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Oral tolerance is inducible during active dextran sulfate sodium-induced colitis

World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 242-253页

作者： Satoshi Ino Chikara Kohda Kosuke Takeshima Hiroki Ishikawa Tomoko Norose Toshiko Yamochi masafumi takimoto Hiroshi Takahashi Kazuo Tanaka Department of Microbiology and Immunology School of Medicine Showa University Department of Pathology and Laboratory Medicine School of Medicine Showa University Division of Gastroenterology Department of Internal Medicine Showa University

AIM:To investigate whether oral tolerance is inducible during the active phase of dextran sulfate sodium(DSS)-induced ***:Colitis was induced in 6-to 8-wk-old female BALB/c mice by the administration of 2%*** induce oral tolerance,mice that received water with DSS[DSS(+)]and mice that received autoclaved water[DSS(-)]were intragastrically(i.g.)administered ovalbumin(OVA)as a tolerogen before systemic challenge with *** this,serum levels of OVA-specific Ig E antibodies were *** mice with activecolitis,CD4+CD25+Foxp3+cell and B10 cell frequencies were evaluated using flow *** m RNA expression profiles were evaluated by reverse transcription real-time polymerase chain ***:Regardless of the presence of DSS colitis,OVA-specific immunoglobulin E concentrations were significantly reduced in mice that were *** OVA compared to mice that were *** PBS[DSS(+):4.4(4.2-9.5)ng/m L vs 83.9(66.1-123.2)ng/m L,P<0.01;DSS(-):27.7(0.1-54.5)ng/m L vs116.5(80.6-213.6)ng/m L,P<0.01].These results demonstrated that oral tolerance was induced in both the presence and absence of *** the spleen and mesenteric lymph nodes(MLN),the frequencies of CD4+CD25+Foxp3+cells and B10 cells,both of which are associated with oral tolerance,did not significantly *** the spleen,interferon-γm RNA expression significantly decreased in mice with colitis[DSS(+):0.42(0.31-0.53)vs DSS(-):1.00(0.84-1.39),P<0.01].The expression levels of other cytokines did not significantly ***:Oral tolerance is inducible during active DSS *** stability of regulatory cell populations in the spleen and MLN in colitis might correlate with these results.

关键词： Cytokine Dextran sulfate sodium colitis Oral tolerance Regulatory T cell Regulatory B cell

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Effect of Flood Peak Discharge Control by a Small Reservoir in an Urbanized Area—Case Study in the Kurabe River Basin, Japan

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Open Journal of Modern Hydrology 2017年第4期7卷 314-330页

作者： Kouzo Ito Manabu Segawa Hiroshi takimoto Toshisuke Maruyama Faculty of Environmental Science Ishikawa Prefectural University Ishikawa Japan

Recently severe damage of flooding by urbanization was frequently occurred. To prevent this damage, small reservoir was constructed in the urbanized residential area. This paper describes an effect of flood peak discharge control by a small reservoir (control reservoir) caused by rapidly developed urbanization. Although work for this purpose was conducted, research on the effects of the control reservoir was not conducted until now. This research, conducted by simulation, was a case study in the Kurabe River Basin in the Tedori River Alluvial Fan Area, Japan, based on the precise investigation of the reservoir in the actual field. The study was conducted to determine not only the actual control reservoir capacity for the newly developed residential area but also the ideal capacity for all present residential areas and the largest capacity allowable for a maximum rainfall event that recently occurred. The control reservoir effects between individual blocks and the entire basin area were compared by dividing the test basin into 15 blocks (sub-basins). The results showed that the effects on the capacity per unit area of the residential area in blocks have close relationship with the decreasing ratio of peak discharge in blocks. Consequently, the effects of control reservoir capacity and the limitation were clarified. In the future, control reservoirs should be constructed for all of the already developed residential areas, for example, by utilizing underground car parking lot. The results of this research can contribute to the design of the control reservoir for protection against flooding damage in urbanized areas.

关键词： Flood Control Reservoir Discharge from Urbanized Area Unit Flood Discharge Peak Discharge Decreasing Ratio Simulation of Drainage Discharge

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Decision Making in Children with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Pediatrics 2016年第2期6卷 158-162页

作者： Akira Yasumura Yoshiyuki takimoto Eisuke Nakazawa Masumi Inagaki Department of Developmental Disorders National Institute of Mental Health National Center of Neurology and Psychiatry Tokyo Japan Department of Neuropsychiatry The University of Tokyo Hospital Tokyo Japan Department of Biomedical Ethics The University of Tokyo Tokyo Japan

Background: Informed consent forms and clinical study participation explanations contain many specialized words including medical terms that are difficult to understand. The difficulty is particularly obvious for children with developmental disorders who show attention or similar problems. This study quantitatively evaluated the decision-making ability of these children using the Wechsler Intelligence Scale for Children-III (WISC-III) as a preliminary study for a multi-faceted investigation that would also use physiological indices. Methods: Participants were 11 children with Attention Deficit/Hyperactivity Disorder (AD/HD). The WISC-III was used for quantitative evaluation of their decision-making ability. Results of intelligence quotients (IQs), group indices, and subtest scores were analyzed. Results: The mean Performance IQ was four points lower than the mean Verbal IQ. The mean score for the Processing Speed index was lower by more than one standard deviation (SD). The mean scores for the Coding and Object Assembly subtests were lower by more than two SDs. Conclusion: The WISC-III results for IQ and group indices suggested the efficacy of auditory explanations. In addition, the subtest results suggested the necessity to pay sufficient attention to risk-benefit weighting in explanations. These findings suggested that the decision-making ability of children with AD/HD could be assessed using the WISC-III.

关键词： Attention-Deficit/Hyperactivity Disorder (AD/HD) Decision Making Informed Consent

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Phenol-based endoscopic ultrasound-guided celiac plexus neurolysis for East Asian alcohol-intolerant upper gastrointestinal cancer patients:A pilot study

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World Journal of Gastroenterology 2014年第30期20卷 10512-10517页

作者： Hirotoshi Ishiwatari Tsuyoshi Hayashi Makoto Yoshida Michihiro Ono Hiroyuki Masuko Tsutomu Sato Koji Miyanishi Yasushi Sato Rishu takimoto Masayoshi Kobune Atsushi Miyamoto Tomoko Sonoda Junji Kato Department of Medical Oncology and Hematology Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Hospital Pharmacy Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Public Health Sapporo Medical University School of MedicineSapporo 0600061Japan

AIM: To investigate the effectiveness of phenol for the relief of cancer pain by endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN).

关键词： Celiac plexus neurolysis Celiac plexus blockade Endoscopic ultrasound Phenol Pain management Upper gastrointestinal cancer

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Relationship between Nitrogen Atmospheric Deposition, Discharge and Concentration, and Monthly Change of Those in a River

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Journal of Water Resource and Protection 2013年第3期5卷 283-293页

作者： Toshisuke Maruyama Masashi Yoshida Keiji Takase Hiroshi takimoto Shigeo Ishikawa College of Bioresource Science Nihon University Tokyo Japan Faculty of Environmental Science Ishikawa Prefectural University Nonoichi Japan

The hypothesis that the product of discharge and concentration of nitrogen (N) in river water is equal to the atmospheric deposition was verified in the mountainous basin of the Tedori River in Japan. To verify this relationship, long-term data?are required to eliminate the effect of short-term variation of the N components. The basin has very high mountains, including Mount Hakusan (2702 maltitude), which is covered with deep snow in winter. Therefore, limited data were used for the estimation of the deposition of the entire basin by assuming a linear relationship of altitude. As a result, it was found that the estimated N concentration coincided well with observed concentrations at six sites—the Shiramine and Kuwajima (upper stream), Nakajima (lower stream) and Dainichi dam, Tedori dam and Senami sites (middle stream). The seasonal variation of N concentrations was low in the snowmelt period and high in autumn through to winter. This was not due to the larger discharge in snowmelt season as it was also found that N deposition was high in winter and low in spring, which indicated a clear relationship between N concentration and monthly atmospheric deposition including N storage in snow pack.

关键词： Nitrogen Balance Wet and Dry Deposition Altitude Dependence of Atmospheric Deposition and Precipitation Nitrogen in Snowpack

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Simultaneous measurements of aeroacoustic sounds and wall vibration for exploring the contribution of tooth vibration in the production of sibilant sounds/s/

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Journal of Biomedical Science and Engineering 2011年第2期4卷 83-89页

作者： Masanori Nakamura Kazunori Nozaki Haruka takimoto Kazuya Nagamune Motoharu Fujigaki Shigeo Wada 不详

In order to understand the contribution of teeth vibration to the production of sibilant/s/, the pre-sent study was designed to develop a method of simultaneously measuring aeroacoustic sounds and the vibration of an obstacle. To measure the vibration without disturbing flow, the Michelson interferometer was employed. The flow channel, which had an obstacle wall inside of it, was fabricated such that it morphologically mimicked the simplified geometry of the oral cavity. Given airflows at a flow rate of 7.5 × 10–4 m3/s from the inlet, aeroacoustic sounds were generated. A spectrum analy-sis of the data demonstrated two prominent peaks in the sound at 1,300 and 3,500 Hz and one peak in the wall vibration at 3,500 Hz. The correlation in peak frequencies between the sound and wall vibration suggests that the sound at 3,500 Hz was induced by the wall vibration. In fact, the sound amplitude at 3,500 Hz decreased when the obstacle wall was thickened, which increased its rigidity (p < 0.05, t-test). The experimental results demonstrate that the developed techniques are capable of measuring aeroacoustic sound and obstacle wall vibration simultaneously, and suggest the potential to pave the way for detailed analysis of the production of sibilant sounds /s/.

关键词： Acoustic Measurement Vibration Measurement Michelson Interferometer Aeroacoustics Sibilant/s/

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Quantitative Analysis of the Rate of Geochemical Weathering of Sulfur from Sedimentary Rocks Using Atmospheric Deposition, Concentration and River Discharge Data

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Journal of Water Resource and Protection 2013年第5期5卷 511-519页

作者： Toshisuke Maruyama Masashi Yoshida Keiji Takase Hiroshi takimoto Shigeo Ishikawa Sadao Nagasaka College of Bioresource Science Nihon University Kanagawa Japan Faculty of Environmental Science Ishikawa Prefectural University Ishikawa Japan

Quantitative analysis of the rate of geochemical weathering of sulfur (S) from sedimentary rocks (GeoS) was conducted using concentration (Cs) and discharge (Qs) data from the Tedori River and atmospheric deposition (AtdepS) in the basin. First, S fluxes were calculated using 16 years of Cs and Qs data. The annual average discharge of S (TotalS) was estimated at 8597 ton·year-1 (117.3 kg·ha-1·year-1). Of this, 1331 ton·year-1 was AtdepS (18.2 kg·ha-1·year-1) and another 7266 ton·year-1 was GeoS (99.1 kg·ha-1·year-1). Monthly changes in TotalS were investigated, which showed that GeoS was highest in summer, because of the air temperature, while AtdepS peaked in winter because of seasonal wind. Using Qs and AtdepS corrected for altitude, TotalS, AtdepS and GeoS were estimated at six sites, and among these sites we found that the TotalS per unit area values were random, depending on the site characteristics. In particular, the discharge from the Kuwajima site was remarkably high suggesting that the sedimentary rocks at this site had higher pyrite content than at the other sites. Finally, we also assessed the relationship between the characteristics of sedimentary rocks and GeoS in a range of rivers in the Hokuriku Region, and found that there was a close relationship between concentrations of SO42- greater than 10 mg·l-1 and sedimentary rocks containing the pyrite group. In addition, we estimated that the influence of GeoS was present when the concentration of SO42- in river water was greater than 2 - 3 mg·l-1 in the Hokuriku region.

关键词： Sulfur Balance Wet and Dry Deposition Sulfur Concentration Altitude Dependence Sulfur Discharge from Pyrite

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Long-Term Assessment of Nitrogen Pollution Load Potential for Groundwater by Mass Balance Analysis in the Tedori River Alluvial Fan Area, Japan

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Journal of Water Resource and Protection 2013年第2期5卷 171-182页

作者： Toshisuke Maruyama Masashi Yoshida Keiji Takase Hiroshi takimoto Shigeo Ishikawa Sadao Nagasaka College of Bioresource Sciences Nihon University Nonoichi Japan Faculty of Bioresources and Environmental Science Ishikawa Prefectural University Nonoichi Japan

To evaluate the nitrogen pollution load in an aquifer, a water and nitrogen balance analysis was conducted over a thirty-five year period at five yearly intervals. First, we established a two-horizon model comprising a channel/soil horizon, and an aquifer horizon, with exchange of water between the aquifer and river. The nitrogen balance was estimated from the product of nitrogen concentration and water flow obtained from the water balance analysis. The aquifer nitrogen balance results were as follows: 1) In the aquifer horizon, the total nitrogen pollution load potential (NPLP) peaked in the period 1981-1990 at 1800 t·yr-1;following this the NPLP rapidly decreased to about 600 t·yr-1 in the period 2006-2010. The largest NPLP input component of 1000 t·yr-1 in the period 1976-1990 was from farmland. Subsequently, farmland NPLP decreased to only 400 t·yr-1 between 2006 and 2010. The second largest input component, 600 t·yr-1, was effluent from wastewater treatment works (WWTWs) in the period 1986-1990;this also decreased markedly to about 100 t·yr-1 between 2006 and 2010;2) The difference between input and output in the aquifer horizon, used as an index of groundwater pollution, peaked in the period 1986-1990 at about 1200 t·yr-1. This gradually decreased to about 200 t·yr-1 by 2006-2010. 3) The temporal change in NPLP coincided with the nitrogen concentration of the rivers in the study area. In addition, nitrogen concentrations in two test wells were 1.0 mg·l-1 at a depth of 150 m and only 0.25 mg·l-1 at 50 m, suggesting gradual percolation of the nitrogen polluted water deeper in the aquifer.

关键词： Water Balance Nitrogen Balance Groundwater Pollution Sewage Treatment Water Pollution from Farmland Nitrogen Pollution Load Potential

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Whole circumferential endoscopic submucosal dissection of superficial adenocarcinoma in long-segment Barrett's esophagus:A case report

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World Journal of Gastrointestinal Surgery 2021年第10期13卷 1285-1292页

作者： Keiichiro Abe Kenichi Goda Akira Kanamori Tsunehiro Suzuki Akira Yamamiya Yoichi takimoto Takahiro Arisaka Koki Hoshi Takeshi Sugaya Yuichi Majima Keiichi Tominaga Makoto Iijima Shinichi Hirooka Hidetsugu Yamagishi Atsushi Irisawa Department of Gastroenterology Dokkyo Medical UniversityMibu 321-0293TochigiJapan Department of Pathology The Jikei University School of MedicineNishishimbashi 105-8471TokyoJapan Academic Institutional Research Center Dokkyo Medical UniversityMibu 321-0293TochigiJapan

BACKGROUND Esophageal adenocarcinoma(EAC)derived from long-segment Barrett’s esophagus(LSBE)is extremely rare in ***-related EAC is often difficult to diagnose in the horizontal *** the tumor has spread throughout the LSBE,whole circumferential endoscopic submucosal dissection(ESD)should be performed,which is difficult to complete ***,whole circumferential ESD can bring refractory postoperative *** hereby report a case of EAC involving the whole circumference of the LSBE,achieving complete endoscopic removal without *** SUMMARY An 85-year-old man with the chief complaint of dysphagia underwent *** suspected a flat-type cancerous lesion that extended the whole circumference of the LSBE(C 3.5,M 4.0)using narrow-band imaging magnification endoscopy(NBI-M).We achieved circumferential en bloc resection of the lesion safely with special ESD *** of the ESD specimens demonstrated that the superficial EAC extended the whole circumference of the LSBE,and papillary or well-differentiated tubular adenocarcinoma was confined in the lamina propria mucosa showing a vertical negative *** prevent post-ESD stenosis,we performed endoscopic local injection of steroids,followed by oral administration of *** was no evidence of esophageal refractory stenosis or tumor recurrence 30 mo after *** summary,we experienced a rare case of LSBE-related *** horizontal tumor extent was accurately diagnosed by ***,we achieve whole circumferential ESD safely without postoperative refractory *** NBI-M,ESD,and steroid therapy enabled the curative resection of superficial full circumferential LSBE-related EAC without refractory postoperative stenosis.

关键词： Endoscopic submucosal dissection Long-segment Barrett's esophagus Superficial esophageal adenocarcinoma Steroid Magnification endoscopy Case report

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Acute esophageal necrosis caused by alcohol abuse

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World Journal of Gastroenterology 2005年第35期11卷 5568-5570页

作者： Tetsu Endo Juichi Sakamoto Ken Sato Miyako takimoto Koji Shimaya Tatsuya Mikami Akihiro Munakata Tadashi Shimoyama Shinsaku Fukuda First Department of Internal Medicine Hirosaki University School of Medicine 5 Zaifucho Hirosaki Aomori 036-8562 Japan

Acute esophageal necrosis (AEN) is extremely rare and the pathogenesis of this is still unknown. We report a case of AEN caused by alcohol abuse. In our case, the main pathogenesis could be accounted for low systemic perfusion caused by severe alcoholic lactic acidosis. After the healing of AEN, balloon dilatation was effective to manage the stricture.

关键词： Esophagus Lactic acidosis Alcohol drinking Balloon dilatation

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