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Changes in hydrological regime in High Arctic non-glaciated catchment in 1979-2020 using a multimodel approach

Advances in Climate Change Research 2022年第4期13卷 517-530页

作者： marzena osuch Tomasz WAWRZYNIAK Marta MAJERSKA Institute of Geophysics Polish Academy of SciencesWarsaw 01-452Poland

Assessing hydrological consequences of climate change at the catchment scale is recently among key problems in *** study focuses on the estimation of changes in the hydrological regime in the Fuglebekken catchment in SW Spitsbergen(Svalbard).For this purpose,50 rainfll-runoff models were calibrated using available hydrometeorological *** models were validated based on archival flow and SWE observations,and proxy data from time-lapse *** models(FLEX-IS,GSM-SOCONT,PRMS,HBV,Nordic HBV,and GR4J)with the best performance were applied to reconstruct the past hydrological conditions and analyse the trends in flow regime in the period *** significant changes at 0.05 level in the flow regime indicators were detected,including the number of days with the active flow during the calendar year(10.8 d per decade),during the mid-May-November period(9.8 d per decade),the date of the first day with the flow(-4.7 d per decade),and the last day with the flow during mid-May-November(8.4 d per decade).A statistically significant increase in runoff was estimated for two periods from mid-May to the end of June and the second part of August till *** changes in the first period result from increases in air temperature and earlier snowmelt-driven *** estimated runoff increase in the second period corresponds to large increases in *** increase in air temperature,earlier disappearance of snow,and decrease in precipitation in July and the first part of August result in runoff *** presented results show that the Fuglebekken‘catchment's hydrological regime has already *** magnitude of the changes is larger compared to catchments located in lower latitudes.

关键词： Hydrological regime Climate change Svalbard High Aretic catchment hydrology Multimodel approach

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Unveiling the silent crisis:global burden of suicide‑related deaths among children aged 10–14 years

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World Journal of Pediatrics 2024年第4期20卷 371-391页

作者： Irmina Maria Michalek Pawel Koczkodaj marzena Michalek Florentino Luciano Caetano dos Santos Department of Cancer Epidemiology and Primary Prevention Maria Sklodowska-Curie National Research Institute of Oncologyul.Wawelska 15 BWarsawPoland Private Psychiatric Practice-marzena Michalek MDSiedlcePoland Harvard Business School Harvard UniversityBostonMAUSA

Background The rise in suicides among children aged 10–14 years demands urgent attention *** study aims to assess the global burden of suicide-related deaths in this age group from 1990 to 2019,considering factors such as sex,geography,and sociodemographics,to inform prevention strategies and *** The data from Global Burden of Disease 2019,encompassing 204 countries and territories,were analyzed to investigate deaths and years of life lost(YLLs)due to suicide among children aged 10–14 *** analyses,including mortality rates,YLLs,and the sociodemographic index(SDI),were conducted using standardized *** In 2019,a total of 8327[95%uncertainty interval(UI)=7073–9685]children aged 10–14 years died globally due to suicide,with a mortality rate of 1.30(95%UI=1.10–1.51)per 100,*** rates varied across countries/territories ranging between 0.05(95%UI=0.02–0.10)in South Africa and 7.49(95%UI=5.13–10.57)in *** contribution of suicide-related deaths to all-cause mortality ranged from 0.07%(95%UI=0.04%–0.15%)in South Africa to 33.02%(95%UI=24.36%–41.53%)in ***,there were approximately 636,196(95%UI=540,383–740,009)YLLs due to suicide,with a rate of 99.07(95%UI=84.15–115.23)per 100,*** association between SDI and suicide-related deaths was evident,with higher contributions observed in countries with higher *** This study reveals a concerning global burden of suicide-related deaths among children aged 10–14 *** progress in reducing mortality rates,suicide remains a significant *** overall rates have declined,the percentage of deaths caused by suicide in this age group is increasing.

关键词： Early adolescent Global Burden of Disease Incidence Suicide Years of life lost

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Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey Alexandra Jimenez-Armijo marzena Kawczynski Naji Kharouf Marie-Cecile Maniere Yann Herault Agnes Bloch-Zupan Virginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and Dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type Ⅱ,among others.

关键词： diseases den rigidity

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To treat or not to treat Alzheimer’s disease by the ketogenic diet? That is the question

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Neural Regeneration Research 2020年第5期15卷 857-858页

作者： marzena Ulamek-Koziol Ryszard Pluta Laboratory of Ischemic and Neurodegenerative Brain Research Mossakowski Medical Research CentrePolish Academy of SciencesWarsawPoland First Department of Neurology Institute of Psychiatry and NeurologyWarsawPoland

Alzheimer’s disease (AD) and current treatments: AD is a serious neurological disorder worldwide that affects about 26 million people,and whose prevalence has been calculated to quadruple by 2050,thus reaching over 1% of the total population,with the highest prevalence occurring in both adults and elderly (Pluta et al.,2018).Neurodegenerative processes of the sporadic form of AD probably start 20 years before the clinical onset of the disorder (Pluta et al.,2018).This disease is the most important cause of dementia in world aged society (~75%).AD is a disorder that affects not only patients but also their *** social and economic burden associated with AD was calculated as an example in the United States alone;600 billion dollars annually is spent on caring for AD patients (Pluta et al.,2018).AD is the one of the great health-care challenges of the 21st *** incidence of AD,a chronic and progressive neurodegenerative disorder,is increasing,as well as the need for efficient methods of diagnosis,prevention and treatment (Pluta et al.,2018).The characteristic clinical and neuropathological hallmarks of AD are: dementia as the main clinical symptom and in post-mortem neuropathological examination,the presence of amyloid plaques as well as neurofibrillary tangles and loss of neurons in the brain of AD *** role of amyloid and tau protein is questioned in the etiology of AD and other causes such as ischemic etiology are being considered (Pluta and U?amek-Kozio?,2019).There are several treatments that are not causal but symptomatic that are not effective,especially for advanced *** date,only a few drugs are approved,such as acetylcholinesterase inhibitors and *** that regulate partly the activity of neurotransmitters and partly alleviate behavioral *** treatment options include active and passive immunization,anti-aggregation specifics,and secretase *** road to clarity AD etiology,early final ante mortem dia

关键词： diagnosis Alzheimer prevention protein vitamin or cause has

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Simplified Numerical Study of Evaporation Processes Inside Vertical Tubes

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Journal of Thermal Science 2014年第2期23卷 177-186页

作者： Pawe Ocoń marzena Nowak Stanisaw Lopata Cracow University of Technology Faculty of Mechanical EngineeringInstitute of Thermal Power EngineeringAl.Jana PawaII 3731-864 CracowPoland

The paper presents a simplified numerical model of evaporation processes inside vertical *** this model only the temperature fields in the fluid domain(the liquid or two-phase mixture) and solid domain(a tube wall) are *** its performance and efficiency is *** analytical formulas,which allow calculating the pressure drop and the distribution of heat transfer coefficient along the tube length,are used in this *** energy equation for the fluid domain is solved with the Control Volume Method and for the solid domain with the Finite Element Method in order to determine the temperature field for the fluid and solid domains.

关键词： Numerical modeling heat transfer evaporation vertical tubes Finite Element Method

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The role of degenerative pathways in the development of irreversible consequences after brain ischemia

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Neural Regeneration Research 2019年第6期14卷 982-983页

作者： Ryszard Pluta marzena U?amek-Kozio? Laboratory of Ischemic and Neurodegenerative Brain Research Mossakowski Medical Research CentrePolish Academy of Sciences First Department of Neurology Institute of Psychiatry and Neurology

Ischemic stroke and irreversible consequences:Ischemic stroke in humans is the second most common cause of death in the world(Mozaffarian et al.,2016).The outcomes after a stroke are often dependent on complications,including motor disorders,depression and dementia(Pluta et al.,2018a),which causes a high risk of re-hospitalization and/or palliative *** is also the main reason for long-term disability in people after stroke,with up to half of those who survived the stroke will not regain their independence until the end of their lives(Mozaffarian et al.,2016).According to epidemiological forecasts,human ischemic stroke will soon become the dominant cause of death worldwide(Bejot et al.,2016)as well as dementia with the phenotype of Alzheimer’s disease(AD;Kim and Lee 2018).It is suggested that human ischemic stroke and experimental brain ischemia in animals are associated with the possible development of AD neuropathology(Pluta et al.,2018a).

关键词： degenerative pathways irreversible consequences brain ischemia

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Genes associated with Alzheimer's disease affecting ischemic neurodegeneration of the hippocampal CA3 region

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Neural Regeneration Research 2021年第7期16卷 1392-1393页

作者： Ryszard Pluta marzena Ułamek-Kozioł Laboratory of Ischemic and Neurodegenerative Brain Research Mossakowski Medical Research CentrePolish Academy of SciencesWarsawPoland

Neurodegeneration in the brain after ischemia with reperfusion mimicking the neuropathology of Alzheimer's disease:Brain ischemia with reperfusion,which is one of the main causes of morbidity and mortality in the world,triggers various neuropathological changes characteristic for Alzheimer's disease(AD)such as increased blood-brain barrier permeability,excitotoxicity,necrosis,autophagy,mitophagy,apoptosis,neuroinflammation,amyloid plaques,neurofibrillary tangles,cerebral vessel pathology,and brain atrophy that lead to the death of neurons,deteriorating motor,sensory and cognitive functions(Figure 1)(Kato et al.,1988;Wisniewski et al.,1995;Van Groen et al.,2005;Kocki et al.,2015;Ułamek-Koziołet al.,2016,2017,2019).Brain ischemia is recognized as a major contributor to the dysfunction of an aging brain and the development of neurodegenerative diseases,including AD(Pluta,2019).

关键词： Alzheimer ischemia cerebral

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The study of biological activity of transformation products of diclofenac and its interaction with chlorogenic acid

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Journal of Environmental Sciences 2020年第5期32卷 128-141页

作者： marzena Matejczyk Piotr Ofman Katarzyna Dabrowska Renata Swislocka Wlodzimierz Lewandowski Bialystok University of Technology Faculty of Civil Engineering and Environmental SciencesDepartment of ChemistryBiology and Biotechnology15-341BialystokPoland Bialystok University of Technology Department of Environmental Engineering TechnologyBialystok15-341Poland Waclaw Dabrowski Institute of Agricultural and Food Biotechnology Department of Microbiology02-532WarsawPoland

In the present work we compared the biological activity of DCF,4’-OHDCF and 5-OHDCF as molecules of most biodegradation pathways of DCF and selected transformation products(2-hydroxyphenylacetic acid;2,5-dihydroxyphenylacetic acid and 2,6-dichloroaniline)which are produced during AOPs,such as ozonation and UV/H2 *** also examined the interaction of DCF with chlorogenic acid(CGA).CGA is commonly used in human diet and entering the environment along with waste mainly from the processing and brewing of coffee and it can be toxic for microorganisms included in activated *** the present experiment the evaluation of following parameters was performed:*** K-12 cells viability,growth inhibition of *** K-12 culture,LC50 and mortality of Chironomus aprilinus,ge no toxicity,sodA promoter induction and ROS *** addition the reactivity of *** SM recA:luxCDABE biosensor strain in wastewater matrices was *** results showed the influence of DCF,4’-OHDCF and 5-OHDCF on *** K-12 cells viability and bacteria growth,comparable to AOPs *** highest toxicity was observed for selected,tested AOPs by-products,in comparison to the DCF,4’-OHDCF and *** assay indicated that 2,6-dichloroaniline(AOPs by-product)had the highest toxic *** oxidative stress assays revealed that the highest level of ROS generation and sodA promoter induction were obtained for DCF,4’-OHDCF and 5-OHDCF,compared to other tested *** have also found that there is an interaction between chlorogenic acid and DCF,which resulted in increased toxicity of the mixture of the both compounds to *** K-12,comparable to parent *** strongest response of *** SM biosensor strain with recA:luxCDABE genetic construct in filtered treated wastewaters,comparable to control sample was *** indicates,that *** SM recA:luxCDABE biosensor strains is a good tool for bacteria monitoring in wastewater *** to toxicity and biological

关键词： Diclofenac Biodegradation Chlorogenic acid Advances oxidation processes (AOPs) Wastewaters Microbial biosensors

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Co-integration-based analysis of energy assurance for steady economic growth in China

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Journal of China University of Mining and Technology 2008年第2期18卷 250-254页

作者： HE Ya-qun LAO Guo-hong osuch Chris E ZUO Wei-ran WEN Bao-feng China Lixin Risk Management Research Institute Shanghai 201620 China School of Chemical Engineering and Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221116 China Telephotonics Inc. Wilmington MA 01887 USA

By applying co-integration analysis,the Granger causality test and an error correction model,the dependency between the energy consumption and the gross domestic product of China was *** a further step an analysis was done to establish a correlation between the economic growth of different industries and China's energy *** evidence-based study showed that a co-integration relationship exists between the gross energy consumption and the GDP of China and that the two variables possess bi-directional *** energy consumption for the secondary industry has a markedly stimulative effect to the economic *** paper also uses an error correction model(ECM)to explain the short-term behavior of energy demands.

关键词： energy consumption co-integration examination Granger causality error correction model

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Homocysteine in pregnancies complicated by preeclampsia with and without IUGR: a comparison with normotensive pregnant women with isolated IUGR and healthy pregnant women

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Open Journal of Obstetrics and Gynecology 2011年第4期1卷 191-196页

作者： marzena Laskowska Jan Oleszczuk 不详

Objective: The aim of this study was to analyze homocysteine levels in maternal serum in women with pregnancies complicated by preeclampsia and/or IUGR. Patients and methods: The study was carried out on 49 pregnant patients with normotensive pregnancies complicated by intrauterine fetal growth restriction (group IUGR), 31 patients with preeclampsia complicated by IUGR (group PRE-IUGR), and 35 preeclamptic patients with appropriate-for-gestational-age weight fetuses (group PRE). The control group consisted of 47 healthy normotensive pregnant patients with singleton uncomplicated pregnancies and with proper intrauterine fetal growth. Results: We revealed higher levels of maternal serum homocysteine in the group of pregnant patients with isolated fetal intrauterine growth restriction in comparison with the control subjects. The concentrations of homocysteine were also higher in both groups of patients with pregnancy complicated by preeclampsia with and without IUGR. The highest levels of homocysteine were observed in preeclamptic women with appropriate-for-gestational-age fetal growth. The mean values were 9.004 +/– 2.820 umol/L in the IUGR group, 10.815 +/– 3.785 umol/ L in the group PRE, 9.808 +/– 2.543 umol/L in the group PRE-IUGR and 7.639 +/– 2.728 umol/L in the control group. Conclusions: Increased levels of homocysteine are involved in pathogenesis IUGR and preeclampsia and may contribute to endothelial cells activation or dysfunction observed in these pregnancy disorders. Further studies are needed to explain these aspects in order to improve the management and therapeutic strategies for pregnancies complicated by IUGR and/or preeclampsia.

关键词： Homocysteine Intrauterine Fetal Growth Restriction (IUGR) Preeclampsia

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