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联合两性霉素B和四环素对真菌菌丝生长的影响

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国外医药（抗生素分册） 1990年第3期11卷 217-220页

作者： masamichi Otsuka 朱汝锦

1956年Gold等发现了两性霉素B(AMPHB),并用于深度和浅表真菌病的治疗。AMPH B具有广的杀真菌谱和有效性,其耐药性获得也非常缓慢。然而,AMPH B尚存在某些缺点:对一些组织包括肾有毒性;它难溶于水,口服时很少进入血液;AMPH B对小鼠的急... 详细信息

1956年Gold等发现了两性霉素B(AMPHB),并用于深度和浅表真菌病的治疗。AMPH B具有广的杀真菌谱和有效性,其耐药性获得也非常缓慢。然而,AMPH B尚存在某些缺点:对一些组织包括肾有毒性;它难溶于水,口服时很少进入血液;AMPH B对小鼠的急性毒性相当高,小鼠静注时ED_(50)。为11～15mg/kg;当人静注AMPH B可观察到呕吐、寒战和血尿,因此尽可能减少剂量以降低毒性。尽管四环素(TC)没有抗真菌作用,但是它能阻止70S核糖体或氨酰-t-RNA30S亚基的结合而抑制细菌生长。不过。

关键词：两性霉素B 四环素真菌菌丝生长

Prosthetic Ring Endocarditis with Shrunken Mitral Annulus Late After Undersized Mitral Annuloplasty

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Open Journal of Thoracic Surgery 2014年第3期4卷 62-65页

作者： Masaki Hamamoto Taira Kobayashi masamichi Ozawa Hiroshi Kodama Department of Cardiovascular Surgery JA Hiroshima General Hospital Hiroshima Japan

We report a case of supra-annular mitral valve replacement for a patient with prosthetic ring endocarditis that developed late after undergoing undersized mitral annuloplasty (UMAP). A 58-year-old man had undergone left ventriculoplasty and UMAP with a 26-mm semi-rigid full ring for dilated cardiomyopathy and functional mitral regurgitation. The mitral valve had progressively stenosed and he developed prosthetic ring endocarditis 5 years after the operation. In the surgery, there were brownish fresh vegetations around the anterior mitral leaflet and the prosthetic ring. The mitral annulus was very small, even after removal of the infected ring prosthesis and debridement of the infected tissues. We implanted a 22-mm mechanical prosthesis in the supra-annular position using everting mattress sutures to prevent the valve leaflets from getting stuck by the thickened subannular tissue. Herein, we discuss the surgical procedures for a shrunken mitral annulus.

关键词： Undersized Mitral Annuloplasty Shrunken Mitral Annulus Supra-Annular Mitral Valve Replacement

Pediatric Cardiac Surgical Patterns of Practice and Outcomes in Europe and China:An Analysis of the European Congenital Heart Surgeons Association Congenital Heart Surgery Database

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Congenital Heart Disease 2021年第1期16卷 17-25页

作者： Claudia Herbst Haibo Zhang Renjie Hu Jürgen Hörer masamichi Ono Vladimiro Vida Tjark Ebels Andrzej Kansy Jeffrey P.Jacobs Zdzislaw Tobota Bohdan Maruszewski Department of Surgery Division of Cardiac Surgery and Pediatric Heart CenterMedical University ViennaViennaAustria Department of Pediatric Cardiothoracic Surgery Shanghai Children’s Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Department for Congenital and Pediatric Heart Surgery German Heart Center MunichTechnische Universität MünchenDivision for Congenital and Pediatric Heart SurgeryUniversity Hospital of MunichLudwig-Maximilians-UniversitätMunichGermany Pediatric and Cardiac Surgery Unit Department of Cardio Thoracic Vascular Sciences and Public HealthUniversity of PaduaPaduaItaly Department of Cardiothoracic Surgery University Medical Center GroningenGroningenThe Netherlands Cardiothoracic Surgery Amsterdam University Medical CenterAmsterdamThe Netherlands Pediatric Cardiothoracic Surgery Children’s Memorial Health InstituteWarsawPoland St.Petersburg FLUSA

Background:The European Congenital Heart Surgeons Association(ECHSA)Congenital Heart Surgery Database(CHSD)was founded in 1999 and is open for worldwide *** current dataset includes a large amount of surgical data from both Europe and *** purpose of this analysis is to compare patterns of practice and outcomes among pediatric congenital heart defect surgeries in Europe and China using the ***:We examined all European(125 centers,58,261 operations)and Chinese(13 centers,23,920 operations)data in the ECHSA-CHSD from *** mortality,postoperative length of stay,median patient age and weight were calculated for the ten benchmark operations for China and Europe,***:Benchmark procedure distribution frequencies differed between Europe and *** China,ventricular septal defect repair comprised approximately 70%of procedures,while Norwood operations comprised less than one percent of all *** cardiac procedures were rare in China *** procedures in STAT mortality category 1,Chinese centers had lower operative mortality rates,while procedures in categories 3 and 5 mortality is lower in European *** mortality over the time period decreased from 3.89%to 1.64%for the whole cohort,with a sharper decline in *** drop coincides with an increase of submitted procedures over this ***:Chinese centers had higher programmatic volume of congenital heart surgeries,while European centers have a more complex case *** for patients with functionally univentricular heart was performed less commonly in *** comparison of patterns of practice and outcomes demonstrate opportunities for continuing bidirectional transcontinental collaboration and quality improvement.

关键词： Outcomes congenital heart surgery China Europe database

Potential Power of the Pyramidal Structure III: Discovery of Pyramid Effects with and without Seasonal Variation

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Natural Science 2020年第12期12卷 743-753页

作者： Osamu Takagi masamichi Sakamoto Hideo Yoichi Kimiko Kawano Mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Since October 2007, we have been conducting rigorous scientific research on the unexplained “power” of a pyramidal structure (PS). From our research results so far, we could classify the pyramid effects by the PS into the following two types. (i) The pyramid effects in which the PS converted the test subject’s unexplained energy to affect biosensors when the test subject entered the PS and meditated. (ii) The pyramid effects in which the potential power of the PS affected biosensors if the test subject had not been inside the PS for at least 20 days and the test subject’s unexplained energy was excluded. In this paper, we report new results regarding (ii). As a result of dividing a year according to the four seasons of winter, spring, summer, and autumn and analyzing the pyramid effect of each period, the following points were found. 1) There was a pyramid effect without seasonal variation. The pyramid effect on the lower and upper layers was different throughout the year for the biosensors placed at the PS apex in two layers, regardless of the season. 2) There was a pyramid effect with seasonal variation. The value of the psi index, which indicates the magnitude of the pyramid effect, changed as the seasons changed, while different pyramid effects were maintained on the lower and upper layers. Regarding the change in the pyramid effect depending on the season, the psi index in summer was larger than that in winter in both the lower and upper layers. From these results, we found that there are two types of potential power at the PS apex: seasonal potential power and non-seasonal potential power.

关键词： Pyramid Potential Power Meditation Non-Contact Effect Seasonal Variation Biosensor Cucumis sativus Gas Psi Index

Liver resection for hepatocellular carcinoma using a microwave tissue coagulator: Experience of 1118 cases

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World Journal of Gastroenterology 2015年第36期21卷 10400-10408页

作者： Kazunari Sasaki masamichi Matsuda Masaji Hashimoto Goro Watanabe Department of Digestive Surgery Hepato-pancreatobiliary Surgery UnitToranomon Hospital

A I M : To present our extensive experience of hepatectomy for hepatocellular carcinoma using a microwave tissue coagulator to demonstrate the effectiveness of this device. METHODS: A total of 1118 cases(1990-2013) were reviewed,with an emphasis on intraoperative blood loss,postoperative bile leakage and fluid/abscess formation,and adaptability to anatomical resection and hepatectomy with hilar ***: The median intraoperative blood loss was 250 m L; postoperative bile leakage and fluid/abscess formation were seen in 3.0% and 3.3% of cases,respectively. Anatomical resection was performed in 275 cases,including 103 cases of hilar dissection that required application of microwave coagulation near the hepatic hilum. There was no clinically relevant biliary tract stricture or any vascular problems due to heat injury. Regarding the influence of cirrhosis on intraoperative blood loss,no significant difference was seen between cirrhotic and non-cirrhotic patients(P = 0.38),although cirrhotic patients tended to have smaller tumors and underwent less invasive operations. CONCLUSION: This study demonstrated outcomes of an extensive experience of hepatectomy using heat coagulative necrosis by microwave tissue coagulator.

关键词： Hepatectomy Hepatocellular carcinoma Microwave Mic

Potential Power of the Pyramidal Structure II

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Natural Science 2020年第5期12卷 248-272页

作者： Osamu Takagi masamichi Sakamoto Hideo Yoichi Kimiko Kawano Mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Research on “pyramid power” began in the late 1930s. To date, many documents on “pyramid power” have been published. We have been conducting scientific research on the unexplained “power” of a pyramidal structure (PS) since October 2007. The research focuses on the detection of a non-contact effect of the unexplained “power” of the PS on biosensors (i.e., edible cucumber sections of Cucumis sativus “white spine type”) placed at the top of the PS. In this paper, in particular, we compared the non-contact effect of upper and lower biosensors placed in two layers on the PS apex, and we analyzed the difference of the non-contact effect due to the difference in the layers. The magnitude of the non-contact effect was represented by the calibrated psi index Ψ(E-CAL) calculated from gas concentrations emitted from the biosensors. A method to determine the presence or absence of the non-contact effect by analyzing the gas concentrations was developed by the International Research Institute (IRI). Ψ(E-CAL), which represents the magnitude of the non-contact effect, was the average value of the respective non-contact effect of the upper and lower biosensors stacked in two layers on the PS apex. We conducted the analysis on the assumption that the non-contact effect on the upper and lower biosensors might be different. Therefore, we considered that upper and lower biosensor calibration was required for Ψ(E-CAL), and we introduced a new calibrated psi index Ψ(E-CAL)Layer. Scientifically rigorous experiments to date have detected Ψ(E-CAL) with statistical significance and have demonstrated potential power of the PS (p = 6.0 × 10-3;Welch’s t-test, two-tails, the following p values are also the Welch’s t-test values). Based on data demonstrating the potential power of the PS, we analyzed the non-contact effects on the upper and lower biosensors of the PS apex. We obtained a surprising result that the non-contact effect on the upper biosensors (farther from the PS) was larger than th

关键词： Pyramid Potential Power Meditation Unconsciousness Non-Contact Effect Delay Biosensor Cucumis sativus Gas

用氧化镁铝热还原原位产生的镁蒸气改善铁水脱氧效率

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钢铁 2003年第Z1期38卷 116-119页

作者： Jiayi SHAN Takashi ITOH Kuniyuki KITAGAWA masamichi SANO 名古屋大学名古屋大学名古屋大学名古屋大学

提出了一种用氧化镁铝热还原原位产生的镁蒸气进行铁水脱氧的新方法.建立了反应模型来研究控速机理和镁蒸气的脱氧效率.模型计算结果显示,要获得高脱氧效率,必须控制喷吹气泡中的镁蒸气压力.

关键词：脱氧铁水镁蒸气铝热还原洁净钢

New Strategy for Unresectable Colorectal Liver Metastases

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New Strategy for Unresectable Colorectal Liver Metastases

Potential Power of the Pyramidal Structure

第六次全国大肠癌会议暨中日韩大肠癌会议

作者： masamichi Yasuno Takeo Mori Keiichi Takahashi Dept.of Surgery Tokyo Metropolitan Komagome Hospital TokyoJapan Dept.of Surgery Tokyo Metropolitan Komagome Hospital TokyoJapan Dept.of Surgery Tokyo Metropolitan Komagome Hospital TokyoJapan

＜正＞We report the results of hepatic resection in patients with unresectable liver mtetastases becomin, gpossi ble to resect curatively after hepatic arterial infusion of chemotherapy From 1985 to97,continu-ous intra hepatic chemotherapy（5-FU 2SOmg/body/day over 7days, followed by a 7-day therapy-free interval for a mean 6 months） was performed in 34 patients with unresectable liver metastases of colorectal cancer

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Natural Science 2019年第8期11卷 257-266页

作者： Osamu Takagi masamichi Sakamoto Hideo Yoichi Kimiko Kawano Mikio Yamamoto International Research Institute (IRI) Inage Chiba Japan Aquavision Academy Narita Chiba Japan

There have been various traditions and books which describe a so-called “pyramid power”, but there have been almost no reliable academic studies and no statistically significant data about it. We have continued scientifically rigorous experiments using biosensors to elucidate unexplained functions of a pyramidal structure (PS) since 2007. We used edible cucumber sections as biosensors and measured the concentrations of gas emitted from the sections by a technique developed by our group. From them we have demonstrated with high statistical accuracy the existence of the “pyramid power”, which was often recognized as having no scientific basis. We reached two conclusions from the work. 1) The PS converted the unconsciousness of a human (the test subject) more than 6 km away to energy detectable by the biosensors (1% significance). 2) The PS accumulated the influence that a human (the test subject) had when meditating within the PS. Then the PS converted the influence into the energy detectable by the biosensors (10-3% significance). These two conclusions showed that the functions of the PS were detected when “the PS and a human were related”. On the other hand, we hypothesized that the potential power of the PS could be detected even when “the PS and a human were not related”. In this paper, our purpose is to verify the existence of the potential power of the PS alone by experiment when “the PS and a human were not related”. The following three results were obtained by experiment. 1) The presence of the potential power of the PS was demonstrated with 1% significance. 2) The potential power of the PS changed in value between summer and winter, and it was clear that the non-contact effect on the biosensors was larger in summer and smaller in winter. 3) The potential power of the PS affected only the biosensors placed at the PS apex, and did not affect the biosensors placed at the calibration control point 8 m away from the PS. This paper is the first report in the world

关键词： Pyramid Potential Power Meditation Unconsciousness Non-Contact Effect Delay Biosensor Cucumber Gas