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Submucosal hematoma is a highly suggestive finding for amyloid light-chain amyloidosis:Two case reports

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World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 434-437页

作者： Shinji Yoshii Katsuhiro Mabe Katsuhiko Nosho Hiroyuki Yamamoto Hiroshi Yasui Hiroyuki Okuda Akira Suzuki masahiro fujita Toshihiro Sato Department of Gastroenterology Keiyukai Sapporo HospitalSapporo 003-0027Japan Third Department of Internal Medicine Hokkaido University Graduate School of MedicineSapporo 060-8648Japan First Department of Internal Medicine Sapporo Medical University School of MedicineSapporo 060-8556Japan Department of Medical Oncology Keiyukai Sapporo HospitalSapporo 003-0027Japan Department of Pathology KKR Sapporo Medical CenterSapporo 062-0931Japan Keiyukai Institute of Clinical Pathology Sapporo 003-0027Japan

The clinical and endoscopic features of amyloid lightchain(AL) amyloidosis are diverse and mimic various other ***,few reports on submucosal hematomas of the gastrointestinal(GI) tract are available in the ***,we report two cases of AL amyloidosis presenting as submucosal hematomas in the absence of clinical disease elsewhere in the *** 2 cases were referred to our hospital because of *** endoscopic findings in both cases were similar in submucosal hematoma ***,the clinical courses *** the first case,there was no evidence of systemic amyloidosis and the disease was conservatively *** the second case,the disease progressed to systemic amyloidosis and the patient died within a short *** conclude that the endoscopic detection of a submucosal hematoma in the setting of GI bleeding should raise suspicion of AL *** to a hematologist should be done immediately for treatment while the involvement is limited to the GI tract.

关键词： Amyloid light-chain amyloidosis Submucosal hematoma Gastrointestinal bleeding Colonoscopy

IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions

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World Journal of Gastroenterology 2014年第29期20卷 10050-10061页

作者： Takafumi Naito Katsuhiko Nosho Miki Ito Hisayoshi Igarashi Kei Mitsuhashi Shinji Yoshii Hironori Aoki Masafumi Nomura Yasutaka Sukawa Eiichiro Yamamoto Yasushi Adachi Hiroaki Takahashi Masao Hosokawa masahiro fujita Toshinao Takenouchi Reo Maruyama Hiromu Suzuki Yoshifumi Baba Kohzoh Imai Hiroyuki Yamamoto Shuji Ogino Yasuhisa Shinomura Department of Gastroenterology Rheumatology and Clinical ImmunologySapporo Medical University School of Medicine Department of Gastroenterology Keiyukai Sapporo Hospital Center for Gastroenterology Teine-Keijinkai Hospital Department of Medical Oncolo-gy Dana-Farber Cancer InstituteBostonMA 02115United States Department of Surgery Keiyukai SapporoHospital Department of Pathology Keiyukai Sapporo Hospital Department of Molecular Biology Sapporo Medical University School of Medicine Department of Gastroenterological Surgery Graduate School of Medical ScienceKumamoto University Division of Cancer Research The Institute of Medical ScienceThe University of Tokyo Division of Gastroenterology and Hepatology Department of Internal MedicineSt.Marianna University School of Medicine

AIM: To investigate insulin-like growth factor 2 (IGF2) differentially methylated region (DMR)0 hypomethylation in relation to clinicopathological and molecular features in colorectal serrated lesions.

关键词： BRAF Colon polyp Colorectal neoplasia Colorectum Genome Insulin-like growth factor Long interspersed nucleotide element-1 Microsatellite instability Serrated pathway

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含DNA嵌段的共聚物的合成与溶液自组装

含DNA嵌段的共聚物的合成与溶液自组装

DNA功能化的共聚物的合成与胶束化行为研究

2012年全国高分子材料科学与工程研讨会

作者：潘鹏举 masahiro fujita Mizuo Maeda 浙江大学化工系化学工程联合国家重点实验室 Bioengineering Laboratory RIKEN

利用ATRP和点击化学,合成了线性和星形的聚异丙基丙烯酰胺（PNIPAAm）/DNA的共聚物,并且研究了其在水溶液中的胶束化行为。与PNIPAAm均聚物相比,亲水性DNA链段的引入使PNIPAAm在水溶液中的最低临界溶解温度（LCST）升高,相转变过程中焓... 详细信息

利用ATRP和点击化学,合成了线性和星形的聚异丙基丙烯酰胺（PNIPAAm）/DNA的共聚物,并且研究了其在水溶液中的胶束化行为。与PNIPAAm均聚物相比,亲水性DNA链段的引入使PNIPAAm在水溶液中的最低临界溶解温度（LCST）升高,相转变过程中焓变减小。在LCST温度以上,PNIPAAm-co-DNA共聚物发生胶束化,形成了以PNIPAAm疏水性链段为核、ssDNA亲水性链段为壳的胶束粒子。共聚物的组成和拓扑结构是影响胶束粒子尺寸和结构的主要因素。该类DNA修饰的软纳米粒子在水溶液中的稳定性对目标ssDNA的序列非常敏感,在基因检测中将有潜在的应用前景。

关键词： DNA 聚异丙基丙烯酰胺原子转移自由基聚合点击化学胶束

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DNA功能化的共聚物的合成与胶束化行为研究

PERCIST用于头颈部鳞状细胞癌患者放化疗疗效评价及预后预测

2011年全国高分子学术论文报告会

作者：潘鹏举 masahiro fujita Mizuo Maeda 浙江大学化工系化学工程国家联合重点实验室 Bioengineering Laboratory RIKENHirosawa 2-1WakoSaitama 351-0198Japan

＜正＞DNA接枝修饰的无机纳米粒子已经广泛应用于基因的快速检测、生物传感器等领域。结合原子转移自由基聚合（ATRP）和点击化学的方法,我们合成了线性两嵌段和星形的聚异丙基丙烯酰胺（PNIPAAm）/单螺旋

关键词： DNA 聚异丙基丙烯酰胺原子转移自由基聚合点击化学胶束

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中华核医学与分子影像杂志 2018年第12期38卷 839-839页

作者：唐军(译) Takayuki Katsuura Kazuhiro Kitajirma Masayuki Fujiwara Tomonori Terada Nobuhiro Uwa Kazuma Noguchi Hiroshi Doi Yukihisa Tamaki Rika Yoshida Tatsuya Tsuchitani masahiro fujita Koichiro Yamakado 上海交通大学医学院附属苏州九龙医院核医学科 215021 Division of Nuclear Medicine and PET Center Department of Radiology Hyogo College of MedicineNishinomiya Japan

目的探讨PET实体瘤疗效评价标准(PERCIST)评价头颈部鳞状细胞癌(HNSCC)患者放化疗疗效及预测复发和死亡的价值。方法42例患者(平均年龄63岁,范围20~79岁)在放化疗前及放化疗后约3个月(平均95d,范围70~119d)行脱氧葡萄糖(FDG)-PET/CT显像... 详细信息

目的探讨PET实体瘤疗效评价标准(PERCIST)评价头颈部鳞状细胞癌(HNSCC)患者放化疗疗效及预测复发和死亡的价值。方法42例患者(平均年龄63岁,范围20~79岁)在放化疗前及放化疗后约3个月(平均95d,范围70~119d)行脱氧葡萄糖(FDG)-PET/CT显像,其中包括10例鼻咽癌、13例口咽癌、11例下咽癌及8例喉癌。与PERCIST相关的无进展生存时间(PFS)和总生存时间(OS)采用对数秩检验和Cox回归分析进行统计学处理。结果PERCIST确定的完全代谢反应(CMR,即病灶FDG摄取降低至肝脏的平均活度水平以下或病灶FDG摄取与周围组织无明显差别)、部分代谢反应[PMR,即经去脂体质量校正的高峰标准摄取值(SULpeak)下降30%及以上]、稳定代谢反应(SMD,即FDG摄取无明显变化)和病灶代谢增加(PMD,即SULpeak增加30%及以上)的患者数分别为30例(71.4%)、9例(21.4%)、3例(7.1%)和0例。

关键词：头颈部鳞状细胞癌 FDG-PET/CT PERCIST 治疗效果预后

Broadly tunable lens-coupled nonlinear quantum cascade lasers in the sub-THz to THz frequency range

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Photonics Research 2022年第3期10卷 703-710页

作者： Kazuue fujita Shohei Hayashi Akio Ito Tatsuo Dougakiuchi masahiro Hitaka Atsushi Nakanishi Central Research Laboratory Hamamatsu Photonics K.K.5000 HirakuchiHamakita WardHamamatsu 434-8601Japan

Room-temperature terahertz(THz)quantum cascade laser sources with intracavity difference-frequency nonlinear mixing are electrically pumped monolithic semiconductor laser sources operating in the 0.6–6 THz spectral *** report widely tunable,low-frequency THz quantum cascade laser sources using a lens-coupled Cherenkov waveguide *** on a watt-class high-power,λ∼13.7μm quantum cascade laser,the monolithic THz source is strongly coupled with a high-resistivity silicon lens,which causes a major increase in the THz coupling efficiency and demonstrates significant performance improvements.A room-temperature 1.5 THz device produces a 0.2 mW peak output power with a high-quality beam *** THz outcoupling efficiency using the lens-coupled scheme enabled the demonstration of a high-performance external-cavity semiconductor THz source that is tunable from 420 GHz to 2 *** external-cavity,lens-coupled device configuration can technically be assembled into a butterfly-style package for a thumb-sized,widely frequency tunable THz semiconductor source.

关键词： tunable waveguide pumped

Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor

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Bone Research 2024年第3期12卷 571-581页

作者： Hideyuki Kobayashi M.Alaa Terkawi masahiro Ota Tomoka Hasegawa Tomomaya Yamamoto Tomohiro Shimizu Dai Sato Ryo fujita Toshifumi Murakami Norio Amizuka Norimasa Iwasaki Masahiko Takahata Department of Orthopaedic Surgery Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Department of Developmental Biology of Hard Tissue Graduate School of Dental MedicineHokkaido UniversitySapporoJapan Department of Orthopaedic Surgery Dokkyo Medical UniversityMibu Shimotsuga 321-0293Japan

DNAX-associated protein 12 kD size(DAP12)is a dominant immunoreceptor tyrosine-based activation motif(ITAM)-signaling adaptor that activates costimulatory signals essential for *** several DAP12-associated receptors(DARs)have been identified in osteoclasts,including triggering receptor expressed on myeloid cells 2(TREM-2),C-type lectin member 5 A(CLEC5A),and sialic acid-binding Ig-like lectin(Siglec)-15,their precise role in the development of osteoclasts and bone remodeling remain poorly *** this study,mice deficient in Trem-2,Clec5a,Siglec-15 were generated.

关键词： remodeling osteoclast stimulating

Two cases of pancreatic ductal adenocarcinoma with intrapancreatic metastasis

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World Journal of Gastroenterology 2016年第41期22卷 9222-9228页

作者： Yusuke fujita Minoru Kitago Yohei Masugi Osamu Itano masahiro Shinoda Yuta Abe Taizo Hibi Hiroshi Yagi Yoko Fujii-Nishimura Michiie Sakamoto Yuko Kitagawa Department of Surgery Keio University School of Medicine Department of Pathology Keio University School of Medicine

There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma(PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature.

关键词： Carcinoma Pancreatic ductal Neoplasm micrometastasis Recurrence Carcinogenesis

Wind Tunnel Test for Videogrammetric Deformation Measurement of UAV for Mars Airplane Balloon Experiment-1 (MABE-1)

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Journal of Flow Control, Measurement & Visualization 2019年第2期7卷 87-100页

作者： Koji fujita Akira Oyama Daisuke Kubo masahiro Kanazaki Hiroki Nagai Institute of Fluid Science Tohoku University Sendai Japan Institute of Space and Astronautical Science Japan Aerospace Exploration Agency Sagamihara Japan Japan Aerospace Exploration Agency Mitaka Japan Tokyo Metropolitan University Hino Japan

This paper reports the results of the aerodynamic deformation measurements of the meter-scale, entire shape, actual UAV in the wind tunnel using a video grammetry technique. The measured airplane was the airplane for Mars exploration being developed by Japan Aerospace Exploration Agency (JAXA) and Japanese universities. Its main wing span length was 2.4 m. The video grammetry measurement was performed using VICON’s system. Retroactive markers and stickers were put on the airplane. JAXA’s 6.5 m × 5.5 m Low-Speed Wind Tunnel was used. The airplane was mounted on the strut support with pitch-free or pitch-locked conditions. The deformations of the main wing bending, the main wing twisting, the tail boom bending, and the elevator deflection angle change were revealed quantitatively. The bending stiffness of a main wing spar that was designed as a safety factor of 2.8 at load factor of 5 was sufficient. The main wing spar was located around a center of pressure of an airfoil and it showed enough stiffness for twisting at nominal condition. The effects of the main wing bending and twisting, and the tail boom bending on the aerodynamic performance were estimated but they were in an acceptable range from the standpoint of the controllability of the aerodynamic performance using control surfaces. Even though the servo motor was located near the elevator and the linkage between the servo motor and the elevator was short, the measured elevator deflection angle was at most 4% smaller than the angle at no-wind condition. The obtained results and presented method are useful for control, flight data analysis, and design of lightweight airplanes.

关键词： Wind Tunnel UAV Deformation Video Grammetry Mars Exploration