检索结果-南通市图书馆

The NF-Number of a Simplicial Complex

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Algebra Colloquium 2022年第4期29卷 643-650页

作者： Takayuki hibi Hasan Mahmood Department of Pure and Applied Mathematics Graduate School of Information Science and Technology Osaka University SuitaOsaka 565-0871Japan Department of Mathematics Government College University LahorePakistan

Let△bea simplicial complex on[n].TheNF-complex of△is the simplicial complexδ_(NF)(△)on[n]for which the facet ideal of△is equal to the Stanley-Reisner ideal ofδ_(NF)(△).Furthermore,for each k=2,3,....,we introduce the kth NF-complexδ_(NF)^(k)(△),which is inductively defined asδ_(NF)(k)(△)=δ_(NF)(δ_(NF)^(k-1)(△))by settingδ_(NF)^(1)(△)=δ_(NF)(△).One canδ_(NF)^(0)(△)=△.The NF-number of△is the smallest integer k>0 for whichδ_(NF)^(k)(△)■△.In the present paper we are especilly interested in the NF-number of a finite graph,which can be regraded as a simplicial complex of dimension *** is shown that the NF-number of the finite graph K_(n)■K_(m)on[n+m],which is the disjoint union of the complete graphs K_(n)on[n]and K_(m)on[m]for n≥2 and m≥2 with(n,m)≠(2,2),is equal to n+m+*** a corollary,we find that the NF-number of the complete bipartite graph K_(n,m)on[n+m]is also equal to n+m+2.

关键词： Stanley-Reisner complex facet ideal simplicial complex vertex cover

Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第15期29卷 2283-2293页

作者： Weijie Xue Masaki Honda Taizo hibi Department of Transplantation and Pediatric Surgery Kumamoto UniversityKumamoto 860-8556Japan

Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a major global public health event,resulting in a significant social and economic *** COVID-19 was initially characterized as an upper respiratory and pulmonary infection,recent evidence suggests that it is a complex disease including gastrointestinal symptoms,such as diarrhea,nausea,and ***,it remains unclear whether the gastrointestinal symptoms are caused by direct infection of the gastrointestinal tract by SARS-CoV-2 or are the result of systemic immune activation and subsequent dysregulation of homeostatic *** review provides a brief overview of the mechanisms by which SARS-CoV-2 disrupts the integrity of the gastrointestinal barrier including the mechanical barrier,chemical barrier,microbial barrier,and immune barrier.

关键词： Gastrointestinal barrier dysfunction SARS-CoV-2 COVID-19 Angiotensinconverting enzyme 2 Microbiome Immune cells

Locoregional therapy as a bridge to liver transplantation for hepatocellular carcinoma within Milan criteria:from a transplant oncology viewpoint

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2018年第2期7卷 134-135页

作者： Taizo hibi Yasuhiko Sugawara Department of Transplantation and Pediatric Surgery Kumamoto University Graduate School of Medical SciencesChuo-kuKumamotoJapan

The role of bridging locoregional therapy(LRT)for patients with hepatocellular carcinoma(HCC)within Milan criteria before liver transplantation(LT)has been ***,Agopian et al.(1)retrospectively investigated the impact of bridging LRT on post-LT HCC recurrence and survival based on 3,601 patients undergoing LT from 2002 to 2013,collected in the US Multicenter HCC Transplant *** observed no significant differences in the recurrence-free survival(RFS)among patients not receiving RT and the type and combination of treatment modality[transarterial chemoembolization(TACE),thermal ablation(radiofrequency or microwave ablation),and others]*** increasing number of LRT and the dynamic serum alpha-fetoprotein(AFP)changes were correlated with a higher risk of HCC *** authors concluded that LRT improved survival only in the subset of patients who achieved complete pathologic response(cPR)with a superior 5-year RFS of 72%compared to both untreated patients(69%;P=0.01)and LRT-treated patients not achieving cPR(67%;P=0.01).Admittedly,this is a benchmark study,and the authors should be congratulated on undertaking a sophisticated analysis in a large,heterogeneous cohort of patients.

关键词： hepatocellular viewpoint bridging

“Passive-bending colonoscope”significantly improves cecal intubation in difficult cases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第32期18卷 4454-4456页

作者： Takeshi Mizukami Haruhiko Ogata Toshihumi hibi Endoscopy Center NHO Kurihama Medical and Addiction CenterKanagawa 239-0841Japan Endoscopy Center Keio UniversityTokyo 160-0016Japan Department of Gastroenterology Keio UniversityTokyo 160-0016Japan

Colonoscopy sometimes causes pain during insertion,especially in difficult ***-insufflation of air causes elongation or acute angulations of the colon,making passage of the scope difficult and causing *** previously reported a sedative-risk-free colonoscopy insertion technique,namely,"Water Navigation Colonoscopy".Complete air suction after water infusion not only improves the vision,but also makes water flow down to the descending colon,while the sigmoid colon collapses and *** non-sedative colonoscopy can be carried out without pain in most cases,some patients do complain of *** of these patients have abnormal colon morphology,and the pain is caused while negotiating the "hairpin" bends of the *** "hairpin" bends of the colon should be negotiated by gently pushing the full-angled *** proximal 10-20 cm from the angulated part of the conventional colonoscope is stiff,with a wide turning radius,therefore,a conventional colonoscope cannot be negotiated through the "hairpin" bends of the colon without stretching them and causing *** "passive-bending colonoscope" has a flexible tip with a narrow turning radius,so that the scope can be negotiated through the "hairpin" bends of the colon with a minimum turning radius and minimal ***,the intubation and pain-reducing performance of the "passive-bending colonoscope" was assessed in difficult cases.

关键词： Computed tomographic colonography Water navigation colonoscopy Passive-bending colonoscope Cecal intubation

Improved method of plasma 8-Isoprostane measurement and association analyses with habitual drinking and smoking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第36期12卷 5846-5852页

作者： Soichi Kitano Hisashi Hisatomi Nozomu hibi Katsumi Kawano Shoji Harada Technology Development Department SRL Inc. Hachioji Tokyo Japan Center for Molecular Biology and Cytogenetics SRL Inc. Hino Tokyo Japan

AIM: To develop a simple and accurate method for quantifying 8-isoprostane in plasma by employing a combination of two-step solid-phase extraction of samples and a commercially available ELISA kit, and by this method to examine the effects of drinking and smoking habits against the levels of plasma 8-isoprostane in healthy Japanese ***: Plasma 8-isoprostane was extracted with ODS gel suspension followed by NH2 Sep-Pak column. The 8-isoprostane fractions were assayed using a commercially available ELISA kit. We measured plasma 8-isoprostane levels in 157 healthy Japanese volunteers divided into three groups (64 non-habitual drinkers, 56 moderate drinkers and 37 habitual drinkers) according to their alcohol consumption per week. Genotypes of aldehyde dehydrogenase 2 (ALDH2) were also determined to investigate the plasma 8-isoprostane levels with reference to drinking habits. In addition, the plasma 8-isoprostane levels of 96 non-smokers and 61 smokers from the same subjects were ***: Our method fulfilled all the requirements for use in routine clinical assays with respect to sensitivity, intra- and inter-assay reproducibility, accuracy and dynamic assay range. Significant increases of plasma 8-isoprostane levels were observed in female habitual drinkers when compared with those of non-habitual drinkers (t = 5.494, P < 0.0001) as well as moderate drinkers (t = 3.542, P < 0.005), and 8-isoprostane levels were also significantly different between ALDH2*2/1 and ALDH2*1/1 in the female habitual drinkers (t = 6.930, P < 0.0001), suggesting that excessive drinking of alcohol may increase oxidization stress, especially in females. On the contrary, no significant difference of the plasma 8-isoprostane levels was observed between non-smokers and ***: Our present method was proved to be a simple and accurate tool for measuring plasma 8-isoprostane. However, the clinical utility of plasma 8-isoprostane for drinking and smoking habits was

关键词： 8-Isoprostane ELISA Lipid peroxidation Drinking Smoking

Pre-hepatectomy type Ⅳ collagen 7S predicts post-hepatectomy liver failure and recovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第7期26卷 725-739页

作者： Masatsugu Ishii Osamu Itano Masahiro Shinoda Minoru Kitago Yuta Abe Taizo hibi Hiroshi Yagi Ayano Takeuchi Hanako Tsujikawa Tokiya Abe Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery International University of Health and Welfare School of MedicineChiba 286-8686Japan Department of Pediatric Surgery and Transplantation Kumamoto UniversityKumamoto 860-8556Japan Department of Public Health Keio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Liver resection is an effective treatment for benign and malignant liver ***,a method for preoperative evaluation of hepatic reserve has not yet been *** reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic *** determining eligibility for hepatectomy,the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative *** To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function *** This study was a retrospective cohort *** retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December *** post-hepatectomy liver failure(PHLF)was defined using the International Study Group of Liver Surgery’s definition of ***-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of2.8 g/dL,respectively,and the time taken for Child-Pugh score to return to Child-Pugh class *** Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver *** analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S≤6 ng/mL than in those with type IV collagen 7S>6 ng/*** additional analyses,similar results were observed in patients without chronic viral hepatitis associated with *** Preoperative type IV collagen 7S is a preoperative predictor of PHLF and longterm postoperative liver function *** can also be used in patients without chron

关键词： Hepatectomy Liver failure Type Ⅳ collagen 7S Liver fibrosis Postoperative complications Long-term postoperative liver function recovery

Method for Detecting NADPH-Cytochrome P450 Reductase in Liver Microsomal Fractions by Using Native Polyacrylamide Gel Electrophoresis and NADPH-Diaphorase Staining

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Analytical Chemistry 2013年第6期4卷 301-305页

作者： Hirokazu Yokoyama Yukishige Okamura Toshifumi hibi Department of Internal Medicine School of Medicine Keio University Shinanomachi Shinjukuku Tokyo Japan

By combining native polyacrylamide gel electrophoresis (PAGE) and nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase staining, a simple method for detecting NADPH-cytochrome P450 reductase in tissue samples was established. When rat liver microsomal fractions were examined by this method, several bands with different mobility were visualized. Western blot analysis indicated that the band which appeared in the most anodal position among them represented NADPH-cytochrome P450 reductase. SDS-PAGE/Western blot analysis revealed that the molecular weight of the protein forming the band was around 80 kDa, which was identical to that of rat NADPH-cytochrome P450 reductase. The intensity level of NADPH-diaphorase staining assigned to this enzyme estimated by this method increased four times in microsomal fractions prepared from rat fed ethanol chronically compared to that from controls. When a dilution series of a rat liver microsomal fraction was examined by this method and SDS-PAGE/Western blot analysis, their staining intensities representing this enzyme were significantly correlated with each other. Using the naive PAGE/NADPH-diaphorase staining method, NADPH-cytochrome P450 reductase is detected in rat liver microsomes. This method is beneficial because compared with the conventional SDS-PAGE/Western blot analysis, the quantification of NADPH-cytochrome P450 reductase in tissue samples is allowed to be more easily done.

关键词： NADPH-Cytochrome p450 Reductase Native PAGE NADPH-Diaphorase Staining Chronic Ethanol Consumption

Two cases of pancreatic ductal adenocarcinoma with intrapancreatic metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第41期22卷 9222-9228页

作者： Yusuke Fujita Minoru Kitago Yohei Masugi Osamu Itano Masahiro Shinoda Yuta Abe Taizo hibi Hiroshi Yagi Yoko Fujii-Nishimura Michiie Sakamoto Yuko Kitagawa Department of Surgery Keio University School of Medicine Department of Pathology Keio University School of Medicine

There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma(PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature.

关键词： Carcinoma Pancreatic ductal Neoplasm micrometastasis Recurrence Carcinogenesis

An antioxidant resveratrol significantly enhanced replication of hepatitis C virus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第2期16卷 184-192页

作者： Mitsuyasu Nakamura Masanori Ikeda Ryota Hokari Nobuyuki Kato Toshifumi hibi Soichiro Miura Department of Internal Medicine 2 National Defense Medical Collage3-2 NamikiTokorozawaSaitama 3598513Japan Department of Internal Medicine School of MedicineKeio University35 ShinanomachiShinjuku-kuTokyo 1608582 Japan Department of Internal Medicine School of MedicineKeio University35 ShinanomachiShinjuku-kuTokyo 1608582 Japan Masanori Ikeda Department of Molecular Biology Okayama University Graduate School of Medicine and Dentistry2-5-1 Shikada-choOkayama 7008558Japan Department of Internal Medicine School of MedicineKeio University35 ShinanomachiShinjuku-kuTokyo 1608582 Japan Masanori Ikeda

AIM:To elucidate the effect of antioxidants,resveratrol (RVT)and astaxanthin(AXN),on hepatitis C virus(HCV) replication. METHODS:We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system *** is a strong antioxidant and a kind of polyphenol that inhibits replication of various *** is also a strong *** replication of HCV RNA was assessed by the luciferase reporter *** additive effect of antioxidants on antiviral effects of interferon(IFN)and ribavirin(RBV) was ***:This is the first report to investigate the effect of RVT and AXN on HCV *** contrast to other reported viruses,RVT significantly enhanced HCV RNA *** E also enhanced HCV RNA replication as reported previously,although AXN didnot affect *** and RBV significantly reduced HCV RNA replication,but these effects were dose-dependently hampered and attenuated by the addition of *** didnot affect antiviral effects of IFN or RBV. CONCLUSION:These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis C.

关键词： Replicon system Luciferase assay Ribavirin Interferon Polyphenol Astaxanthin