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Synchronous multiple lung cancers with hilar lymph node metastasis of small cell carcinoma:A case report

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世界临床病例杂志 2023年第25期11卷 5919-5925页

作者： Ryusei Yoshino Nana yoshida Shunsuke Yasuda Akane Ito Masaki Nakatsubo Sayaka Yuzawa masahiro Kitada Thoracic Surgery and Breast Surgery Asahikawa Medical UniversityAsahikawa 078-8510Japan Diagnostic Pathology Asahikawa Medical University HospitalHokkaido 078-8510Japan

BACKGROUND Synchronous multiple lung cancers are rare and refer to the simultaneous presence of two or more primary lung tumors,which present significant challenges in terms of diagnosis and *** SUMMARY We report a case of multiple synchronous lung cancers with hilar lymph node metastasis of small cell carcinoma of unknown origin in a 73-year-old *** lung biopsy revealed squamous cell *** enlargement of lymph node 12u was detected,no distant metastases were *** patient was preoperatively diagnosed with T1cN0M0 and underwent thoracoscopic right upper lobectomy with nodal dissection(ND2a).Based on histopathological findings,the primary lesion was squamous cell carcinoma.A microinvasive adenocarcinoma was also observed on the cranial side of the primary *** were detected in two resected lymph nodes(#12u and#11s).Both tumors were pathologically diagnosed as small cell *** primary lesion of the small cell carcinoma could not be identified even by whole-body imaging;however,chemotherapy was initiated for hilar lymph node metastasis of the small cell carcinoma of unknown *** Multiple synchronous lung cancers can be accompanied by hilar lymph node metastasis of small cell carcinomas of unknown origin.

关键词： Small cell carcinoma Synchronous multiple lung cancers Squamous cell carcinoma Adenocarcinoma Chemotherapy Case report

Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study

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World Journal of Gastroenterology 2017年第2期23卷 318-327页

作者： masahiro Sakaguchi Noriaki Manabe Nobuo Ueki Jun Miwa Tomoki Inaba Norimasa yoshida Kouichi Sakurai masahiro Nakagawa Hajime Yamada Michiya Saito Koji Nakada Katsuhiko Iwakiri Takashi Joh Ken Haruma Department of Gastroenterology Moriguchi Keijinkai Hospital Division of Endoscopy and Ultrasonography Department of Clinical Pathology and Laboratory MedicineKawasaki Medical School Department of Internal Gastroenterology and Hepatology Tokyo Rosai Hospital Department of Gastroenterology Toshiba General Hospital Department of Gastroenterology Kagawa Prefectural Central Hospital Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital Hattori Clinic Department of Endoscopy Hiroshima City Hospital Department of Gastroenterology and Hepatology Shinko Hospital1 Michiya Clinic1 Department of Laboratory Medicine Daisan Hospital Jikei University School of Medicine1 Department of Gastroenterology Nippon Medical School Graduate School of Medicine1 Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences1 Department of General Internal Medicine 2 Kawasaki Medical School General Medical Center

AIMTo assess the clinical characteristics of patients with complicated erosive esophagitis (EE) and their associated *** prospective, cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between October 2014 and March 2015 at 106 Japanese hospitals. Data on medical history, general condition, gastrointestinal symptoms, lifestyle habits, comorbidities, and endoscopic findings were collected using a standard form to create a dedicated database. Logistic regression analysis was used to calculate adjusted odds ratios (aOR) and 95%CI for the association with complicated *** the study period, 1749 patients diagnosed with EE, 38.3% of whom were prescribed proton pump inhibitors (PPIs) were included. Of them, 143 (8.2%) had EE complications. Esophageal bleeding occurred in 84 (4.8%) patients, esophageal strictures in 45 (2.6%) patients, and 14 (0.8%) patients experienced both. Multivariate analysis showed that increased age (aOR: 1.05; 95%CI: 1.03-1.08), concomitant use of psychotropic agents (aOR: 6.51; 95%CI: 3.01-13.61), and Los Angeles grades B (aOR: 2.69; 95%CI: 1.48-4.96), C (aOR: 15.38; 95%CI: 8.62-28.37), and D (aOR: 71.49; 95%CI: 37.47-142.01) were significantly associated with complications, whereas alcohol consumption 2-4 d/wk was negatively associated (aOR: 0.23; 95%CI: 0.06-0.61). Analyzing associated factors with each EE complication separately showed esophageal ulcer bleeding were associated with increased age (aOR: 1.05; 95%CI: 1.02-1.07) and Los Angeles grades B (aOR: 3.60; 95%CI: 1.52-8.50), C (aOR: 27.61; 95%CI: 12.34-61.80), and D (aOR: 119.09; 95%CI: 51.15-277.29), while esophageal strictures were associated with increased age (aOR: 1.07; 95%CI: 1.04-1.10), gastroesophageal reflux symptom (aOR: 2.51; 95%CI: 1.39-4.51), concomitant use of psychotropic agents (aOR: 11.79; 95%CI: 5.06-27.48), Los Angeles grades C (aOR: 7.35; 95%CI: 3.32-16.25), and D (aOR: 20.34; 95%CI: 8.36-49.53) and l

关键词： Complication Erosive esophagitis Proton pump inhibitor Esophageal ulcer bleeding Esophageal stricture

HER2 Type Male Breast Cancer Successfully Treated with Pertuzumab, Trastuzumab, and Eribulin Therapy: A Case Report

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Journal of Cancer Therapy 2020年第3期11卷 154-159页

作者： masahiro Kitada Shunsuke Yasuda masahiro Abe Nana yoshida Satoshi Okazaki Kei Ishibashi Department of Breast Disease Center Asahikawa Medical University Asahikawa Japan

Background:?Male breast cancer is rare, accounting for approximately 0.5% - 1.0% of all breast cancer cases;hormone-dependent luminal type male breast cancer is the most common. The proportion of hormone receptor-negative and human epithelial growth factor Receptor type 2-positive breast cancer is?extremely low among male breast cancer.?A patient with advanced HER2 type breast cancer, a rare male breast cancer, was successfully treated with pertuzumab, trastuzumab, and eribulin therapy. Case Presentation:?A 75-?year-old man presented to our hospital with induration of the right anterior chest and lymphoedema of the right upper limb. Based on the results of core needle biopsy, he was diagnosed with HER2 type invasive ductal carcinoma associated with bone metastasis (stage IV). Chemotherapy with pertuzumab, trastuzumab, and eribulin was started. The drugs were remarkably effective, and his lymphoedema tended to improve.?Conclusion:?We reported a successful case of chemotherapy and targeted therapy for a rare male breast cancer of HER2 positive and hormone negative type.

关键词： Male Breast Cancer HER2 Type

EFFECT OF SPACE DIVERSITY TECHNIQUE IN UHF BAND RADIO INDOOR PROPAGATION

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EFFECT OF SPACE DIVERSITY TECHNIQUE IN UHF BAND RADIO INDOOR...

Effectiveness and safety of chemotherapy for patients with malignant gastrointestinal obstruction:A Japanese populationbased cohort study

第六届无线与电波传播国际会议（ISAPE）

作者： masahiro NISHI Akira YABUKI Teruaki yoshida Faculty of Information Sciences Hiroshima City University 3-4-1 Ozuka-higashi Asa-minami-ku Hiroshima 731-3194 Japan Faculty of Information Sciences Hiroshima City University 3-4-1 Ozuka-higashi Asa-minami-ku Hiroshima 731-3194 Japan Faculty of Information Sciences Hiroshima City University 3-4-1 Ozuka-higashi Asa-minami-ku Hiroshima 731-3194 Japan

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World Journal of Clinical Cases 2022年第16期10卷 5253-5265页

作者： Gota Fujisawa Ryota Niikura Takuya Kawahara Tetsuro Honda Kenkei Hasatani Naohiro yoshida Tsutomu Nishida Tetsuya Sumiyoshi Shu Kiyotoki Takashi Ikeya masahiro Arai Yoku Hayakawa Takashi Kawai Mitsuhiro Fujishiro Department of Gastroenterology Graduate school of MedicineThe University of TokyoTokyo 1138655Japan Gastroenterological Endoscopy Tokyo Medical UniversityTokyo 1600023Japan Clinical Research Support Center The University of Tokyo HospitalTokyo 1138655Japan Department of Gastroenterology Nagasaki Harbor Medical CenterNagasaki 8508555Japan Department of Gastroenterology Fukui Prefectural HospitalFukui 9108526Japan Department of Gastroenterology Ishikawa Prefectural Central HospitalIshikawa 9208530Japan Department of Gastroenterology Toyonaka Municipal HospitalOsaka 5608565Japan Department of Gastroenterology Tonan HospitalHokkaido 0600004Japan Department of Gastroenterology Shuto General HospitalYamaguchi 7420032Japan Department of Gastroenterology St.Luke's International HospitalTokyo 1048560Japan Department of Gastroenterology Nerima Hikarigaoka HospitalTokyo 1790072Japan

BACKGROUND The impacts of chemotherapy on patients with malignant gastrointestinal obstructions remain unclear,and multicenter evidence is *** To evaluate the effectiveness and safety of chemotherapy in patients with unresectable malignant gastrointestinal *** We conducted a multicenter retrospective cohort study that compared the chemotherapy group who received any chemotherapeutics after interventions,including palliative surgery or selfexpandable metal stent placement,for unresectable malignant gastrointestinal obstruction vs the best supportive care(BSC)group between 2014 and 2019 in nine *** primary outcome was overall survival,and the secondary outcomes were patency duration and adverse events,including gastrointestinal perforation and gastrointestinal *** In total,470 patients in the chemotherapy group and 652 patients in the BSC group were *** the follow-up period of 54.1 mo,the median overall survival durations were 19.3 mo in the chemotherapy group and 5.4 mo in the BSC group(log-rank test,P<0.01).The median patency durations were 9.7 mo[95% confidence interval(CI):7.7-11.5 mo]in the chemotherapy group and 2.5 mo(95%CI:2.0-2.9 mo)in the BSC group(log-rank test,P<0.01).The perforation rate was 1.3%(6/470)in the chemotherapy group and 0.9%(6/652)in the BSC group(P=0.567).The gastrointestinal bleeding rate was 1.5%(7/470)in the chemotherapy group and 0.5%(3/652)in the BSC group(P=0.105).CONCLUSION Chemotherapy after interventions for unresectable malignant gastrointestinal obstruction was associated with increased overall survival and patency duration.

关键词： Gastrointestinal cancer Chemotherapy Malignant gastrointestinal obstruction Self-expandable metal stent Palliative surgery

Diurnal Variation of Nuclear Receptors in Mice with or without Fasting

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Pharmacology & Pharmacy 2013年第2期4卷 240-243页

作者： Atsushi Kawase Tetsuya Ohgami Iho yoshida Yu Tsunokuni masahiro Iwaki Department of Pharmacy School of Pharmacy Kinki University Osaka Japan Department of Physiology Hyogo College of Medicine Nishinomiya Japan.

Nuclear receptors such as pregnane X receptor (PXR) and constitutive androstane receptor (CAR) regulate the transcription of transporter and cytochrome P450 (CYP). The diurnal variation was observed in some transporters regulated by nuclear receptors. We investigated whether diurnal variation in PXR and CAR exists in mice. We also examined the effect of food intake on the diurnal rhythm of hepatic PXR and CAR using fed and fasted mice. In liver and small intestine of fed mice, the mRNA levels of PXR and CAR were unchanged between 7:00 AM and 7:00 PM. In contrast to fed mice, fasting mice partly exhibited the diurnal variation in PXR, not in CAR. The mRNA levels of PXR at 7:00 AM were significantly higher than that those at 7:00 PM in liver of fasting mice. These results indicated the different effects of fasting in mice on diurnal variation of PXR in each tissue.

关键词： CAR Circadian Rhythm Diurnal Variation Fasting Nuclear Receptor PXR

High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis

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World Journal of Gastroenterology 2016年第26期22卷 6083-6088页

作者： Kazuhiro Shimazu Koji Fukuda Taichi yoshida masahiro Inoue Hiroyuki Shibata Department of Clinical Oncology Graduate School of Medicine Akita University

AIM: To clarify the biological feature contributing to gastric cancer with diffuse bone metastases at ***: The participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at diagnosis includes over 29 hot spots of bone scintigraphy. Circulating tumor cell were collected from 20 m L of peripheral venous blood drawn using a Cell Search kit and a Cell Tracks Auto Prep system by SRL, a clinical laboratory. The endpoints of this study were correlations between circulating tumor cells(CTC) count and therapeutic outcomes. RESULTS: Among 39 patients with gastric cancer, 5 patients met the criterion. The incidence of this subtype was 12.8%. CTC counts ranged from 235 to 6440 cells/7.5 m L of peripheral blood(median of 1724). These values were much higher than common gastric cancers(2 cells). In chemo-sensitive cases, CTC counts decreased within 14 d(median) from 275, 235 and 1724 to 2, 7 and 66, respectively. On the other hand, CTC counts increased after treatment failure or insensitive case from 2, 7 and 6440 to 787, 513 and 7885, respectively. The correlation between CTC count and survival time showed a trend, but did not reach significance(Y = 234.6- 0.03 X, P = 0.085).CONCLUSION: High CTC count is a biological hallmark of this subtype, and can be used as a direct and definitive indicator of therapeutic outcome.

关键词： Bone metastasis Circulating tumor cell Gastric cancer Predictive biomarker Prognostic biomarker

cDNA Cloning of Paramyosin from Several Kinds of Squid Mantle Muscle

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Advances in Bioscience and Biotechnology 2018年第1期9卷 11-25页

作者： Takayuki Kajita Yoshiko Takeda Saki yoshida Koki Yamada masahiro Matsumiya Hideto Fukushima Department of Marine Science and Resources College of Bioresource Science Fujisawa Japan

Paramyosin is a rod-shaped muscle protein found exclusively in invertebrates, with α-helices coiled around each other to form a coiled-coil structure. Marine organisms in which the primary structure of paramyosin has been determined are mollusks, including abalone (Haliotis discus), mussels (Mytilus galloprovincialis), octopus (Octopus bimaculoides), and oyster (Crassostrea gigas). In contrast, the primary structure of squid paramyosin, which is of particular interest, has yet to be reported. In the present study, cDNA cloning of paramyosins from four squid species, the neon flying squid (Ommastrephes bartramii), the Humboldt squid (Dosidicus gigas), the golden cuttlefish (Sepia esculenta), and the clawed armhook squid (Gonatus onyx), was performed to determine the following: the 2605-bp O. bartramii paramyosin gene containing a 2574-bp open reading frame (ORF), the 2691-bp D. gigas paramyosin gene containing a 2640-bp ORF, the 2631-bp S. esculenta paramyosin gene containing a 2574 ORF, and the 2609-bp G. onyx paramyosin gene containing a 2574-bp ORF. The primary structure of the four squid paramyosins was found to contain heptad repeats and an ACD (assembly competence domain), which are characteristic of a coiled coil. A phylogenetic analysis was performed with paramyosin sequences from species including the four squid species examined in this study, the results of which indicated that the four squid paramyosins form a group independent from the paramyosins of other species, to which octopus paramyosins are closest.

关键词： Paramyosin Squid cDNA Cloning Mantle Muscle Phylogenetic Analysis

Hyperdry human amniotic membrane application as a wound dressing for a full-thickness skin excision after a third-degree burn injury

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Burns & Trauma 2020年第1期8卷 186-203页

作者： Jiro Oba Motonori Okabe Toshiko yoshida Chika Soko Moustafa Fathy Koji Amano Daisuke Kobashi masahiro Wakasugi Hiroshi Okudera Department of Emergency and Disaster Medicine University of ToyamaToyama 930-0194Japan Department of Regenerative Medicine Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyama 930-0194Japan Department of Biochemistry Faculty of PharmacyMinia UniversityMinia 61519Egypt Department of Emergency Surgery Sakai City Medical CenterSakaiOsaka 594-8304Japan

Background:Severe burn injuries create large skin defects that render the host susceptible to bacterial *** wound infection often causes systemic sepsis and severe septicemia,resulting in an increase in the mortality of patients with severe burn ***,appropriate wound care is important to prevent infection and improve patient ***,it is difficult to heal a third-degree burn *** aim of this studywas to investigate whether hyperdry human amniotic membrane(HD-AM)could promote early granulation tissue formation after full-thickness skin excision in third-degree burn injury sites in ***:After the development of HD-AM and creation of a third-degree burn injury model,the HD-AM was either placed or not placed on the wound area in the HD-AM group or HD-AM group,*** groups were prepared for evaluation on postoperative days 1,4 and *** staining was used for granulation tissue evaluation,and estimation of CD163,transforming growth factor beta-1(TGF-β1),vascular endothelial growth factor(VEGF),CD31,alpha-smooth muscle actin(α-SMA)and Iba1 expression was performed by immunohistochemical *** reverse-transcription polymerase chain reaction(PCR)was used to investigate gene expression of growth factors,cell migration chemokines and angiogenic and inflammatory ***:The HD-AM group showed significant early and qualitatively good growth of granulation tissue on the full-thickness skin excision ***-AM promoted early-phase inflammatory cell infiltration,fibroblast migration and angiogenesis in the granulation ***,the early infiltration of cells of the immune system was ***:HD-AM may be useful as a new wound dressing material for full-thickness skin excision sites after third-degree burn injuries,and may be a new therapeutic technique for improving the survival rate of patients with severe burn injuries.

关键词： Hyperdry human amniotic membrane Third-degree burn Granulation Cell migration Inflammation Angiogenesis