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国外畜牧学（猪与禽） 2007年第4期27卷 48-51页

作者：任彬（译）常飞（校） Takemi OHBA Tomoyuki Shibahara Hideki Kobayashi masanori kubo Ariko Takaahima ShigenoriImai Satoshi Murakami Koichi Kadota 不详富土山县肉品检验中心日本国家动物健康协会流行病学部东京大学农业专科学校动物科学系日本国家动物健康协会北海道研究所

六月龄去势公猪表现昏睡、食欲不振、站立困难。尸检发现脾脏边缘呈多重出血灶。从脾脏、肾脏、肌肉和肝脏中分离出革兰氏阳性杆菌,对分离株(TO16177)的16S rDNA基因序列比较分析发现,其可能与未发表过的隐秘杆菌属HJ57-14E菌株(登记号:... 详细信息

六月龄去势公猪表现昏睡、食欲不振、站立困难。尸检发现脾脏边缘呈多重出血灶。从脾脏、肾脏、肌肉和肝脏中分离出革兰氏阳性杆菌,对分离株(TO16177)的16S rDNA基因序列比较分析发现,其可能与未发表过的隐秘杆菌属HJ57-14E菌株(登记号:gi18873551)(比较675bp个碱基,相似性达99.7%)为同一个属。脾脏组织切片的组织学检查发现呈广泛性坏死和炎症,其中革兰氏阳性杆菌显而易见。肝脏中可见多病灶的坏死斑。免疫组织化学检测发现,分离株与抗化脓性隐秘杆菌属(Arcanobacterium pyogenes)和内氏放线菌(Actinomyces naeslundii)的多克隆抗体具有交叉反应,且与后者的交叉反应更强烈。相似的反应也见于扁桃体的化脓灶中分离株,偶尔也见于脾脏和淋巴结中的分离株。本研究结果表明,这种未公开发布的隐秘杆菌属的细菌会引起生长肥育猪多器官功能衰竭,而后继发急性出血性坏死性脾炎。

关键词：隐秘杆菌属出血性坏死性脾炎 HJ57-14E菌株

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Heparin bridge therapy and post-polypectomy bleeding

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World Journal of Gastroenterology 2016年第45期22卷 10009-10014页

作者： Toshiyuki kubo Kentaro Yamashita Kei Onodera Tomoya Iida Yoshiaki Arimura masanori Nojima Hiroshi Nakase Department of Gastroenterology and Hepatology Sapporo Medical University Department of Gastroenterology Otaru City General Hospital Center for Translational Research the Institute of Medical Science the University of Tokyo

AIM To identify risk factors for post-polypectomy bleeding(PPB), focusing on antithrombotic agents. METHODS This was a case-control study based on medical records at a single center. PPB was defined as bleeding that occurred 6 h to 10 d after colonoscopic polypectomy and required endoscopic hemostasis. As risk factors for PPB, patient-related factors including anticoagulants, antiplatelets and heparin bridge therapy as well as polyp- and procedure-related factors were evaluated. All colonoscopic hot polypectomies, endoscopic mucosal resections and endoscopic submucosal dissections performed between January 2011 and December 2014 were reviewed. RESULTS PPB occurred in 29(3.7%) of 788 polypectomies performed during the study period. Antiplatelet or anticoagulant agents were prescribed for 210(26.6%)patients and were ceased before polypectomy except for aspirin and cilostazol in 19 cases. Bridging therapy using intravenous unfractionated heparin was adopted for 73 patients. The univariate analysis revealed that anticoagulants, heparin bridge, and anticoagulants plus heparin bridge were significantly associated with PPB(P < 0.0001) whereas antiplatelets and antiplatelets plus heparin were not. None of the other factors including age, gender, location, size, shape, number of resected polyps, prophylactic clipping and resection method were correlated with PPB. The multivariate analysis demonstrated that anticoagulants and anticoagulants plus heparin bridge therapy were significant risk factors for PPB(P < 0.0001). Of the 29 PPB cases, 4 required transfusions and none required surgery. A thromboembolic event occurred in a patient who took anticoagulant. CONCLUSION Patients taking anticoagulants have an increased risk of PPB, even if the anticoagulants are interrupted before polypectomy. Heparin-bridge therapy might be responsible for the increased PPB in patients taking anticoagulants.

关键词： Post-polypectomy 流血肝磷脂桥治疗结肠的 polypectomy 抗凝剂 Antiplatelets 内视镜的外科

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Solar power sail mission of OKEANOS

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Astrodynamics 2020年第3期4卷 233-248页

作者： Osamu Mori Jun Matsumoto Toshihiro Chujo masanori Matsushita Hideki Kato Takanao Saiki Yuichi Tsuda Jun'ichiro Kawaguchi Fuyuto Terui Yuya Mimasu Go Ono Naoko Ogawa Yuki Takao Yuki kubo Kaoru Ohashi Ahmed Kiyoshi Sugihara Tatsuaki Okada Takahiro Iwata Hajime Yano Japan Aerospace Exploration Agency Sagarmihara 252-5210Japan Tokyo Institute of Technology Tokyo 152-8550Japan The University of Tokyo Tokyo 113-8654Japan Patchedconics LLCSagarmihara 252-5210Japan

The solar power sail is an original Japanese concept in which electric power is generated by thin-film solar cells attached on the solar sail *** Aerospace Exploration Agency(JAXA)successfully demonstrated the world’s first solar power sail technology through IKAROS(Interplanetary Kite-craft Accelerated by Radiation of the Sun)mission in *** demonstrated photon propulsion and power generation using thin-film solar cells during its interplanetary *** up,solar power sails can generate enough power to drive high specific impulse ion thrusters in the outer planetary *** this concept,we propose a landing or sample return mission to directly explore a Jupiter Trojan asteroid using solar power sail-craft OKEANOS(Oversize Kite-craft for Exploration and AstroNautics in the Outer Solar System).After rendezvousing with a Trojan asteroid,a lander separates from OKEANOS to collect samples,and perform in-situ analyses in three proposed mission sequences,including sending samples back to *** paper proposes a system design for OKEANOS and includes analyses of the latest mission.

关键词： solar power sail Trojan asteroid landing in-situ analysis outer solar system OKEANOS

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Hepatoma-derived growth factor expression as a prognostic marker in cervical cancer

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World Journal of Obstetrics and Gynecology 2015年第1期4卷 16-23页

作者： Misa Song Miki Tomoeda Yu-Feng Jin Chiaki kubo Hidenori Yoshizawa masanori Kitamura Shigenori Nagata Yukinobu Ohta Shoji Kamiura Hideji Nakamura Yasuhiko Tomita Department of Pathology Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Gynecology Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Internal Medicine Nissay Hospital

AIM: To examine the association of hepatoma-derived growth factor(HDGF) expression with the prognosis of patients with cervical cancer of the uterus(CC). METHODS: HDGF is a unique nuclear growth factor, and it may play an important role in the development and progression of carcinoma. HDGF expression in 88 CC patients aged 23 to 76 years(median, 54 years) was analyzed by immunohistochemistry. A rabbit polyclonal antibody against the C-terminal amino acids(aa 231-240) of the human HDGF sequence was used as primary antibody at a dilution of 1:5000. This specific anti-HDGF antibody was purified using C-terminal peptide-conjugated Sepharose columns. Staining of endothelial cells in the noncancerous areas of each specimen was used as an internal positive control. Samples with more than 80% of tumor cells showing positive immunoreactivity in both the nucleus and cytoplasm were regarded as HDGF index level 2, more than 80% positive immunoreactivity in either the nucleus or cytoplasm as level 1, and less than 80% in both the nucleus and cytoplasm as level 0. The chisquare test and Fisher's exact probability test were used to examine the relationship between HDGF expression and clinicopathologic parameters, and statistical significance was examined by the log-rank test. Multivariate analysis of factors related to survival was performed using Cox's proportional hazards regression model. Statistical significance was set at P < 0.05. RESULTS: The five-year overall survival rate was 82.9%. Fourteen patients died due to tumors, nine of whom had tumor recurrence at 2-21 mo(median, 10 mo) after surgery. Tumor recurrence in five patients was determined at the time of the patients' deaths. Nineteen cases were regarded as HDGF index level 0, 11 as level 1, and 58 as level 2. Patients with level 2 expression showed higher rates of histological classification of keratinized squamous cell carcinomaand adenosquamous carcinoma(44.8% of level 2 patients and 13.3% in levels 0 and 1), deep in

关键词：肝癌宫颈癌治疗方法临床分析

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