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Efficacy of cytapheresis in patients with ulcerative colitis showing insufficient or lost response to biologic therapy

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World Journal of Gastroenterology 2022年第34期28卷 4959-4972页

作者： masahiro Iizuka Takeshi Etou Shiho Sagara Akita Health Care Center Akita Red Cross HospitalAkita 010-0001Japan Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan

For the optimal management of refractory ulcerative colitis(UC),secondary loss of response(LOR)and primary non-response to biologics is a critical *** article aimed to summarize the current literature on the use of cytapheresis(CAP)in patients with UC showing a poor response or LOR to biologics and discuss its advantages and ***,we summarized the efficacy of CAP in patients with UC showing insufficient response to thiopurines or immunomodulators(IM).Eight studies evaluated the efficacy of CAP in patients with UC with inadequate responses to thiopurines or *** were no significant differences in the rate of remission and steroid-free remission between patients exposed or not exposed to thiopurines or *** studies evaluated the efficacy of CAP in patients with UC showing an insufficient response to biologic *** remission rates of biologics exposed or unexposed patients were 29.4%and 44.2%,*** studies evaluated the efficacy of CAP in combination with biologics in patients with inflammatory bowel disease showing a poor response or LOR to *** rates of remission/response and steroid-free remission in patients with UC ranged 32%-69%(mean:48.0%,median:42.9%)and 9%-75%(mean:40.7%,median:38%),*** had the same effectiveness for remission induction with or without prior failure on thiopurines or IM but showed little benefit in patients with UC refractory to *** heterogeneity existed in the efficacy of the combination therapy with CAP and biologics,these combination therapies induced clinical remission/response and steroid-free remission in more than 40%of patients with UC refractory to biologics on *** the excellent safety profile of CAP,this combination therapy can be an alternative therapeutic strategy for UC refractory to *** prospective studies are needed to understand the efficacy of combination therapy with CAP and biologics.

关键词： Ulcerative colitis Inflammatory bowel disease Cytapheresis Granulocyte and monocyte adsorptive apheresis Anti-tumor necrosis factor-αantibody Combination therapy

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Efficacy and safety of emergency endoscopic retrograde cholangiopancreatography for acute cholangitis in the elderly

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World Journal of Gastroenterology 2016年第37期22卷 8382-8388页

作者： Gen Tohda masahiro Ohtani Masaki Dochin Department of Gastroenterology Fukui Kosei Hospital Fukui Fukui 918-8537 Japan Second Department of Internal Medicine Faculty of Medical SciencesUniversity of Fukui Eiheji-cho Fukui 910-1193 Japan

AIM To investigate the efficacy and safety of emergency endoscopic retrograde cholangiopancreatography(ERCP) in elderly patients with acute cholangitis. METHODS From June 2008 to May 2016, emergency ERCPs were performed in 207 cases of acute cholangitis at our institution. Patients were classified as elderly if they were aged 80 years and older(n = 102); controls were under the age of 80 years(n = 105). The patients' medical records were retrospectively reviewed for comorbidities, laboratory data, etiology of cholangitis(presence of biliary stones, biliary stricture and malignancy), details of the ERCP(therapeutic approaches, technical success rates, procedure duration), ERCP-related complications and mortality. RESULTS The frequency of comorbidities was higher in the elderly group than the control group(91.2% vs 67.6%). Periampullary diverticulum was observed in the elderly group at a higher frequency than the control group(24.5% vs 13.3%). Between the groups, there was no significant difference in the technical success rates(95.1% vs 95.2%) or endoscopicprocedure durations. With regard to the frequency of ERCP-related complications, there was no significant difference between the two groups(6.9% vs 6.7%), except for a lower rate of post-ERCP pancreatitis in the elderly group than in the control group(1.0% vs 3.8%). Neither angiographic nor surgical intervention was required in any of the cases with ERCP-related complications. There was no mortality during the observational periods. CONCLUSION Emergency ERCP for acute cholangitis can be performed safely even in elderly patients aged 80 years and older.

关键词： Acute cholangitis Endoscopic retrograde cholangiopancreatography Complication Comorbidity Elderly

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Carleman Estimates for Parabolic Equations with Nonhomogeneous Boundary Conditions

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Chinese Annals of Mathematics,Series B 2009年第4期30卷 333-378页

作者： Oleg Yu IMANUVILOV Jean Pierre PUEL masahiro YAMAMOTO Department of Mathematics Colorado State University 101 Weber Building Fort Collins CO 80523USA Laboratoire de Mathematiques de Versailles Universit de Versailles-St. Quentin 45 Avenue des Etats Unis 78035 Versailles France. Department of Mathematical Sciences University of Tokyo Komaba Meguro Tokyo 153 Japan.

The authors prove a new Carleman estimate for general linear second order parabolic equation with nonhomogeneous boundary conditions. On the basis of this estimate, improved Carleman estimates for the Stokes system and for a system of parabolic equations with a penalty term are obtained. This system can be viewed as an approximation of the Stokes system.

关键词： Controllability Parabolic equations Carleman estimates

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Rate of hexabromocyclododecane decomposition and production of brominated polycyclic aromatic hydrocarbons during combustion in a pilot-scale incinerator

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Journal of Environmental Sciences 2017年第11期29卷 91-96页

作者： Yuichi Miyake masahiro Tokumura Qi Wang Takashi Amagai Yuichi Horii University of Shizuoka 52-1 Yada Suruga-ku Shizuoka 422-8526 Japan Center for Environmental Science in Saitama 914 Kamitanadare Kazo Saitama 34F-0115 Japan

Here, we examined the incineration of extruded polystyrene containing hexabromocyclododecane（HBCD） in a pilot-scale incinerator under various combustion temperatures（800–950℃） and flue gas residence times（2–8 sec）. Rates of HBCD decomposition ranged from 99.996%（800℃, 2 sec） to 99.9999%（950℃, 8 sec）; the decomposition of HBCD, except during the initial stage of combustion（flue gas residence time 〈 2 sec）, followed a pseudo-first-order kinetics model. An Arrhenius plot revealed that the activation energy and frequency factor of the decomposition of HBCD by combustion were 14.2 kJ/mol and 1.69 sec^（-1）,respectively. During combustion, 11 brominated polycyclic aromatic hydrocarbons（BrPAHs）were detected as unintentional by-products. Of the 11 BrPAHs detected, 2-bromoanthracene and 1-bromopyrene were detected at the highest concentrations. The mutagenic and carcinogenic BrPAHs 1,5-dibromoanthracene and 1-bromopyrene were most frequently detected in the flue gases analyzed. The total concentration of BrPAHs exponentially increased（range,87.8–2,040,000 ng/m^3） with increasing flue gas residence time. Results from a qualitative analysis using gas chromatography/high-resolution mass spectrometry suggest that bromofluorene and bromopyrene（or fluoranthene） congeners were also produced during the combustion.

关键词： Brominated polycyclic aromatic hydrocarbons Flame retardant Hexabromocyclododecane(HBCD) Incinerator Persistent organic pollutants(POPs)

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Control of Secondary Flow in a Low Solidity Circular Cascade Diffuser

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Journal of Thermal Science 2012年第4期21卷 384-390页

作者： Daisaku Sakaguchi Takuji Fujii Hironobu Ueki masahiro Ishida Hiroshi Hayami Nagasaki University 1-14 Bunkyo-machi Kyushu University (retired)

According to the previous experimental works on the low solidity circular cascade diffuser (LSD), a pressure recovery of a centrifugal blower was improved by the LSD significantly in a wide range of flow rate, and the pres-sure recovery was improved further by the LSD with a tandem cascade in comparison with the LSD with a sin-gle-row cascade. In the present study, the flow behavior in the LSD with the tandem cascade has been analyzed numerically by using the commercial CFD code of ANSYS-CFX12. It was shown clearly that the higher pressure recovery was achieved by applying the LSD with the tandem cascade, and the high pressure recovery is based on the high pressure rise in the vaneless space upstream of the LSD and the high blade loading of the front blade of the LSD. The high pressure recovery in the LSD could be achieved by controlling the flow separation on the suc-tion surface of the front blade and also on that of the rear blade due to formation of the favorable secondary flow and due to increase in mass flow passing through the slit section between the front and rear blades.

关键词： LSD (Low solidity circular cascade diffuser) Centrifugal blower Range enhancement Tandem cascade

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Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells

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Neural Regeneration Research 2024年第11期19卷 2341-2342页

作者： Masato Kanazawa Itaru Ninomiya Yutaka Otsu masahiro Hatakeyama Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Stroke is the second leading cause of death and the third leading cause of disability worldwide after heart *** predict that stroke deaths and permanent disabilities will increase worldwide by the year ***-target therapies may be insufficient,because ischemic cerebral injury involves several ***-mediated therapies are ideal,because they target multiple cell types to enhance protection and recovery.

关键词： ischemic death cerebral

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Field survey of a sustainable sanitation system in a residential house

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Journal of Environmental Sciences 2006年第6期18卷 1088-1093页

作者： Naoko NAKAGAWA masahiro OTAKI Shinji MIURA Hironobu HAMASUNA Katsuyoshi ISHIZAKI Department of Human Environmental Sciences Ochanomizu University2-1-1OtsukaBunkyo-KuTokyo 112-8610Japan. City Maintenance Technical Research Center 2-9-23ShinjuShinjuku-KuTokyo 160-0023Japan Nagasaki Institute of Applied Science 536Abama-choNagasaki-shiNagasaki Pref.851-0123Japan Research Institute for a Sustainable Future Waseda University513 Tsurumaki-ChouWasedaShinjuku-KuTokyo 169-8050Japan

Sustainable sanitation is an approach for more ecological and sustainable water resources management. In this paper, we proposed one of the new integrated waste treatment systems： an ＂sustainable sanitation system＂ that includes separation of the black water from water system by a non-flushing toilet （bio-toilet）, and a gray water treatment based on a biological and ecological concept. Sustainable sanitation system also converts the domestic waste to soil conditioners and fertilizers, for farmland use. As one of the case studies, Environmentally Symbiotic Housing in which people actually live using the bio-toilet for the black water treatment and the household wastewater treatment facility for the gray water was introduced. The availability of this system was investigated by analyzing the sawdust used in the bio-toilet and the quality of the effluent in the household wastewater treatment facility. As the result, the water content of the sawdust did not exceed 60% in any of the sampling points and the BOD and COD of the effluent of the household wastewater treatment facility were below 10 and 20 mg/L respectively, due to the low loading. Compared to the pollution load on the water environment created by the conventional system, it was found that the effluent of the house has a lower load than the tertiary treatment and the volume of the water consumption is 75% of the conventional system.

关键词： bio-toilet pollution load sustainable sanitation system water consumption

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Study on Radial Position of Impurity Ions in Core and Edge Plasma of LHD Using Space-Resolved EUV Spectrometer

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Plasma Science and Technology 2011年第2期13卷 140-144页

作者：董春风 Shigeru MORITA Motoshi GOTO masahiro KOBAYASH Graduate University for Advanced Studies National Institute for Fusion Science

Radial profiles of impurity ions of carbon, neon and iron were measured for high- temperature plasmas in large helical device （LHD） using a space-resolved extreme ultraviolet （EUV） spectrometer in the wavelength range of 60A to 400 A. The radial positions of the impurity ions obtained are compared with the local ionization energies, El of these impurity ions and the electron temperatures T,z there. The impurity ions with 0.3 keV 〈_ Ei ≤ 1.0 keV are always located in outer region of plasma, i.e., 0.7 ≤ p ≤ 1.0, and those with Ei ≤ 0.3 keV are located in the ergodic layer, i.e., 1.0 ≤ p≤ 1.1, with a sharp peak edge, where p is the normalized radial position. It is newly found that Tez is approximately equal to Ei for the impurity ions with Ei ≤ 0.3 keV, whereas roughly half the value of El for the impurity ions with 0.3 keV≤ Ei ≤ 1.0 keV. It is known that Tez is considerably lower than Ei in the plasma edge and approaches to Ei in the plasma core. Therefore, this result seems to originate from the difference in the transverse transport between the plasma edge at p 〈1.0 and the ergodic layer at p ≥ 1.0. The transverse transport is studied with an impurity transport simulation code. The result revealed that the difference appearing in the impurity radial positions can be qualitatively explained by the different values of diffusion coefficient, e.g., D=0.2 m2/s and 1.0 m2/s, which can be taken as a typical index of the transverse transport.

关键词： impurity radial profile EUV spectrometer diffusion coefficient

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Effects of silicon addition on optical properties of mould flux with iron oxide and estimation of apparent thermal conductivity of flux

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Journal of Iron and Steel Research International 2019年第4期26卷 365-373页

作者： Rie Endo Yo Kan Takashi Watanabe Miyuki Hayashi masahiro Susa Department of Materials Science and Engineering Tokyo Institute of TechnologyTokyo 152-8552Japan Department of Metallurgy and Ceramics Science Tokyo Institute of TechnologyTokyo 152-8552Japan

Mould flux with high absorptivity had been obtained in the reduction process of mould flux by *** further utilisation of the mould flux with high absorptivity,the effect of silicon addition on the optical property has been *** synthesised mould flux powder with iron oxide was melted with the addition of silicon powder at 1703 K followed by quenching,thus forming a glassy *** 5-30-min reduction,the samples exhibited black opaque ***,the samples that were reduced for 45-60 min had a bluish grey *** iron-based particles dispersed in the samples were micrometre order in *** determine the effect of iron particles on the optical properties of the sample,extinction,scattering and absorption efficiencies were calculated according to Mie *** showed that both scattering on the iron particle and absorption by iron effectively increase the extinction efficiency in the mould ***,the silicon particle in the flux has large scattering *** black opaque colour is contributed by the existence of silicon and iron *** apparent thermal conductivity was calculated for the solid *** also indicated that the entire glassy mould flux would effectively work for mild cooling in a continuous casting process owing to high absorptivity and small thermal conductivity.

关键词： Mould flux Reduction Iron oxide Thermal conductivity Optical property

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Advances in quantum dots for classical and non-classical light sources Invited Paper

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Chinese Optics Letters 2008年第10期6卷 718-723页

作者： Yasuhiko Arakawa Satoshi Iwamoto Satoshi Kako masahiro Nomura Denis Guimard Research Center for Advanced Science and Technology Institute for Nano Quantum Information ElectronicsThe University of Tokyo4-6-1 Meguro-ku153-8505 TokyoJapan

Recent advances in quantum dots （QDs） for classical and non-classical light sources are presented. We have established metal organic chemical vapor deposition （MOCVD） technology for InAs-based QD lasers at 1.3 μm and achieved ultralow threshold in QD lasers with photonic crystal （PhC） nanocavity. In addition, single photon emitters at 1.55 μm, GaN-based single photon sources operating at 200 K, and high-Q PhC nanocavity have been demonstrated.

关键词： QDs Advances in quantum dots for classical and non-classical light sources Invited Paper AIN InAs

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