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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha Charles R.pedlar Shane C.Burgess Michael p.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

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Determinants of infant behavior and growth in breastfed late preterm and early term infants:a secondary data analysis

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World Journal of pediatrics 2023年第10期19卷 983-991页

作者： Xinzhuo Zhang Jinyue Yu Zhuang Wei mary Fewtrell Division of Medicine University College LondonLondonUK population Policy and Practice Research and Teaching DepartmentUCL Great Ormond Street Institute of Child HealthUniversity College LondonLondonUK Department of Child Healthcare Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Background Late preterm and early term infants are at increased risk of poor growth,behavioral problems,and developmental *** study aimed to investigate the impact of maternal and infant characteristics,feeding practices,and breastmilk composition on infant behavior following late preterm and early term delivery,and to evaluate the association between infant behavior and *** Data from 52 Chinese mothers and their late preterm/early term infants participating in the Breastfeed a Better Youngster study were *** and infant characteristics were collected using questionnaires at 1 week *** macronutrient content was measured using a human milk analyzer,and infant behavior was assessed using a 3-day infant behavior diary at 8 weeks *** practices were collected at both time points using *** models were used to assess associations between potential predictors and infant behavior and between infant behavior and *** Exclusive breastfeeding was associated with greater sleep duration(p=0.02)and shorter crying duration(p=0.01).Mothers with a vocational education reported greater distress duration(p=0.006).Greater colic duration was associated with higher maternal annual income(p=0.004).There was no significant association between infant behavior and growth(all p>0.05).Conclusions Exclusive breastfeeding might promote more favorable infant behaviors in late preterm/early term infants,while the development of infant distress behaviors was associated with some maternal characteristics(maternal education and annual income).However,due to the limitations of diary methods,determinants of infant behavior should ideally be assessed using more objective measures in larger samples.

关键词： Breastfeeding Growth and development Infant behavior premature infant

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Efficient Technique for Image Cryptography Using Sudoku Keys

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Computers, Materials & Continua 2023年第10期77卷 1325-1353页

作者： M.A.p.Manimekalai M.Karthikeyan I.Thusnavis Bella mary K.Martin Sagayam Ahmed A Elngar Unai Fernandez-Gamiz Hatıra Günerhan Department of ECE Karunya Institute of Technology and SciencesCoimbatore641114India Faculty of Computer and Artificial Intelligence Beni-Suef UniversityBeni-Suef62511Egypt Nuclear Engineering and Fluid Mechanics Department University of the Basque CountryBilbao48940Spain Department of Mathematics Faculty of EducationKafkas UniversityKars36100Turkey

This paper proposes a cryptographic technique on images based on the Sudoku *** is a number puzzle,which needs applying defined protocols and filling the empty boxes with *** a small size of numbers as input,solving the sudoku puzzle yields an expanded big size of numbers,which can be used as a key for the Encryption/Decryption of *** this way,the given small size of numbers can be stored as the prime key,which means the key is compact.A prime key clue in the sudoku puzzle always leads to only one solution,which means the key is always *** feature is the background for the paper,where the Sudoku puzzle output can be innovatively introduced in image *** solution is expanded to any size image using a sequence of expansion techniques that involve filling of the number matrix,Linear X-Y rotational shifting,and reverse shifting based on a standard zig-zag *** crypto key for an image dictates the details of positions,where the image pixels have to be *** is made at two levels,namely pixel and sub-pixel(RGB)levels for an image,with the latter having more effective *** brought-out technique falls under the Image scrambling method with partial *** metrics are impressive and are given by a Histogram deviation of 0.997,a Correlation coefficient of 10−2 and an NpCR of 99.98%.Hence,it is evident that the image cryptography with the sudoku kept in place is more efficient against plaintext and Differential attacks.

关键词： Sudoku image cryptography pixels performance metrics

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Application of quantum computing in discrete portfolio optimization

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Journal of Management Science and Engineering 2023年第4期8卷 453-464页

作者： Justus Shunza mary Akinyemi Chika Yinka-Banjo Operations Research&Information Engineering Cornell University36 Hoy RoadIthaca14853New YorkUnited States Department of Mathematics University of LagosAkokaLagos101017LagosNigeria Department of Computer Sciences University of LagosAkokaLagos10101zLagosNigeria

This study proposes a novel and more efficient quantum algorithm for portfolio optimization using quantum combinatorial optimization(Qco)techniques.A recent construction developed in 2021 has sparked the field of financial portfolio optimization through the Quantum Walk Optimization Algorithm(QWOA).In this study,we investigated the complexity and efficiency of quantum optimization algorithms with a special interest in *** objective is to minimize investment risk by having a good combination of assets in the *** also focused on reducing the number of iterations while attaining a high-quality resolution through contraction of the solution space to ease *** concept of QwOA was extended by constructing a newly outperforming scheme known as the"Quantum Mix Optimization Algorithm(QMOA)."QMOA algorithm codes were provided for the implementation and simulation of numerical *** addition,the efficiency of QMOA,which is better than the existing QCO algorithms,was *** instance,the least QWOA number of computations required to execute the initial state equation was p>2,whereas this value was p≥2 in the proposed QMOA.

关键词： Combinatorial optimization Induced tadpolegraph Lattice Qubits Trajectory

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Differences between delusional disorder and schizophrenia:A mini narrative review

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World Journal of psychiatry 2022年第5期12卷 683-692页

作者： Alexandre González-Rodríguez mary V Seeman Department of Mental Health Mutua Terrassa University HospitalUniversity of BarcelonaBarcelona 08280Spain Department of psychiatry University of TorontoToronto M5P 3L6OntarioCanada

psychotic syndromes are divided into affective and non-affective *** among the non-affective forms,substantial differences *** aim of this relatively brief review is to synthesize what is known about the differences between two non-affective psychoses,schizophrenia and delusional disorder(DD),with respect to clinical,epidemiological,sociodemographic,and treatment response characteristics.A pubMed literature search revealed the following:in schizophrenia,hallucinations,negative symptoms and cognitive symptoms are *** are rare in *** to schizophrenia patients,individuals with DD maintain relatively good function,and their delusions are believable;many are beliefs that are widely held in the general *** are generally similar in these two forms of psychosis,with the exception that antidepressants are used more frequently in DD and,for acute treatment,effective antipsychotic doses are lower in DD than in *** is with the hope that the contrasts between these two conditions will aid in the provision of safe and effective treatment for both that this review has been conducted.

关键词： Non-affective psychosis Delusional disorder Schizophrenia Epidemiology Symptoms Treatment response

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Intestinal parasitic infections in Aetas and domesticated swine in pampanga,philippines

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Asian pacific Journal of Tropical Medicine 2022年第11期15卷 522-524页

作者： Jessica Joyce R De Guia mary Jane C Flores Derick Erl p Sumalapao Eligio Santiago V Maghirang Vicente Y Belizario Jr. Department of Biology College of ScienceDe La Salle UniversityManilaPhilippines Biological Control Research Unit(BCRU) Center for Natural Sciences and Environmental Research(CENSER)College of ScienceManila Ehime University-De La Salle University International Collaborative Research Laboratory De La Salle UniversityLaguna CampusLaguna ProvincePhilippines Department of Epidemiology and Biostatistics College of Public HealthUniversity of the PhilippinesManilaPhilippines Department of Internal Medicine-Section of General Medicine Department of Medical Education and Research the Makati Medical Center Department of Emergency Medicine Asian Hospital and Medical CenterMetro ManilaPhilippines Department of parasitology College of Public HealthUniversity of the PhilippinesManilaPhilippines

Indigenous peoples account for about 6%of the world’s population and are highly vulnerable to parasitic infections[1,2].Aetas,one of the indigenous people groups in the philippines,rely on backyard swine production as their primary means of livelihood[3].Literature indicated that zoonoses arise from close physical contact and the cohabitation of humans with domesticated animals[4].Ascaris spp.

关键词： swine domestica habitat

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Estimation of Burden of Kidney Dysfunction in HIV-Infected pediatrics and Adolescents by Use of Urinary Neutrophil Gelatinase-Associated Lipocalin: A Single Center Experience in Kenya

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Infectious Diseases & Immunity 2022年第1期2卷 9-14页

作者： Anne p.Lomole William M.Macharia mary S.Limbe Doris W.Kinuthia Samuel K.Kabinga Aga Khan University Medical College East AfricaAga Khan University HospitalNairobiKenya University of Nairobi East African Kidney InstituteNairobiKenya

Background:About 75%of patients infected with human immunodeficiency virus(HIV)live in sub-Saharan *** Kenya,about 1.5 million Kenyans are living with HIV,of whom almost 100,000 are children and *** active antiretroviral therapy(HAART)has converted HIV infection to a chronic illness with its attendant *** disease is a common complication of HIV infection and its *** disease in HIV-infected persons can be asymptomatic,insidious onset and may lack specific clinical *** can only be detected on active *** urine albumin-to-creatinine ratio and estimated glomerular filtration rate(eGFR)using serum creatinine are not sensitive in identification of early kidney *** neutrophil gelatinase-associated lipocalin(uNGAL)has been used as marker of early kidney ***:This cross-sectional study used uNGAL and serum creatinine to determine the prevalence of kidney dysfunction in HIVinfected children and adolescents with HAART at Gertrude’s Children’s Hospital,Nairobi,Kenya,from March 2016 to February *** samples were assayed for uNGAL using the Bio porto®enzyme-linked immunosorbent *** creatinine was assayed using the Jaffe reaction in the Cobas®6000 biochemistry analyzer and eGFR calculated using the Schwartz *** plot of eGFR against log uNGAL levles was performed by Statistical package for Social Sciences and pearson correlation coefficeint between log uNGAL levles and eGFR was ***:Ninety-three patients were *** mean age was 11.8±3.6 years and the median duration on HAART was 72.6 *** were 47(50.5%).The prevalence of kidney dysfunction using uNGAL was 15.1%(95%CI 7.6%–22.5%)and 5.4%(95%CI 1.8%–12.1%)by *** mean eGFR was 131±25mL·min1·1.73m2 and median uNGAL was 10 ng/*** every one ng/mL increase in uNGAL value above the normal value,eGFR decreases by 4.8mL·min1·1.73m2(p=0.038).patients with elevated uNGAL were older when co

关键词： HIV Estimated glomerular filtration rate Highly active antiretroviral therapy Kidney disease Serum creatinine uNGAL

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Free radical scavenging and reducing power of Lawsonia inermis ***

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Asian pacific Journal of Tropical Medicine 2011年第6期4卷 457-461页

作者： philip Jacob p Madhumitha G mary Saral A pharmaceutical Chemistry Division School of Advanced SciencesVIT UniversityVellore-632014India

Objective:To determine the antioxidant activity,total phenolic and flavonoid content of petroleum ether extract（pE）,Dichloromethane extract（DCM）,Ethanol extract（ET） and aqueous extract（AQ） of henna ***:Total antioxidant assay（phosphomolybenum method）, DppH radical scavenging assay,reducing power assay and lipid peroxidation inhibition assay were used to ascertain the potential of seeds as an ***:In all the assays carried out ET showed a greater potential to scavenge DppH radical,reduce MO（Ⅳ） to MO（Ⅴ） complex and Fe（Ⅲ） to Fe（Ⅱ） and to inhibit lipid *** IC50 of ET was far greater than that of the standard,ascorbic acid（AS） in the lipid peroxidation *** activity of AQ was lesser when compared with that of ET but greater than pE and *** amount of phenolics and flavonoids were present in higher amounts in ET followed by *** amounts of phenolics were detected in pE and DCM,but the amount of flavonoids were below the detection *** study showed that the antioxidant activity and the concentrations of phenolics and flavonoids are proportionate to each ***:Ethanolic extract of henna seeds are efficient antioxidants,which can be utilized for further isolation of active compounds and pharmaceutical applications.

关键词： Lawsonia inermis Antioxidant Reducing free radical phenolics Flavonoids

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Brain Tumour Detection by Gamma DeNoised Wavelet Segmented Entropy Classifier

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Computers, Materials & Continua 2021年第11期69卷 2093-2109页

作者： Simy mary Kurian Sujitha Juliet Devaraj Vinodh p.Vijayan Karunya Institute of Technology and Science CoimbatoreIndia Albertian Institute of Science and Technology KochiIndia

Magnetic resonance imaging(MRI)is an essential tool for detecting brain ***,identification of brain tumours in the early stages is a very complex task since MRI images are susceptible to noise and other environmental *** order to overcome these problems,a Gamma MAp denoised Strömberg wavelet segmentation based on a maximum entropy classifier(GMDSWS-MEC)model is developed for efficient tumour detection with high accuracy and low time *** GMDSWS-MEC model performs three steps,namely pre-processing,segmentation,and *** the GMDSWS-MEC model,the Gamma MAp filter performs the pre-processing task and achieves a significant increase in the peak signal-tonoise ratio by removing noisy artefacts from the input brain *** pre-processing,Strömberg wavelet transform segmentation is carried out to partition the pre-processed image into a number of blocks based on the features extracted from the ***,the maximum entropy classifier identifies and locates the tumour from the input image based on extracted features with high accuracy and minimal error *** a number of MRI images,experimental evaluation and comparison of the proposed model and existing methods is carried out on the basis of four metrics:peak signalto-noise ratio,tumour detection accuracy,error rate,and tumour detection time with respect to MRI image *** proposed model offers superior performance in terms of all four metrics.

关键词： Gamma MAp filter Strömberg wavelet transform maximum entropy classifier

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Trends in gastrointestinal disease hospitalizations and outcomes during the first year of the coronavirus pandemic

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World Journal of Gastroenterology 2023年第4期29卷 744-757页

作者： Ayooluwatomiwa Deborah Adekunle Muni Rubens mary Sedarous Tahniyat Tariq philip N Okafor Division of Internal Medicine St.Luke's HospitalChesterfieldMI 63017United States Office of Clinical Research Miami Cancer InstituteMiamiFL 33176United States Division of Internal Medicine McMaster UniversityHamilton ON L8S 4L8OntarioCanada Division of Gastroenterology Stanford University School of MedicineRedwood CityCA 94063United States Division of Gastroenterology Stanford University College of MedicineRedwood CityCA 94063United States

BACKGROUND The impact of the coronavirus on hospitalizations for gastrointestinal(GI)disease,particularly at a population level is *** To investigate trends in hospitalizations,inpatient endoscopy resource utilization,and outcomes during the first year of the coronavirus pandemic and subsequent *** Using the California State Inpatient Database for 2018-2020,we explored year-toyear and 2020 month-to-month trends in hospitalizations,length of stay,and inpatient mortality(all-cause&viral pneumonia-specific)for common inpatient GI diagnoses including acute pancreatitis,diverticulitis,cholelithiasis,noninfectious gastroenteritis,upper and lower GI bleeding(LGIB),Clostridium difficile,viral gastroenteritis,inflammatory bowel disease,and acute *** Disease-specific hospitalizations decreased for all included conditions except nonvariceal upper GI bleeding(NVUGIB),LGIB,and ulcerative colitis(UC)(ptrendpatient mortality was higher in 2020 vs 2019,for acute pancreatitis(p=0.029),diverticulitis(p=0.04),NVUGIB(p=0.003),and Crohn’s disease(p=0.004).In 2020,hospitalization rates were lowest in April,November,and *** was no significant corresponding increase in inpatient mortality except in UC(ptrend=0.048).Viral pneumonia and viral pneumonia complicated by respiratory failure increased(ppt NVUGIB(ppitalization rates for common GI conditions significantly declined in California during the COVID pandemic,particularly in April,November and December *** mortality was significantly higher among acute pancreatitis,diverticulitis,NVUGIB,and Crohn’s disease *** endoscopy rates were mostly comparable between 2020 and 2019.

关键词： COVID-19 Shelter-in-place procedure utilization Outcomes Hospitalizations Gastrointestinal diseases

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