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第六届无线与电波传播国际会议（ISAPE）

作者： masahiro nishi Akira YABUKI Teruaki YOSHIDA Faculty of Information Sciences Hiroshima City University 3-4-1 Ozuka-higashi Asa-minami-ku Hiroshima 731-3194 Japan Faculty of Information Sciences Hiroshima City University 3-4-1 Ozuka-higashi Asa-minami-ku Hiroshima 731-3194 Japan Faculty of Information Sciences Hiroshima City University 3-4-1 Ozuka-higashi Asa-minami-ku Hiroshima 731-3194 Japan

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STRUCTURE OF THE ELECTRIFIED IONIC LIQUID|WATER INTERFACE STUDIED BY SECOND HARMONIC GENERATION

STRUCTURE OF THE ELECTRIFIED IONIC LIQUID|WATER INTERFACE ST...

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第十二届北京分析测试学术报告会暨展览会(BCEIA 2007)

作者： Naoya nishi Ryoichi ISHIMATSU Yukinori YASUI masahiro YAMAMOTO Takashi KAKIUCHI Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering Kyoto University

Two-phase systems composed of water(W)and hydrophobic room-temperature ionic liquids(ILs)have been studied by many researchers for possible applications such as liquid-liquid extraction and two-phase *** far,we have studied the IL-W two-phase systems from the electrochemical viewpoint[1-4].Some of characteristics of the IL-W two-phase systems we found,such as high selectivity of dibenzo-18-crown-6 to Kover Na[1]and adsorptivity of hydrophilic anions at the

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Polaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide:Relevant to cytoprotective heat shock proteins

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World Journal of Gastroenterology 2006年第38期12卷 6178-6181页

作者： Tatsuya Ohkawara Jun nishihira Rika Nagashima Hiroshi Takeda masahiro Asaka Department of Gastroenterology and Hematology Hokkaido University Graduate School of Medicine Kita15 Nishi7 Kita-ku Sapporo 060-8678 Japan Department of Research and Development GeneticLab Co. Ltd. Kita9 Nishi15 Chuou-ku Sapporo 060-0009 Japan Department of Research and Development GeneticLab Co. Ltd. Kita9 Nishi15 Chuou-ku Sapporo 060-0009 Japan Department of Gastroenterology and Hematology Hokkaido University Graduate School of Medicine Kita15 Nishi7 Kita-ku Sapporo 060-8678 Japan

AIM： To investigate the effect of polaprezinc on cellular damage induced by hydrogen peroxide （H202） in human colon CaCo2 cells. METHODS： CaCo2 cells were treated with polaprezinc （10-100 pmol/L） for 6 h. After polaprezinc treatment, the cells were incubated with H202 （20μmol/L） for 1 h. Cell viability was measured by MTT assay. Western blot analysis for heat shock protein （HSP） 27 and HSP72 in the cells was performed. Moreover, cells were pretreated with quercetin （200 μmol/L）, an inhibitor of HSP synthesis, 2 h before polaprezinc treatment, and cell viability and the expression of HSP27 and 72 were assessed in these cells. RESULTS： Polaprezinc significantly protected CaCo2 cells from cell damage induced by H2O2, and up-regulated the expressions of HSP27 and HSP72 in the cells （10, 30 and 100 pmol/L of polaprezinc; 35.0% ± 7.7%, 58.3% ± 14.6% and 64.2% ± 8.2%, respectively. P 〈 0.01 versus polaprezinc-nontreated cells; 6.0% ± 4.4%）. Quercetin inhibited the up-regulation of HSP27 and HSP72 by polaprezinc and diminished the protective effect of polaprezinc against H2O2-caused injury in the cells. CONCLUSION： Polaprezinc is a useful therapeutic agent for treatment of colitis and its effects depend on the function of cytoprotective HSP in colon.

关键词： Heat shock protein Oxidative injury Polaprezinc

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Easy removing of phenol from wastewater using vegetable oil-based organic solvent in emulsion liquid membrane process

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Chinese Journal of Chemical Engineering 2017年第1期25卷 45-52页

作者： Norasikin Othman Norul Fatiha Mohamed Noah Lim Yin Shu Zing-Yi Ooi Norela Jusoh Mariani Idroas masahiro Goto Centre of Lipids Engineering and Applied Research (CLEAR) Ibnu Sina Institute for Scientuific and Industrial Research (Ibnu Sina ISIR) Universiti Teknologi Malaysia 81310 UTM Johor BahruJohor Malaysia Faculty of Chemicul and Energy Engineering Universiti Teknologi Malaysia 81310 UTM Johor BahruJohor Malaysia Department of Applied Chemistry Graduate School of Engineering Kyushu University 744 Motooka Nishi-ka Fukuoka-shi fukuoka 819-0395Japan

Phenol is considered as pollutant due to its toxicity and carcinogenic ***,variety of innovative methods for separation and recovery of phenolic compounds is developed in order to remove the unwanted phenol from wastewater and obtain valuable phenolic *** of potential method is extraction using green based liquid organic ***,the feasibility of using palm oil was *** this research,palm oil based organic phase was used as diluents to treat a simulated wastewater containing 300×10^(-6) of phenol solution using emulsion liquid membrane process(ELM).The stability of water-in-oil(W/O) emulsion on diluent composition and the parameters affecting the phenol removal efficiency and stability of the emulsion;such as emulsification speed,emulsification time,agitation speed,surfactant concentration,pH of external phase,contact time,stripping agent concentration and treat ratio were carried *** results of ELM study showed that at ratio7 to 3 of palm oil to kerosene,5 min and 1300 r·min^(-1) of emulsification process the stabile primary emulsion were ***,no carrier is needed to facilitate the phenol *** experimental conditions of500 r·min^(-1) of agitation speed,3%Span 80,pH 8 of external phase,5 min of contact time,0.1 mol·L^(-1) NaOH as stripping agent and 1:10 of treat ratio,the ELM process was very promising for removing the phenol from the *** extraction performance at about 83%of phenol was removed for simulated wastewater and an enrichment of phenol in recovery phase as phenolate compound was around 11 times.

关键词： Vegetable palm oil-based Liquid membrane Phenol removal Wastewater

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Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA

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World Journal of Gastroenterology 2011年第29期17卷 3459-3464页

作者： Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Nobuyuki Ehira Hiroaki Yamato Kazunori Eto Kanako Kubota masahiro Asaka Department of Gastroenterology Hokkaido University Graduate School of MedicineKita 15Nishi 7Kita-kuSapporo060-8638Japan Department of Surgical pathology Hokkaido University HospitalKita 14Nishi 5Kita-kuSapporo060-8638Japan

Schwannomas are peripheral nerve tumors that are typically solitary and *** diagnosis is largely based on surgically resected ***,a number of case reports have indicated that retroperitoneal schwannomas could be diagnosed with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).We report the diagnosis of three cases of schwannoma using *** were two males and one female,ages 22,40,and 46 years,respectively,all of whom were *** findings showed well-circumscribed round ***,as the tumors could not be diagnosed using these findings alone,EUS-FNA was ***-eosin staining of the resulting tissue fragments revealed bland spindle cells with nuclear *** was no disparity in nuclear *** revealed S-100 protein positivity and all cases were diagnosed as ***-67 indexes were 3%-15%,2%-3%,and 3%,*** case showed any signs of *** most schwannomas are benign tumors and seldom become malignant,we observed these patients without *** tumors demonstrated no enlargement and no change in *** are almost always benign and can be observed following diagnosis by EUS-FNA.

关键词： Schwannoma Endoscopic ultrasonography Fine-needle aspiration Retroperitoneal tumor S100 proteins Ki-67 index

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Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press

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Asian Journal of Pharmaceutical Sciences 2017年第5期12卷 412-417页

作者： Takashi Osamura Yoshiko Takeuchi Risako Onodera masahiro Kitamura Yoshiteru Takahashi Kohei Tahara Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University1-25-4Daigaku-NishiGifu501-1196Japan Pharmaceutical Technology Department Sawai Pharmaceutical Co.Ltd12-34HiroshibachoSuita-ShiOsaka564-0052Japan

We previously determined 'Tableting properties' by using a multi-functional single-punch tablet press(GTP-1). We proposed plotting 'Compactability' on the x-axis against'Manufacturability' on the y-axis to allow visual evaluation of 'Tableting properties'. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure'Tableting properties' with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad 'Manufacturability', leading to sticking of powder on *** also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine.

关键词： Tableting Formulation design Lubricant Punch shape Single-punch tablet press Losartan potassium

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