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Corticospinal activity during a single-leg stance in people with chronic ankle instability

Journal of Sport and Health Science 2022年第1期11卷 58-66页

作者： masafumi terada Kyle B.Kosik Ryan S.McCann Colin Drinkard Phillip A.Gribble College of Sport and Health Science Ritsumeikan UniversityKusatsuShiga 525-8577Japan Department of Athletic Training&Clinical Nutrition University of KentuckyLexingtonKY 40536-0200USA School of Rehabilitation Sciences Old Dominion UniversityNorfolkVA 23529USA Westlake High School Athletics AustinTX 78746USA

Purpose:The aim of the study was to determine whether corticospinal excitability and inhibition of the tibialis anterior during single-leg standing differs among individuals with chronic ankle instability(CAI),lateral ankle sprain copers,and healthy ***:Twenty-three participants with CAI,23 lateral ankle sprain copers,and 24 healthy control participants *** motor threshold(AMT),normalized motor-evoked potential(MEP),and cortical silent period(CSP)were evaluated by transcranial magnetic stimulation while participants performed a single-leg standing ***:Participants with CAI had significantly longer CSP at 100%of AMT and lower normalized MEP at 120%of AMT compared to lateral ankle sprain copers(CSP100%:p=0.003;MEP120%:p=0.044)and controls(CSP100%:p=0.041;MEP120%:p=0.006).Conclusion:This investigation demonstrate altered corticospinal excitability and inhibition of the tibialis anterior during single-leg standing in participants with *** research is needed to examine the effects of corticospinal maladaptations to motor control of the tibial anterior on postural control performance in those with CAI.

关键词： Ankle sprain Joint instability Motor cortex Postural control

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Treatment Outcomes in Head and Neck Cancer Patients 80 Years Old and over

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第6期4卷 401-408页

作者： Tomonori terada Nobuhiro Uwa Kosuke Sagawa Takeshi Mohri Nobuo Saeki Kota Kida Kenzo Tsuzuki masafumi Sakagami Department of Otolaryngology—Head and Neck Surgery Hyogo College of Medicine Nishinomiya City Japan

Background: With the recent aging of society, the need for medical treatment of elderly patients with head and neck cancer seems to have been increasing. Method: The present study analyzed all 103 patients with head and neck cancer ≥80 years, and we compared results with those of the previous generation (Group P;range: 75 - 79 years) comprising 104 patients treated in the same period. Results: We provided treatment just as wanted and could not choose it often. The reasons were oncological factors such as unresectable tumor or distant metastasis, refusal of treatment, and physical factors such as poor PS or number of comorbidities. Conclusion: Treatment choices should be based on the wishes and motivations of the patient and the medical assessment of physical function. When a patient ≥80 years old is treated, the high incidence of complications and severity of the disease should be considered.

关键词： 80 Years Old and over Elderly Patients Head and Neck Cancer Treatment

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Histopathological Evidence for Irradiation Angiopathy in Head and Neck Cancer

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第2期4卷 108-114页

作者： Nobuhiro Uwa Hiroyuki Hao Yoshitane Tsukamoto Tomonori terada Kosuke Sagawa Takeshi Mohri Takashi Daimon Hiroshi Doi Yohei Sotsuka Guillaume van Eys Marie-Luce Bochaton-Piallat Seiichi Hirota masafumi Sakagami Department of Otolaryngology Hyogo College of Medicine Nishinomiya Japan Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Japan Department of Biostatistics Hyogo College of Medicine Nishinomiya Japan Department of Radiology Hyogo College of Medicine Nishinomiya Japan Department of Plastic Surgery Hyogo College of Medicine Nishinomiya Japan Department of Genetics and Cell Biology University of Maastricht Maastricht The Netherlands Department of Pathology and Immunology University of Geneva-CMU Geneva Switzerland

Objective: To evaluate the incidence of cervical angiopathy caused by radiation therapy for head and neck cancer. Methods: Segments of 57 cervical arteries were obtained during surgery for head and neck malignant tumors and divided into two groups (irradiated group and non-irradiated group) based on the treatment prior to vascular resection. In order to evaluate vascular injury after radiation therapy, we examined the degree of medial atrophy, medial fibrosis, smooth muscle cell (SMC) differentiation in the media and intima, intimal hyperplasia and endothelial cell (EC) injury. Sections of arterial segments were stained with hematoxylin-eosin, Elastica van Gieson and Masson’s trichrome, and immunohistochemistry for α-smooth muscle actin (α-SMA), smoothelin, S100A4 and CD31 in the resected vessels was conducted. Results: The median interval between the completion of radiation therapy and vascular resection was nine months. No significant differences were observed between the two groups in terms of medial atrophy, medial fibrosis and intimal hyperplasia. The ratio of the smoothelin-positive area per α-SMA-positive area in the media and the S100A4-positive proportion in the intima, indicating the degree of differentiation of the medial SMC and dedifferentiation of the intimal SMC, respectively, showed no significant differences, despite the tendency toward a lower smoothelin-positive area per α-SMA-positive area in the media of the irradiated arteries. The EC coverage revealed on CD31 immunohistochemistry was significantly decreased, with mural thrombus adhesion, in the irradiated group. Conclusions: The ECs of small arteries are damaged by irradiation. Although we did not confirm the statistical significance of medial SMC dedifferentiation, a decreased expression of smoothelin tended to be observed in the media of the irradiated arteries. Our findings provide histopathological evidence of irradiation angiopathy in head and neck cancer and may help to improve the surgi

关键词： Angiopathy Endothlial Cell Pathology Radiation Head and Neck

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