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Evaluation of bacterial contamination and medium-term oncological outcomes of intracorporeal anastomosis for colon cancer:A propensity score matching analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 670-680页

作者： Hajime Kayano Nana Mamuro Yutaro Kamei Takashi Ogimi Hiroshi Miyakita Toshio Nakagohri Kazuo Koyanagi masaki mori Seiichiro Yamamoto Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

BACKGROUND Although intracorporeal anastomosis(IA)for colon cancer requires longer operative time than extracorporeal anastomosis(EA),its short-term postoperative results,such as early recovery of bowel movement,have been reported to be equal or *** IA requires opening the intestinal tract in the abdominal cavity under pneumoperitoneum,there are concerns about intraperitoneal bacterial infection and recurrence of peritoneal dissemination due to the spread of bacteria and tumor ***,intraperitoneal bacterial contamination and medium-term oncological outcomes have not been *** cavity in *** Of 127 patients who underwent laparoscopic colon resection for colon cancer from April 2015 to December 2020,75 underwent EA(EA group),and 52 underwent IA(IA group).After propensity score matching,the primary endpoint was 3-year disease-free survival rates,and secondary endpoints were 3-year overall survival rates,type of recurrence,surgical site infection(SSI)incidence,number of days on antibiotics,and postoperative biological *** Three-year disease-free survival rates did not significantly differ between the IA and EA groups(87.2%and 82.7%,respectively,P=0.4473).The 3-year overall survival rates also did not significantly differ between the IA and EA groups(94.7%and 94.7%,respectively;P=0.9891).There was no difference in the type of recurrence between the two *** addition,there were no significant differences in SSI incidence or the number of days on antibiotics;however,postoperative biological responses,such as the white blood cell count(10200 vs 8650/mm^(3),P=0.0068),C-reactive protein(6.8 vs 4.5 mg/dL,P=0.0011),and body temperature(37.7 vs 37.5℃,P=0.0079),were significantly higher in the IA *** IA is an anastomotic technique that should be widely performed because its risk of intraperitoneal bacterial contamination and medium-term oncological outcomes are comparable to those of EA.

关键词： Colon cancer Intracorporeal anastomosis 3-year disease-free survival Recurrence Surgical site infection Postoperative biological response

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Immunotherapy for esophageal cancer:Where are we now and where can we go

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World Journal of Gastroenterology 2024年第19期30卷 2496-2501页

作者： Yoshiaki Shoji Kazuo Koyanagi Kohei Kanamori Kohei Tajima Mika Ogimi Yamato Ninomiya Miho Yamamoto Akihito Kazuno Kazuhito Nabeshima Takayuki Nishi masaki mori Department of Gastroenterological Surgery Tokai University School of MedicineKanagawa 259-1193Japan

Immune checkpoint inhibitor therapy has dramatically improved patient prognosis,and thereby transformed the treatment in various cancer types including esophageal squamous cell carcinoma(ESCC)in the past *** antibodies that selectively inhibit programmed cell death-1(PD-1)activity has now become standard of care in the treatment of ESCC in metastatic settings,and has a high expectation to provide clinical benefit during perioperative ***,anti-cytotoxic T-lymphocyte–associated protein 4(CTLA-4)monoclonal antibody has also been approved in the treatment of recurrent/metastatic ESCC in combination with anti-PD-1 *** understanding of the existing evidence of immune-based treatments for ESCC,as well as recent clinical trials on various combinations with chemotherapy for different clinical settings including neoadjuvant,adjuvant,and metastatic diseases,may provide future prospects of ESCC treatment for better patient outcomes.

关键词： Esophageal cancer Immunotherapy Immune checkpoint inhibitor Programmed cell death-1 Anti-cytotoxic T-lymphocyte-associated protein 4 Neoadjuvant therapy Adjuvant therapy Clinical trials Combination therapy

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Photoluminescence and radioluminescence properties of (Gd8Ca2)(SiO4)6O2 crystals with different concentrations of Ce

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Journal of Rare Earths 2017年第11期35卷 1071-1076页

作者： Takuya Igashira masaki mori Go Okada Noriaki Kawaguchi Takayuki Yanagida Graduate School of Materials Science Nara Institute of Sdence and Technology (NAIST) 8916-5 Takayama Ikoma Nam Japan

(GdCa)(SiO)Oapatite crystals doped with different concentrations of Ce were synthesized by the Floating Zone(FZ) method, and we have evaluated the photoluminescence(PL) and radio luminescence(RL) properties. In PL, an emission band appeared around 400 nm under excitation at 300 nm due to the5 d-4 f transitions of Ce3+. The PL decay curves were approximated by a second-order exponential decay function, and the derived decay time constants ranged around 20-25 ns and 40-480 ns. Similar emission was observed in RL, but the decay time constants were much longer than those in PL. The RL afterglow was the lowest in the 1.0% Ce-doped sample. The 1.0% and 2.0% Ce-doped samples showed a full-energy peak in the pulse height spectrum measured underAm 5.5 MeV α-ray irradiation, and the absolute scintillation light yields were estimated to be around 55 and 36 ph/5.5 MeV-a, respectively.

关键词： Scintillator Apatite Ce^(3+) 5d-4f transition

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Is sarcopenic obesity superior to sarcopenia as a predicting indicator in patients with hepatocellular carcinoma following hepatic resection?

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 202-204页

作者： Shinji Itoh Tomoharu Yoshizumi masaki mori Department of Surgery and Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

The most common primary cancer derived from the liver is hepatocellular carcinoma(HCC),and its incidence is increasing globally(1).Hepatic resection has been established as a safe and effective treatment in patients with ***,the number of patients who develop recurrence after hepatic resection remains high(2).The body composition,which consists of the skeletal muscle mass and fat area,is an important used to determine the perioperative risk and prognosis in patients with cancer.

关键词： patients resection hepatic

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Scintillation and optical properties of Ce-doped YAGG transparent ceramics

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Journal of Rare Earths 2016年第8期34卷 763-768页

作者： masaki mori Jian Xu Go Okada Takayuki Yanagida Jumpei Ueda Setsuhisa Tanabe Graduate School of Materials' Science Nara Institute of Science and Technology (NAIST) 8916-5 Takayama-cho Ikoma-shi Nara 630-0192 Japan Graduate School of Human and Environmental Studies Kyoto University Yoshida-nihonmatsu-eho Sakyo-ku Kyoto 606-8501 Japan

We investigated photoluminescence （PL） and scintillation properties of Ce3＋-doped Y3A12Ga3OI2 （Ce：YAGG） trans- parent ceramics synthesized by vacuum sintering with different Ce3＋ concentrations （mol.%） from 0.3% to 1% （0.3%Ce：YAGG, 0.5%Ce：YAGG, 0.8%Ce：YAGG and I%Ce：YAGG）. The samples were synthesized by the vacuum sintering technique. The obtained samples showed a very strong and broad PL emission by the 5dl-4f transition of Ce3＋ in the wavelength range from 470 to 600 nm. The PL decay profiles were approximated by a single exponential decay function with the time constants of around 33-39 ns, Fur- thermore, the scintillation spectra induced by X-rays showed similar features with those observed in PL. The scintillation decay time profiles followed a second-order exponential decay function. The fast component group （ranged 3542 ns） were dominantly contrib- uted by the 5d1-4f transition of Ce3＋. The pulse height spectra utilizing the latter emissions showed a clear photoabsorption peak. Among those samples tested, 0.5%Ce：YAGG sample showed the highest scintillation light yield of 21,400 ph/MeV under 13VCs y-ray irradiation.

关键词： YAGG cerium transparent ceramic scintillation photoluminescence rare earths

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It is time to abandon the Milan criteria

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Hepatobiliary Surgery and Nutrition 2019年第1期8卷 56-58页

作者： Tomoharu Yoshizumi Ken Shirabe masaki mori Department of Surgery and Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of General Surgical Science Gunma University Graduate School of MedicineGunmaJapan

Hepatocellular carcinoma(HCC)is the fifth most common neoplasm worldwide and the third most common cause of cancer-related *** transplantation(LT),which offers the theoretical advantage of removing both the tumor and the organ that are at risk of developing future malignancy,is an established therapy for HCC in patients with liver cirrhosis.A shortage of cadaveric organs for transplantation continues to impair our ability to provide LT despite progress in surgical techniques and ***,it is important to allocate the deceased donor livers with excellent results,and to ensure reasonable outcome for living donors who need to undergo invasive surgery.

关键词： organs Liver surgery

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High-throughput Three-dimensional Gel Electrophoresis for Versatile Utilities: A Stacked Slice-gel System for Separation and Reactions (4SR)

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Genomics, Proteomics & Bioinformatics 2006年第1期4卷 26-33页

作者： Md. Salimullah masaki mori Koichi Nishigaki Department of Functional Materials Science Saitama University Saitama 338-8570 Japan Rational Evo-lutionary Design of Advanced Biomolecules (REDS) Group Saitama Small Enterprise Promotion CorporationSKIP City Kawaguchi 333-0844 Japan.

A novel high-throughput system, called the stacked slice-gel system for separation and reactions （4SR）, was developed for the analysis of DNA/RNA and protein/peptide. The system provides a novel three-dimensional gel electrophoresis approach that exploits the property of stacked slice gels. It allows multiple samples simultaneously to react as well as to be separated, offering a two-dimensional （m×n） sample loading system. For this purpose, high-throughput multi-micro vessels （MMVs） containing variable numbers of wells （100 wells in this paper） have been used, which are made of 25 mm square-size polyacrylamide gels. Furthermore, after electrophoretic separation, a slice gel containing a desired sample can be easily removed and proceeded to the next step. Different biological reactions as well as successive separation of products were effectively carried out dealing with DNA/RNA and protein/peptide. It shows that this system has a diversity of potentials to be developed.

关键词： three-dimensional polyacrylamide gel electrophoresis (3D-PAGE) high-throughput screening three-dlmensional separation microarray technology

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Current status of function-preserving surgery for gastric cancer

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World Journal of Gastroenterology 2014年第46期20卷 17297-17304页

作者： Takuro Saito Yukinori Kurokawa Shuji Takiguchi masaki mori Yuichiro Doki Department of Gastroenterological Surgery Osaka University Graduate School of MedicineOsaka 565-0871Japan

Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer(GC)at an early *** to the low incidence of lymph node metastasis and favorable prognosis in early GC,function-preserving surgery which improves postoperative quality of life may be ***-preserving gastrectomy(PPG)is one such function-preserving procedure,which is expected to offer advantages with regards to dumping syndrome,bile reflux gastritis,and the frequency of flatus,although PPG may induce delayed gastric *** gastrectomy(PG)is another functionpreserving procedure,which is thought to be advantageous in terms of decreased duodenogastric reflux and good food reservoir function in the remnant stomach,although the incidence of heartburn or gastric fullness associated with this procedure is ***,these disadvantages may be overcome by the reconstruction method *** other important problem after PG is remnant GC,which was reported to occur in approximately 5%of ***,the reconstruction technique used with PG should facilitate postoperativeendoscopic examinations for early detection and treatment of remnant gastric *** safety seems to be assured in both procedures,if the preoperative diagnosis is *** selection should be carefully *** many retrospective studies have demonstrated the utility of function-preserving surgery,no consensus on whether to adopt functionpreserving surgery as the standard of care has been *** prospective randomized controlled trials are necessary to evaluate survival and postoperative quality of life associated with function-preserving surgery.

关键词： Gastric cancer Function preserving surgery Quality of life Pylorus preserving surgery Proximal gastrectomy

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Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第10期14卷 1553-1558页

作者： Tohru Utsunomiya Masahiro Okamoto Toshihumi Kameyama Ayumi Matsuyama Manabu Yamamoto Megumu Fujiwara masaki mori Shiomi Aimitsu Teruyoshi Ishida Department of Surgery Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital Hiroshima Japan Department of Pathology Hiroshima RedCross Hospital and Atomic Bomb Survivors Hospital Hiroshima730-8619 Japan Department of Radiology Hiroshima Red CrossHospital and Atomic Bomb Survivors Hospital Hiroshima730-8619 Japan Department of Internal Medicine of the Liver Hiroshima Red Cross Hospital and Atomic Bomb SurvivorsHospital Hiroshima 730-8619 Japan

AIM: To evaluate the impact of obesity on the posto- perative outcome after hepatic resection in patients with hepatocellular carcinoma (HCC). METHODS: Data from 328 consecutive patients with primary HCC and 60 patients with recurrent HCC were studied. We compared the surgical outcomes between the non-obese group (body mass index: BMI < 25 kg/m2) and the obese group (BMI ≥ 25 kg/m2). RESULTS: Following curative hepatectomy in patients with primary HCC, the incidence of postoperative complications and the long-term prognosis in the non- obese group (n = 240) were comparable to those in the obese group (n = 88). Among patients with recurrent HCC, the incidence of postoperative complications after repeat hepatectomy was not significantly different between the non-obese group (n = 44) and the obese group (n = 16). However, patients in the obese group showed a significantly poorer long-term prognosis than those in the non-obese group (P < 0.05, five-yearsurvival rate; 51.9% and 92.0%, respectively). CONCLUSION: Obesity alone may not have an adverse effect on the surgical outcomes of patients with primary HCC. However, greater caution seems to be required when planning a repeat hepatectomy for obese patients with recurrent HCC.

关键词： Body mass index Hepatocellular carcinoma Hepatectomy Prognosis

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Advantage of autologous blood transfusion in surgery for hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第32期17卷 3709-3715页

作者： Yoshito Tomimaru Hidetoshi Eguchi Shigeru Marubashi Hiroshi Wada Shogo Kobayashi Masahiro Tanemura Koji Umeshita Yuichiro Doki masaki mori Hiroaki Nagano Department of Surgery Graduate School of Medicine Osaka University 2-2 Yamadaoka Suita 565-0871 Osaka Japan Division of Health Sciences Graduate School of Medicine Osaka University 2-2 Yamadaoka Suita 565-0871 Osaka Japan

AIM: To evaluate the significance of autologous blood transfusion (AT) in reducing homologous blood transfusion (HT) in surgery for hepatocellular carcinoma (HCC). METHODS: The proportion of patients who received HT was compared between two groups determined by the time of AT introduction; period A (1991-1994, n = 93) and period B (1995-2000, n = 201). Multivariate logistic regression analysis was performed in order to identify independent significant predictors of the need for HT. We also investigated the impact of AT and HT on long-term postoperative outcome after curative surgery for HCC. RESULTS: The proportion of patients with HT was significantly lower in period B than period A (18.9% vs 60.2%, P < 0.0001). Multivariate logistic regression analysis identified AT administration as a significant independent predictor of the need for HT (P < 0.0001). Disease-free survival in patients with AT was comparable to that without any transfusion. Multivariate analysis identified HT administration as an independent significant factor for poorer disease-free survival (P = 0.0380). CONCLUSION: AT administration significantly decreased the need for HT. Considering the postoperative survival disadvantage of HT, AT administration could improve the long-term outcome of HCC patients.

关键词： Hepatocellular carcinoma Surgery Autologous blood transfusion Homologous blood transfusion

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