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Direct-acting antivirals for hepatitis C virus-infected patients with hepatocellular carcinoma

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World Journal of Hepatology 2022年第6期14卷 1190-1199页

作者： Kazuto Tajiri Hiroyuki Ito Kengo Kawai Yoshiro Kashii Yuka Hayashi Aiko Murayama masami minemura Terumi Takahara Yukihiro Shimizu Ichiro Yasuda Department of Gastroenterology Toyama University HospitalToyama 930-0194Japan Department of Gastroenterology Takaoka Municipal HospitalTakaoka 933-8550Japan Gastroenterology Center Nanto Municipal HospitalNanto 932-0211Japan Department of Gastroenterology Saiseikai Toyama HospitalToyama 931-8533Japan

BACKGROUND Hepatocellular carcinoma(HCC)in hepatitis C virus(HCV)-infected patients has a high risk of *** eradication of HCV is expected to reduce this risk,the risk in patients with a history of HCC may be high after treatment with direct-acting antivirals(DAAs).AIM To determine the risk factors for HCC recurrence in patients with HCV and a history of *** The risk of HCC recurrence in patients with a history of HCC and/or of HCC occurrence in patients without a history of HCC after DAA therapy was retrospectively analyzed in 311 HCV patients treated at our institution and several neighboring *** frequency and predictors of HCC recurrence/occurrence after DAA treatment were included in these *** clinical course of HCC before and after DAA treatment was also *** HCV patients with a history of HCC were older and had greater progression of liver fibrosis and diabetes than patients without a history of *** recurrence-free survival(RFS)was 1092 d in patients with a history of HCC,and post-DAA HCC recurrence/occurrence was observed in 29 patients(53.7%)with and 5(1.9%)without a history of HCC over 6 years(P<0.001).RFS in patients with a history of HCC did not differ significantly before and after DAA *** frequency of HCC recurrence/occurrence in patients with a history of HCC was lower after than before DAA *** analysis showed that the incidence rate of HCC recurrence/occurrence before DAA treatment was the only independent predictor of HCC recurrence/occurrence after DAA *** function was well preserved and clinical course was good in patients with HCC recurrence/occurrence after DAA *** DAA therapy in patients infected with HCV is also effective in patients with a history of *** treatment for HCC is desirable before DAA *** frequency of HCC recurrence/occurrence before DAA therapy was associated with a significantly increased risk of H

关键词： Direct-acting antivirals Hepatitis C virus Hepatocellular carcinoma Recurrence Liver fibrosis Curative treatment

Gut microbiota and liver diseases

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World Journal of Gastroenterology 2015年第6期21卷 1691-1702页

作者： masami minemura Yukihiro Shimizu Third Department of Internal Medicine Faculty of Medicine University of Toyama Gastroenterology Center Nanto Municipal Hospital

Several studies revealed that gut microbiota are associated with various human diseases,e.g.,metabolic diseases,allergies,gastroenterological diseases,and liver *** liver can be greatly affected by changes in gut microbiota due to the entry of gut bacteria or their metabolites into the liver through the portal vein,and the liver-gut axis is important to understand the pathophysiology of several liver diseases,especially non-alcoholic fatty liver disease and hepatic ***,gut microbiota play a significant role in the development of alcoholic liver disease and *** on theseprevious findings,trials using probiotics have been performed for the prevention or treatment of liver *** this review,we summarize the current understanding of the changes in gut microbiota associated with various liver diseases,and we describe the therapeutic trials of probiotics for those diseases.

关键词： Gut microbiota Immune system Liver disease Metabol

Liver involvement in systemic infection

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World Journal of Hepatology 2014年第9期6卷 632-642页

作者： masami minemura Kazuto Tajiri Yukihiro Shimizu The Third Department of Internal Medicine Faculty of MedicineUniversity of Toyama Gastroenterology Unit Nanto Municipal Hospital

The liver is often involved in systemic infections,resulting in various types of abnormal liver function test *** particular,hyperbilirubinemia in the range of 2-10 mg/dL is often seen in patients with sepsis,and several mechanisms for this phenomenon have been *** this review,we summarize how the liver is involved in various systemic infections that are not considered to be primarily *** most patients with systemic infections,treatment for the invading microbes is enough to normalize the liver function ***,some patients may show severe liver injury or fulminant hepatic failure,requiring intensive treatment of the liver.

关键词： Liver dysfunction Liver function test Systemic infection Immunology Liver failure

Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil

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World Journal of Hepatology 2010年第12期2卷 442-446页

作者： masami minemura Yoshiharu Tokimitsu Kazuto Tajiri Yasuhiro Nakayama Kengo Kawai Hiroshi Kudo Katsuharu Hirano Yoshinari Atarashi Yutaka Yata Satoshi Yasumura Terumi Takahara Toshiro Sugiyama Third Department of Internal Medicine Faculty of MedicineUniversity of Toyama

We report the case of a patient treated with living donor-related liver transplantation who suffered from osteomalacia during adefovir dipivoxil (ADV)-containing antiviral therapy for lamivudine-resistant hepatitis B virus infection. The patient had generalized bone pain,with severe hypophosphatemia after 20 mo of ADV therapy. Radiographic studies demonstrated the presence of osteomalacia. The peak plasma ADV level was 38 ng/mL after administration of ADV at 10mg/day. It was also found that ADV affected the metabolism of tacrolimus,a calcineurin-inhibitor,and caused an increase in the plasma levels of tacrolimus. The disability was reversed with the withdrawal of ADV and with mineral supplementation. ADV can cause an elevation of plasma tacrolimus levels,which may be associated with renal dysfunction. High levels of ADV and tacrolimus can cause nephrotoxicity and osteomalacia. This case highlights the importance of considering a diagnosis of osteomalacia in liver transplantation recipients treated with both ADV and tacrolimus.

关键词： Hepatitis B virus Osteomalacia Adefovir dipivoxil Living donor-related liver transplantation Tacrolimus

Application of Photon-Counting X-ray Computed Tomography to Aluminum-Casting Inspection

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World Journal of Nuclear Science and Technology 2013年第3期3卷 106-108页

作者： Koichi Kan Yukino Imura Hisashi Morii Koji Kobayashi Teruo minemura Toru Aoki Graduate School of Science and Technology Shizuoka University Hamamatsu Japan Research Institute of Electronics Shizuoka University Hamamatsu Japan Graduate School of Science and Technology Shizuoka University HamamatsuJapan Hamamatsu TSC Chuo Hatsumei Institute Hamamatsu Japan Hamamatsu TSC Chuo Hatsumei Institute Hamamatsu Japan Research Institute of Electronics Shizuoka University Hamamatsu Japan

One of the issues in the aluminum-alloy die casting industry is the space occurring inside the casting, and the improvement of the verification technology is expected. The purpose of this research is to seal holes inside the aluminum metal by resin and verify them by photon-counting X-ray computed tomography (CT) using an energy-discrimination 64-channel cadmium-telluride (CdTe) line detector. Moreover, it is important to estimate the image of the effective atomic number and the electronic density by the energy mapping of the attenuation coefficient utilizing photon-counting X-ray CTto distinguish both the aluminum metal and the resin filler in the aluminum hole. As a result, the energy discrimination of the resin filler in the space of aluminum casting has been attained. We could observe the atomic number image utilizing dual-energyX-ray CTmethod with the 64-channel CdTe photon-counting detector.

关键词： X-Ray CT Photon-Counting Aluminum-Alloy Die Casting Impregnation

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Setonomori的住宅

城市环境设计 2015年第2期 46-49页

作者： Nikki minemura 韩苗

该住宅综合体由26个单元组成,建于濑户内海附近的一个山坡上.项目场地依然保留了古老的分层模式的痕迹.住宅点缀着场地四周,房屋后面是山脉,还有陡峭的道路和楼梯穿梭其中,将它们连接起来,令人印象深刻.将住宅与周围环境看做一个整体,...

该住宅综合体由26个单元组成,建于濑户内海附近的一个山坡上.项目场地依然保留了古老的分层模式的痕迹.住宅点缀着场地四周,房屋后面是山脉,还有陡峭的道路和楼梯穿梭其中,将它们连接起来,令人印象深刻.将住宅与周围环境看做一个整体,建筑师想到的第一个问题就是如何将其改造成一道新的景观,激发创造未来生活形态的可能.建筑师预感到这将会无意之中带来新的可能性.

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Setonomori的住宅

城市环境设计 2015年第Z1期 47-49页

作者： Nikki minemura 韩苗

该住宅综合体由26个单元组成,建于濑户内海附近的一个山坡上。项目场地依然保留了古老的分层模式的痕迹。住宅点缀着场地四周,房屋后面是山脉,还有陡峭的道路和楼梯穿梭其中,将它们连接起来,令人印象深刻。将住宅与周围环境看做一个整体... 详细信息

该住宅综合体由26个单元组成,建于濑户内海附近的一个山坡上。项目场地依然保留了古老的分层模式的痕迹。住宅点缀着场地四周,房屋后面是山脉,还有陡峭的道路和楼梯穿梭其中,将它们连接起来,令人印象深刻。将住宅与周围环境看做一个整体,建筑师想到的第一个问题就是如何将其改造成一道新的景观,激发创造未来生活形态的

关键词：住宅 Setonomori 建筑师美术家

Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

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World Journal of Gastroenterology 2014年第43期20卷 16318-16322页

作者： Makoto Arai Tomoaki Matsumura Kenichiro Okimoto Arata Oyamada Keiko Saito Shoko minemura Daisuke Maruoka Takeshi Tanaka Tomoo Nakagawa Tatsuro Katsuno Osamu Yokosuka Department of Gastroenterology and Nephrology (K1) Graduate School of MedicineChiba UniversityChiba 260-8670Japan

AIM:To investigate the optimum period of treatment for post endoscopic submucosal dissection(ESD)***:Patients who underwent ESD for gastric cancer were randomized to two groups and treated with esomeprazole 20 mg per day for 4 wk(4W group)or 2 wk(2W group).At 4 wk after ESD,we measured the size of the artificial ulcers by endoscopy and determined the ulcer healing rate,compared with the size of the ESD *** randomized controlled trial study was approved by our ethics committee and registered in the UMIN Clinical Trial ***:A total of 60 consecutive patients were included in the *** patients received rebamipide 300 mg per day for 4 *** patient in 2W group who showed bleeding within two weeks and received endoscopic treatment was excluded from further *** numbers of patients with ulcers in the healing/scar stage in the 2W and 4W groups at 4 wk after ESD were 20/6 and 28/5,respectively,with no significant *** ulcer healing rate in the 2W and 4W groups were 96.1%[95%confidence interval(CI):94.6%-97.55]vs 94.8%(95%CI:92.6%-97.1%),respectively,with no statistical difference(UMIN000006951).CONCLUSION:Two-wk treatment with a proton pump inhibitor is as effective as four-week treatment for healing post ESD ulcers.

关键词： Proton pump inhibitor Endoscopic submucosal dissec

1.5μm波长光通信用高灵敏度高—低(Hi-Lo)锗雪崩光电二极管

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半导体光电 1985年第2期 63-65页

作者： M.Niwa Y.Tashiro K.minemura H.Iwasaki 程泰平

研制出用于1.55μm波长光通信系统的高灵敏度,小探测面积的Hi-Lo锗雪崩光电二极管。这种器件具有Hi-Lo（p;nn;）杂质分布。其光敏区直径是30μm,这有利于单模光纤使用。在传输速率为450Mb/S、λ=1.55μm、误码率等于10;、归零制系统中... 详细信息

研制出用于1.55μm波长光通信系统的高灵敏度,小探测面积的Hi-Lo锗雪崩光电二极管。这种器件具有Hi-Lo（p;nn;）杂质分布。其光敏区直径是30μm,这有利于单模光纤使用。在传输速率为450Mb/S、λ=1.55μm、误码率等于10;、归零制系统中得到最小平均可接收信号电平是-40.5dBm。这个值比80μm直径同样结构锗雪崩光电二极管的优0.7dB。

关键词：光通信系统结电容光波通信系统高灵敏度 Hi-Lo 波长暗电流保护环耗尽层杂质分布误码率出错率