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Cost-effectiveness of remdesivir for the treatment of hospitalized patients with COVID-19:a systematic review

Infectious Diseases of Poverty 2023年第2期12卷 112-112页

作者： Aziz Rezapour Zahra Behroozi Mostafa Nasirzadeh Mohsen Rezaeian Mohammad barzegar Mahsa Tashakori-Miyanroudi Abdollah Sayyad Aghdas Souresrafil Health Management and Economics Research Center Health Management Research InstituteIran University of Medical SciencesTehranIran Physiology Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKermanIran Department of Health Education and Health Promotion School of HealthOccupational Environment Research CenterRafsanjan University of Medical SciencesRafsanjanIran Department of Epidemiology and Biostatistics School of MedicineOccupational Environment Research CenterRafsanjan University of Medical SciencesRafsanjanIran Department of English Language Teaching School of Health Management and Information SciencesIran University of Medical SciencesTehranIran Psychiatry and Behavioral Sciences Research Center Addiction InstituteMazandaran University of Medical SciencesSariIran Department of Health Services and Health Promotion School of HealthOccupational Environment Research CenterRafsanjan University of Medical SciencesRafsanjanIran

Background Remdesivir is being studied and used to treat coronavirus disease 2019(COVID-19).This study aimed to systematically identify,critically evaluate,and summarize the findings of the studies on the cost-effectiveness of remdesivir in the treatment of hospitalized patients with *** In this systematic review,PubMed,EMBASE,Web of Science,SCOPUS,and the Cochrane Library were searched for studies published between 2019 and *** included all full economic evaluations of remdesivir for the treatment of hospitalized patients with *** were summarized in a structured and narrative *** Out of 616 articles obtained in this literature search,12 studies were included in the final *** mean score of the Quality of Health Economic Studies(QHES)for the studies was 87.66(high quality).All studies were conducted in high-income countries(eight studies in the USA and one study in England),except for three studies from middle-to-high-income countries(China,South Africa,and Turkey).Six studies conducted their economic analysis in terms of a health system perspective;five studies conducted their economic analysis from a payer perspective;three studies from the perspective of a health care *** results of five studies showed that remdesivir was cost-effective compared to standard ***,the therapeutic strategy of combining remdesivir with baricitinib was cost-effective compared to remdesivir *** Based on the results of the present study,remdesivir appears to be cost-effective in comparison with the standard of care in China,Turkey,and South *** conducted in the United States show conflicting results,and combining remdesivir with baricitinib is cost-effective compared with remdesivir ***,the cost-effectiveness of remdesivir in low-income countries remains ***,more studies in different countries are required to determine the cost-effectiveness of this drug.

关键词： Cost-effectiveness Remdesivir COVID-19 SARS-CoV-2

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Ultrasound Guided Port-A-Cath Implantation

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Surgical Science 2014年第4期5卷 159-163页

作者： Hossein Hemmati Mohammad Sadegh Esmaeli Delshad Mohammad Reza barzegar Ali Babaei Jandaghi Behruz Najafi Mohammad Reza Asgary Acieh Es-Haghi Departement of Radiology Poursina Hospital Guilan University of Medical Sciences Rasht Iran Division of Oncology Department of Internal Medicine Razi Hospital Guilan University of Medical Sciences Rasht Iran Division of Vascular Surgery Department of Surgery Razi Hospital Guilan University of Medical SciencesRasht Iran

Purpose: The use of port catheters is well accepted in the management of patients with malignancy. In this study, we compare the technical success and the complication rates of ultrasound guided Port-A-Cath implantation with doing this procedure by using the anatomical landmark method. Methods: In a retrospective study, from 2006 to 2009, medical files of 104 patients who had undergone Port-A-Cath implantation were reviewed. The indication for port catheter implantation was malignancy in all cases. Among our patients, Port-A-Cath implantation was done in 63 patients by using landmark method and in 41 patients by guidance of ultrasound. All patients had been observed for complications including pain, port infection, and port thrombus, thrombus of central veins, skin necrosis, and success in using of Port-A-Cath for at least one month following the procedure, in the vascular clinic. Results: in landmark method group, 2 catheters were non-functional just after placement (3.2%) while all Port-A-Caths in ultrasound-guided group were functional. Ten patients (15.9%) in land mark group and 1 patient (2.4%) in ultrasound-guided group were complicated. The difference between complication rate in anatomic landmarks method and ultrasound-guided method was statistically significant (p There was no significant difference in two groups in duration of port placement (p < 0.345), age (p < 0.444), site of port placement (p < 0.244) or type of malignancy (p < 0.18). Conclusion: Considering high rate of success and low complications in placement of Port-A-Cath with ultrasound guidance, this method is superior to the land mark method in patients with malignancy.

关键词： Ultrasound Guided Port-A-Cath Implantation

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Study of the effects of natural toothbrush (<i>Salva-dora persica</i>) in prevention of dental caries and plaque index

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Health 2012年第9期4卷 612-618页

作者： Fatemeh Ezoddini-Ardakani Mahmoud Nouri Shadkam Hasan Fotouhi Farah Bolouri Kashani Mahin Abbassi Zahra Hashemian Hossein Dehghani Mohammad Ali Jaffari Hossein barzegar Faezeh Nazarinejhad Mohammad Kazem Jafari Abas Heydaripour Mohammad Javad Dashti Atefesadat Hedayati Masoud Masoumi Somaye Ebrahimi Faculty of Dentistry Shahid Sadoughi University of Medical Sciences Yazd Iran Faculty of Medicine Shahid Sadoughi University of Medical Sciences Yazd Iran Shahid Sadoughi University of Medical Sciences Yazd Iran

Background: Nowadays, though more attention is being paid to oral and dental hygiene all over the world, dental caries and periodontal diseases are increasing daily. We decided to study the effectiveness of natural toothbrush in prevention of dental caries and plaque formation. Methods: This analytic, semi-experimental clinical trial included 390 individuals. Subjects were divided into 3 groups: using natural toothbrush, using artificial toothbrush and using both natural and artificial toothbrush. The plaque index and DMFT was assessed at the beginning of the study until 1 year. ANOVA, Kruskal Wallis, LSD, Paired t-test, chi square, Fisher exact and Mc-Nemar tests were used for data analysis. Results: The plaque index in all three groups showed a mean reduction of 0.71. The mean DMFT in the samples before intervention was 8.38 ± 4.14 and increased to 9.1 ± 4.56. At the end of the study, the lowest plaque index was observed in the group using both the natural and artificial methods. During one year follow-up, the plaque index decreased 1.16, 0.83, and 0.21 degrees in the first, second and third groups. Conclusion: The increase in DMFT in the group that used artificial toothbrush was more than other groups. Thus, use of natural toothbrush leads to a decrease in growth rate of DMFT. Therefore natural toothbrush can be used for the cleaning of teeth and prevention of dental caries.

关键词： Salvadora persica Natural Toothbrush Toothbrush and Tooth Paste Caries Plaque Index

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