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Prolonged survival in patients with hand-foot skin reaction secondary to cooperative sorafenib treatment

World Journal of Gastroenterology 2021年第32期27卷 5424-5437页

作者： masanori Ochi Toshiro Kamoshida Masahiro Araki Tadashi Ikegami Department of Gastroenterology Hitachi General HospitalIbaraki 317–0077Japan Department of Gastroenterology and Hepatology Ibaraki Prefectural Central HospitalIbaraki Cancer CenterIbaraki 309-1793Japan Division of Gastroenterology and Hepatology Tokyo Medical University Ibaraki Medical CenterIbaraki 309-1793Japan

BACKGROUND Sorafenib is an oral drug that prolongs overall survival(OS)in patients with hepatocellular *** events,including hand-foot skin reaction(HFSR),lead to permanent sorafenib *** To clarify the association between interventions for adverse events and patient *** We performed a retrospective,multicenter study of patients treated with sorafenib monotherapy between May 2009 and March *** developed a mutual cooperation system that was initiated at the start of sorafenib treatment to effectively manage adverse *** mutual cooperation system entailed patients receiving consultations during which pharmacists provided accurate information about sorafenib to alleviate the fear and anxiety related to adverse *** stratified the patients into three groups:Group A,patients without HFSR but with pharmacist intervention;Group B,patients with HFSR and pharmacist interventions unreported to oncologists(nonmutual cooperation system);and Group C,patients with HFSR and pharmacist interventions known to oncologists(mutual cooperation system).OS and time to treatment failure(TTF)were evaluated using the Kaplan-Meier *** We enrolled 134 patients(Group A,n=41;Group B,n=30;Group C,n=63).The median OS was significantly different between Groups A and C(6.2 vs 13.9 mo,p<0.01)but not between Groups A and B(6.2 vs 7.7 mo,P=0.62).Group A vs Group C was an independent OS predictor(HR,0.41;95%CI:0.25-0.66;P<0.01).In Group B alone,TTF was significantly lower and the nonadherence rate was higher(P<0.01).In addition,the Spearman’s rank correlation coefficients between OS and TTF in each group were 0.41(Group A;P<0.01),0.13(Group B;P=0.51),and 0.58(Group C;P<0.01).There was a highly significant correlation between OS and TTF in Group ***,there was no correlation between OS and TTF in Group *** The mutual cooperation system increased treatment duration and improved prognosis in patients with *** prospect

关键词： Hepatocellular carcinoma Sorafenib Pharmacists Oncologists Prognosis Duration of therapy

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Biodegradability of four phthalic acid esters under anaerobic condition assessed using natural sediment

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Journal of Environmental Sciences 2006年第4期18卷 793-796页

作者： Ruttapol Lertsirisopon Satoshi Soda Kazunari Sei Michihiko Ike masanori Fuj ita Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita Osaka Japan.

Biodegradability of di-n-butyl phthalate （DBP）, butylbenzyl phthalate （BBP）, di-ethylhexyl phthalate （DEHP）, and di-isononyl phthalate （DINP） under an anaerobic condition was evaluated using three natural sediment microcosms obtained from ponds in Osaka, which had not been significantly polluted by the chemicals. The degradabilities of the four phthalic acid esters（PAEs） were analyzed by a first-order kinetic model with a lag phase and ranked as DBP〉BBP〉〉DEHP〉DINP. The PAEs with shorter alkyl-chains, DBP and BBP, were degraded with quite short lag phases near to zero and short half-lives of a few days. The PAEs with longer alkyl-chains, DEHP and DINP, were degraded with lag phases of 5-30 d and the quite long half-lives of a couple of hundred days. Although no data was available on the anaerobic biodegradability of D1NP before this study, it was clarified that DINP can be degraded with slow degradation rates. The fact that all the three intact sediments were capable of biodegradation of the PAEs suggests that potential of anaerobic biodegradation of PAEs is widespread in the aquatic environment.

关键词： phthalic acid esters anaerobic biodegradation sediment first-order kinetics

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Two-dimensional optical tomography of hemodynamic changes in a preterm infant brain

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Chinese Optics Letters 2007年第8期5卷 472-474页

作者：高峰薛媛赵会娟 Takashi Kusaka masanori Ueno Yukio Yamada College of Precision Instrument and Optoelectronics Engineering Tianjin University Faculty of Medicine Kagawa University Kagawa 761-0793Japan Department of Mechanical Engineering and Intelligent Systems University of Electro-Communications Tokyo 182-8585Japan

Our preliminary results on two-dimensional （2D） optical tomographic imaging of hemodynamic changes in a preterm infant brain are reported. We use the established 16-channel time-correlated single photon counting system for the detection and generalized pulse spectrum technique based algorithm for the image reconstruction. The experiments demonstrate that diffuse optical tomography may be a potent means for investigating brain functions and neural development of infant brains in the perinatal period.

关键词： In Two-dimensional optical tomography of hemodynamic changes in a preterm infant brain

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Prediction of Acoustic Absorption Performance of a Perforated Plate with Air Jets

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Journal of Thermal Science 2017年第4期26卷 378-384页

作者： Hiromitsu Hamakawa masanori Miyazaki Yuta Asai Eru Kurihara Eiichi Nishida Hidechito Hayashi Department of Mechanical Engineering Oita University700 DannoharuOita 870-1192Japan Graduate Student Oita University700 DannoharuOita 870-1192Japan Department of Mechanical Systems Engineering Shonan Institute of Technology1-1-25 Tsujido-NishikaiganFuji-sawaKanagawa 251-8511Japan Department of Mechanical Engineering Nagasaki University1-14 Bunkyo machiNagasaki852-8521Japan

The present study focuses on the prediction of acoustic absorption performance of a perforated plate with air jets by theoretical calculations. In addition, we experimentally measured the flow rate, internal pressure, acoustic pressure, and transfer function using an acoustic impedance tube. The normal incidence absorption coefficient was calculated from the measured transfer function using transfer function methods. We investigated the influences of background air space, flow velocity, thickness, aperture rate, and aperture diameter of a perforated plate on the acoustic absorption characteristics. The frequency characteristics of the acoustic absorption coefficient showed a maximum value at a local frequency. As the background air space increased, the peak frequency of acoustic absorption characteristics decreased. As the flow velocity passing through the apertures increased, the peak level of the acoustic absorption coefficient also increased. The theoretical results agreed well with the experimental ones qualitatively.

关键词： acoustic absorption perforated plate theoretical prediction acoustic impedance tube air jets

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A Study of Under-expanded Moist Air Jet Impinging on a Flat Plate

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Journal of Thermal Science 2005年第4期14卷 334-340页

作者： Yumiko OTOBE Shigeru MATSUO masanori TANAKA Hideo KASHIMURA Heuy-Dong KIM Toshiaki SETOGUCHI Department of Control and Information Systems Engineering Kitakyushu National College of Technology5-20-1ShiiKokuraminami-kuKitakyushu-shiFukuoka 802-0985Japan Department of Mechanical Engineering Saga University1Honjo-machiSaga-shiSaga 840-8502Japan School of Mechanical Engineering College of Natural ScienceAndong National University388Song Cheon DongAndongKyung PookKorea

When a gas expands through a convergent nozzle in which the ratio of the ambient to the stagnation pressures is higher than that of the critical one, the issuing jet from the nozzle is under-expanded. If a flat plate is placed normal to the jet at a certain distance from the nozzle, a detached shock wave is formed at a region between the nozzle exit and the plate. In general, supersonic moist air jet technologies with non-equilibrium condensation are very often applied to industrial manufacturing processes. In spite of the importance in major characteristics of the supersonic moist air jets impinging to a solid body, its qualitative characteristics are not known satisfactorily. In the present study, the effect of the non-equilibrium condensation on the under-expanded air jet impinging on a vertical flat plate is investigated numerically in the case with non-equilibrium condensation, frequency of oscillation for the flow field becomes larger than that without the non-equilibrium condensation, and amplitudes of static pressure become small compared with those of dry air. Furthermore, the numerical results are compared with experimental ones.

关键词： compressible flow non-equilibrium condensation impinging jet simulation.

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Effect of Axisymmetric Sonic Nozzle Geometry on Characteristics of Supersonic Air Jet

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Journal of Thermal Science 2004年第2期13卷 121-126页

作者： Shigeru MATSUO masanori TANAKA Yumiko OTOBE Hideo KASHIMURA Heuy-Dong KIM Toshiaki SETOGUCHI Department of Mechanical Engineering Saga University 1 Honjo-machi Saga-shi Saga 840-8502 Japan Department of Control and Information Systems Engineering Kitakyushu National College of Technology 5-20-1 Shii Kokuraminami-ku Kitakyushu-shi Fukuoka 802-0985 Japan School of Mechanical Engineering College of Natural Science Andong National University 388 Song-Cheon Dong Andong Kyung-Pook Korea

The effect of nozzle geometry on sonic line and characteristics of supersonic air jet was studied. Computational fluid dynamics was applied in this study. The axisymmetric nozzle geometries investigated were two different contour converging nozzles, two different conically converging sharp-edged nozzles and a sharp-edged orifice. The results show that the supersonic jet structure, sonic line and streamlines in supersonic jet are strongly influenced by the nozzle geometry, and the total pressure loss increases with the increase of Mach disk diameter. The present numerical simulation is an effective tool to evaluate compressible flows in supersonic air jet.

关键词： compressible flow supersonic jet non-equilibrium condensation simulation.

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Sorption of biodegradation end products of nonylphenol polyethoxylates onto activated sludge

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Journal of Environmental Sciences 2004年第4期16卷 564-569页

作者： Nguyen Viet Hung Masafumi Tateda Michihiko Ike masanori Fujita Shinji Tsunoi Minoru Tanaka Department of Environmental Engineering Graduate School of EngineeringOsaka University 2-1 Yamada-oka Suita Osaka 565-0871 Japan Department of Environmental Systems Technology College of Technology Toyama Prefectural University 5180 Kurokawa Kosugi Imizu Toyama 939-0398 Japan Research Center for Environmental Preservation Osaka University 2-4 Yamada-oka Suita Osaka 565-0871 Japan

Nonylphenol(NP), nonylphenoxy acetic acid(NP1EC), nonylphenol monoethoxy acetic acid(NP2EC), nonylphenol monoethoxylate(NP1EO) and nonylphenol diethoxylate(NP2EO) are biodegradation end products(BEPs) of nonionic surfactant nonylphenolpolyethoxylates (NPnEO). In this research, sorption of these compounds onto model activated sludge was characterized. Sorption equilibrium experiments showed that NP, NP1EO and NP2EO reached equilibrium in about 12 h, while equilibrium of NP1EC and NP2EC were reached earlier, in about 4 h. In sorption isotherm experiments, obtained equilibrium data at 28℃ fitted well to Freundlich sorption model for all investigated compounds. For NP1EC, in addition to Freundlich, equilibrium data also fitted well to Langmuir model. Linear sorption model was also tried, and equilibrium data of all NP, NP1EO, NP2EO and NP2EC except NP1EC fitted well to this model. Calculated Freundlich coefficient(K F) and linear sorption coefficient(K D) showed that sorption capacity of the investigated compounds were in order NP>NP2EO>NP1EO>NP1EC≈NP2EC. For NP, NP1EO and NP2EO, high values of calculated K F and K D indicated an easy uptake of these compounds from aqueous phase onto activated sludge. Whereas, NP1EC and NP2EC with low values of K F and K D absorbed weakly to activated sludge and tended to preferably remain in aqueous phase.

关键词： activated sludge biodegradation end products endocrine disruptor nonylphenol polyethoxylates sorption

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Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis

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World Journal of Gastroenterology 2006年第1期12卷 10-16页

作者： masanori Ito Shinji Tanaka Tomoari Kamada Ken Haruma Kazuaki Chayama Department of Medicine and Molecular Science Hiroshima UniversityHiroshimaJapan Department of Endoscopy Hiroshima University HospitalHiroshimaJapan Gastroenterology Unit Department of Internal MedicineKawasaki Medical SchoolKurashikiJapan

Many epidemiological reports indicate that Helicobacter pylori （H pylori） infection plays an important role in gastric carcinogenesis. Several genetic and epigenetic alterations contribute to the initiation, promotion, and progression of the cancer cells in a multi-step manner. H pylori is known to induce chronic inflammation in the gastric mucosa. Its products, including superoxides, participate in the DNA damage followed by initiation, and the inflammation-derived cytokines and growth factors contribute to the promotion of gastric carcinogenesis. By eradicating H pylori, gastric inflammation can be cured; the therapy diminishes the levels not only of inflammatory cell infiltration, but also atrophy/ intestinal metaplasia in part. A randomized controlled trial revealed that the eradication therapy diminished the gastric cancer prevalence in cases without precancerous conditions. In addition, recent epidemiological studies from Japanese groups demonstrated that the development of gastric cancer, especially of the intestinal type, was decreased by successful eradication therapy, although these were designed in a non- randomized manner. However, it should be mentioned that endoscopic detection is the only way to evaluate the degree of gastric carcinogenesis. We have reported that the endoscopic and histological morphologies could be modified by eradication therapy and it might contribute to the prevalence of gastric cancer development. Considering the biological nature of cancer cell proliferation, it is considered that a sufficiently long-term follow-up would be essential to discuss the anticancer effect of eradication therapy.

关键词： H pylori Eradication Gastritis Gastric neoplasm, Endoscopy

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Construction of Design Guidelines for Optimal Automotive Frame Shape Based on Statistical Approach and Mechanical Analysis

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Computer Modeling in Engineering & Sciences 2021年第8期128卷 731-742页

作者： masanori Honda Chikara Kawamura Isamu Kizaki Yoichi Miyajima Akihiro Takezawa Mitsuru Kitamura Mazda Motor Corporation 3-1 ShinchiFuchu-choAki-gunHiroshima730-8670Japan Department of Applied Mechanics and Aerospace Engineering School of Fundamental Science and EngineeringWaseda University3-4-1 OkuboShinjuku-kuTokyo169-8555Japan Division of Advanced Science and Engineering Graduate School of Advanced Science and EngineeringHiroshima University1-4-1 KagamiyamaHigashihiroshimaHiroshima739-8527Japan

A body frame composed of thin sheet metal is a crucial structure that determines the safety performance of a *** a correct weight and high-performance automotive body is an emerging engineering *** improve the performance of the automotive frame,we attempt to reconstruct its design criteria based on statistical and mechanical *** first,a fundamental study on the frame strength is conducted and a cross-sectional shape optimization problem is developed for designing the cross-sectional shape of an automobile frame having a very high mass efficiency for *** optimization is carried out using the nonlinear finite element method and a meta-modeling-based genetic *** analysis of the obtained set of optimal results is performed to identify the dominant design variables by employing the smoothing spline analysis of variance,the principal component analysis,and the self-organizing map *** relationship between the cross-sectional shape and the objective function is also analyzed by hierarchical clustering.A design guideline is obtained from these statistical approach results.A comparison between the statistically obtained design guideline and the conventional one based on the designers’experience is performed based on mechanical interpretation of the optimal cross-sectional ***,a mechanically reasonable new general-purpose design guideline is proposed for the cross-sectional shape of the automotive frame.

关键词： Automotive structure shape optimization data mining statistical approach crash-performance

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Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis

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World Journal of Gastroenterology 2012年第47期18卷 6935-6942页

作者： Kazuya Shinmura masanori Goto Hong Tao Shun Matsuura Tomonari Matsuda Haruhiko Sugimura Department of Tumor Pathology Hamamatsu University School of MedicineShizuoka 431-3192Japan Research Center for Environmental Quality Management Kyoto UniversityShiga 520-0811Japan

AIM:To investigate the suppressive activity of MUTYH variant proteins against mutations caused by oxidative lesion,8-hydroxyguanine(8OHG),in human ***:p.R154H,p.M255V,p.L360P,and p.P377L MUTYH variants,which were previously found in patients with colorectal polyposis and cancer,were selected for use in this *** H1299 cancer cell lines inducibly expressing wild-type(WT) MUTYH(type 2) or one of the 4 above-mentioned MUTYH variants were established using the piggyBac transposon vector system,enabling the genomic integration of the transposon sequence for MUTYH *** expression was examined after cumate induction using Western blotting analysis and immunofluorescence *** intracellular localization of MUTYH variants tagged with FLAG was also immunofluorescently ***,the mutation frequency in the supF of the shuttle plasmid pMY189 containing a single 8OHG residue at position 159 of the supF was compared between empty vector cells and cells expressing WT MUTYH or one of the 4 MUTYH variants using a supF forward mutation ***:The successful establishment of human cell lines inducibly expressing WT MUTYH or one of the 4 MUTYH variants was concluded based on the detection of MUTYH expression in these cell lines after treatment with *** of the MUTYH variants and WT MUTYH were localized in the nucleus,and nuclear localization was also observed for FLAG-tagged *** mutation frequency of supF was 2.2 × 10-2 in the 8OHG-containing pMY189 plasmid and 2.5 × 10-4 in WT pMY189 in empty vector cells,which was an 86-fold increase with the introduction of *** mutation frequency(4.7 × 10-3) of supF in the 8OHG-containing pMY189 plasmid in cells overexpressing WT MUTYH was significantly lower than in the empty vector cells(P < 0.01).However,the mutation frequencies of the supF in the 8OHG-containing pMY189 plasmid in cells overexpressing the p.R154H,p.M255V,p.L360P,or p.P377L MUTYH variant were 1.84 × 10-2,1.55 × 10-2

关键词： 8-hydroxyguanine Mutation MUTYH MUTYH-associated polyposis Oxidative mutagenesis supF forward mutation assay piggyBac transposon Colorectal polyposis

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