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南京师范大学文学院学报 2002年第4期 33-36页

作者：芳村弘道荻原正树立命馆大学文学部小樽商科大学语言中心

唐圭璋先生早年致中田勇次郎先生的两封信 ,反映了唐先生编纂《全宋词》用力之勤、网罗之广、校勘之精谨以及中田先生的真诚合作 ,是近代日中学术交流的珍贵资料。

关键词：唐圭璋中田勇次郎《全宋词》

Clinical Characteristics of Japanese Type 2 Diabetic Patients Responsive to Sitagliptin

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Journal of Diabetes Mellitus 2014年第3期4卷 172-178页

作者： Kouichi Inukai Takumi Hirata Takashi Sumita masaki Watanabe Yuichi Ikegami Daisuke Ito Susumu Kurihara Nobuyuki Yasukawa Jiro Morimoto Nobuki Takata Kenta Kanazawa Tamotsu Neda Yoshikazu Sumitani Kiyoaki Inoue Yuichi Noguchi Toshio Hosaka Hitoshi Ishida Shigehiro Katayama Department of Internal Medicine Saitama Social Insurance Hospital Saitama Japan Division of Endocrinology and Diabetes Saitama Medical University Saitama Japan Foundation for Biomedical Research and Innovation Hyogo Japan Sakado Central Hospital Saitama Japan Third Department of Internal Medicine Division of Diabetes Endocrinology and Metabolism Kyorin University School of Medicine Tokyo Japan Watanabe Medical Clinic Hiroshima Japan

Japanese type 2 diabetic patients were treated with sitagliptin to evaluate the efficacy of this agent, and also to investigate the clinical characteristics of those who responded to sitagliptin. In total, 1001 diabetic patients, inadequately controlled (HbA1c ≥ 6.5%) with oral hypoglycemic agents (OHA) other than DPP-4 inhibitors or with diet and exercise only, were enrolled. We added 50mg of sitagliptin to the therapeutic regimens of 410 patients including 68 OHA naive patients, while the other 591 patients were switched from a single OHA to 50 mg of sitagliptin. After 6 months, glycemic control was significantly improved due to both reduced insulin resistance, as demonstrated by a significant HOMA-R reduction, and recovery of pancreatic β cell function, as assessed by HOMA-β and the proinsulin/insulin (PI/I) ratio. In the bivariable analysis, a good response, defined as an HbA1c reduction during the 6 months of at least 0.9%, was associated with high HbA1c and PI/I at baseline and combination treatments with sulfonylurea, biguanide and α-glucosidase inhibitors, but not with obesity. On the other hand, in the multivariable regression analysis, only high baseline HbA1c and combination treatment with anα-glucosidase inhibitor were significantly associated with a good response to sitagliptin. In patients with type 2 diabetes, the addition of sitagliptin or switching from another OHA to this agent achieved an HbA1c reduction without overloading β cells. In particular, we suggest that a good response to sitagliptin can be expected when this agent is combined with an α-glucosidase inhibitor (UMIN No. #000014157).

关键词： Sitagliptin Type 2 Diabetes DPP-4 Inhibitors

克隆人神经母细胞瘤细胞株鲀毒素抵抗型钠通道的序列分析

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中国药理学与毒理学杂志 2005年第3期19卷 186-193页

作者：欧绍武龟山亚砂子郝丽英龟山正树李金鸣中国医科大学附属第一医院神经外科辽宁沈阳110001 鹿儿岛大学医学部第二生理教研室中国医科大学基础医学院药理学教研室辽宁沈阳110001

目的　为了弄清人神经母细胞瘤(NB 1)细胞上的毒素抵抗型(TTX R)电压依赖性钠通道的编码基因及分子特性。方法　使用逆转录聚合酶链反应方法,对NB 1细胞TTX R钠通道α亚单位进行克隆。结果　该克隆命名为hNbR1,其开放阅读框架(ORF)为2... 详细信息

目的　为了弄清人神经母细胞瘤(NB 1)细胞上的毒素抵抗型(TTX R)电压依赖性钠通道的编码基因及分子特性。方法　使用逆转录聚合酶链反应方法,对NB 1细胞TTX R钠通道α亚单位进行克隆。结果　该克隆命名为hNbR1,其开放阅读框架(ORF)为2 0 16个氨基酸残基。序列分析显示,hNbR1与心肌Nav1.5 /SCN5A氨基酸相似性达99.1% ,并具有电压依赖性钠通道的结构特点。4个相似的跨膜结构域(DⅠ～DⅣ) ,其中包括6个推定的α螺旋跨膜片段(S1～S6 ) ,每个结构域的电压感受器跨膜片段(S4 )均有正电荷残基;在DⅠ的P 环存在的半胱氨酸残基(C373)提示该通道为TTX R钠通道。DⅠS3～S4一个位于第3号染色体的新的外显子(第6A外显子)编码了该通道α亚单位。另外,一个删除了DⅡ～DⅢ第18外显子的选择性剪切体(hNbR1 2 )被发现。结论Nav1.5 /SCN5A比以往所知具有更加广泛的分布,而且发现一个新的外显子在神经肿瘤组织中编码了这个TTX R钠通道的α亚单位。

关键词：神经母细胞瘤细胞,培养的钠通道基因克隆,分子

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词典驱动的联机手写日文病名识别研究

计算机工程与应用 2010年第20期46卷 116-118页

作者：梁建娟朱碧兰刘本永中川正樹贵州大学计算机科学与信息学院贵阳550025 日本东京农工大学

研究了一种有效的词典驱动的联机手写日文病名识别方法。病名词典以树结构存储,包含21713个病名短语。在切分中,手写病名字符串通过分析相邻笔划之间的空间信息等特征被切分为原始的片段序列。连续的片段动态地合并为候选字符模式,不同... 详细信息

研究了一种有效的词典驱动的联机手写日文病名识别方法。病名词典以树结构存储,包含21713个病名短语。在切分中,手写病名字符串通过分析相邻笔划之间的空间信息等特征被切分为原始的片段序列。连续的片段动态地合并为候选字符模式,不同的合并方式产生不同的候选字符序列,这样可构成一个切分候选网格。在识别过程中,结合病名词典匹配来限制候选字符模式的类别扩展,采用集束搜索策略来寻找到一条最优路径作为识别结果。用500个实际的手写病名样本做实验,平均每个病名的识别时间为0.87s,识别正确率为83.16%。

关键词：病名识别词典驱动识别手写字符串识别集束搜索

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鲁迅的复仇观

华文文学 2010年第2期 81-90页

作者：中井政喜许丹诚日本名古屋大学名古屋外国语大学汕头大学中文系

鲁迅在不同时期的不同的复仇观,既受到了局势的深刻影响,也在某种程度上展示了作为希望中国变革的知识分子的鲁迅,在认识和生活方式方面的变化。鲁迅性格中爱憎强度的变化在各个复仇观中所展现的强弱程度也是显而易见的。

关键词：鲁迅复仇观改革者献身者

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Equipment Planning for Renewable Energy Wide-Area Network in Hokkaido and Consideration of Transmission Capacity for the Increase in the Amount of Introduction

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Journal of Mechanics Engineering and Automation 2018年第6期8卷 250-258页

作者： Terumi Onishi Shin’ya Obara masaki Okada Yuji Ito Electrical and Electronic Engineering Kitami Institute of Technology Hokkaido 090-8507Japan Mechanical System Engineering National Institute of Technology Asahikawa College Hokkaido 071-8142Japan Substation Division Hokkaido Electric Power Company Hokkaido 060-8677Japan

In order to expand the introduction amount of renewable energy,it is necessary to solve various problems such as suppression of output fluctuation,cost of power supply compensator for reducing output fluctuation,and lack of transmission *** the other hand,it is known that output fluctuation of renewable energy is leveled by interconnecting renewable energy dispersedly arranged in a wide ***,it is possible to reduce the cost of the system by optimally distributing and linking the renewable energy to a wide ***,in this study,we developed computer algorithms to optimize the location and introduction amount of renewable energy that will conduct wide area interconnections based on actual transmission network *** target of the analysis was the Hokkaido area in Japan with extensive land and abundant natural *** the proposed algorithm,we evaluate the relationship between economical renewable energy location and capacity,renewable energy supply rate and grid *** a result,it was possible to realize an economical power system with a high percentage power supply ratio of renewable energy.

关键词： Renewable energy genetic algorithm wide interconnection transmission capacity

Inferring the Tree of Life of the order Cypriniformes, the earth＇s most diverse clade of freshwater fishes： Implications of varied taxon and character sampling

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植物分类学报 2008年第3期46卷 424-438页

作者： Richard L. MAYDEN Kevin L. TANG Robert M. WOOD Wei-Jen CHEN Mary K. AGNEW Kevin W. CONWAY Lei YANG Andrew M. SIMONS Henry L. BART Phillip M. HARRIS Junbing LI Xuzhen WANG Kenji SAITOH Shunping HE Huanzhang LIU Yiyu CHEN Mutstmi NISHIDA masaki MIYA Department of Biology Saint Louis University St. Louis MO 63103 USA Department of Fisheries Wildlife and Conservation Biology Bell Museum of Natural History University of Minnesota St. Paul MN 55108 USA Department of Ecology and Evolutionary Biology Tulane University New Orleans LA 70118 USA Department of Biological Sciences The University of Alabama Tuscaloosa AL 35487 USA Laboratory ofFish Phylogenetics and Biogeography Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China Tohoku National Fisheries Research Institute Fisheries Research Agency Miyagi 985-0001 Japan Ocean Research Institute University of Tokyo Tokyo 164-8639 Japan Department of Zoology Natural History Museum ＆ Institute Chiba 260-8682 Japan

The phylogenetic relationships of species are fundamental to any biological investigation, including all evolutionary studies. Accurate inferences of sister group relationships provide the researcher with an historical framework within which the attributes or geographic origin of species (or supraspecific groups) evolved. Taken out of this phylogenetic context, interpretations of evolutionary processes or origins, geographic distributions, or speciation rates and mechanisms, are subject to nothing less than a biological experiment without controls. Cypriniformes is the most diverse clade of freshwater fishes with estimates of diversity of nearly 3,500 species. These fishes display an amazing array of morphological, ecological, behavioral, and geographic diversity and offer a tremendous opportunity to enhance our understanding of the biotic and abiotic factors associated with diversification and adaptation to environments. Given the nearly global distribution of these fishes, they serve as an important model group for a plethora of biological investigations, including indicator species for future cli-matic changes. The occurrence of the zebrafish, Danio rerio, in this order makes this clade a critical component in understanding and predicting the relationship between mutagenesis and phenotypic expressions in vertebrates, including humans. With the tremendous diversity in Cypriniformes, our understanding of their phylogenetic relationships has not proceeded at an acceptable rate, despite a plethora of morphological and more recent mo-lecular studies. Most studies are pre-Hennigian in origin or include relatively small numbers of taxa. Given that analyses of small numbers of taxa for molecular characters can be compromised by peculiarities of long-branch attraction and nodal-density effect, it is critical that significant progress in our understanding of the relationships of these important fishes occurs with increasing sampling of species to mitigate these potential p

关键词：进化系统生命科学淡水鱼分类单元

克隆的人神经母细胞瘤细胞株鲀毒素抵抗型钠通道的功能分析

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中国药理学与毒理学杂志 2005年第4期19卷 284-288页

目的作者已经克隆了人神经母细胞瘤(NB-1)细胞株毒素抵抗型(TTX-R)钠通道α亚单位及其选择性剪切体,分别命名为hNbR1和hNbR1-2,本实验观察这两个钠通道同型异构体的电生理特性。方法使用全细胞膜片钳技术在转染了hNbR1和hNbR1-2的人... 详细信息

目的作者已经克隆了人神经母细胞瘤(NB-1)细胞株毒素抵抗型(TTX-R)钠通道α亚单位及其选择性剪切体,分别命名为hNbR1和hNbR1-2,本实验观察这两个钠通道同型异构体的电生理特性。方法使用全细胞膜片钳技术在转染了hNbR1和hNbR1-2的人胚肾细胞(HEK-293)上记录这两个钠通道的钠电流。结果这两个变构体在稳态激活和失活方面略微不同,hNbR1和hNbR1-2的半数激活电压分别为-(37.8±1.3)和-(43.5±1.7)mV,半数失活电压分别为-(74.4±1.1)和-(81.5±1.1)mV,hNbR1-2的稳态激活和稳态失活曲线较hNbR1分别负向移位5.7mV和7.1mV。TTX阻断hNbR1和hNbR1-2的IC50分别为(7.9±2.3)和(8.3±2.5)μmol·L-1,二者对TTX的敏感性无显著性差异。结论两个钠通道变构体hNbR1和hNbR1-2均可在HEK-293细胞上表达并产生钠电流,二者在稳态激活和失活方面略微不同,对TTX的敏感性无显著性差异。

关键词：神经母细胞瘤钠通道膜片钳技术,全细胞

The Significance of the Expression of FBXO31 in Gastric Cancer

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Journal of Cancer Therapy 2013年第1期4卷 75-79页

作者： Tomoya Sudo Ryunosuke Kogo Naohiro Nishida Keisuke Takahahi Genta Sawada Masahisa Ishibashi Junji Kurashige Ryutaro Uchi Tae Matsumura Hiroki Ueo Kousuke Mima Sayuri Akiyoshi Keishi Sugimachi Kouhei Shibata Hiromasa Fujita Kazuo Shirouzu masaki Mori Koshi Mimori Department of Surgery Kurume University School of Medicine Kurume Japan Department of Surgery Medical Institute of Bioregulation Kyushu University Beppu Japan Department of Surgery Medical Institute of Bioregulation Kyushu University Beppu Japan&Department of Surgery Kurume University School of Medicine Kurume Japan Department of Surgical Oncology Graduate School of Medicine Osaka University Osaka Japan.

Loss of Heterozygosity (LOH) is commonly considered to be one of a reason when some genes lose their function. Numbers of tumor suppressor genes are existing on the LOH lesion and chromosome 16q24 had been reported as a LOH region in gastric cancer. Little is known about what kind of tumor suppressor genes locates around the position. F-box protein, (FBXO31) is a candidate tumor suppressor gene encoded in chromosome 16q24.3 and LOH of the gene was reported in breast cancer, hepatocellular carcinoma and ovarian cancer but the status of FBXO31 was not analyzed in gastric cancer so far. One hundred twenty-seven pairs of tumor and corresponding normal tissue specimens collected from gastric cancer patients who underwent gastrectomy. Total RNAs were extracted from those samples and the expression of FBXO31 was investigated using real time quantitative RT-PCR analysis. Patients were classified into FBXO31 high expression group and low expression group. Clinicopahological factors were compared between the two groups and importance of FBXO31 was investigated. The standardized expression of FBXO31 was not significantly different between tumor (0.43 ± 0.46) and the corresponding 0.49 ± 0.55 in normal tissue (p = 0.39). Two years survival rate was 77% in FBXO31 high expression group and 54% in low expression group however the chance of survival rate of high expression group was dropped in 5 years (Wilcoxon p = 0.01). Clinicopathological factors were compared between the two groups and peritoneal dissemination was observed significantly higher in FBXO31 low expression group than did in high expression group (p = 0.0398). In order to predict existence of peritoneal dissemination of gastric cancer before surgery, FBXO31 may become a favorite marker for the low risk of peritoneal dissemination.

关键词： FBXO31 LOH Gastric Cancer

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腹腔镜内侧径路法乙状结肠癌切除术

中国内镜杂志 2005年第8期11卷 820-821,839页

作者：李志新福永正氣戚晓东武爱文首都医科大学附属北京同仁医院肿瘤外科北京100730 日本顺天堂大学浦安病院外科北京大学临床肿瘤学院外科北京100036

目的探讨腹腔镜内侧径路法治疗乙状结肠癌的手术方法.方法分析2001年4月～2002年11月施行的13例腹腔镜乙状结肠癌切除术患者的手术方法,采用内侧径路法,即先处理肠系膜根部及中枢侧淋巴、血管,后处理病变肠管.结果13例患者均成功完成腹... 详细信息

目的探讨腹腔镜内侧径路法治疗乙状结肠癌的手术方法.方法分析2001年4月～2002年11月施行的13例腹腔镜乙状结肠癌切除术患者的手术方法,采用内侧径路法,即先处理肠系膜根部及中枢侧淋巴、血管,后处理病变肠管.结果13例患者均成功完成腹腔镜手术,平均手术时间130 min,术中平均出血30mL,平均术后住院日7d,无手术并发症和死亡发生,随诊6～21个月,未发现局部或全身肿瘤复发、转移.结论只要严格掌握手术指征,合理选择手术方式,腹腔镜内侧径路法治疗结肠肿瘤是安全、有效的.

关键词：腹腔镜乙状结肠癌内侧径路手术