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Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study

Journal of Integrative Medicine 2015年第5期13卷 306-313页

作者： Deborah J.Engen Samantha J.Mc Allister mary o.whipple Stephen S.Cha Liza J.Dion Ann Vincent Brent A.Bauer Dietlind L.Wahner-Roedler Department of Physical Medicine and Rehabilitation Mayo Clinic Division of General Internal Medicine Mayo Clinic Division of Biomedical Statistics and Informatics Mayo Clinic

BACKGRoUND： Fibromyalgia is a syndrome characterized by chronic pain, fatigue, depression, and sleep disturbances. Its primary cause is unclear. Several studies have reported decreased intracellular magnesium levels in patients with fibromyalgia and have found negative correlation between magnesium levels and fibromyalgia symptoms.oBJECTIVE： To gather preliminary data on whether transdermal magnesium can improve quality of life for women who have fibromyalgia. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIoNS： This is a patient questionnaires and survey in a fibremyalgia clinic at a tertiary medical center. Forty female patients with the diagnosis of fibremyalgia were enrolled. Each participant was provided a spray bottle containing a transdermal magnesium chloride solution and asked to apply 4 sprays per limb twice daily for 4 weeks. Participants were asked to complete the Revised Fibromyalgia Impact Questionnaire, SF-36v2 Health Survey, and a quality-of-life analog scale at baseline, week 2, and week 4. MAIN oUTCoME MEASURE： Questionnaire and survey scores, evaluated through intent-to-treat and per-protocol analyses. RESULTS： Twenty-four patients completed the study （mean [SD] age, 57.2 [7.6] years; white, 95%; mean body mass index, 31.3 kg/m2）. With intention-to-treat analysis, Revised Fibromyalgia Impact Questionnaire subscale and total scores were significantly improved at week 2 and week 4 （total score, P = 0.001）. Per-protocol analysis results were similar： all subscales of the Revised Fibremyalgia Impact Questionnaire were significantly improved at week 2 and week 4 （total score, P = 0.001）. CoNCLUSIoN： This pilot study suggests that transdermal magnesium chloride applied on upper and lower limbs may be beneficial to patients with fibromyalgia.

关键词： fibromyalgia magnesium chloride Revised Fibromyalgia Impact Questionnaire clinical trial

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Forgiveness education in fibromyalgia: A qualitative inquiry

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Pain Studies and Treatment 2014年第1期2卷 11-16页

作者： Loren L. Toussaint Ann Vincent mary o. whipple Samantha J. McAllister Dawn M. Finnie Julie C. Hathaway Terry H. oh Kevin C. Fleming Kristin S. Vickers Douglas Department of Psychology Luther College Decorah USA Division of Health Care Policy and Research Mayo Clinic Rochester USA Division of Health Care Policy and Research Mayo Clinic Rochester USA Department of Psychiatry and Psychology Mayo Clinic Rochester USA Fibromyalgia and Chronic Fatigue Clinic Mayo Clinic Rochester USA Patient Education Research Mayo Clinic Rochester USA

The purpose of this qualitative study was to assess perspectives on the acceptability and the potential applicability of a forgiveness education in patients with fibromyalgia. The concept and tools of forgiveness were presented to thirteen women (age: 40 - 54 years) with a previous diagnosis of fibromyalgia. Subjects participated in 1 of 2 focus groups following a 90-minute education session in which forgiveness was presented as an emotion-focused coping strategy to deal with interpersonal stressors. Qualitative assessment of focus group discussions reveals 3 themes: 1) forgiveness is healthy and reduces pain, 2) forgiveness is within a patient’s personal control, and 3) forgiveness education is similar to other types of patient education and is well received. our results suggest that forgiveness education is acceptable and feasible in patients with fibromyalgia. This justifies further exploration of forgiveness as an emotion-focused self- management strategy to decrease psychological distress.

关键词： Fibromyalgia Forgiveness Intervention Pain Patient Education

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Neoadjuvant therapy for pancreatic ductal adenocarcinoma:opportunities for personalized cancer care

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World Journal of Gastroenterology 2021年第27期27卷 4383-4394页

作者： Ahmad Hamad Zachary J Brown Aslam M Ejaz mary Dillhoff Jordan M Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43215United States

Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignancy that is best treated in a multidisciplinary fashion using surgery,chemotherapy,and *** chemotherapy has shown to have a significant survival benefit in patients with resected ***,up to 50%of patients fail to receive adjuvant chemotherapy due to postoperative complications,poor patient performance status or early disease *** order to ensure the delivery of chemotherapy,an alternative strategy is to administer systemic treatment prior to *** oncology refers to the application of diverse strategies to target therapies specific to characteristics of a patient’s *** traditionally emphasized in selecting targeted therapies based on molecular,genetic,and radiographic biomarkers for patients with metastatic disease,the neoadjuvant setting is a prime opportunity to utilize personalized *** this article,we describe the current evidence for the use of neoadjuvant therapy(NT)and highlight unique opportunities for personalized care in patients with PDAC undergoing NT.

关键词： Pancreatic cancer Preoperative therapy FoLFIRINoX Precision oncology Patient-reported outcomes Personalized medicine Targeted therapy whipple Pancreatectomy

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