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Antitumor effect of VEGFR2-targeted microbubble destruction with gemcitabine using an endoscopic ultrasound probe:In vivo mouse pancreatic ductal adenocarcinoma model

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 478-485页

作者： Nana Shimamoto Masaki Ito masafumi Chiba Sadamu Honma Hiroo Imazu Kazuki Sumiyama Department of Endoscopy The Jikei University School of Medicine3-25-8 Nishi ShinbashiMinato-kuTokyo 105-8461Japan Division of Oncology Research Center for Medical Science3-25-8 Nishi ShinbashiMinato-kuTokyo 105-8461Japan Division of Gastroenterology and Hepatology Department of MedicineNihon University School of Medicine30-1 Oyaguchikami-choItabashi-kuTokyo 173-8610Japan

Background:Ultrasound-targeted microbubble destruction(UTMD)induces cellular inflow of drugs at low intensity,while high intensity eradicates tumor *** vascular endothelial growth factor receptor 2(VEGFR2)is highly expressed in pancreatic ductal adenocarcinoma(PDAC),VEGFR2-targeted microbubble(MB)might additionally increase the tissue specificity of drugs and thus improve antitumor *** addition,fixing the dual pulse intensity could maximize MB *** study evaluated the one-off(experiment 1)and cumulative(experiment 2)treatment effect of UTMD by regulating the dual pulse output applied to PDAC using VEGFR2-targeted ***:C57BL/6 mice inoculated with Pan-02 cells were allocated to five groups:VEGFR2-targeted MB+gemcitabine(GEM),VEGFR2-targeted MB,non-targeted MB+GEM,GEM,and control *** injection of GEM or GEM and either VEGFR2-targeted or non-targeted MB,UTMD was applied for several minutes at low intensity followed by high intensity *** experiment 1,mice were treated by the protocol described above and then euthanized immediately or at the tumor diameter doubling time(TDT).In experiment 2,the same protocol was repeated weekly and mice were euthanized at TDT regardless of protocol *** analysis by CD31 and VEGFR2 staining provided microvascular density(MVD)and VEGFR2 expression along vessels(VEGFR2v)or intra/peripheral cells(VEGFR2c).Results:In experiment 1,TDT was significantly longer in the VEGFR2-targeted MB+GEM group compared to the non-targeted MB+GEM,GEM,and control groups,while the VEGFR2-targeted MB group showed no statistical *** and VEGFR2v in the immediate euthanasia was significantly lower in the VEGFR2-targeted MB+GEM and VEGFR2-targeted MB groups than other *** experiment 2,the VEGFR2-targeted MB+GEM group produced significantly longer TDT than the GEM or control groups,whereas the VEGFR2-targeted MB group showed no significant *** revealed sign

关键词： Ultrasound-targeted microbubble destruction VEGFR2-targeted microbubble Pancreatic ductal adenocarcinoma Gemcitabine

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Control of Snow Falling Flow around NACA0015 Blade using a Plasma Electrode with Weather Resistant Design

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Journal of Thermal Science 2022年第1期31卷 72-81页

作者： MATSUDA Hisashi CHIBA Takahiro YAGAMI Masaki TAJIMA Yusuke WATANABE Nobuyoshi SATO Hideaki TAKEYAMA masafumi Hokkaido University of Science Hokkaido 006-8585Japan Asahi Rubber Inc. Saitama 330-0801Japan

The plasma actuation (PA) effect on the snow falling flow was investigated using a plasma electrode with weather resistant design and the natural snow wind facility of the Hokkaido University of Science. NACA0015 test blade with chord length c of 300 mm was used. Wind tunnel tests were carried out under the angle of the attack of the blade was fixed at 15 degrees, and the main flow velocity is U=5 m/s. PIV (Particle image velocimetry) measurements were conducted on various PA conditions using natural dry snowflakes as a tracer. When the actuator was driven under the condition of the fundamental frequency of F=50 kHz, and the pulsed modulated frequency f of fc/U=1 and Duty ratio (Ratio of plasma ON time to pulse duration time) =1%, movement of snowflakes was controlled the most effectively tested. It was clarified that the fundamental frequency of PA also affects the control of snow flow. Under snowfall conditions, the weather resistant designed plasma electrode has suffered no damage and operated successfully.

关键词： plasma actuator weather resistant design snow falling flow control experiment PIV

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Molecular Phylogeny and Evolution of Two Rhacophorus Species Endemic to Mainland Japan

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Asian Herpetological Research 2019年第2期10卷 86-104页

作者： masafumi MATSUI Yasuhiro KAWAHARA Kanto NISHIKAWA Seiji IKEDA Koshiro ETO Yusuke MIZUNO Graduate School of Human and Environmental Studies Kyoto UniversityYoshida Nihonmatsu-choSakyo-kuKyoto 606-8501Japan Hagi City Museum Horiuchi 355HagiYamaguchi 758-0057Japan Hiroshima University Museum Kagamiyama 1-1-1Higashi Hiroshima CityHiroshima 739-8524Japan Kitakyushu Museum of Natural History and Human History Higashida 2-4-1Yahatahigashi-kuKitakyushuFukuoka 805-0071Japan Takahari 4-1002 Meito-kuNagoya 465-0061Japan

We conducted molecular phylogenetic analyses of Japanese Rhacophorus species, especially of R. schlegelii and R. arboreus from the mainland, based on samples encompassing their known distribution ranges, and discussed about evolutionary history of Rhacophorus species within Japan. The common ancestor of Japanese Rhacophorus, except for R. owstoni from southern Ryukyus, was estimated to have diverged from a lineage occurring mainly in China about 7 MYBP. Both R. schlegelii and R. arboreus are genetically largely divergent between regions of eastern and western Japan, and this seems to have been promoted mainly by retreat to refugia. Retreats of the two species to different refugia sometimes in the past seem to have led restricted distribution of R. schlegelii in eastern and R. arboreus in western Japan, and brought their intraspecific variation patterns in morphology and breeding habit.

关键词： glacial period mitochondrial DNA differentiation refugia Rhacophorus arboreus Rhacophorus schlegelii

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Immunological effect of local ablation combined with immunotherapy on solid malignancies

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Chinese Journal of Cancer 2017年第6期36卷 252-257页

作者： Yusuke Takahashi Noriyuki Matsutani Takashi Nakayama Hitoshi Dejima Hirofumi Uehara masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to ***,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical *** enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to *** ablations have considerable advantages as an alternative therapeutic option,especially its minimal *** addition,local ablations have shown immune-regulatory effect in preclinical and clinical *** the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid *** article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused *** also discuss the value of local ablations combined with *** ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated.

关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

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Emittance measurement & optimization for the photocathode RF gun with laser profile shaping

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Chinese Physics C 2010年第5期34卷 584-588页

作者：刘圣广 masafumi Fukuda Sakae Araki Nobuhiro Terunuma Junji Urakawa Institute of High Energy Physics Chinese Academy of Sciences High Energy Accelerator Research Organization 1-1OhoTsukubaIbaraki305-0801Japan

The Laser Undulator Compact X-ray source （LUCX） is a test bench for a compact high brightness X-ray generator, based on inverse Compton Scattering at KEK, which requires high intensity multi-bunch trains with low transverse emittance. A photocathode RF gun with emittance compensation solenoid is used as an electron source. Much endeavor has been made to increase the beam intensity in the multi-bunch trains. The cavity of the RF gun is tuned into an unbalanced field in order to reduce space charge effects, so that the field gradient on the cathode surface is relatively higher when the forward RF power into gun cavity is not high enough. A laser profile shaper is employed to convert the driving laser profile from Gaussian into uniform. In this research we seek to find the optimized operational conditions for the decrease of the transverse emittance. With the uniform driving laser and the unbalanced RF gun, the RMS transverse emittance of a 1 nC bunch has been improved effectively from 5.46 πmm·mrad to 3.66 πmm·mrad.

关键词： laser shaping space charge effect emittance photocathode RF gun

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Identification of cerebral response to balloon distention of the bile duct

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World Journal of Gastroenterology 2010年第14期16卷 1772-1775页

作者： masafumi Suyama Yoshihiro Kubokawa Yuuji Matsumura Koichi Inami Sumio Watanabe Eiji Kirino Department of Gastroenterology Juntendo University Tokyo 113-8421 Japan Department of Psychiatry Juntendo University Tokyo 113-8421 Japan

AIM: To identify the brain loci that process human biliary sensation. METHODS: In 6 patients (age range: 42-74 years; 4 men), who underwent percutaneous transhepatic biliary drainage (PTBD), the distal biliary tract was stimulated by repeatedly inflating the balloon of the PTBD catheter so that it reached volumes that produced a definite painless sensation. The functional magnetic resonance imaging (fMRI) of the cortical response to biliary sensation was examined. RESULTS: Biliary balloon stimulation elicited activation of the insular cortex, prefrontal cortex, and somato- sensory cortex (P < 0.001). CONCLUSION: Biliary balloon stimulation evoked a cerebral cortical response detectable by fMRI.

关键词： Biliary Sensation Functional magneticresonance imaging Stimulation Brain-gut axis

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Nicotine Treatment Induces Expression of Matrix Metalloproteinases in Human Osteoblastic Saos-2 Cells

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Acta Biochimica et Biophysica Sinica 2006年第12期38卷 874-882页

作者： Tomoko KATONO Takayuki KAWATO Natsuko TANABE Naoto SUZUKI Kazuhiro YAMANAKA Hitoshi OKA masafumi MOTOHASHI Masao MAENO Kanda Surugadai Chiyoda-kuTokyo 101-8310Japan Department of Oral Health Sciences Nihon UniversitySchool of DentistryTokyo 101-8310Japan Japan Department of Biochemistry Nihon University School of Dentistry.Tokyo 101-8310Japan

Tobacco smoking is an important risk factor for the development of severe ***,we showed that nicotine affected mineralized nodule formation,and that nicotine andlipopolysaccharide stimulated the formation of osteoclast-like cells by increasing production of macrophagecolony-stimulating factor （M-CSF） and prostaglandin E2（PGE2） by human osteoblastic Saos-2 *** thepresent study,we examined the effects of nicotine on the expression of matrix metalloproteinases （MMPs）,tissue inhibitors of matrix metalloproteinases （TIMPs）,the plasminogen activation system including thecomponent of tissue-type plasminogen activator （tPA）,urokinase-type PA （uPA）,and PA inhibitor type 1（PAI-1）,α7 nicotine receptor,and *** also examined the effect of the nicotine antagonist D-tubocurarineon nicotine-induced expression of *** expression was examined using real-time polymerase chainreaction （PCR） to estimate mRNA *** addition,expression of the MMP,TIMP,uPA,tPA,and PAI-1proteins was determined by Western blotting *** treatment caused expression of MMP-1,2,3,and 13,but not MMP-14,to increase significantly after 5 or 10 d of culture;MMP-14 expression did notchange through day *** of MMP-1 expression by nicotine treatment was eliminated bysimultaneous treatment with *** the presence of nicotine,expression of uPA,PAI-1,orTIMP-1,2,3,or 4 did not change over 14 d of culture,whereas expression of tPA increased significantly byday *** also increased expression of the α7 nicotine receptor and c-fos *** results suggestthat nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1,2,3,and 13,thereby tipping the balance between bone matrix formation and resorption toward the latter process.

关键词： nicotine matrix metalloproteinase tissue inhibitor of matrix metalloproteinase plasminogen activation system

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Phylogenetic placement and diet of homalopsid snake Miralia alternans (Ruess,1833)

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Zoological Research 2022年第5期43卷 734-737页

作者： Ibuki Fukuyama Tomonori Kodama Koshiro Eto masafumi Matsui Mohamad Yazid Hossman Kanto Nishikawa Graduate School of Human and Environmental Studies Kyoto UniversityYoshida-NihonmatsuSakyoKyoto 606-8501Japan Graduate School of Science Kyoto UniversityKitashirakawa-OiwakeSakyoKyoto 606-8502Japan Kitakyushu Museum of Natural History&Human History Higashida 2-4-1YahatahigashiKitakyushuFukuoka 805-0071Japan Research Developmentand Innovation DivisionForest Department SarawakKuchingSarawak 93250Malaysia Graduate School of Global Environmental Studies Kyoto UniversityYoshida-HonmachiSakyoKyoto 606-8501Japan

DEAR EDITOR,Miralia alternans(Ruess,1833)is distributed in Borneo,Sumatra,and Java in Southeast *** species is morphologically similar to Raclitia indica,a monotypic genus known from Peninsular ***,we collected a juvenile specimen of *** from Borneo,and report on its coloration in life and first prey item recovered from the *** also explored the phylogenetic position of the genus using molecular phylogenetic analysis of mitochondrial DNA(mtDNA)gene cytochrome b(cyt b)and nuclear gene prolactin receptor(PRLR),confirming *** as sister to ***,with the two genera exhibiting relatively high genetic divergence in cyt b(13.0%-13.1%).

关键词： EDIT fir Java

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Prognosis of hepatocellular carcinoma accompanied by microscopic portal vein invasion

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World Journal of Gastroenterology 2009年第21期15卷 2632-2637页

作者： Ken Shirabe Kiyoshi Kajiyama Norifumi Harimoto Hideaki Masumoto Tatsuro Fukuya masafumi Ooya Yoshihiko Maehara Department of Hepatogastroenterological Surgery Aso Iizuka Hospital Department of Surgery and Science Graduate School of Medical SciencesKyushu University Department of Surgery Aso Iizuka Hospital Department of Hepatology Aso Iizuka Hospital Department of Radiology Aso Iizuka Hospital

AIM:To investigate the prognostic factors in patients with hepatocellular carcinoma(HCC) accompanied by microscopic portal vein invasion(PVI).METHODS:Of the 267 patients with HCC undergoing hepatic resection at Aso Iizuka Hospital,71 had *** excluding 16 patients with HCC that invaded the main trunk and the first and second branches of the portal vein,55 patients with microscopic PVI were ***:The patients with HCC accompanied by microscopic invasion were divided into two groups:solitary PVI(PVI-S:n = 44),and multiple PVIs(PVI-M:n = 11).The number of portal vein branches invaded by tumor thrombi was 5.4 ± 3.8(2-16) in patients with *** cumulative survival,PVI-M was found to be a significantly poor prognostic factor(P = 0.0019);while PVI-M and non-anatomical resection were significantly poor prognostic factors in disease-free survival(P = 0.0213,and 0.0115,respectively).In patients with PVI-M,multiple intrahepatic recurrence was more common than in the patients with PVI-S(P = 0.0049).In patients with PVI-S,non-anatomical resection was a significantly poor prognostic factor in disease-free survival(P = 0.0370).Operative procedure was not a significant prognostic factor in patients with ***:The presence of PVI-M was a poor prognostic factor in patients with HCC,accompanied by microscopic *** resection is recommended in these patients with *** with HCC and PVI-M may also be good candidates for adjuvant chemotherapy.

关键词： Hepatocellular carcinoma Microscopic portalvein invasion Hepatectomy Prognosis Recurrence

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Two cases of childhood absence epilepsy who showed seizure disappearance after ethosuximide drug eruption

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Acta Epileptologica 2022年第4期5卷 281-285页

作者： Takuji Nakamura Keiko Uda Muneaki Matsuo masafumi Zaitsu Department of Pediatrics Faculty of MedicineSaga UniversitySagaJapan Department of Pediatrics National Hospital Organization Ureshino Medical Center4279-3 Shimojuku KouUreshino CitySaga843-0393Japan

Background Recent studies suggest potential roles of immune response in the pathophysiology of ***-seizure medications(ASMs)are known to have side effects of drug eruption caused by immune responses.A few reports in adults have demonstrated disappearance of seizures after an ASM drug eruption *** this paper,we described 2 cases of childhood absence epilepsy(CAE)who showed seizure disappearance after ethosuximide(ESM)drug eruption,suggesting the possibility that the epilepsy disappears due to immune responses to *** presentation Case 1 was an 8-year-old girl diagnosed with *** was treated with valproate acid(VPA)initially,and then ESM was administered as an additional *** epileptic seizure disappeared 4 days after initiation of ***,drug eruption appeared 1 week after the administration of *** after discontinuation of ESM administration,she maintains no seizure after the drug *** 2 was a 5-year-old boy diagnosed as *** was treated with VPA initially,and ESM was administered *** eruption appeared 1 month after the administration of *** after ESM was terminated,he maintained seizure freedom after the appearance of *** Epileptic seizures may have been suppressed due to the immune responses caused by ASM *** studies are needed to elucidate the pathophysiologic effects of drug eruption on epilepsy through immune responses.

关键词： Childhood absence epilepsy Drug eruption Ethosuximide Seizure disappearance

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