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Synchronous multiple lung cancers with hilar lymph node metastasis of small cell carcinoma:A case report

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世界临床病例杂志 2023年第25期11卷 5919-5925页

作者： Ryusei Yoshino Nana Yoshida Shunsuke Yasuda Akane Ito masaki Nakatsubo Sayaka Yuzawa Masahiro Kitada Thoracic Surgery and Breast Surgery Asahikawa Medical UniversityAsahikawa 078-8510Japan Diagnostic Pathology Asahikawa Medical University HospitalHokkaido 078-8510Japan

BACKGROUND Synchronous multiple lung cancers are rare and refer to the simultaneous presence of two or more primary lung tumors,which present significant challenges in terms of diagnosis and *** SUMMARY We report a case of multiple synchronous lung cancers with hilar lymph node metastasis of small cell carcinoma of unknown origin in a 73-year-old *** lung biopsy revealed squamous cell *** enlargement of lymph node 12u was detected,no distant metastases were *** patient was preoperatively diagnosed with T1cN0M0 and underwent thoracoscopic right upper lobectomy with nodal dissection(ND2a).Based on histopathological findings,the primary lesion was squamous cell carcinoma.A microinvasive adenocarcinoma was also observed on the cranial side of the primary *** were detected in two resected lymph nodes(#12u and#11s).Both tumors were pathologically diagnosed as small cell *** primary lesion of the small cell carcinoma could not be identified even by whole-body imaging;however,chemotherapy was initiated for hilar lymph node metastasis of the small cell carcinoma of unknown *** Multiple synchronous lung cancers can be accompanied by hilar lymph node metastasis of small cell carcinomas of unknown origin.

关键词： Small cell carcinoma Synchronous multiple lung cancers Squamous cell carcinoma Adenocarcinoma Chemotherapy Case report

Comparative Study of Segmentation Methods of Rat Sinusoidal Network to Evaluate Nonalcoholic Steatohepatitis for Small Number of Medical Samples

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Journal of Biosciences and Medicines 2022年第11期10卷 192-202页

作者： masaki Murakishi Hiroto Shoji Department of Science and Technology Kwansei Gakuin University Hyogo Japan

Extracting portions of pathology images to determine disease states is a challenging task, and several segmentation approaches have been developed. This study evaluated four well-known methods to classify changes in rat hepatic sinusoidal network morphology in nonalcoholic stetohepatitis were evaluated. The classical methods of morphological transformation (MT), convex hull (CH), and counter extraction (CE), and a machine learning method, U-net, were compared using fractal dimensions as feature quantities. The findings show that MT and CH are more effective than U-net when the number of samples is small, as is usually the case with pathology images. U-net required a large number of images and was the best method in terms of extracting the morphology. When the number of samples is small, such as the case with pathological images, it may be advantageous to use a combination of basic segmentation methods rather than advanced machine learning techniques, such as U-net. The segmentation methods must be carefully chosen depending on the diseases to be discriminated and on the number of samples.

关键词： Segmentation Deep Learning Fractal Dimensions

Numerical analysis on element creation by nuclear transmutation of fission products

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Nuclear Science and Techniques 2015年第1期26卷 113-120页

作者： Atsunori Terashima masaki Ozawa Department of Nuclear Engineering Graduate School of Science and EngineeringTokyo Institute of Technology Research Laboratory for Nuclear Reactors Tokyo Institute of Technology

A burnup calculation was performed to analyze the Apr`es ORIENT process, which aims to create highlyvaluable elements from fission products separated from spent nuclear fuels. The basic idea is to use nuclear transmutation induced by a neutron capture reaction followed by a β-decay, thus changing the atomic number Z of a target element in fission products by 1 unit. LWR(PWR) and FBR(MONJU) were considered as the transmutation devices. High rates of creation were obtained in some cases of platinum group metals(44Ru by FBR,46 Pd by LWR) and rare earth(64Gd by LWR,66 Dy by FBR). Therefore, systems based on LWR and FBR have their own advantages depending on target elements. Furthermore, it was found that creation rates of even Z(= Z + 1) elements from odd Z ones were higher than the opposite cases. This creation rate of an element was interpreted in terms of "average 1-group neutron capture cross section of the corresponding target element σc Z defined in this work. General trends of the creation rate of an even(odd) Z element from the corresponding odd(even) Z one were found to be proportional to the 0.78th(0.63th) power of σc Z, however with noticeable dispersion. The difference in the powers in the above analysis was explained by the difference in the number of stable isotopes caused by the even-odd effect of Z.

关键词：裂变产物元素数值分析嬗变快中子增殖反应堆轻水反应堆稳定同位素 LWR

Diagonal reflection symmetries and universal four-zero texture

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Chinese Physics C 2021年第4期45卷 87-97页

作者： masaki J.S.Yang Department of Physics Saitama UniversityShimo-okuboSakura-kuSaitama338-8570Japan

In this paper,we consider a set of new symmetries in the SM:diagonal reflection symmetries Rm_(u,v)^(*),R=m_(u,v),m_(d,e)^(*)=mde with R=diag(-1,1,1).These generalized CP symmetries predict the Majorana phases to beα_(2.3)/2-0π/*** of diagonal reflection symmetries implies a broken chiral U(1)po symmetry only for the first *** axion scale is suggested to be(θ_(u,d))~△GuT√m_(u,dm_(c,s))/v-10^(12)[GeV].By combining the symmetries with the four-zero texture,the mass eigenvalues and mixing matrices of quarks and leptons are reproduced *** scheme predicts the normal hierarchy,the Dirac phase ocp≈203°,and|ml|≈2.5 or 6.2[meV].In this scheme,the type-I seesaw mechanism and a given neutrino Yukawa matrix Y_(y)completely determine the structure of the right-handed neutrino mass M_(R).A u-y unification predicts the mass eigenvalues to be(M_(RI),M_(R2),M_(R3))=(O(10^(5)).O(10^(9)),O(10^(14))[Gev].

关键词： μ-t reflection symmetry four-zero texture generalized CP symmetry

Plate and plume tectonics:Numerical simulation and seismic tomography

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Geoscience Frontiers 2015年第1期6卷 1-2页

作者： masaki Yoshida Department of Deep Earth Structure and Dynamics Research Jaan Agency for Marine-Earth Science and Technology(JAMSTEC)

About three decades after the establishment of the plate tec- tonics theory in the late 1960s, Maruyama （1994） proposed the ＂plume tectonics＂ theory based on whole-mantle seismic tomogra- phy image （Fukao, 1992; Fukao et al., 1994）. According to this the- ory, the earth＇s interior is divided into three regimes： the earth＇s surface region governed by lateral motions of tectonic plates, the mantle governed by vertical motions of ＂superplumes＂（i.e., large- scale mantle upwelling/downwelling plumes）, and the core, whose convection style is probably controlled by superplumes in the mantle. With the rapid progress in earth science after the birth of the plume tectonics theory, it is now widely accepted that various geological phenomena observed in the earth＇s surface are closely linked to the fluid motion in the deep mantle （e.g., Davies, 2011）.

关键词： Plate and plume tectonics UHT deep LVL

Dynamic robust optimal reorder point with uncertain lead time and changeable demand distribution

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 938-945页

作者： masaki TAMURA Kazuko MORIZAWA Hiroyuki NAGASAWA Department of Electrical and Information Systems Engineering Graduate School of EngineeringOsaka Prefecture University Osaka Prefectural College of Technology

In fixed order quantity systems,uncertainty in lead time is expressed as a set of scenarios with occurrence probabilities,and the mean and variance in demand distribution are supposed to be changeable according to a known pattern.A new concept of "dynamic robust optimal reorder point" is proposed in this paper and its value is calculated as a "robust optimal reorder point function with respect to reorder time".Two approaches were employed in determining the dynamic optimal reorder *** first is a shortage rate satisfaction approach and the second is a backorder cost minimization *** former aims at finding the minimum value of reorder point at each reorder time which satisfies the condition that the cumulative distribution function (CDF) of shortage rate under a given set of scenarios in lead time is greater than or equal to a basic CDF of shortage rate predetermined by a *** the latter approach,the CDF of closeness of reorder point is defined at each reorder time to express how close to the optimal reorder points under the set of scenarios,and the dynamic optimal reorder point is defined according to stochastic *** numerical examples demonstrate the features of these dynamic robust optimal reorder points.

关键词： Reorder point Lead time Robust optimum Uncertainty Scenario

A sulfur–microporous carbon composite positive electrode for lithium/sulfur and silicon/sulfur rechargeble batteries

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Progress in Natural Science:Materials International 2015年第6期25卷 612-621页

作者： Takuya Takahashi masaki Yamagata Masashi Ishikawa Department of Chemistry and Materials Engineering Faculty of ChemistryMaterials and BioengineeringKansai University

Sulfur is an advantageous material as a promising next-generation positive electrode material for high-energy lithium batteries due to a high theoretical capacity of 1672 m A h g 1although its discharge potential is somewhat modest:ca.2 V vs Li/***,a sulfur positive electrode has some crucial problems for practical use,which are mainly attributed to the dissolution of its intermediate products in charge–discharge *** order to resolve the dissolution problem of lithium polysulfide,we attempted to synthesize a sulfur–microporous activated carbon(AC) composite positive ***,we have systematically researched the battery performance of sulfur–microporous AC positive electrode with variations of electrolytes as well as negative electrodes,and found its promising positive electrode performance for a nextgeneration rechargeable battery.

关键词： Sulfur Micropore Ionic liquid Silicon Lithium-ion battery

Throughfall and stemflow chemical dynamics of Satoyama, a traditional secondary forest system under threat in Japan

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Journal of Forestry Research 2022年第3期33卷 813-826页

作者： Satoshi Asaoka Fuyuhiko Sumikawa Yoshifumi Watanabe Waqar Azeem Jadoon masaki Ohno Nobumichi Shutoh Yuki Wakamatsu Lawrence M.Liao Akane Kanazawa Yuka Sato Natsumi Fujiwara Graduate School of Integrated Sciences for Life Hiroshima University1-4-4 KagamiyamaHigashi-Hiroshima739-8528Japan Research Center for Inland Seas Kobe University5-1-1 FukaeminamiHigashinadaKobe658-0022Japan Naragakuen Senior High School 430 YamadaYamatokoriyamaNara639-1093Japan Department of Environmental Sciences Faculty of Natural and Computational SciencesHazara UniversityDhodiaMansehra21130Khyber PakhtunkhwaPakistan Niigata University of Pharmacy and Applied Life Sciences 265-1 HigashijimaAkihaNiigata956-8603Japan Faculty of Science and Engineering Kindai University3-4-1 KowakaeHigashi-OsakaOsaka577-8502Japan Department of Maritime Science and Technology Japan Coast Guard Academy5 WakabaKureHiroshima737-8512Japan

The term 'Satoyama' refers to traditional and unique secondary forests in Japan that occupy intermediate zones between villages ('sato') and hills or mountains ('yama'). Satoyama landscapes help sustain ecosystem services and the diversity of secondary natural environments. As Japan relies more heavily on foreign timber imports, the traditional role of Satoyama in providing forest products has diminished, and this has led to their abandonment and poor management. The chemical behavior of cations, anions, and dissolved organic matter in throughfall and stemflow from one such threatened Satoyama system in central Japan was investigated. From autumn to winter, the atmospheric deposition of sulfates and nitrates was 2.5–6.0 times higher compared to the amounts in summer due to the intrusion of air masses from the Asian continent. The dissolved organic matter in the throughfall and stemflow was composed mainly of humic substances and protein derivatives. The deposition fluxes of dissolved organic carbon from throughfall (7.31–10.1 g m^(−2) a^(−1)) and stemflow (1.79–3.84 g m^(−2) a^(−1)) in this study were within ranges seen in temperate forests in previous studies. The deposition flux of sulfates was low compared to that in other forest types because canopy interaction was lower, suggesting higher canopy openness than in primary forests. If a shift from a mixed species Satoyama forest to a conifer-dominated forest occurs after the mass mortality of oak, the deposition flux of dissolved organic carbon and K^(+) might decrease by 33% and 62%, respectively, while NO_(3)^(−) might increase by 20%. In the near future, the degradation of Satoyama landscapes might change the levels of dissolved organic carbon and nitrogen loads, resulting in imbalances in river-ocean linkages affecting forested catchments and aquatic ecosystems in Japan.

关键词： Atmospheric deposition Dissolved organic matter Humic substance Mass mortality Oak trees Sustainable development goals

Voyage of the Indian subcontinent since Pangea breakup and driving force of supercontinent cycles: Insights on dynamics from numerical modeling

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Geoscience Frontiers 2018年第5期9卷 1279-1292页

作者： masaki Yoshida M.Santosh Department of Deep Earth Structure and Dynamics Research Japan Agency for Marinee Earth Science and Technology (JAMSTEC) School of Earth Sciences and Resources China University of Geosciences Department of Earth Sciences School of Physical Sciences University of Adelaide Faculty of Science Kochi University

Recent advances in three-dimensional numerical simulations of mantle convection have aided in approximately reproducing continental movement since the Pangea breakup at 200 Ma. These have also led to a better understanding of the thermal and mechanical coupling between mantle convection and surface plate motion and predictions of the configuration of the next supercontinent. The simulations of mantle convection from 200 Ma to the present reveals that the development of large-scale cold mantle downwellings in the North Tethys Ocean at the earlier stage of the Pangea breakup triggered the northward movement of the Indian subcontinent. The model of high temperature anomaly region beneath Pangea resulting from the thermal insulation effect support the breakup of Pangea in the real Earth time scale, as also suggested in previous geological and geodynamic models. However, considering the low radioactive heat generation rate of the depleted upper mantle, the high temperature anomaly region might have been generated by upwelling plumes with contribution of deep subducted TTG(tonalite-trondhjemite-granite) materials enriched in radiogenic elements. Integrating the numerical results of mantle convection from 200 Ma to the present, and from the present to the future, it is considered that the mantle drag force acting on the base of continents may be comparable to the slab pull force, which implies that convection in the shallower part of the mantle is strongly coupled with surface plate motion.

关键词： Numerical modeling Plate tectonics Supercontinent Geodynamics Indian subcontinent Pangea