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Intravesical Non-Alkalinized Lidocaine Instillation for Interstitial Cystitis/Bladder Pain Syndrome Patients

Open Journal of Urology 2012年第4期2卷 223-226页

作者： Teiichiro Aoyagi masaaki tachibana Tokyo Medical University Ibaraki Medical Center Inashiki Japan

Purpose: The effectiveness of daily or weekly instillation of non-alkalinized lidocaine for patients suffering interstitial cystitis and/or bladder pain syndrome was evaluated retrospectively. Patients and methods: Five female patients (40 - 71 years old) diagnosed as interstitial cystitis by cystoscopic findings and a 68 year-old bladder pain syndrome patient were enrolled. All patients, having interstitial cystitis, had undergone hydrodistention therapy previously and had not improved their symptoms by empirical therapies. Daily or weekly (upon their severity of symptoms) intravesical instillation of 20 ml of 4% non-alkalinized (pH 6.0 - 7.0) lidocaine solution was performed for several times, and patients were asked to keep them in the bladder as long as two hours each time. Previous medications such as anti-cholinergic drugs and analgesics were continued according to patient's requirements and symptoms. The treatment effect was evaluated comparing O'Leary-Sant Symptom Index for interstitial cystitis patients and visual analog pain scale before and after the series of lidocaine therapies. Results: Instillation was made 6 to 16 times. Patients with interstitial cystitis improved their symptoms from O'Leary-Sant Symptom Index 17.5 to 10, Problem Index from 14.8 to 6 in an average. Crouching pain disappeared in all these patients after the instillation therapy. Severe interstitial cystitis findings on cystoscopy disappeared completely in one patient after the therapy. One patient having bladder pain syndrome reduced her analgesics use, and bladder-filling pain decreased from 7 to 3 as a visual analog scale score. One patient complained palpitation at 11th instillation and abandoned treatment thereafter, otherwise, none of these patients showed side effect concerning lidocaine toxicity. Conclusions: Intravesical non-alkalinized lidocaine instillation therapy for interstitial cystitis/bladder pain syndrome patients were an easy, safe and effective treatment.

关键词： Bladder Pain Syndrome Interstitial Cystitis Lidocaine Instillation Therapy

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Tips for Office-Based Transurethral Biopsy and Fulguration as a Treatment of Tiny Bladder Tumors

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Open Journal of Urology 2013年第6期3卷 253-255页

作者： Teiichiro Aoyagi Isao Kuroda masaaki tachibana Tokyo Medical University Ibaraki Medical Center Inashiki Japan Tokyo Medical University Tokyo Japan

Among the patients who underwent outpatient cystoscopy as a follow up of bladder cancer, quite a few patients are observed tiny papillary lesions suspicious for tumor recurrence. Transurethral biopsy and/or resection under spinal or general anesthesia in a hospitalized setting are the usual procedures for this kind of patients, even though these procedures are simple and brief. We tried transurethral biopsy and fulguration as a treatment for very small bladder tumor in an outpatient setting and here describe tips for these procedures. Olympus CYF-VA flexible cystoscope, a 3 Fr. diathermy probe, monopolar electrosurgical unit were used. No additional anesthetics except for 10 ml of 2% Xylocaine gel applied to (male patient’s) urethra as an initial flexible cystoscopic procedure, was required for tumor treatment. Distilled water was used as an irrigation fluid. Experienced tips of the procedures to avoid tumor recurrence are as follows: tumor should be one location, size of the tumor should be less than 5 mm, bladder should be washed several times after the fulguration with hundreds ml of distilled water. We conclude that outpatient biopsy and fulguration for tiny bladder tumor is effective and less invasive procedure as a treatment of bladder cancer patients.

关键词： Transurethral Surgery Bladder Cancer Office Urology Fulguration Biopsy

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Sarcomatoid Carcinoma of the Urinary Bladder

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Case Reports in Clinical Medicine 2014年第4期3卷 187-191页

作者： Kenji Shimodaira Isao Kuroda Naohiro Kamoda Takuya Ishida Teiichiro Aoyagi masaaki tachibana Department of Urology Ibaraki Medical Center Tokyo Medical University Ibaraki Japan Department of Urology Tokyo Medical University Hospital Tokyo Japan

The patient was a 62-year-old female with bladder carcinoma. TUR-BT was performed in March 2010, and the pathological finding was UC, G2 > G1, pTa. However, the cancer recurred in the urinary bladder 3 months after TUR-BT. Radical cystectomy was performed, and the disease was considered to have been cured, but metastasis developed in the skin, lung, liver, and bone several months after surgery. Chemotherapy was ineffective, and the patient died. On pathological examination at the time of radical cystectomy, the lesion was sarcomatoid carcinoma of the urinary bladder. Although the prognosis associated with this carcinoma is known to be poor, the possibility of underestimation on preoperative staging cannot be ruled out from the cause, in addition to the insufficiency of the current therapeutic strategy.

关键词： Sarcomatoid Carcinoma Bladder Cancer

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Pathologic and Prognostic Outcomes of Very Low- and Low-Risk Prostate Cancer According to the National Comprehensive Cancer Network Guidelines in Japanese Patients with Radical Prostatectomy

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Journal of Cancer Therapy 2016年第4期7卷 239-246页

作者： Issei Takizawa Makoto Ohori Yoshio Ohno Jun Nakashima Rie Inoue Toshitaka Nagao masaaki tachibana Department of Urology Tokyo Medical University Tokyo Japan Department of Pathology Tokyo Medical University Tokyo Japan

Background: The purpose of this study was to validate the treatment strategy for a cohort of Japanese patients with very low-risk (VLR) and low-risk (LR) prostate cancer according to the National Comprehensive Cancer Network (NCCN) guidelines. Methods: We studied 751 patients with T1- 3N0M0 prostate cancer treated with radical prostatectomy at our institution between 2000 and 2012. Patients with neoadjuvant treatments were excluded. We retrospectively reviewed the clinical and pathological outcomes for patients with VLR or LR prostate cancers that were classified by NCCN guidelines. Results: We identified 45 patients with VLR and 137 with LR prostate cancer. Non-biochemical recurrence rate at 5-year for 45 patients with VLR was 86.9% and 81.2% for 137 patients with LR (p = 0.56). However, none of the 19 patients >65 years old with VLR progressed, while 19% of 26 patients ≤65 years old with VLR cancer, 14% of patients >65 years old with LR cancer, and 17% of patients ≤65 years old with LR cancer progressed during the follow-up period (p = 0.04, p = 0.04 and p = 0.05, respectively). In analyses of prostatectomy specimens, both VLR and LR had similarly favorable outcomes, but patients >65 years old with VLR had the smallest tumors, with a mean of 5 mm in diameter. Conclusions: Our results support the treatment strategy of the NCCN that patients with VLR cancer and age >65 years old are good candidates for active surveillance, and that other treatment options—including active surveillance and aggressive treatments—can be applied to the remaining patients with VLR or LR cancers.

关键词： Prostate Cancer NCCN Guideline Very Low-Risk Low-Risk Active Surveillance

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Problems in Japan’s Aging Society from the Perspective of Lichen Sclerosus

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Case Reports in Clinical Medicine 2015年第2期4卷 69-71页

作者： Naohiro Kamoda Isao Kuroda Kenji Shimodaira Issei Takizawa masaaki tachibana Teiichiro Aoyagi Department of Urology Ibaraki Medical Center Tokyo Medical University Ibaraki Japan Department of Urology Tokyo Medical University Hospital Tokyo Japan

We encountered 12 elderly patients with lichen sclerosus (LS), a relatively high percentage of whom were living with their families. There is a tendency to assume that elderly people living alone or older facility users with paralysis are more likely to require social care, but we note that elderly people living with their families are also likely to develop LS.

关键词： Lichen Sclerosus Aging Society

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An Information-Based Elite-Guided Evolutionary Algorithm for Multi-Objective Feature Selection

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 264-266页

作者： Ziqian Wang Shangce Gao Zhenyu Lei masaaki Omura the Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan IEEE

Dear Editor, This letter is concerned with the evolution strategy for addressing multi-objective feature selection problems in classification. Previous methods suffer from limitations such as being trapped in local optima and lacking stability. To overcome them, we propose a novel eliteguided mechanism based on information theory. Firstly, an elite solution is generated through a dimension reduction strategy and incorporated to the initialization population.

关键词： stability theory overcome

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Dendritic Learning-Incorporated Vision Transformer for Image Recognition

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 539-541页

作者： Zhiming Zhang Zhenyu Lei masaaki Omura Hideyuki Hasegawa Shangce Gao Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan IEEE

Dear Editor,This letter proposes to integrate dendritic learnable network architecture with Vision Transformer to improve the accuracy of image *** this study,based on the theory of dendritic neurons in neuroscience,we design a network that is more practical for engineering to classify visual *** on this,we propose a dendritic learning-incorporated vision Transformer(DVT),which out-performs other state-of-the-art methods on three image recognition benchmarks.

关键词： Image network image

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Dendritic Deep Learning for Medical Segmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 803-805页

作者： Zhipeng Liu Zhiming Zhang Zhenyu Lei masaaki Omura Rong-Long Wang Shangce Gao the Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan the Faculty of Engineering University of FukuiFukui-shi 910-8507Japan IEEE

Dear Editor,This letter presents a novel segmentation approach that leverages dendritic neurons to tackle the challenges of medical imaging *** this study,we enhance the segmentation accuracy based on a SegNet variant including an encoder-decoder structure,an upsampling index,and a deep supervision ***,we introduce a dendritic neuron-based convolutional block to enable nonlinear feature mapping,thereby further improving the effectiveness of our approach.

关键词： thereby Deep enable

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Principals’and Teachers’Awareness,Knowledge,and Differentiation of Privatization-A Secondary Publication

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Journal of Contemporary Educational Research 2024年第2期8卷 183-186页

作者： masaaki Katsuno Department of School Improvement and Policy Studies School of EducationUniversity of TokyoJapan

Based on the keynote report by Professor Martin Thrupp,this paper discusses the hollowing out of education provision by the state and the permeation of *** was pointed out that principals and boards of trustees in socioeconomically advantaged areas may not be willing to share their benefits with schools in less advantaged *** new liberal policies have hollowed out state provision of education,so the education system has come to rely heavily on private *** paper also presents the current stage of privatization in Japan and the principals’and teachers’perceptions of privatization.

关键词： Privatization Education Principals and teachers

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Formation and Properties of Organic Long Persistent Luminescence Crystals Containing Benzidine Derivatives by Melt Crystallization

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Advances in Chemical Engineering and Science 2024年第1期14卷 1-7页

作者： Norihito Doki Kiyoka Maruyama masaaki Yokota Department of Chemistry and Bioengineering Faculty of Engineering Iwate University Morioka Japan

Organic molecules that exhibit long persistent luminescence (LPL) are rapidly gaining attention for a variety of applications. In this study, organic molecules with simple structures were selected and organic long persistent luminescence (OLPL) crystals were prepared. The crystal structure of the prepared OLPL crystal was elucidated and the guideline for the design of OLPL crystal was clarified. LPL was observed in OLPL crystals prepared with TMB as the guest molecule and 1,2-bis(diphenylphosphino)ethane as the host molecule. XRD measurements of the OLPL crystals suggest that the guest molecule is a solid solution substituted in the stable crystal structure of the host molecule in a lattice-shrinking direction.

关键词： Melt Crystallization Host-Guest Chemistry

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