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Journal of Environmental Science and Engineering(A) 2024年第2期13卷 50-60页

作者： Yoshimi Okada Kaji Naohiro Osamu Ikeda Kenichi Imagawa Hironori Kawai Masashi nagai Yasuhiro Inoue Frontier Business Division Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan Hydrogen Business Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan R&D Center Chiyoda Corporation3-13 Moriya-cho Kanagawa-kuYokohama 2208765Japan Technology Development Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan

Expanding the hydrogen energy utilization is essential for decarbonization,and the commercialization of hydrogen energy carrier systems that can“store”and“transport”hydrogen in a large scale is *** organic chemical hydride method incorporates hydrogen atoms into the molecular structure of a LOHC(Liquid Organic Hydrogen Carrier)to store and transport hydrogen in a liquid state under normal temperature and pressure,and is a highly safe method with low business *** has been developing the technology since 2002,completed a pilot demonstration in 2014 and named it the SPERA Hydrogen^(TM) System,and successfully completed an international supply chain demonstration that transports hydrogen from Brunei to Japan in a large scale in 2020,moving to the commercialization ***,Chiyoda is conducting feasibility studies with a number of domestic and foreign companies with the aim of commercializing the system as soon as *** this paper,outline,features,development status and our efforts in commercialization of SPERA HydrogenTM System are introduced.

关键词： Hydrogen carrier LOHC Methylcyclohexane MCH toluene

Optimal Building Frame Column Design Based on the Genetic Algorithm

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Computers, Materials & Continua 2019年第3期58卷 641-651页

作者： Tao Shen Yukari nagai Chan Gao Knowledge Science Japan Advanced Institute of Science and TechnologyNomi CityIshikawa 923-1292Japan Architecture Department Huzhou UniversityHuzhouZhejiang313000China.

Building structure is like the skeleton of the building,it bears the effects of various forces and forms a supporting system,which is the material basis on which the building *** building structure design is a vital part in architecture design,architects often explore novel applications of their technologies for building structure ***,such searches relied on experiences,expertise or gut *** this paper,a new design method for the optimal building frame column design based on the genetic algorithm is *** of all,in order to construct the optimal model of the building frame column,building units are divided into three categories in general:building bottom,main building and building ***,the genetic algorithm is introduced to optimize the building frame *** the meantime,a PGA-Skeleton based concurrent genetic algorithm design plan is proposed to improve the optimization efficiency of the genetic ***,effectiveness of the mentioned algorithm is verified through the simulation experiment.

关键词： Structure optimization genetic algorithm concurrent computation conceptual design simulation experiment.

Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans,Staphylococcus aureus,and Candida spp.

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World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle nagai de Lima Thaís Cristine Pereira Lara Steffany de Carvalho Letícia Ferreira dos Santos Carlos Eduardo Rocha Oliveira Lucas de Paula Ramos Maria Cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon Schoenanthus and Pelargonium graveolens essential oils against Streptococcus mutans,Staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).RESULTS *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei Staphylococcus aureus Streptococcus mutans

Diffuse large B-cell lymphoma successfully treated with amplified natural killer therapy alone: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7432-7439页

作者： Kenjiro nagai Syo nagai Yuji Okubo Keisuke Teshigawara Department of Internal Medicine Medical Corporation Ebino Centro ClinicEbino 889-4304Japan Department of Internal Medicine Higashinotoin ClinicKyoto 604-8175Japan

BACKGROUND The prognosis of patients with advanced diffuse large B-cell lymphoma(DLBCL)is poor,with a 5-year survival rate of approximately 50%.The mainstay of treatment is multidrug combination chemotherapy,which has been associated with serious side *** natural killer(ANK)cell therapy amplifies and activates natural killer(NK)cells to attack only malignant *** ANK cells attack programmed death ligand 1(PD-L1)-positive tumor cells,ANK therapy is considered effective against adult T-cell lymphoma and malignant *** SUMMARY Herein,we report a case of an older patient with advanced DLBCL who was successfully treated with ANK immunotherapy.A 91-year-old female visited our hospital with sudden swelling of the right axillary lymph node in April *** patient was diagnosed with stage II disease,given the absence of splenic involvement or contralateral *** therapy was *** rounds of lymphocyte sampling were performed on July 28,*** reduce the occurrence of side effects,the six samples were diluted by half to obtain 12 *** NK cells were administered twice *** treatment efficacy was evaluated by performing computed tomography and serological tests every 1 or 2 *** treatment suppressed lesion growth,and the antitumor effect persisted for several *** patient experienced mild side ***-L1 immunostaining was positive,indicating that the treatment was highly *** ANK therapy can be used as a first-line treatment for malignant lymphoma;the PD-L1 positivity rate can predict treatment efficacy.

关键词： Diffuse large B-cell lymphoma Natural killer cells Immunostaining Hodgkin's lymphoma Older adult Case report

Completing density functional theory by machine learning hidden messages from molecules

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npj Computational Materials 2020年第1期6卷 1306-1313页

作者： Ryo nagai Ryosuke Akashi Osamu Sugino Department of Physics The University of TokyoHongoBunkyo-KuTokyo 113-0033Japan Institute for Solid State Physics The University of TokyoKashiwaChiba 277-8581Japan

Kohn–Sham density functional theory(DFT)is the basis of modern computational approaches to electronic *** accuracy heavily relies on the exchange-correlation energy functional,which encapsulates electron–electron interaction beyond the classical *** its universal form remains undiscovered,approximated functionals constructed with heuristic approaches are used for practical ***,there are problems in their accuracy and transferability,while any systematic approach to improve them is yet *** this study,we demonstrate that the functional can be systematically constructed using accurate density distributions and energies in reference molecules via machine ***,a trial functional machine learned from only a few molecules is already applicable to hundreds of molecules comprising various first-and second-row elements with the same accuracy as the standard *** is achieved by relating density and energy using a flexible feed-forward neural network,which allows us to take a functional derivative via the back-propagation *** addition,simply by introducing a nonlocal density descriptor,the nonlocal effect is included to improve accuracy,which has hitherto been *** approach thus will help enrich the DFT framework by utilizing the rapidly advancing machine-learning technique.

关键词： technique functional theory

Optimal consumption–investment under partial information in conditionally log-Gaussian models

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Probability, Uncertainty and Quantitative Risk 2023年第1期8卷 95-120页

作者： Hideo nagai MMDS Osaka UniversityToyonaka 560-8531OsakaJapan

Certain Merton type consumption−investment problems under partial information are reduced to the ones of full information and within the framework of a complete market ***,specializing to conditionally log−Gaussian diffusion models,concrete analysis about the optimal values and optimal strategies is performed by using analytical tools like Feynman−Kac formula,or HJB *** explicit solutions to the related forward-backward equations are also given.

关键词： Optimal consumption-investment problem Conditionally log−Gaussian models HJB equations Feynman−Kac formula Forward-backward equations

INTEGRATED CONTROL FOR VEHICLE YAW MOTION USING DOUBLE-COST-FUNCTION LQR

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Chinese Journal of Mechanical Engineering 2000年第3期13卷 228-233页

作者： Jiang Lan Wang Xinyi nagai Masao 北京理工大学北京 Tokyo University of Agriculture and Technology 日本 Tokyo

The front steering angle control and its integration with the direct yaw moment control are suggested to enhance the handling performance for heavy-duty vehicles based on a 3D vehicle model. The double-cost-function LQR methodology (DLQR), which extends the concept and the applicable field of LQR to express the practical requirements more plainly, is proposed to determine the control input value: compensation value of front steering angle in the optimal model. A simple auto-tuning proportion controller is employed in direct yaw moment control to regulate the moment timely. The simulation results show that front steering angle control using DLQR has good ability to achieve the desired steering output in the different running conditions. DLQR is more powerful to balance many factors effectively based on the explicit mathematics expression of the physics of the problem than LQR does.

关键词： In INTEGRATED CONTROL FOR VEHICLE YAW MOTION USING DOUBLE-COST-FUNCTION LQR

Improve Computer Visualization of Architecture Based on the Bayesian Network

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Computers, Materials & Continua 2019年第2期58卷 307-318页

Computer visualization has marvelous effects when it is applied in various fields,especially in architectural *** an emerging force in the innovation industry,architects and design agencies have already demonstrated the value of architectural visual products in actual application *** on the digital image technology,virtual presentation of future scenes simulates architecture design,architectural renderings and multimedia ***,it can help design agencies transform the theoretical design concept into a lively and realistic visual which can provide the audience with a clearer understanding of the engineering and construction ***,it is challenging for designers to produce satisfactory renderings due to the frequent fault data during *** this paper,we use the 3Ds MAX as the operating platform and we present an algorithm based on the Bayesian network to construct a vector representation of the fault *** this basis,a case study of 3D Max’application has also been presented.

关键词： 3Ds MAX architectural visualization application geometric reconstruction Bayes.

Biological efficacy of perpendicular type-I collagen protruded from TiO_(2)-nanotubes

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International Journal of Oral Science 2020年第4期12卷 346-355页

作者： Chia-Yu Chen David M.Kim Cliff Lee John Da Silva Shigemi nagai Toshiki Nojiri Masazumi nagai Department of Oral Medicine Infection and ImmunityHarvard School of Dental Medicine188 Longwood AvenueBostonMAUSA Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental Medicine188 Longwood AvenueBostonMAUSA Department of Prosthodontics and Oral Implantology School of Dental MedicineIwate Medical University19-1 UchimaruMoriokaIwateJapan

The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen(Col-I)from TiO2 nanotubes(NT-EPF surface).We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating plateletmediated fibroblast recruitment and anchoring fibroblast-derived Col-I to form a perpendicular collagen assembly,mimicking the connective tissue attachment around natural teeth for the long-term maintenance of dental *** surface modification was accomplished in two ***,TiO2 nanotubes(NT)array was fabricated via *** and depths of NTs were controlled by applied voltage and ***,an electrophoretic fusion(EPF)method was applied to fuse Col-I into nanotube arrays in a perpendicular *** wettability was assessed by contact angle *** bioactivity of modified TiO2 surfaces was evaluated in terms of NIH3T3 fibroblast attachment,platelet activation,and collagen *** attachment,aggregation,and activation of platelets as well as release of platelet-related growth factors were demonstrated on NTEPF ***-mediated NIH3T3 cells migration toward NT-EPF was significantly increased and the attached cells showed a typical fibrous morphology with elongated spindle shape.A direct linkage between pseudopod-like processes of fibroblasts to NTEPF surfaces was ***,the engineered EPF collagen protrusion linked with cell-derived collagen in a perpendicular *** the limitation of this in vitro study,the TiO2 nanotube with perpendicular Col-I surface(NT-EPF)promoted better cell attachment,induced a strong platelet activation which suggested the ability to create a more robust soft tissue seal.

关键词： activation linkage sized