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Difficulty in differentiating two cases of sigmoid stenosis by diverticulitis from cancer

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World Journal of Gastroenterology 2012年第27期18卷 3623-3626页

作者： Noriko Nishiyama Hirohito Mori Hideki Kobara Kazi Rafiq Shintarou Fujihara Mitsuyoshi Kobayashi Tsutomu masaki Department of Gastroenterology and Neurology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of Pharmacology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan

The incidence of colonic diverticulosis with or without diverticulitis has increased in the Japanese population due to the modernization of food and aging. The rate of diverticulitis in colon diverticulosis ranges from 8.1% to 9.6%. However, few cases of stenosis due to diverticulitis have been reported. These reports suggest that the differentiation between sigmoid diverticulitis and colon cancer is difficult. This report describes two cases of colon stenosis due to diverticulitis that were difficult to differentiate from colon cancer. Case i was a 70-year-old woman with narrowed stools for 1 month who underwent colonofiberscopy （CFS）. CFS revealed a diverticulum and circumferential stenosis in the sigmoid colon. Barium enema revealed a marked, hourglass- shaped, 2-cm circumferential stenosis in the sigmoid colon. Fluorodeoxyglucose （FDG）-positron emission tomography computed tomography （CT） revealed an increased FDG uptake at the affected portion of the sigmoid colon. Sigmoid colon cancer was suspected,and laparoscopic sigmoidectomy was performed. Patho- logical examination demonstrated active inflammation with no evidence of malignancy. Case 2 was a 50-year- old man who presented to a nearby clinic with reduced stool output despite the urge to defecate. CFS detected severe stenosis in the sigmoid colon approximately 25 cm from the dentate line. Contrast-enhanced abdomi- nal CT revealed multiple diverticula, wall thickening, and swelling of the lymph nodes around the peritoneal aorta and the inferior mesenteric artery. A partial sig- moidectomy was performed. Pathological examination of the resected specimen revealed no changes in the mucosal epithelial surface, but a marked infiltration of inflammatory cells was observed.

关键词： Diverticulosis Colon cancer Colon stenosisPositron emission tomography-computed tomographyMagnetic resonance imaging

Radiofrequency ablation in a porcine liver model:Effects of transcatheter arterial embolization with iodized oil on ablation time,maximum output,and coagulation diameter as well as angiographic characteristics

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World Journal of Gastroenterology 2007年第20期13卷 2841-2845页

作者： Motoki Nakai Morio Sato Shinya Sahara Nobuyuki Kawai Hirohiko Tanihata Masashi Kimura masaki Terada Department of Radiology Hidaka General Hospi-tal116-2 SonoGobo ShiWakayama 644-8655Japan Department of Radiol-ogy Wakayama Medical University 811-1KimiideraWakayama ShiWakayama 641-8510Japan

AIM:To evaluate the effects of combined radiofrequen-cy ablation and transcatheter arterial embolization with iodized oil on ablation time,maximum output,coagula-tion diameter,and portal angiography in a porcine liver model. METHODS: Radiofrequency ablation (RFA) was applied to in vivo livers of 10 normal pigs using a 17-gauge 3.0 cm expandable LeVeen RF needle electrode with or with-out transcatheter arterial embolization (TAE) with iodized oil (n = 5). In each animal,2 areas in the liver were ab-lated. Direct portography was performed before and af-ter RFA. Ablation was initiated at an output of 30 W,and continued with an increase of 10 W per minute until roll-off occurred. Ablation time and maximum output until roll-off,and coagulated tissue diameter were compared between the 2 groups. Angiographic changes on portog-raphy before and after ablation were also reviewed. RESULTS: For groups with and without TAE with iodized oil,the ablation times until roll-off were 320.6 ± 30.9 seconds and 445.1 ± 35.9 seconds,respectively,maxi-mum outputs were 69.0 ± 7.38 W and 87.0 ± 4.83 W and maximal diameters of coagulation were 41.7 ± 3.85 mm and 33.2 ± 2.28 mm. Significant reductions of abla-tion time and maximum output,and significantly larger coagulation diameter were obtained with RFA following TAE with iodized oil compared to RFA alone. Portography after RFA following TAE with iodized oil revealed more occlusion of the larger portal branches than with RFA alone. CONCLUSION: RFA following TAE with iodized oil can increase the volume of coagulation necrosis with lower output and shorter ablation time than RFA alone in nor-mal pig liver tissue.

关键词： Liver Radiofrequency ablation Transcatheter arterial embolization Iodized oil Angiography Hepatocellular carcinoma

High expressions of caveolins on the proliferating bile ductules in primary biliary cirrhosis

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World Journal of Gastroenterology 2005年第24期11卷 3710-3713页

作者： Hiroaki Yokomori Masaya Oda Go Wakabayashi masaki Kitajima Kazunori Yoshimura Masahiko Nomura Toshifumi Hibi Department of Internal Medicine Organized Center of Clinical Medicine Department of Surgery Department of Physiology

AIM: An increase in bile ductular structures is observed in diverse human liver diseases, especially in primary biliary cirrhosis (PBC). These structures harbor the progenitor cell component of the liver. Caveolins are cholesterol-binding proteins involved in the regulation of several intracellular processes including cholesterol transport. This study aims to examine the role of caveolin in ***: Immunohistochemical and Western blottingstudies were performed on human liver specimens obtained from patients with PBC and normal liver samples. The expression of caveolin (CAV)-1 and -2 was determined using specific ***: In normal liver, scanty immunostaining for CAV1 and -2 was observed in bile ductules. In PBC liver samples, the expression levels of CAV-1 and -2 were increased on proliferating bile ductules especially in stage 3 cases, but was sparse on interlobular bile duct in stage 1 specimens. Especially, the regenerating bile ductules at the interface of portal tracts and necrotic areas were immunostained intensely for CAV-1 and -2. These phenomena were confirmed by Western ***: The present results demonstrate increased expression of caveolins in proliferating bile ductules in PBC, which may be related to the homeostasis of cholesterol transport in regenerating bile ductules in PBC liver.

关键词： Proliferating bile ductule Caveolin Immunohis tochemistry Primary biliary cirrhosis

A case of invasive hemolymphangioma of the pancreas

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World Journal of Gastroenterology 2008年第18期14卷 2932-2934页

作者： Yoshikazu Toyoki Kenichi Hakamada Shunji Narumi masaki Nara Daisuke Kudoh Keinosuke Ishido Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University School of Medicine 5 Zaifu-cho Hirosaki Aomori 0368652 Japan

Hemolymphangioma of the pancreas is a very rare benign tumor. There were only five reports of this disease until March 2008. Herein, we report a case of hemolymphangioma of the pancreas with gastrointestinal bleeding due to duodenal invasion. A 53-year-old man had been admitted a referral hospital because of severe anemia due to gastrointestinal bleeding in December 2005. He was then transferred to our institute with a diagnosis of a tumor of the head of the pancreas with duodenal invasion in January 2006. No abnormalities were revealed except for anemia in laboratory data including CEA and CA19-9. Gastrointestinal endoscopy revealed bleeding at the duodenum. Computed tomography also demonstrated a heterogenous mass at the pancreatic head and suspected invasion to the duodenal wall. Ultrasonography showed a huge mass at the pancreatic head with a mixture of high and low echoic areas. Pylorous-preserving pancreatoduodenectomy was performed. The pancreatic tumor was soft and had invaded to the duodenum. The pathological diagnosis was a hemolymphangioma of the pancreas invaded to the duodenum. His postoperative course was uneventful and he was discharged on the 26th d after surgery. Hemolymphangioma of the pancreas is a very rare benign tumor. In a literature review until March 2008, we found five case reports. Major symptoms are abdominal pain and distension due to the enlarged tumor. However, we experienced a case of hemolymphangioma of the pancreas with gastrointestinal bleeding due to invasion to the duodenum. This disease is a very rare entity, but should be considered when patients have gastrointestinal bleeding.

关键词： Hemolymphangioma Duodenal invasion Gastrointestinal bleeding

Bleeding duodenal hemangioma: Morphological changes and endoscopic mucosal resection

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World Journal of Gastroenterology 2012年第22期18卷 2872-2876页

作者： Noriko Nishiyama Hirohito Mori Hideki Kobara Shintarou Fujihara Takako Nomura Mitsuyoshi Kobayashi Tsutomu masaki Department of Gastroenterology and Neurology Faculty of Medicine Kagawa Medical University

Recently, the development of endoscopic procedures has increased the availability of minimally invasive treatments; however, there have been few case reports of duodenal hemangioma treated by endoscopic mucosal resection. The present report describes a case of duodenal hemangioma that showed various endoscopic changes over time and was treated by endoscopic mucosal resection. An 80-year-old woman presented with tarry stools and a loss of appetite. An examination of her blood revealed severe anemia, and her hemoglobin level was 4.2 g/dL. An emergency upper gastrointestinal endoscopy was performed. A red, protrusive, semipedunculated tumor (approximately 20 mm in diameter) with spontaneous bleeding on its surface was found in the superior duodenal angle. Given the semipedunculated appearance of the tumor, it was suspected to be an epithelial tumor with a differential diagnosis of hyperplastic polyp. The biopsy results suggested a telangiectatic hemangioma. Because this lesion was considered to be responsible for her anemia, endoscopic mucosal resection was performed for diagnostic and treatment purposes after informed consent was obtained. A histopathological examination of the resected specimen revealed dilated and proliferated capillary lumens of various sizes, which confirmed the final diagnosis of duodenal hemangioma. Neither anemia nor tumor recurrence has been observed since the endoscopic mucosal resection (approximately 1 year). Duodenal hemangiomas can be treated endoscopically provided that sufficient consideration is given to all of the possible treatment strategies. Interestingly, duodenal hemangiomas show morphological changes that are influenced by various factors, such as mechanical stimuli.

关键词： Duodenal hemangioma Endoscopic muco-sal resection Gastrointestinal bleeding Morphologicalchanges Capillary hemangioma

Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy:Report of a case and a review of the literature

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World Journal of Gastroenterology 2008年第1期14卷 132-135页

作者： Kenichi Hakamada Takuya Miura Akitoshi Kimura masaki Nara Yoshikazu Toyoki Shunij Narumi Mutsuo Sasak Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan

Oncogenesis of anaplastic carcinoma of the pancreas is a subject of controversy, because it shows sarcomatous nature with extremely poor prognosis. We herein report an unusual case of anaplastic carcinoma occurring with a recurrent mucinous cystic neoplasm in a 38-year-old female. A 10-cm retroperitoneal cystic mass was pointed out in the first pregnancy and a probable diagnosis of mucinous cystic neoplasm was made in October 2000. She refused surgery first and delivered her baby uneventfully. During her second pregnancy in 2002, however, she presented hematemesis and underwent urgent distal pancreatectomy, splenectomy and partial resection of the gastric wall where the tumor perforated. A diagnosis of borderline-type mucinous cystic neoplasm with ovarian-like stroma was made. Nine months later, CT visualized a recurrent cystic tumor near the pancreatic stump, which was subsequently resected. Pathology revealed that the tumor was composed of two different components of borderline-type mucinous cystic neoplasm and anaplastic carcinoma. The latter was intensely positive for vimentin, CD68, p53 and focally for cytokeratin, suggesting both sarcomatous and carcinomatous differentiation. She survived four years after the second surgery without tumor recurrence. Although the origin of anaplastic carcinoma has not been determined yet, it should be remembered that anaplastic carcinoma can occur in association with mucinous cystic neoplasm of more benign histology.

关键词： Mucinous cystic neoplasm Anaplastic carcinoma Pancreatic tumor Ovarian-like stroma Pregnancy

Cryoseismologic Studies for Polar Environment—Recent Progress of Japanese Contribution

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International Journal of Geosciences 2021年第1期12卷 6-22页

作者： masaki Kanao National Institute of Polar Research (NIPR) Organization of Information and Systems (ROIS) Midori-Cho Tachikawa-Shi Tokyo Japan

Majority areas of Antarctica and Greenland are under the thick ice sheet and characterized by evolving cryosphere surroundings. In the polar region, associated with the recent trend on climate change such as global warming, glacier relating earthquakes are increasing during this 21st century. In this paper, a decade of progress in “Cryoseismology” at bi-polar regions is re-viewed by focusing on the contribution from Japanese researchers. In particular, the specific cryoseismic events are treated, which occurred in the coastal area of East Antarctica, around the Lützow-Holm Bay, together with the coast and whole inland area of Greenland. As the major scientific results, frequency-overtone signals in the harmonic cryoseismic tremors were analyzed by assuming constant sources, suggesting inter-glacial asperities that generate characteristic tremors. Infrasound source locations were also determined by using the array deployment at the coastal regions in the Antarctic. In contrast, characteristics of glacial earthquakes and seismic interferometry approach have been conducted so as to achieve the fine structure of the Greenland Ice Sheet (GrIS) in particular the basal condition beneath the ice sheet.

关键词： Ice-Quakes Glacial Earthquakes Dynamic Cryosphere Cryoseismology Climate Change Polar Regions

GRACE-based estimates of groundwater variations over North America from 2002 to 2017

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Geodesy and Geodynamics 2022年第1期13卷 11-23页

作者： Hansheng Wang Longwei Xiang Holger Steffen Patrick Wu Liming Jiang Qiang Shen Zhen Li masaki Hayashi State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China University of Chinese Academy of Sciences Beijing 100049China School of Geosciences Yangtze UniversityWuhan 430100China Lantmateriet 80182GavleSweden Department of Geoscience University of CalgaryCalgaryCanada

GRACE-based estimates for groundwater storage(GWS)changes in North America substantially depend upon correction of glacialisostatic adjustment(GIA)effects,which are usually removed with GIA *** this study,GIA effects are eliminated by employing an independent separation approach with the aid of Global Navigation Satellite System(GNSS)vertical velocity *** goal is to provide an independent estimate for monthly GWS changes within North America in 1-degree-grids and their trends over the whole GRACE mission lifetime from April 2002 to June *** estimate is derived from the release-6 version of GRACE monthly level-2 data,GNSS data,land surface models for soil moisture and snow wa-ter equivalent,and satellite altimetric lake *** find a GWS anomaly in form of an increasing trend in Saskatchewan,which affects the Saskatchewan Province and the states of Montana,North Dakota and Minnesota,and 4 GWS anomalies with declining trends in Nevada,California,Arizona and Texas,*** monthly changes of these GWS anomalies,except for the one in Nevada,are validated by well level *** provide results for average monthly GWS changes and the trends for the 5 anomalies but also in separate form for the 13 affected states or *** increasing trends of the Saskatchewan GWS anomaly and the affected 3 states are related to increasing precipitation and can be elucidated by the decreasing drought intensity *** the contrary,the declining trends in GWS can be explained by weakening precipitation and are mostly supported by the increasing drought intensity level in the other 4 anomalies and the affected states,which are Nevada,California,Arizona,New Mexico,Texas,Oklahoma,Kansas,and *** of monthly GWS changes and their trendscan serveas alternativeand beneficial input for the sustainable management of groundwater resources in North America.

关键词： North America Gravity recovery and climate experiment (GRACE) GNSS Groundwater Precipitation Drought

Advances in legged robots control,perception and learning

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IET Cyber-Systems and Robotics 2022年第4期4卷 265-267页

作者： Qiuguo Zhu Rui Song Jun Wu Yamakita masaki Zhangguo Yu Zhejiang University HangzhouChina Shandong University JinanChina Tokyo Institute of Technology TokyoJapan Zhejiang Beijing Institute of Technology BeijingChina

This is the Institution of Engineering and Technology(IET)Cyber-systems and Robotics Special Issue of Advances in Legged Robots:Control,Perception and *** mammals are found everywhere in *** legged animals can reach anywhere on Earth,adapt to uneven,discontinuous and obstructed *** locomotion patterns are flexible and diverse to better adapt to the living *** these real animals,legged robots have potential advantages over wheeled or tracked vehicles in regard to the traversal of rough and unstructured ***,there are still many challenges for legged systems in solving the technical problems of the real world.

关键词： environment. Institution terrain