity between nanogold and bulk gold for some oxidation reactions. In this work,the Au–O interactions in various surroundings were investigated by DFT calculations and compared with the Ag–O interactions. We have found the three ***,only Au–O bond can be significantly strengthened by the linear O–Au–O structure. Second,the Au–O bond is always stronger than the Ag–O bond when the bonds are embedded in common surroundings. Third,the Au–O bond becomes weaker than the Ag–O bond when the number of neighboring Au atoms becomes large,because the Au–O interactions are suppressed by the presence of neighboring gold atoms. The origin of these three points can be attributed to wider spatial extension of d orbitals of gold,induced by strong relativistic effects. The strong relativistic effects make nanogold with smaller coordinate numbers highly active due to the ease in forming strong Au–O bonds,especially for the O–Au–O bond,whereas gold atoms in bulk with larger coordination numbers chemically inert due to the strong suppression by neighboring gold atoms destabilizing the O–Au–O bond.

关键词： Nanogold Au–O interactions Relativistic effects DFT calculations